UniProtKB - P16388 (KCNA1_MOUSE)
Potassium voltage-gated channel subfamily A member 1
Kcna1
Functioni
Miscellaneous
Activity regulationi
GO - Molecular functioni
- delayed rectifier potassium channel activity Source: UniProtKB
- disordered domain specific binding Source: MGI
- voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: MGI
- voltage-gated ion channel activity involved in regulation of presynaptic membrane potential Source: MGI
- voltage-gated potassium channel activity Source: UniProtKB
GO - Biological processi
- brain development Source: UniProtKB
- cell communication by electrical coupling Source: UniProtKB
- cellular protein localization Source: MGI
- cellular response to magnesium ion Source: UniProtKB
- detection of mechanical stimulus involved in sensory perception of pain Source: UniProtKB
- detection of mechanical stimulus involved in sensory perception of touch Source: UniProtKB
- hippocampus development Source: UniProtKB
- magnesium ion homeostasis Source: UniProtKB
- neuroblast proliferation Source: UniProtKB
- neuromuscular process Source: UniProtKB
- neuronal action potential Source: UniProtKB
- neuronal signal transduction Source: UniProtKB
- positive regulation of voltage-gated potassium channel activity Source: MGI
- potassium ion transmembrane transport Source: UniProtKB
- protein homooligomerization Source: InterPro
- regulation of membrane potential Source: UniProtKB
- regulation of muscle contraction Source: UniProtKB
- startle response Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily A member 1Alternative name(s): MBK11 Publication MKI Voltage-gated potassium channel subunit Kv1.1 |
Gene namesi | Name:Kcna1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96654, Kcna1 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein Curated
- presynaptic cell membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- axon 6 Publications
- Membrane 1 Publication
- Perikaryon 2 Publications
- dendrite 1 Publication
- Cell junction 1 Publication
- synapse 1 Publication
- Cytoplasmic vesicle 1 Publication
- presynapse 1 Publication
Note: Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity).By similarity1 Publication
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic membrane Source: MGI
- integral component of presynaptic membrane Source: MGI
- presynaptic membrane Source: UniProtKB
- voltage-gated potassium channel complex Source: UniProtKB
Other locations
- axon Source: UniProtKB
- axon terminus Source: UniProtKB
- calyx of Held Source: MGI
- cell junction Source: UniProtKB
- cell surface Source: MGI
- cytoplasmic vesicle Source: UniProtKB-KW
- dendrite Source: UniProtKB
- glutamatergic synapse Source: MGI
- integral component of membrane Source: GO_Central
- juxtaparanode region of axon Source: UniProtKB
- neuronal cell body Source: UniProtKB
- paranode region of axon Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- potassium channel complex Source: MGI
- synapse Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 164 | CytoplasmicBy similarityAdd BLAST | 164 | |
Transmembranei | 165 – 186 | Helical; Name=Segment S1By similarityAdd BLAST | 22 | |
Topological domaini | 187 – 220 | ExtracellularBy similarityAdd BLAST | 34 | |
Transmembranei | 221 – 242 | Helical; Name=Segment S2By similarityAdd BLAST | 22 | |
Topological domaini | 243 – 253 | CytoplasmicBy similarityAdd BLAST | 11 | |
Transmembranei | 254 – 274 | Helical; Name=Segment S3By similarityAdd BLAST | 21 | |
Topological domaini | 275 – 287 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 288 – 308 | Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST | 21 | |
Topological domaini | 309 – 323 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 324 – 345 | Helical; Name=Segment S5By similarityAdd BLAST | 22 | |
Topological domaini | 346 – 359 | ExtracellularBy similarityAdd BLAST | 14 | |
Intramembranei | 360 – 371 | Helical; Name=Pore helixBy similarityAdd BLAST | 12 | |
Intramembranei | 372 – 379 | By similarity | 8 | |
Topological domaini | 380 – 386 | ExtracellularBy similarity | 7 | |
Transmembranei | 387 – 415 | Helical; Name=Segment S6By similarityAdd BLAST | 29 | |
Topological domaini | 416 – 495 | CytoplasmicBy similarityAdd BLAST | 80 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, SynapsePathology & Biotechi
Involvement in diseasei
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL2429705 |
DrugCentrali | P16388 |
GuidetoPHARMACOLOGYi | 538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053969 | 1 – 495 | Potassium voltage-gated channel subfamily A member 1Add BLAST | 495 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 243 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 322 | Phosphoserine; by PKASequence analysis | 1 | |
Modified residuei | 437 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 446 | Phosphoserine; by PKABy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MaxQBi | P16388 |
PaxDbi | P16388 |
PeptideAtlasi | P16388 |
PRIDEi | P16388 |
PTM databases
GlyGeni | P16388, 1 site |
iPTMneti | P16388 |
PhosphoSitePlusi | P16388 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000047976, Expressed in sciatic nerve and 186 other tissues |
Genevisiblei | P16388, MM |
Interactioni
Subunit structurei
Homotetramer and heterotetramer with other channel-forming alpha subunits, such as KCNA2, KCNA4, KCNA5, KCNA6 and KCNA7 (PubMed:8361541). Channel activity is regulated by interaction with the beta subunits KCNAB1 and KCNAB2 (PubMed:15361858).
Identified in a complex with KCNA2 and KCNAB2.
Interacts (via C-terminus) with the PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1 (By similarity).
Interacts (via N-terminus) with STX1A; this promotes channel inactivation (By similarity).
Interacts (via N-terminus) with the heterodimer formed by GNB1 and GNG2; this promotes channel inactivation (By similarity). Can interact simultaneously with STX1A and the heterodimer formed by GNB1 and GNG2 (By similarity).
Interacts (via cytoplasmic N-terminal domain) with KCNRG; this inhibits channel activity (By similarity).
Interacts with ANK3; this inhibits channel activity (PubMed:23903368).
By similarityCurated3 PublicationsGO - Molecular functioni
- disordered domain specific binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200876, 9 interactors |
IntActi | P16388, 3 interactors |
MINTi | P16388 |
STRINGi | 10090.ENSMUSP00000055225 |
Miscellaneous databases
RNActi | P16388, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 128 | Tetramerization domainBy similarityAdd BLAST | 128 | |
Regioni | 310 – 323 | S4-S5 linkerBy similarityAdd BLAST | 14 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 372 – 377 | Selectivity filterBy similarity | 6 | |
Motifi | 493 – 495 | PDZ-bindingBy similarity | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000158576 |
HOGENOMi | CLU_011722_4_0_1 |
InParanoidi | P16388 |
OMAi | GHPQDPY |
OrthoDBi | 695337at2759 |
PhylomeDBi | P16388 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR004048, K_chnl_volt-dep_Kv1.1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01508, KV11CHANNEL PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTVMSGENAD EASTAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET
60 70 80 90 100
QLKTLAQFPN TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG
110 120 130 140 150
RLRRPVNVPL DMFSEEIKFY ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ
160 170 180 190 200
RQVWLLFEYP ESSGPARVIA IVSVMVILIS IVIFCLETLP ELKDDKDFTG
210 220 230 240 250
TIHRIDNTTV IYTSNIFTDP FFIVETLCII WFSFELVVRF FACPSKTDFF
260 270 280 290 300
KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF
310 320 330 340 350
RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE
360 370 380 390 400
EAESHFSSIP DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI
410 420 430 440 450
ALPVPVIVSN FNYFYHRETE GEEQAQLLHV SSPNLASDSD LSRRSSSTIS
460 470 480 490
KSEYMEIEED MNNSIAHYRQ ANIRTGNCTT ADQNCVNKSK LLTDV
RNA editingi
Partially edited. RNA editing varies from 35% in the frontal cortex to 75% in the spinal chord.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 400 | I → V in RNA edited version. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30439 Genomic DNA Translation: AAA39711.1 Y00305 mRNA Translation: CAA68408.1 |
CCDSi | CCDS20555.1 |
PIRi | A40090 S09042 |
RefSeqi | NP_034725.3, NM_010595.3 |
Genome annotation databases
Ensembli | ENSMUST00000055168; ENSMUSP00000055225; ENSMUSG00000047976 ENSMUST00000203094; ENSMUSP00000144947; ENSMUSG00000047976 |
GeneIDi | 16485 |
KEGGi | mmu:16485 |
UCSCi | uc009dvb.1, mouse |
Keywords - Coding sequence diversityi
RNA editingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30439 Genomic DNA Translation: AAA39711.1 Y00305 mRNA Translation: CAA68408.1 |
CCDSi | CCDS20555.1 |
PIRi | A40090 S09042 |
RefSeqi | NP_034725.3, NM_010595.3 |
3D structure databases
SMRi | P16388 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200876, 9 interactors |
IntActi | P16388, 3 interactors |
MINTi | P16388 |
STRINGi | 10090.ENSMUSP00000055225 |
Chemistry databases
ChEMBLi | CHEMBL2429705 |
DrugCentrali | P16388 |
GuidetoPHARMACOLOGYi | 538 |
PTM databases
GlyGeni | P16388, 1 site |
iPTMneti | P16388 |
PhosphoSitePlusi | P16388 |
Proteomic databases
MaxQBi | P16388 |
PaxDbi | P16388 |
PeptideAtlasi | P16388 |
PRIDEi | P16388 |
Protocols and materials databases
ABCDi | P16388, 3 sequenced antibodies |
Antibodypediai | 22315, 415 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000055168; ENSMUSP00000055225; ENSMUSG00000047976 ENSMUST00000203094; ENSMUSP00000144947; ENSMUSG00000047976 |
GeneIDi | 16485 |
KEGGi | mmu:16485 |
UCSCi | uc009dvb.1, mouse |
Organism-specific databases
CTDi | 3736 |
MGIi | MGI:96654, Kcna1 |
Phylogenomic databases
eggNOGi | KOG1545, Eukaryota |
GeneTreei | ENSGT00940000158576 |
HOGENOMi | CLU_011722_4_0_1 |
InParanoidi | P16388 |
OMAi | GHPQDPY |
OrthoDBi | 695337at2759 |
PhylomeDBi | P16388 |
TreeFami | TF313103 |
Enzyme and pathway databases
Reactomei | R-MMU-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 16485, 1 hit in 18 CRISPR screens |
PROi | PR:P16388 |
RNActi | P16388, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000047976, Expressed in sciatic nerve and 186 other tissues |
Genevisiblei | P16388, MM |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003972, K_chnl_volt-dep_Kv1 IPR004048, K_chnl_volt-dep_Kv1.1 IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF00520, Ion_trans, 1 hit |
PRINTSi | PR01508, KV11CHANNEL PR01491, KVCHANNEL PR01496, SHAKERCHANEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNA1_MOUSE | |
Accessioni | P16388Primary (citable) accession number: P16388 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families