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Entry version 184 (13 Feb 2019)
Sequence version 1 (01 Aug 1990)
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Protein

Interleukin-4 receptor subunit alpha

Gene

Il4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

Miscellaneous

The sequences from strains C3H, CBA, DBA/2 and FVB/N are all identical to the one displayed.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-4 receptor subunit alpha
Short name:
IL-4 receptor subunit alpha
Short name:
IL-4R subunit alpha
Short name:
IL-4R-alpha
Short name:
IL-4RA
Alternative name(s):
CD_antigen: CD124
Cleaved into the following chain:
Soluble interleukin-4 receptor subunit alpha
Short name:
Soluble IL-4 receptor subunit alpha
Short name:
Soluble IL-4R-alpha
Short name:
sIL4Ralpha/prot
Alternative name(s):
IL-4-binding protein
Short name:
IL4-BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Il4r
Synonyms:Il4ra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:105367 Il4ra

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 233ExtracellularSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei234 – 257HelicalSequence analysisAdd BLAST24
Topological domaini258 – 810CytoplasmicSequence analysisAdd BLAST553

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001088926 – 810Interleukin-4 receptor subunit alphaAdd BLAST785
ChainiPRO_000001089026 – ?Soluble interleukin-4 receptor subunit alpha

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 44By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi75 ↔ 87By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagine1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei165PhosphoserineCombined sources1
Modified residuei500PhosphotyrosineBy similarity1
Modified residuei575PhosphotyrosineBy similarity1
Modified residuei603PhosphotyrosineBy similarity1
Modified residuei631PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On IL4 binding, phosphorylated on C-terminal tyrosine residues.By similarity
Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P16382

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16382

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16382

PRoteomics IDEntifications database

More...
PRIDEi
P16382

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16382

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16382

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both Th1 and Th2 cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030748 Expressed in 191 organ(s), highest expression level in stroma of bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16382 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16382 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP. Interacts with JAK3 (By similarity). Interacts with PIK3C3 (PubMed:8390454). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5 (PubMed:12242343). Interacts with SOCS5; inhibits IL4 signaling (PubMed:12242343). Interacts with CLM1 (PubMed:26124135).By similarity3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200638, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-1168N

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033004

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P16382

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16382

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 224Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 557Required for IRS1 activation and IL4-induced cell growthBy similarityAdd BLAST117
Regioni557 – 653Required for IL4-induced gene expressionBy similarityAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi213 – 217WSXWS motif5
Motifi263 – 271Box 1 motif9
Motifi707 – 712ITIM motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi376 – 381Poly-Glu6
Compositional biasi527 – 530Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain represents the IL4 binding protein (IL4BP).By similarity
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGBQ Eukaryota
ENOG41124QC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000049182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000090263

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052116

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16382

KEGG Orthology (KO)

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KOi
K05071

Identification of Orthologs from Complete Genome Data

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OMAi
GGYKPFQ

Database of Orthologous Groups

More...
OrthoDBi
476828at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16382

TreeFam database of animal gene trees

More...
TreeFami
TF337996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR015319 IL-4_rcpt-alpha_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09238 IL4Ra_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16382-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRLCTKFLT SVGCLILLLV TGSGSIKVLG EPTCFSDYIR TSTCEWFLDS
60 70 80 90 100
AVDCSSQLCL HYRLMFFEFS ENLTCIPRNS ASTVCVCHME MNRPVQSDRY
110 120 130 140 150
QMELWAEHRQ LWQGSFSPSG NVKPLAPDNL TLHTNVSDEW LLTWNNLYPS
160 170 180 190 200
NNLLYKDLIS MVNISREDNP AEFIVYNVTY KEPRLSFPIN ILMSGVYYTA
210 220 230 240 250
RVRVRSQILT GTWSEWSPSI TWYNHFQLPL IQRLPLGVTI SCLCIPLFCL
260 270 280 290 300
FCYFSITKIK KIWWDQIPTP ARSPLVAIII QDAQVPLWDK QTRSQESTKY
310 320 330 340 350
PHWKTCLDKL LPCLLKHRVK KKTDFPKAAP TKSLQSPGKA GWCPMEVSRT
360 370 380 390 400
VLWPENVSVS VVRCMELFEA PVQNVEEEED EIVKEDLSMS PENSGGCGFQ
410 420 430 440 450
ESQADIMARL TENLFSDLLE AENGGLGQSA LAESCSPLPS GSGQASVSWA
460 470 480 490 500
CLPMGPSEEA TCQVTEQPSH PGPLSGSPAQ SAPTLACTQV PLVLADNPAY
510 520 530 540 550
RSFSDCCSPA PNPGELAPEQ QQADHLEEEE PPSPADPHSS GPPMQPVESW
560 570 580 590 600
EQILHMSVLQ HGAAAGSTPA PAGGYQEFVQ AVKQGAAQDP GVPGVRPSGD
610 620 630 640 650
PGYKAFSSLL SSNGIRGDTA AAGTDDGHGG YKPFQNPVPN QSPSSVPLFT
660 670 680 690 700
FGLDTELSPS PLNSDPPKSP PECLGLELGL KGGDWVKAPP PADQVPKPFG
710 720 730 740 750
DDLGFGIVYS SLTCHLCGHL KQHHSQEEGG QSPIVASPGC GCCYDDRSPS
760 770 780 790 800
LGSLSGALES CPEGIPPEAN LMSAPKTPSN LSGEGKGPGH SPVPSQTTEV
810
PVGALGIAVS
Note: Binds IL-4.
Length:810
Mass (Da):87,627
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i536B9E01E938FF6D
GO
Isoform 2 (identifier: P16382-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     225-230: HFQLPL → PSNENL
     231-810: Missing.

Note: Binds IL-4.
Show »
Length:230
Mass (Da):26,456
Checksum:i0E6752D46475D97C
GO
Isoform 3 (identifier: P16382-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-810: Missing.

Note: Lacks the cytoplasmic domain. Binds IL4.
Show »
Length:257
Mass (Da):29,584
Checksum:i7E6E02C8A03045D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNW1A0A0U1RNW1_MOUSE
Interleukin 4 receptor, alpha
Il4ra
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPZ6A0A0U1RPZ6_MOUSE
Interleukin 4 receptor, alpha
Il4ra
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti436S → C in BAC28718 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti59C → R in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti74T → I in strain: BALB/c, AKR/J and SJL/J; reduced IL4-neutralizing capacity of soluble form. 1 Publication1
Natural varianti193M → T in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti334L → P in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti374N → S in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti382I → M in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti472G → D in strain: BALB/c, AKR/J and SJL/J. 1
Natural varianti626D → G in strain: BALB/c, AKR/J and SJL/J. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001675225 – 230HFQLPL → PSNENL in isoform 2. 1 Publication6
Alternative sequenceiVSP_001676231 – 810Missing in isoform 2. 1 PublicationAdd BLAST580
Alternative sequenceiVSP_001677258 – 810Missing in isoform 3. 1 PublicationAdd BLAST553

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M27959 mRNA Translation: AAA39299.1
M27960 mRNA Translation: AAA39300.1
M29854 mRNA Translation: AAA39297.1
M64879
, M64870, M64871, M64872, M64873, M64874, M64876, M64877, M64878 Genomic DNA Translation: AAB59727.1
AF000304 mRNA Translation: AAB87750.1
AK034466 mRNA Translation: BAC28718.1
AK088086 mRNA Translation: BAC40137.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40121.1 [P16382-1]

Protein sequence database of the Protein Information Resource

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PIRi
A33380

NCBI Reference Sequences

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RefSeqi
NP_001008700.1, NM_001008700.3 [P16382-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.233802

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000033004; ENSMUSP00000033004; ENSMUSG00000030748 [P16382-1]
ENSMUST00000206846; ENSMUSP00000145824; ENSMUSG00000030748 [P16382-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
16190

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16190

UCSC genome browser

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UCSCi
uc009jqc.1 mouse [P16382-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27959 mRNA Translation: AAA39299.1
M27960 mRNA Translation: AAA39300.1
M29854 mRNA Translation: AAA39297.1
M64879
, M64870, M64871, M64872, M64873, M64874, M64876, M64877, M64878 Genomic DNA Translation: AAB59727.1
AF000304 mRNA Translation: AAB87750.1
AK034466 mRNA Translation: BAC28718.1
AK088086 mRNA Translation: BAC40137.1
CCDSiCCDS40121.1 [P16382-1]
PIRiA33380
RefSeqiNP_001008700.1, NM_001008700.3 [P16382-1]
UniGeneiMm.233802

3D structure databases

ProteinModelPortaliP16382
SMRiP16382
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200638, 3 interactors
DIPiDIP-1168N
STRINGi10090.ENSMUSP00000033004

PTM databases

iPTMnetiP16382
PhosphoSitePlusiP16382

Proteomic databases

EPDiP16382
jPOSTiP16382
PaxDbiP16382
PRIDEiP16382

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033004; ENSMUSP00000033004; ENSMUSG00000030748 [P16382-1]
ENSMUST00000206846; ENSMUSP00000145824; ENSMUSG00000030748 [P16382-2]
GeneIDi16190
KEGGimmu:16190
UCSCiuc009jqc.1 mouse [P16382-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
16190
MGIiMGI:105367 Il4ra

Phylogenomic databases

eggNOGiENOG410IGBQ Eukaryota
ENOG41124QC LUCA
GeneTreeiENSGT00510000049182
HOGENOMiHOG000090263
HOVERGENiHBG052116
InParanoidiP16382
KOiK05071
OMAiGGYKPFQ
OrthoDBi476828at2759
PhylomeDBiP16382
TreeFamiTF337996

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

Protein Ontology

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PROi
PR:P16382

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030748 Expressed in 191 organ(s), highest expression level in stroma of bone marrow
ExpressionAtlasiP16382 baseline and differential
GenevisibleiP16382 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR015319 IL-4_rcpt-alpha_N
PfamiView protein in Pfam
PF09238 IL4Ra_N, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL4RA_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16382
Secondary accession number(s): O54690, Q60583, Q8CBW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 13, 2019
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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