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Protein

Protein groucho

Gene

gro

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CRD domain binding Source: UniProtKB
  • HMG box domain binding Source: UniProtKB
  • repressing transcription factor binding Source: FlyBase
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-209421 Transcription activation by ARM
R-DME-209441 WG ligand not bound to FZ receptors
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-4641265 Repression of WNT target genes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P16371

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein groucho
Alternative name(s):
Enhancer of split m9/10 protein
Short name:
E(spl)m9/10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gro
Synonyms:E(spl)m9/m10
ORF Names:CG8384
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001139 gro

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510101 – 730Protein grouchoAdd BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei205Phosphoserine1 Publication1
Modified residuei207Phosphoserine1 Publication1
Modified residuei218Phosphoserine1 Publication1
Modified residuei242Phosphoserine; by CK2Sequence analysis1
Modified residuei258Phosphoserine; by CDC2Sequence analysis1
Modified residuei267Phosphoserine1 Publication1
Modified residuei326Phosphothreonine1 Publication1
Modified residuei328Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by XIAP/BIRC4.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16371

PRoteomics IDEntifications database

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PRIDEi
P16371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0001139 Expressed in 18 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16371 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with the hairy/Enhancer of split/deadpan family of basic helix-loop-helix proteins in order to repress transcription. Its activity in regulating transcription depends on other proteins as it lacks a DNA-binding motif.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
68062, 65 interactors

Database of interacting proteins

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DIPi
DIP-40N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P16371

Protein interaction database and analysis system

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IntActi
P16371, 24 interactors

Molecular INTeraction database

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MINTi
P16371

STRING: functional protein association networks

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STRINGi
7227.FBpp0089115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16371

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16371

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati442 – 480WD 1Add BLAST39
Repeati488 – 527WD 2Add BLAST40
Repeati532 – 571WD 3Add BLAST40
Repeati574 – 613WD 4Add BLAST40
Repeati615 – 654WD 5Add BLAST40
Repeati656 – 695WD 6Add BLAST40
Repeati697 – 730WD 7Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 267CCN domainAdd BLAST62
Regioni262 – 425Binding to basic helix-loop-helix domainAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi227 – 230Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 144Gln-richAdd BLAST52
Compositional biasi317 – 423Pro-richAdd BLAST107

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0639 Eukaryota
ENOG410XPX3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153368

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16371

KEGG Orthology (KO)

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KOi
K04497

Database of Orthologous Groups

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OrthoDBi
EOG091G181Y

Database for complete collections of gene phylogenies

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PhylomeDBi
P16371

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR10814 PTHR10814, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 3 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01850 GROUCHOFAMLY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform E (identifier: P16371-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYPSPVRHPA AGGPPPQGPI KFTIADTLER IKEEFNFLQA QYHSIKLECE
60 70 80 90 100
KLSNEKTEMQ RHYVMYYEMS YGLNVEMHKQ TEIAKRLNTL INQLLPFLQA
110 120 130 140 150
DHQQQVLQAV ERAKQVTMQE LNLIIGHQQQ HGIQQLLQQI HAQQVPGGPP
160 170 180 190 200
QPMGALNPFG ALGATMGLPH GPQGLLNKPP EHHRPDIKPT GLEGPAAAEE
210 220 230 240 250
RLRNSVSPAD REKYRTRSPL DIENDSKRRK DEKLQEDEGE KSDQDLVVDV
260 270 280 290 300
ANEMESHSPR PNGEHVSMEV RDRESLNGER LEKPSSSGIK QERPPSRSGS
310 320 330 340 350
SSSRSTPSLK TKDMEKPGTP GAKARTPTPN AAAPAPGVNP KQMMPQGPPP
360 370 380 390 400
AGYPGAPYQR PADPYQRPPS DPAYGRPPPM PYDPHAHVRT NGIPHPSALT
410 420 430 440 450
GGKPAYSFHM NGEGSLQPVP FPPDALVGVG IPRHARQINT LSHGEVVCAV
460 470 480 490 500
TISNPTKYVY TGGKGCVKVW DISQPGNKNP VSQLDCLQRD NYIRSVKLLP
510 520 530 540 550
DGRTLIVGGE ASNLSIWDLA SPTPRIKAEL TSAAPACYAL AISPDSKVCF
560 570 580 590 600
SCCSDGNIAV WDLHNEILVR QFQGHTDGAS CIDISPDGSR LWTGGLDNTV
610 620 630 640 650
RSWDLREGRQ LQQHDFSSQI FSLGYCPTGD WLAVGMENSH VEVLHASKPD
660 670 680 690 700
KYQLHLHESC VLSLRFAACG KWFVSTGKDN LLNAWRTPYG ASIFQSKETS
710 720 730
SVLSCDISTD DKYIVTGSGD KKATVYEVIY
Note: No experimental confirmation available.
Length:730
Mass (Da):80,231
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DA08E1ED343B2F5
GO
Isoform A (identifier: P16371-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     127-137: Missing.

Show »
Length:719
Mass (Da):78,920
Checksum:iD495291FD77026A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LHP1A0A0B4LHP1_DROME
Groucho, isoform J
gro 10, anon-WO0118547.385, BcDNA.LD33829, BcDNA:LD33829, BEST:GM01575
717Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JD02A0A0B4JD02_DROME
Groucho, isoform F
gro 10, anon-WO0118547.385, BcDNA.LD33829, BcDNA:LD33829, BEST:GM01575
719Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4JDF1A0A0B4JDF1_DROME
Groucho, isoform G
gro 10, anon-WO0118547.385, BcDNA.LD33829, BcDNA:LD33829, BEST:GM01575
728Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KH09A0A0B4KH09_DROME
Groucho, isoform I
gro 10, anon-WO0118547.385, BcDNA.LD33829, BcDNA:LD33829, BEST:GM01575
698Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6L6A0A0B4K6L6_DROME
Groucho, isoform H
gro 10, anon-WO0118547.385, BcDNA.LD33829, BcDNA:LD33829, BEST:GM01575
709Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41Q → H in AAA28512 (PubMed:3142687).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022308127 – 137Missing in isoform A. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M20571 mRNA Translation: AAA28512.1
AE014297 Genomic DNA Translation: AAF56557.1
AE014297 Genomic DNA Translation: AAN14068.1
AE014297 Genomic DNA Translation: AAN14069.1
AE014297 Genomic DNA Translation: AAS65218.1
AF145695 mRNA Translation: AAD38670.1

Protein sequence database of the Protein Information Resource

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PIRi
A30047

NCBI Reference Sequences

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RefSeqi
NP_001189293.1, NM_001202364.1 [P16371-2]
NP_524514.2, NM_079790.5 [P16371-2]
NP_733133.1, NM_170254.3 [P16371-2]
NP_733134.1, NM_170255.4 [P16371-2]
NP_733135.1, NM_170256.2 [P16371-2]
NP_996298.1, NM_206575.3 [P16371-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.1340

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084962; FBpp0084336; FBgn0001139 [P16371-2]
FBtr0084963; FBpp0084337; FBgn0001139 [P16371-2]
FBtr0084964; FBpp0084338; FBgn0001139 [P16371-2]
FBtr0084965; FBpp0084339; FBgn0001139 [P16371-2]
FBtr0084966; FBpp0089115; FBgn0001139 [P16371-1]
FBtr0302951; FBpp0292077; FBgn0001139 [P16371-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
43162

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG8384

UCSC genome browser

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UCSCi
CG8384-RA d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20571 mRNA Translation: AAA28512.1
AE014297 Genomic DNA Translation: AAF56557.1
AE014297 Genomic DNA Translation: AAN14068.1
AE014297 Genomic DNA Translation: AAN14069.1
AE014297 Genomic DNA Translation: AAS65218.1
AF145695 mRNA Translation: AAD38670.1
PIRiA30047
RefSeqiNP_001189293.1, NM_001202364.1 [P16371-2]
NP_524514.2, NM_079790.5 [P16371-2]
NP_733133.1, NM_170254.3 [P16371-2]
NP_733134.1, NM_170255.4 [P16371-2]
NP_733135.1, NM_170256.2 [P16371-2]
NP_996298.1, NM_206575.3 [P16371-1]
UniGeneiDm.1340

3D structure databases

ProteinModelPortaliP16371
SMRiP16371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68062, 65 interactors
DIPiDIP-40N
ELMiP16371
IntActiP16371, 24 interactors
MINTiP16371
STRINGi7227.FBpp0089115

PTM databases

iPTMnetiP16371

Proteomic databases

PaxDbiP16371
PRIDEiP16371

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084962; FBpp0084336; FBgn0001139 [P16371-2]
FBtr0084963; FBpp0084337; FBgn0001139 [P16371-2]
FBtr0084964; FBpp0084338; FBgn0001139 [P16371-2]
FBtr0084965; FBpp0084339; FBgn0001139 [P16371-2]
FBtr0084966; FBpp0089115; FBgn0001139 [P16371-1]
FBtr0302951; FBpp0292077; FBgn0001139 [P16371-2]
GeneIDi43162
KEGGidme:Dmel_CG8384
UCSCiCG8384-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43162
FlyBaseiFBgn0001139 gro

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00940000153368
InParanoidiP16371
KOiK04497
OrthoDBiEOG091G181Y
PhylomeDBiP16371

Enzyme and pathway databases

ReactomeiR-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-209421 Transcription activation by ARM
R-DME-209441 WG ligand not bound to FZ receptors
R-DME-3769402 Deactivation of the beta-catenin transactivating complex
R-DME-4641265 Repression of WNT target genes
SignaLinkiP16371

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
gro fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43162

Protein Ontology

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PROi
PR:P16371

Gene expression databases

BgeeiFBgn0001139 Expressed in 18 organ(s), highest expression level in embryo
ExpressionAtlasiP16371 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10814 PTHR10814, 2 hits
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGROU_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16371
Secondary accession number(s): A4V3F6
, Q0KI08, Q7KRZ4, Q9V3F7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 9, 2007
Last modified: December 5, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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