Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytoplasmic protein NCK1

Gene

NCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • cytoskeletal adaptor activity Source: UniProtKB
  • ephrin receptor binding Source: Ensembl
  • eukaryotic initiation factor eIF2 binding Source: ParkinsonsUK-UCL
  • molecular adaptor activity Source: FlyBase
  • protein binding, bridging Source: ParkinsonsUK-UCL
  • protein domain specific binding Source: Ensembl
  • protein kinase inhibitor activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB
  • receptor tyrosine kinase binding Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ParkinsonsUK-UCL
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-186763 Downstream signal transduction
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-373753 Nephrin family interactions
R-HSA-418885 DCC mediated attractive signaling
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P16333

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16333

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P16333 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic protein NCK1
Alternative name(s):
NCK adaptor protein 1
Short name:
Nck-1
SH2/SH3 adaptor protein NCK-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCK1
Synonyms:NCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158092.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7664 NCK1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600508 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16333

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38W → K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-143 and K-229. 1 Publication1
Mutagenesisi143W → K: No effect on RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229. 1 Publication1
Mutagenesisi229W → K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229. 1 Publication1
Mutagenesisi308R → K: No effect on RASA1-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4690

Open Targets

More...
OpenTargetsi
ENSG00000158092

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31466

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4846

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127962

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967662 – 377Cytoplasmic protein NCK1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei105PhosphotyrosineCombined sources1
Modified residuei166PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P16333

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P16333

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16333

PeptideAtlas

More...
PeptideAtlasi
P16333

PRoteomics IDEntifications database

More...
PRIDEi
P16333

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53345
53346 [P16333-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16333

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P16333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158092 Expressed in 234 organ(s), highest expression level in vagina

CleanEx database of gene expression profiles

More...
CleanExi
HS_NCK1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16333 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16333 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005063
HPA030766

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH2 domain and SH3 domain 2) with EGFR. Interacts with PAK1 and SOS1. Interacts (via SH3 domains) with PKN2. Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with SOCS7. This interaction is required for nuclear import. Part of a complex containing PPP1R15B, PP1 and NCK1. Interacts with RALGPS1. Interacts with CAV2 (tyrosine phosphorylated form). Interacts with ADAM15. Interacts with FASLG. Directly interacts with RASA1. Interacts with isoform 4 of MINK1. Interacts with FLT1 (tyrosine phosphorylated). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion. Interacts with EPHA2. Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated). Interacts with the inactive form of EIF2AK2/PKR.19 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABCG5Q9H2222EBI-389883,EBI-1761423
ABL1P005192EBI-389883,EBI-375543
ABL2P426844EBI-389883,EBI-1102694
AGERQ151092EBI-389883,EBI-1646426
AIREO439182EBI-389883,EBI-1753081
ARHGEF11O150853EBI-389883,EBI-311099
ASAP1Q9ULH16EBI-389883,EBI-346622
ASB16Q96NS52EBI-389883,EBI-1751918
BAZ2AQ9UIF92EBI-389883,EBI-934890
BICRAQ9NZM43EBI-389883,EBI-1754943
BRD4O608852EBI-389883,EBI-723869
BRPF3Q9ULD43EBI-389883,EBI-1753470
C6P136712EBI-389883,EBI-1753221
CASTP208102EBI-389883,EBI-1268770
CBLBQ131914EBI-389883,EBI-744027
CD247P209632EBI-389883,EBI-1165705
CD3EP077666EBI-389883,EBI-1211297
CDC27P302603EBI-389883,EBI-994813
CELSR3Q9NYQ72EBI-389883,EBI-308417
CHAF1AQ131112EBI-389883,EBI-1020839
CKAP5Q140083EBI-389883,EBI-310585
CNTNAP1P783572EBI-389883,EBI-1751903
CYP4F2P783292EBI-389883,EBI-1752413
DAB2P980822EBI-389883,EBI-1171238
DAG1Q141182EBI-389883,EBI-1755945
DLGAP1O144904EBI-389883,EBI-1753207
DLGAP2Q9P1A64EBI-389883,EBI-1753397
DLGAP3O958862EBI-389883,EBI-1752541
DLGAP4Q9Y2H05EBI-389883,EBI-722139
DLX4Q929883EBI-389883,EBI-1752755
DNM1Q051932EBI-389883,EBI-713135
DOCK3Q8IZD93EBI-389883,EBI-1752361
DUSP15Q9H1R22EBI-389883,EBI-1752795
ECT2Q9H8V33EBI-389883,EBI-1054039
EGFRP005333EBI-389883,EBI-297353
ELK3P419703EBI-389883,EBI-1758534
EPS15P425662EBI-389883,EBI-396684
F2RL2O002542EBI-389883,EBI-1751853
FAM110AQ9BQ892EBI-389883,EBI-1752811
FASLGP480234EBI-15578122,EBI-495538
FCGR2BP319942EBI-389883,EBI-724784
FCGR2CP319952EBI-389883,EBI-1396036
FLNBO753693EBI-389883,EBI-352089
FOXH1O755932EBI-389883,EBI-1759806
FYB1O151173EBI-389883,EBI-1753267
GAB1Q134803EBI-389883,EBI-517684
GABBR1Q9UBS53EBI-389883,EBI-724156
GAD1Q992592EBI-389883,EBI-743184
GHRP109123EBI-389883,EBI-286316
GNSP155862EBI-389883,EBI-1752200
GSTZ1O437082EBI-389883,EBI-748043
HIST1H1EP104122EBI-389883,EBI-358163
HNRNPRO433902EBI-389883,EBI-713419
ID4P479283EBI-389883,EBI-1754719
ISG20L2Q9H9L32EBI-389883,EBI-751335
JAK2O606742EBI-389883,EBI-518647
KDRP359683EBI-389883,EBI-1005487
KITP107213EBI-389883,EBI-1379503
KMT2BQ9UMN62EBI-389883,EBI-765774
LCP2Q1309414EBI-389883,EBI-346946
LRRC3Q9BY712EBI-389883,EBI-1761329
MAP4P278162EBI-389883,EBI-715255
MAP4K1Q929184EBI-389883,EBI-881
MAP4K5Q9Y4K42EBI-389883,EBI-1279
MEPEQ9NQ763EBI-389883,EBI-1753293
METP085812EBI-389883,EBI-1039152
MYLKQ157462EBI-389883,EBI-968482
NELFBQ8WX926EBI-389883,EBI-347721
NKX2-1P436992EBI-389883,EBI-1391923
NPHS1O605003EBI-389883,EBI-996920
PAK2Q131772EBI-389883,EBI-1045887
PDIA2Q130873EBI-389883,EBI-1752525
PHACTR2O751672EBI-389883,EBI-1754409
PIK3C2BO007503EBI-389883,EBI-641107
PNMA2Q9UL422EBI-389883,EBI-302355
PRXQ9BXM02EBI-389883,EBI-1753064
PTPN4P290743EBI-389883,EBI-710431
RAG1P159182EBI-389883,EBI-1755109
RAPGEF1Q139052EBI-389883,EBI-976876
RASA1P209366EBI-389883,EBI-1026476
RIMS2Q9UQ262EBI-389883,EBI-1756749
RIN3Q8TB242EBI-389883,EBI-1570523
RNGTTO609422EBI-15578122,EBI-1237132
RngttO552363EBI-15578122,EBI-16118241From Mus musculus.
RPL13P263732EBI-389883,EBI-356849
RPP38P783452EBI-389883,EBI-366493
RRASP103013EBI-389883,EBI-968703
SCARF2Q96GP62EBI-389883,EBI-1752088
SELENONQ9NZV52EBI-389883,EBI-1751965
SEMA7AO753262EBI-389883,EBI-1753538
SHANK2Q9UPX86EBI-389883,EBI-1570571
SHANK3Q9BYB04EBI-389883,EBI-1752330
SHROOM2Q137962EBI-389883,EBI-1644065
SLC23A1Q9UHI72EBI-389883,EBI-1759386
SLC24A1O607213EBI-389883,EBI-1753504
SNX12Q9UMY43EBI-389883,EBI-1752602
SNX17Q150363EBI-389883,EBI-1752620
SNX8Q9Y5X22EBI-389883,EBI-1752557
SOS1Q078895EBI-389883,EBI-297487
SOS2Q078903EBI-389883,EBI-298181
SP1P080472EBI-389883,EBI-298336
SPENQ96T583EBI-389883,EBI-765739
SUV39H2Q9H5I12EBI-389883,EBI-723127
SYNJ2O150563EBI-389883,EBI-310513
TGOLN2O434933EBI-389883,EBI-1752146
TMPOP421672EBI-389883,EBI-455283
Tnk2O549672EBI-15578122,EBI-7780354From Mus musculus.
TPSAB1Q156612EBI-389883,EBI-1761369
TPX2Q9ULW04EBI-389883,EBI-1037322
TRAIPQ9BWF23EBI-389883,EBI-1756205
TRIM39Q9HCM92EBI-389883,EBI-739510
TULP1O002942EBI-389883,EBI-1756778
VPS13AQ96RL73EBI-389883,EBI-1752583
WASLO004012EBI-15578122,EBI-957615
WIPF1O435162EBI-389883,EBI-346356

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110770, 121 interactors

Database of interacting proteins

More...
DIPi
DIP-639N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P16333

Protein interaction database and analysis system

More...
IntActi
P16333, 217 interactors

Molecular INTeraction database

More...
MINTi
P16333

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288986

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16333

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P16333

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16333

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini106 – 165SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini190 – 252SH3 3PROSITE-ProRule annotationAdd BLAST63
Domaini282 – 376SH2PROSITE-ProRule annotationAdd BLAST95

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seeem to be involved.

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4226 Eukaryota
ENOG410XRPF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290684

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000719

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16333

KEGG Orthology (KO)

More...
KOi
K07365

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFDYMAQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AD0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16333

TreeFam database of animal gene trees

More...
TreeFami
TF351631

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10408 SH2_Nck1, 1 hit
cd11900 SH3_Nck1_1, 1 hit
cd11901 SH3_Nck1_2, 1 hit
cd11904 SH3_Nck1_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017304 NCK
IPR035882 Nck1_SH2
IPR035562 Nck1_SH3_1
IPR035564 Nck1_SH3_2
IPR035565 Nck1_SH3_3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PF14604 SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037874 Cytoplasmic_NCK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 3 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16333-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF
60 70 80 90 100
VPSNYVERKN SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP
110 120 130 140 150
GERLYDLNMP AYVKFNYMAE REDELSLIKG TKVIVMEKCS DGWWRGSYNG
160 170 180 190 200
QVGWFPSNYV TEEGDSPLGD HVGSLSEKLA AVVNNLNTGQ VLHVVQALYP
210 220 230 240 250
FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG LVPKNYVTVM
260 270 280 290 300
QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG
310 320 330 340 350
HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME
360 370
ELVEHYKKAP IFTSEQGEKL YLVKHLS
Length:377
Mass (Da):42,864
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i554E9B1A936AEF30
GO
Isoform 2 (identifier: P16333-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEEVVVVAK...IVKNLKDTLG → MDWLNVFKDFFS

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,511
Checksum:iD10F0F2DEF1D72F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAB9C9JAB9_HUMAN
Cytoplasmic protein NCK1
NCK1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K098C9K098_HUMAN
Cytoplasmic protein NCK1
NCK1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J869C9J869_HUMAN
Cytoplasmic protein NCK1
NCK1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVV5C9JVV5_HUMAN
Cytoplasmic protein NCK1
NCK1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0K5C9J0K5_HUMAN
Cytoplasmic protein NCK1
NCK1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5C7H7C5C7_HUMAN
Cytoplasmic protein NCK1
NCK1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051228180A → V. Corresponds to variant dbSNP:rs13320485Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431221 – 76MAEEV…KDTLG → MDWLNVFKDFFS in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17576 mRNA Translation: CAA35599.1
AK301460 mRNA Translation: BAH13487.1
AC011597 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79105.1
CH471052 Genomic DNA Translation: EAW79108.1
CH471052 Genomic DNA Translation: EAW79109.1
BC006403 mRNA Translation: AAH06403.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3092.1 [P16333-1]
CCDS54644.1 [P16333-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S08636

NCBI Reference Sequences

More...
RefSeqi
NP_001177725.1, NM_001190796.2 [P16333-2]
NP_001278928.1, NM_001291999.1 [P16333-1]
NP_006144.1, NM_006153.5 [P16333-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.126889
Hs.477693

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288986; ENSP00000288986; ENSG00000158092 [P16333-1]
ENST00000469404; ENSP00000419631; ENSG00000158092 [P16333-2]
ENST00000481752; ENSP00000417273; ENSG00000158092 [P16333-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4690

UCSC genome browser

More...
UCSCi
uc003erh.3 human [P16333-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17576 mRNA Translation: CAA35599.1
AK301460 mRNA Translation: BAH13487.1
AC011597 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79105.1
CH471052 Genomic DNA Translation: EAW79108.1
CH471052 Genomic DNA Translation: EAW79109.1
BC006403 mRNA Translation: AAH06403.1
CCDSiCCDS3092.1 [P16333-1]
CCDS54644.1 [P16333-2]
PIRiS08636
RefSeqiNP_001177725.1, NM_001190796.2 [P16333-2]
NP_001278928.1, NM_001291999.1 [P16333-1]
NP_006144.1, NM_006153.5 [P16333-1]
UniGeneiHs.126889
Hs.477693

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CI8X-ray1.80A281-377[»]
2CI9X-ray1.50A/B281-377[»]
2CUBNMR-A99-173[»]
2JS0NMR-A107-165[»]
2JS2NMR-A1-61[»]
2JW4NMR-A1-63[»]
ProteinModelPortaliP16333
SMRiP16333
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110770, 121 interactors
DIPiDIP-639N
ELMiP16333
IntActiP16333, 217 interactors
MINTiP16333
STRINGi9606.ENSP00000288986

Chemistry databases

BindingDBiP16333
ChEMBLiCHEMBL4846

Protein family/group databases

MoonDBiP16333 Predicted

PTM databases

iPTMnetiP16333
PhosphoSitePlusiP16333

Polymorphism and mutation databases

BioMutaiNCK1
DMDMi127962

Proteomic databases

EPDiP16333
MaxQBiP16333
PaxDbiP16333
PeptideAtlasiP16333
PRIDEiP16333
ProteomicsDBi53345
53346 [P16333-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4690
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288986; ENSP00000288986; ENSG00000158092 [P16333-1]
ENST00000469404; ENSP00000419631; ENSG00000158092 [P16333-2]
ENST00000481752; ENSP00000417273; ENSG00000158092 [P16333-1]
GeneIDi4690
KEGGihsa:4690
UCSCiuc003erh.3 human [P16333-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4690
DisGeNETi4690
EuPathDBiHostDB:ENSG00000158092.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCK1
HGNCiHGNC:7664 NCK1
HPAiCAB005063
HPA030766
MIMi600508 gene
neXtProtiNX_P16333
OpenTargetsiENSG00000158092
PharmGKBiPA31466

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4226 Eukaryota
ENOG410XRPF LUCA
GeneTreeiENSGT00940000156601
HOGENOMiHOG000290684
HOVERGENiHBG000719
InParanoidiP16333
KOiK07365
OMAiKFDYMAQ
OrthoDBiEOG091G0AD0
PhylomeDBiP16333
TreeFamiTF351631

Enzyme and pathway databases

ReactomeiR-HSA-186763 Downstream signal transduction
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-373753 Nephrin family interactions
R-HSA-418885 DCC mediated attractive signaling
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP16333
SIGNORiP16333

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCK1 human
EvolutionaryTraceiP16333

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NCK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4690
PMAP-CutDBiP16333

Protein Ontology

More...
PROi
PR:P16333

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158092 Expressed in 234 organ(s), highest expression level in vagina
CleanExiHS_NCK1
ExpressionAtlasiP16333 baseline and differential
GenevisibleiP16333 HS

Family and domain databases

CDDicd10408 SH2_Nck1, 1 hit
cd11900 SH3_Nck1_1, 1 hit
cd11901 SH3_Nck1_2, 1 hit
cd11904 SH3_Nck1_3, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304 NCK
IPR035882 Nck1_SH2
IPR035562 Nck1_SH3_1
IPR035564 Nck1_SH3_2
IPR035565 Nck1_SH3_3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PF14604 SH3_9, 1 hit
PIRSFiPIRSF037874 Cytoplasmic_NCK, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 3 hits
SUPFAMiSSF50044 SSF50044, 3 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16333
Secondary accession number(s): B7Z751, D3DNE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: December 5, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again