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Entry version 223 (12 Aug 2020)
Sequence version 1 (01 Aug 1990)
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Protein

Cytoplasmic protein NCK1

Gene

NCK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P16333

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-186763, Downstream signal transduction
R-HSA-202433, Generation of second messenger molecules
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-373753, Nephrin family interactions
R-HSA-418885, DCC mediated attractive signaling
R-HSA-428540, Activation of RAC1
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P16333

SIGNOR Signaling Network Open Resource

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SIGNORi
P16333

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P16333, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic protein NCK1
Alternative name(s):
NCK adaptor protein 1
Short name:
Nck-1
SH2/SH3 adaptor protein NCK-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCK1
Synonyms:NCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000158092.6

Human Gene Nomenclature Database

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HGNCi
HGNC:7664, NCK1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600508, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P16333

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38W → K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-143 and K-229. 1 Publication1
Mutagenesisi143W → K: No effect on RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229. 1 Publication1
Mutagenesisi229W → K: Small decrease in RASA1-binding. Almost complete loss of RASA1-binding; when associated with K-38 and K-229. 1 Publication1
Mutagenesisi308R → K: No effect on RASA1-binding. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
4690

Open Targets

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OpenTargetsi
ENSG00000158092

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31466

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P16333, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4846

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NCK1

Domain mapping of disease mutations (DMDM)

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DMDMi
127962

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000967662 – 377Cytoplasmic protein NCK1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei105PhosphotyrosineCombined sources1
Modified residuei166PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB.5 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P16333

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P16333

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P16333

MaxQB - The MaxQuant DataBase

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MaxQBi
P16333

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16333

PeptideAtlas

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PeptideAtlasi
P16333

PRoteomics IDEntifications database

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PRIDEi
P16333

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53345 [P16333-1]
53346 [P16333-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16333

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P16333

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000158092, Expressed in vagina and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16333, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16333, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000158092, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH2 domain and SH3 domain 2) with EGFR.

Interacts with PAK1 and SOS1.

Interacts (via SH3 domains) with PKN2. Associates with BLNK, PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion.

Interacts with SOCS7. This interaction is required for nuclear import.

Part of a complex containing PPP1R15B, PP1 and NCK1.

Interacts with RALGPS1.

Interacts with CAV2 (tyrosine phosphorylated form).

Interacts with ADAM15.

Interacts with FASLG. Directly interacts with RASA1.

Interacts with isoform 4 of MINK1.

Interacts with FLT1 (tyrosine phosphorylated).

Interacts with KDR (tyrosine phosphorylated).

Interacts (via SH2 domain) with EPHB1; activates the JUN cascade to regulate cell adhesion.

Interacts with EPHA2.

Interacts (via SH2 domain) with PDGFRB (tyrosine phosphorylated).

Interacts with the inactive form of EIF2AK2/PKR.

19 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P16333
With#Exp.IntAct
ABCG5 [Q9H222]2EBI-389883,EBI-1761423
ABL1 [P00519]2EBI-389883,EBI-375543
ABL2 [P42684]4EBI-389883,EBI-1102694
AGER [Q15109]2EBI-389883,EBI-1646426
AIRE [O43918]2EBI-389883,EBI-1753081
ARHGEF11 [O15085]3EBI-389883,EBI-311099
ASAP1 [Q9ULH1]6EBI-389883,EBI-346622
ASB16 [Q96NS5]2EBI-389883,EBI-1751918
BAZ2A [Q9UIF9]2EBI-389883,EBI-934890
BICRA [Q9NZM4]3EBI-389883,EBI-1754943
BRD4 [O60885]2EBI-389883,EBI-723869
BRPF3 [Q9ULD4]3EBI-389883,EBI-1753470
C6 [P13671]2EBI-389883,EBI-1753221
CAST [P20810]2EBI-389883,EBI-1268770
CBLB [Q13191]4EBI-389883,EBI-744027
CD247 [P20963]2EBI-389883,EBI-1165705
CD3E [P07766]6EBI-389883,EBI-1211297
CDC27 [P30260]3EBI-389883,EBI-994813
CELSR3 [Q9NYQ7]2EBI-389883,EBI-308417
CHAF1A [Q13111]2EBI-389883,EBI-1020839
CHN2 [P52757]3EBI-389883,EBI-714925
CKAP5 [Q14008]3EBI-389883,EBI-310585
CNTNAP1 [P78357]2EBI-389883,EBI-1751903
CYP4F2 [P78329]2EBI-389883,EBI-1752413
DAB2 [P98082]2EBI-389883,EBI-1171238
DAG1 [Q14118]2EBI-389883,EBI-1755945
DLGAP1 [O14490]4EBI-389883,EBI-1753207
DLGAP2 [Q9P1A6]4EBI-389883,EBI-1753397
DLGAP3 [O95886]2EBI-389883,EBI-1752541
DLGAP4 [Q9Y2H0]5EBI-389883,EBI-722139
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-389883,EBI-12000556
DLX4 [Q92988]3EBI-389883,EBI-1752755
DNM1 [Q05193]2EBI-389883,EBI-713135
DOCK3 [Q8IZD9]3EBI-389883,EBI-1752361
DUSP15 [Q9H1R2]2EBI-389883,EBI-1752795
ECT2 [Q9H8V3]3EBI-389883,EBI-1054039
EGFR [P00533]4EBI-389883,EBI-297353
ELK3 [P41970]3EBI-389883,EBI-1758534
EPS15 [P42566]2EBI-389883,EBI-396684
F2RL2 [O00254]2EBI-389883,EBI-1751853
FAM110A [Q9BQ89]2EBI-389883,EBI-1752811
FCGR2B [P31994]2EBI-389883,EBI-724784
FCGR2C [P31995]2EBI-389883,EBI-1396036
FLNB [O75369]3EBI-389883,EBI-352089
FOXH1 [O75593]2EBI-389883,EBI-1759806
FYB1 [O15117]3EBI-389883,EBI-1753267
GAB1 [Q13480]3EBI-389883,EBI-517684
GABBR1 [Q9UBS5]3EBI-389883,EBI-724156
GAD1 [Q99259]2EBI-389883,EBI-743184
GHR [P10912]3EBI-389883,EBI-286316
GNS [P15586]2EBI-389883,EBI-1752200
GSTZ1 [O43708]2EBI-389883,EBI-748043
H1-4 [P10412]2EBI-389883,EBI-358163
HNRNPR [O43390]2EBI-389883,EBI-713419
ID4 [P47928]3EBI-389883,EBI-1754719
ISG20L2 [Q9H9L3]2EBI-389883,EBI-751335
JAK2 [O60674]2EBI-389883,EBI-518647
KDR [P35968]3EBI-389883,EBI-1005487
KIT [P10721]3EBI-389883,EBI-1379503
KMT2B [Q9UMN6]2EBI-389883,EBI-765774
LCP2 [Q13094]21EBI-389883,EBI-346946
LRRC3 [Q9BY71]2EBI-389883,EBI-1761329
MAP4 [P27816]2EBI-389883,EBI-715255
MAP4K1 [Q92918]4EBI-389883,EBI-881
MAP4K5 [Q9Y4K4]2EBI-389883,EBI-1279
MEPE [Q9NQ76]3EBI-389883,EBI-1753293
MET [P08581]2EBI-389883,EBI-1039152
MYLK [Q15746]2EBI-389883,EBI-968482
NELFB [Q8WX92]6EBI-389883,EBI-347721
NHSL2 [Q5HYW2]3EBI-389883,EBI-2859639
NKX2-1 [P43699]2EBI-389883,EBI-1391923
NPHS1 [O60500]3EBI-389883,EBI-996920
PAK2 [Q13177]5EBI-389883,EBI-1045887
PDIA2 [Q13087]3EBI-389883,EBI-1752525
PHACTR2 [O75167]2EBI-389883,EBI-1754409
PIK3AP1 - isoform 3 [Q6ZUJ8-3]3EBI-389883,EBI-11981743
PIK3C2B [O00750]3EBI-389883,EBI-641107
PNMA2 [Q9UL42]2EBI-389883,EBI-302355
PRX [Q9BXM0]2EBI-389883,EBI-1753064
PTPN4 [P29074]3EBI-389883,EBI-710431
RAG1 [P15918]2EBI-389883,EBI-1755109
RAPGEF1 [Q13905]2EBI-389883,EBI-976876
RASA1 [P20936]6EBI-389883,EBI-1026476
RIMS2 [Q9UQ26]2EBI-389883,EBI-1756749
RIN3 [Q8TB24]2EBI-389883,EBI-1570523
RPL13 [P26373]2EBI-389883,EBI-356849
RPP38 [P78345]2EBI-389883,EBI-366493
RRAS [P10301]3EBI-389883,EBI-968703
SCARF2 [Q96GP6]2EBI-389883,EBI-1752088
SELENON [Q9NZV5]2EBI-389883,EBI-1751965
SEMA7A [O75326]2EBI-389883,EBI-1753538
SHANK2 [Q9UPX8]6EBI-389883,EBI-1570571
SHANK3 [Q9BYB0]4EBI-389883,EBI-1752330
SHROOM2 [Q13796]2EBI-389883,EBI-1644065
SLC23A1 [Q9UHI7]2EBI-389883,EBI-1759386
SLC24A1 [O60721]3EBI-389883,EBI-1753504
SNX12 [Q9UMY4]3EBI-389883,EBI-1752602
SNX17 [Q15036]3EBI-389883,EBI-1752620
SNX8 [Q9Y5X2]2EBI-389883,EBI-1752557
SOS1 [Q07889]5EBI-389883,EBI-297487
SOS2 [Q07890]3EBI-389883,EBI-298181
SP1 [P08047]2EBI-389883,EBI-298336
SPEN [Q96T58]3EBI-389883,EBI-765739
STK38 [Q15208]3EBI-389883,EBI-458376
SUV39H2 [Q9H5I1]2EBI-389883,EBI-723127
SYNJ2 [O15056]3EBI-389883,EBI-310513
TGOLN2 [O43493]3EBI-389883,EBI-1752146
TMPO [P42167]2EBI-389883,EBI-455283
TPSAB1 [Q15661]2EBI-389883,EBI-1761369
TPX2 [Q9ULW0]4EBI-389883,EBI-1037322
TRAIP [Q9BWF2]3EBI-389883,EBI-1756205
TRIM39 [Q9HCM9]2EBI-389883,EBI-739510
TULP1 [O00294]2EBI-389883,EBI-1756778
VPS13A [Q96RL7]3EBI-389883,EBI-1752583
WASL [O00401]2EBI-389883,EBI-957615
WIPF1 [O43516]2EBI-389883,EBI-346356
Isoform 1 [P16333-1]
With#Exp.IntAct
FASLG [P48023]4EBI-15578122,EBI-495538
RNGTT [O60942]2EBI-15578122,EBI-1237132
WASL [O00401]2EBI-15578122,EBI-957615
Rngtt [O55236] from Mus musculus.3EBI-15578122,EBI-16118241
Tnk2 [O54967] from Mus musculus.2EBI-15578122,EBI-7780354

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110770, 132 interactors

Database of interacting proteins

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DIPi
DIP-639N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P16333

Protein interaction database and analysis system

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IntActi
P16333, 251 interactors

Molecular INTeraction database

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MINTi
P16333

STRING: functional protein association networks

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STRINGi
9606.ENSP00000417273

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P16333

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P16333, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16333

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P16333

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 61SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini106 – 165SH3 2PROSITE-ProRule annotationAdd BLAST60
Domaini190 – 252SH3 3PROSITE-ProRule annotationAdd BLAST63
Domaini282 – 376SH2PROSITE-ProRule annotationAdd BLAST95

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Only the first and third SH3 domains seem to be involved in RASA1-binding; the second SH3 domain and the SH2 domains do not seem to be involved.

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4226, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025160_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16333

KEGG Orthology (KO)

More...
KOi
K07365

Identification of Orthologs from Complete Genome Data

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OMAi
KTGMRET

Database of Orthologous Groups

More...
OrthoDBi
1097449at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16333

TreeFam database of animal gene trees

More...
TreeFami
TF351631

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10408, SH2_Nck1, 1 hit
cd11900, SH3_Nck1_1, 1 hit
cd11901, SH3_Nck1_2, 1 hit
cd11904, SH3_Nck1_3, 1 hit

Database of protein disorder

More...
DisProti
DP01114

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017304, NCK
IPR035882, Nck1_SH2
IPR035562, Nck1_SH3_1
IPR035564, Nck1_SH3_2
IPR035565, Nck1_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037874, Cytoplasmic_NCK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16333-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF
60 70 80 90 100
VPSNYVERKN SARKASIVKN LKDTLGIGKV KRKPSVPDSA SPADDSFVDP
110 120 130 140 150
GERLYDLNMP AYVKFNYMAE REDELSLIKG TKVIVMEKCS DGWWRGSYNG
160 170 180 190 200
QVGWFPSNYV TEEGDSPLGD HVGSLSEKLA AVVNNLNTGQ VLHVVQALYP
210 220 230 240 250
FSSSNDEELN FEKGDVMDVI EKPENDPEWW KCRKINGMVG LVPKNYVTVM
260 270 280 290 300
QNNPLTSGLE PSPPQCDYIR PSLTGKFAGN PWYYGKVTRH QAEMALNERG
310 320 330 340 350
HEGDFLIRDS ESSPNDFSVS LKAQGKNKHF KVQLKETVYC IGQRKFSTME
360 370
ELVEHYKKAP IFTSEQGEKL YLVKHLS
Length:377
Mass (Da):42,864
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i554E9B1A936AEF30
GO
Isoform 2 (identifier: P16333-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MAEEVVVVAK...IVKNLKDTLG → MDWLNVFKDFFS

Show »
Length:313
Mass (Da):35,511
Checksum:iD10F0F2DEF1D72F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVV5C9JVV5_HUMAN
Cytoplasmic protein NCK1
NCK1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J869C9J869_HUMAN
Cytoplasmic protein NCK1
NCK1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5C7H7C5C7_HUMAN
Cytoplasmic protein NCK1
NCK1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAB9C9JAB9_HUMAN
Cytoplasmic protein NCK1
NCK1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0K5C9J0K5_HUMAN
Cytoplasmic protein NCK1
NCK1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K098C9K098_HUMAN
Cytoplasmic protein NCK1
NCK1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051228180A → V. Corresponds to variant dbSNP:rs13320485Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0431221 – 76MAEEV…KDTLG → MDWLNVFKDFFS in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17576 mRNA Translation: CAA35599.1
AK301460 mRNA Translation: BAH13487.1
AC011597 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79105.1
CH471052 Genomic DNA Translation: EAW79108.1
CH471052 Genomic DNA Translation: EAW79109.1
BC006403 mRNA Translation: AAH06403.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3092.1 [P16333-1]
CCDS54644.1 [P16333-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S08636

NCBI Reference Sequences

More...
RefSeqi
NP_001177725.1, NM_001190796.2 [P16333-2]
NP_001278928.1, NM_001291999.1 [P16333-1]
NP_006144.1, NM_006153.5 [P16333-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288986; ENSP00000288986; ENSG00000158092 [P16333-1]
ENST00000469404; ENSP00000419631; ENSG00000158092 [P16333-2]
ENST00000481752; ENSP00000417273; ENSG00000158092 [P16333-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4690

UCSC genome browser

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UCSCi
uc003erh.3, human [P16333-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17576 mRNA Translation: CAA35599.1
AK301460 mRNA Translation: BAH13487.1
AC011597 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79105.1
CH471052 Genomic DNA Translation: EAW79108.1
CH471052 Genomic DNA Translation: EAW79109.1
BC006403 mRNA Translation: AAH06403.1
CCDSiCCDS3092.1 [P16333-1]
CCDS54644.1 [P16333-2]
PIRiS08636
RefSeqiNP_001177725.1, NM_001190796.2 [P16333-2]
NP_001278928.1, NM_001291999.1 [P16333-1]
NP_006144.1, NM_006153.5 [P16333-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CI8X-ray1.80A281-377[»]
2CI9X-ray1.50A/B281-377[»]
2CUBNMR-A99-173[»]
2JS0NMR-A107-165[»]
2JS2NMR-A1-61[»]
2JW4NMR-A1-63[»]
5QU1X-ray1.08A/B4-59[»]
5QU2X-ray1.04A/B1-59[»]
5QU3X-ray1.02A/B4-59[»]
5QU4X-ray1.05A/B/C/D1-61[»]
5QU5X-ray1.11A/B1-61[»]
5QU6X-ray1.821/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z1-61[»]
5QU7X-ray1.27A/B4-59[»]
5QU8X-ray0.93A1-61[»]
5QUAX-ray1.51A/B1-61[»]
SMRiP16333
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110770, 132 interactors
DIPiDIP-639N
ELMiP16333
IntActiP16333, 251 interactors
MINTiP16333
STRINGi9606.ENSP00000417273

Chemistry databases

BindingDBiP16333
ChEMBLiCHEMBL4846

Protein family/group databases

MoonDBiP16333, Predicted

PTM databases

iPTMnetiP16333
PhosphoSitePlusiP16333

Polymorphism and mutation databases

BioMutaiNCK1
DMDMi127962

Proteomic databases

EPDiP16333
jPOSTiP16333
MassIVEiP16333
MaxQBiP16333
PaxDbiP16333
PeptideAtlasiP16333
PRIDEiP16333
ProteomicsDBi53345 [P16333-1]
53346 [P16333-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3567, 538 antibodies

The DNASU plasmid repository

More...
DNASUi
4690

Genome annotation databases

EnsembliENST00000288986; ENSP00000288986; ENSG00000158092 [P16333-1]
ENST00000469404; ENSP00000419631; ENSG00000158092 [P16333-2]
ENST00000481752; ENSP00000417273; ENSG00000158092 [P16333-1]
GeneIDi4690
KEGGihsa:4690
UCSCiuc003erh.3, human [P16333-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4690
DisGeNETi4690
EuPathDBiHostDB:ENSG00000158092.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NCK1
HGNCiHGNC:7664, NCK1
HPAiENSG00000158092, Low tissue specificity
MIMi600508, gene
neXtProtiNX_P16333
OpenTargetsiENSG00000158092
PharmGKBiPA31466

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4226, Eukaryota
GeneTreeiENSGT00940000156601
HOGENOMiCLU_025160_0_1_1
InParanoidiP16333
KOiK07365
OMAiKTGMRET
OrthoDBi1097449at2759
PhylomeDBiP16333
TreeFamiTF351631

Enzyme and pathway databases

PathwayCommonsiP16333
ReactomeiR-HSA-186763, Downstream signal transduction
R-HSA-202433, Generation of second messenger molecules
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-373753, Nephrin family interactions
R-HSA-418885, DCC mediated attractive signaling
R-HSA-428540, Activation of RAC1
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP16333
SIGNORiP16333

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4690, 26 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NCK1, human
EvolutionaryTraceiP16333

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NCK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4690
PharosiP16333, Tbio

Protein Ontology

More...
PROi
PR:P16333
RNActiP16333, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158092, Expressed in vagina and 245 other tissues
ExpressionAtlasiP16333, baseline and differential
GenevisibleiP16333, HS

Family and domain databases

CDDicd10408, SH2_Nck1, 1 hit
cd11900, SH3_Nck1_1, 1 hit
cd11901, SH3_Nck1_2, 1 hit
cd11904, SH3_Nck1_3, 1 hit
DisProtiDP01114
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR017304, NCK
IPR035882, Nck1_SH2
IPR035562, Nck1_SH3_1
IPR035564, Nck1_SH3_2
IPR035565, Nck1_SH3_3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PIRSFiPIRSF037874, Cytoplasmic_NCK, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 3 hits
SUPFAMiSSF50044, SSF50044, 3 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16333
Secondary accession number(s): B7Z751, D3DNE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 12, 2020
This is version 223 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. UniProtKB entry view manual
    User manual for the UniProtKB entry view
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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