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Entry version 163 (07 Apr 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Methylmalonyl-CoA mutase, mitochondrial

Gene

Mmut

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

adenosylcob(III)alamin1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.20 µM for adenosylcob(III)alamin1 Publication
  2. KM=0.27 mM for methylmalonyl-CoA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei48malonyl-CoABy similarity1
    Binding sitei226malonyl-CoABy similarity1
    Binding sitei253malonyl-CoABy similarity1
    Binding sitei263malonyl-CoABy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi625Cobalt (cobalamin 2 axial ligand)By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase
    LigandCobalamin, Cobalt, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism
    R-MMU-71032, Propionyl-CoA catabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Methylmalonyl-CoA mutase, mitochondrial (EC:5.4.99.21 Publication)
    Short name:
    MCM
    Alternative name(s):
    Methylmalonyl-CoA isomerase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Mmut
    Synonyms:MutImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:97239, Mmut

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001929531 – 748Methylmalonyl-CoA mutase, mitochondrialAdd BLAST718

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87N6-acetyllysineCombined sources1
    Modified residuei210N6-acetyllysineCombined sources1
    Modified residuei333N6-acetyllysineCombined sources1
    Modified residuei341N6-succinyllysineCombined sources1
    Modified residuei479PhosphoserineBy similarity1
    Modified residuei593N6-succinyllysineCombined sources1
    Modified residuei600N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P16332

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P16332

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P16332

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P16332

    PeptideAtlas

    More...
    PeptideAtlasi
    P16332

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P16332

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    252616

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P16332

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P16332

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P16332

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000023921, Expressed in brown adipose tissue and 310 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P16332, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P16332, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.

    By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    201624, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P16332, 3 interactors

    Molecular INTeraction database

    More...
    MINTi
    P16332

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000130941

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P16332, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P16332

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini612 – 744B12-bindingPROSITE-ProRule annotationAdd BLAST133

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 97malonyl-CoA bindingBy similarity4
    Regioni104 – 108malonyl-CoA bindingBy similarity5
    Regioni214 – 216malonyl-CoA bindingBy similarity3
    Regioni302 – 304malonyl-CoA bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the methylmalonyl-CoA mutase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QQ7X, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000011892

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009523_3_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P16332

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GPYATMY

    Database of Orthologous Groups

    More...
    OrthoDBi
    347581at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313557

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006159, Acid_CoA_mut_C
    IPR016176, Cbl-dep_enz_cat
    IPR006158, Cobalamin-bd
    IPR036724, Cobalamin-bd_sf
    IPR006099, MeMalonylCoA_mutase_a/b_cat
    IPR006098, MMCoA_mutase_a_cat

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02310, B12-binding, 1 hit
    PF01642, MM_CoA_mutase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51703, SSF51703, 1 hit
    SSF52242, SSF52242, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00640, acid_CoA_mut_C, 1 hit
    TIGR00641, acid_CoA_mut_N, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51332, B12_BINDING, 1 hit
    PS00544, METMALONYL_COA_MUTASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    P16332-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLRAKNQLFL LSPHYLKQLN IPSASRWKRL LHQQQPLHPE WAVLAKKQLK
    60 70 80 90 100
    GKNPEDLIWH TPEGISIKPL YSRADTLDLP EELPGVKPFT RGPYPTMYTY
    110 120 130 140 150
    RPWTIRQYAG FSTVEESNKF YKDNIKAGQQ GLSVAFDLAT HRGYDSDNPR
    160 170 180 190 200
    VRGDVGMAGV AIDTVEDTKI LFDGIPLEKM SVSMTMNGAV IPVLATFIVT
    210 220 230 240 250
    GEEQGVPKEK LTGTIQNDIL KEFMVRNTYI FPPEPSMKII ADIFQYTAQH
    260 270 280 290 300
    MPKFNSISIS GYHMQEAGAD AILELAYTIA DGLEYCRTGL QAGLTIDEFA
    310 320 330 340 350
    PRLSFFWGIG MNFYMEIAKM RAGRRLWAHL IEKMFQPKNS KSLLLRAHCQ
    360 370 380 390 400
    TSGWSLTEQD PYNNIVRTAI EAMAAVFGGT QSLHTNSFDE ALGLPTVKSA
    410 420 430 440 450
    RIARNTQIII QEESGIPKVA DPWGGSYMME SLTNDVYEAA LKLIYEVEEM
    460 470 480 490 500
    GGMAKAVAEG IPKLRIEECA ARRQARIDSG SEVIVGVNKY QLEKEDSVEV
    510 520 530 540 550
    LAIDNTSVRK KQIEKLKKIK SSRDQALAEQ CLSALTQCAA SGDGNILALA
    560 570 580 590 600
    VDAARARCTV GEITDALKKV FGEHKANDRM VSGAYRQEFG ESKEITSAIK
    610 620 630 640 650
    RVNKFMEREG RRPRLLVAKM GQDGHDRGAK VIATGFADLG FDVDIGPLFQ
    660 670 680 690 700
    TPREVAQQAV DADVHAVGVS TLAAGHKTLV PELIKELTAL GRPDILVMCG
    710 720 730 740
    GVIPPQDYEF LYEVGVSNVF GPGTRIPRAA VQVLDDIEKC LAEKQQSV
    Length:748
    Mass (Da):82,844
    Last modified:July 27, 2011 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF4A62100A8BD743
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A3B2WCT0A0A3B2WCT0_MOUSE
    Methylmalonyl-CoA mutase, mitochond...
    Mmut
    184Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti256S → P in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti269A → T in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti385T → S in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti407Q → R in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti491Q → H in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti499 – 508EVLAIDNTSV → HLLAIDIISL in CAA36204 (PubMed:1978672).Curated10
    Sequence conflicti561G → P in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti567L → F in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti613 – 614PR → LG in CAA36204 (PubMed:1978672).Curated2
    Sequence conflicti622Q → K in CAA36204 (PubMed:1978672).Curated1
    Sequence conflicti657 – 658QQ → HD in CAA36204 (PubMed:1978672).Curated2
    Sequence conflicti672L → H in CAA36204 (PubMed:1978672).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X51941 mRNA Translation: CAA36204.1
    AK146309 mRNA Translation: BAE27064.1
    CH466559 Genomic DNA Translation: EDL23389.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS37618.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S08680

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_032676.2, NM_008650.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000169611; ENSMUSP00000130941; ENSMUSG00000023921

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    17850

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:17850

    UCSC genome browser

    More...
    UCSCi
    uc008coo.2, mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X51941 mRNA Translation: CAA36204.1
    AK146309 mRNA Translation: BAE27064.1
    CH466559 Genomic DNA Translation: EDL23389.1
    CCDSiCCDS37618.1
    PIRiS08680
    RefSeqiNP_032676.2, NM_008650.3

    3D structure databases

    SMRiP16332
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi201624, 12 interactors
    IntActiP16332, 3 interactors
    MINTiP16332
    STRINGi10090.ENSMUSP00000130941

    PTM databases

    iPTMnetiP16332
    PhosphoSitePlusiP16332
    SwissPalmiP16332

    Proteomic databases

    EPDiP16332
    jPOSTiP16332
    MaxQBiP16332
    PaxDbiP16332
    PeptideAtlasiP16332
    PRIDEiP16332
    ProteomicsDBi252616

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    30809, 169 antibodies

    Genome annotation databases

    EnsembliENSMUST00000169611; ENSMUSP00000130941; ENSMUSG00000023921
    GeneIDi17850
    KEGGimmu:17850
    UCSCiuc008coo.2, mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4594
    MGIiMGI:97239, Mmut

    Phylogenomic databases

    eggNOGiENOG502QQ7X, Eukaryota
    GeneTreeiENSGT00390000011892
    HOGENOMiCLU_009523_3_1_1
    InParanoidiP16332
    OMAiGPYATMY
    OrthoDBi347581at2759
    TreeFamiTF313557

    Enzyme and pathway databases

    ReactomeiR-MMU-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism
    R-MMU-71032, Propionyl-CoA catabolism

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    17850, 3 hits in 54 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Mut, mouse

    Protein Ontology

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    PROi
    PR:P16332
    RNActiP16332, protein

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000023921, Expressed in brown adipose tissue and 310 other tissues
    ExpressionAtlasiP16332, baseline and differential
    GenevisibleiP16332, MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR006159, Acid_CoA_mut_C
    IPR016176, Cbl-dep_enz_cat
    IPR006158, Cobalamin-bd
    IPR036724, Cobalamin-bd_sf
    IPR006099, MeMalonylCoA_mutase_a/b_cat
    IPR006098, MMCoA_mutase_a_cat
    PfamiView protein in Pfam
    PF02310, B12-binding, 1 hit
    PF01642, MM_CoA_mutase, 1 hit
    SUPFAMiSSF51703, SSF51703, 1 hit
    SSF52242, SSF52242, 1 hit
    TIGRFAMsiTIGR00640, acid_CoA_mut_C, 1 hit
    TIGR00641, acid_CoA_mut_N, 1 hit
    PROSITEiView protein in PROSITE
    PS51332, B12_BINDING, 1 hit
    PS00544, METMALONYL_COA_MUTASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUTA_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16332
    Secondary accession number(s): Q3UJU1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: July 27, 2011
    Last modified: April 7, 2021
    This is version 163 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
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