UniProtKB - P16305 (GBRA6_MOUSE)
Gamma-aminobutyric acid receptor subunit alpha-6
Gabra6
Functioni
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
GO - Molecular functioni
- diazepam binding Source: MGI
- GABA-A receptor activity Source: InterPro
- GABA-gated chloride ion channel activity Source: GO_Central
- heterocyclic compound binding Source: MGI
- inhibitory extracellular ligand-gated ion channel activity Source: MGI
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: MGI
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- gamma-aminobutyric acid signaling pathway Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- regulation of membrane potential Source: GO_Central
- regulation of postsynaptic membrane potential Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: MGI
Keywordsi
Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit alpha-6Alternative name(s): GABA(A) receptor subunit alpha-6 |
Gene namesi | Name:Gabra6 Synonyms:Gabra-6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95618, Gabra6 |
VEuPathDBi | HostDB:ENSMUSG00000020428 |
Subcellular locationi
Plasma Membrane
- dendrite membrane Source: GO_Central
- integral component of plasma membrane Source: MGI
- integral component of postsynaptic specialization membrane Source: MGI
- neuronal cell body membrane Source: MGI
- postsynaptic membrane Source: MGI
- presynaptic membrane Source: MGI
Other locations
- cerebellar Golgi cell to granule cell synapse Source: SynGO
- chloride channel complex Source: UniProtKB-KW
- dendrite Source: MGI
- GABA-A receptor complex Source: GO_Central
- GABA-ergic synapse Source: MGI
- hippocampal mossy fiber to CA3 synapse Source: MGI
- membrane Source: MGI
- neuron projection Source: GO_Central
- postsynapse Source: GO_Central
- receptor complex Source: MGI
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 242 | ExtracellularCuratedAdd BLAST | 223 | |
Transmembranei | 243 – 264 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 269 – 290 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 301 – 324 | HelicalCuratedAdd BLAST | 24 | |
Topological domaini | 325 – 419 | CytoplasmicCuratedAdd BLAST | 95 | |
Transmembranei | 420 – 441 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000000448 | 20 – 453 | Gamma-aminobutyric acid receptor subunit alpha-6Add BLAST | 434 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 156 ↔ 170 | By similarity | ||
Modified residuei | 375 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P16305 |
PaxDbi | P16305 |
PeptideAtlasi | P16305 |
PRIDEi | P16305 |
ProteomicsDBi | 273421 [P16305-1] 273422 [P16305-2] 273423 [P16305-3] 273424 [P16305-4] |
PTM databases
GlyConnecti | 2437, 2 N-Linked glycans (2 sites) [P16305-3] |
GlyGeni | P16305, 3 sites |
iPTMneti | P16305 |
PhosphoSitePlusi | P16305 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000020428, Expressed in cerebellum lobe and 62 other tissues |
Genevisiblei | P16305, MM |
Interactioni
Subunit structurei
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.
Protein-protein interaction databases
ComplexPortali | CPX-2981, GABA-A receptor, alpha-6/beta-3/gamma-2 CPX-2986, GABA-A receptor, alpha-6/beta-3/delta CPX-2987, GABA-A receptor, alpha-6/beta-2/delta |
STRINGi | 10090.ENSMUSP00000126114 |
Miscellaneous databases
RNActi | P16305, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156722 |
HOGENOMi | CLU_010920_2_2_1 |
InParanoidi | P16305 |
OMAi | YIILWVE |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P16305 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005436, GABBAa6_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01619, GABAARALPHA6 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVLLLPWLFI ILWLENAQAQ LEDEGNFYSE NVSRILDNLL EGYDNRLRPG
60 70 80 90 100
FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFKGPAEI
110 120 130 140 150
LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRLMQ NGTILYTMRL
160 170 180 190 200
TINADCPMRL VNFPMDGHAC PLKFGSYAYP KTEIIYTWKK GPLYSVEVPE
210 220 230 240 250
ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP
260 270 280 290 300
CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA
310 320 330 340 350
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QSQKAERQAQ TAATPPVAKS
360 370 380 390 400
KASESLQAEI VVHSDSKYHL KKRISSLTLP IVPSSEASKA LSRTPILKST
410 420 430 440 450
PVSPPLLLPA TGGTSKIDQY SRILFPVAFA GFNLVYWIVY LSKDTMEVSS
TVE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 357 | Q → E in CAA36244 (PubMed:2167378).Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAD52001 (Ref. 2) Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAD52002 (Ref. 2) Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAD52003 (Ref. 2) Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAD52004 (Ref. 2) Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAG28024 (Ref. 3) Curated | 1 | |
Sequence conflicti | 357 | Q → E in AAG28025 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000085 | 1 – 13 | MVLLL…FIILW → MRNMKDLEDFSR in isoform 3 and isoform 4. CuratedAdd BLAST | 13 | |
Alternative sequenceiVSP_000086 | 76 – 85 | Missing in isoform 2 and isoform 4. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51986 mRNA Translation: CAA36244.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52001.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52002.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52003.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52004.1 AF256197 mRNA Translation: AAG28024.1 AF256198 mRNA Translation: AAG28025.1 AK135145 mRNA Translation: BAE22438.1 AL645823 Genomic DNA No translation available. BC145158 mRNA Translation: AAI45159.1 BC145702 mRNA Translation: AAI45703.1 |
CCDSi | CCDS24554.1 [P16305-2] CCDS48769.1 [P16305-1] CCDS88145.1 [P16305-3] |
PIRi | S11396 |
RefSeqi | NP_001093111.1, NM_001099641.2 [P16305-1] NP_032094.2, NM_008068.3 [P16305-2] XP_006532260.1, XM_006532197.3 |
Genome annotation databases
Ensembli | ENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428 [P16305-2] ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428 [P16305-3] ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428 [P16305-1] |
GeneIDi | 14399 |
KEGGi | mmu:14399 |
UCSCi | uc007img.2, mouse [P16305-2] uc007imh.2, mouse [P16305-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51986 mRNA Translation: CAA36244.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52001.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52002.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52003.1 U77411, U77409, U77410 Genomic DNA Translation: AAD52004.1 AF256197 mRNA Translation: AAG28024.1 AF256198 mRNA Translation: AAG28025.1 AK135145 mRNA Translation: BAE22438.1 AL645823 Genomic DNA No translation available. BC145158 mRNA Translation: AAI45159.1 BC145702 mRNA Translation: AAI45703.1 |
CCDSi | CCDS24554.1 [P16305-2] CCDS48769.1 [P16305-1] CCDS88145.1 [P16305-3] |
PIRi | S11396 |
RefSeqi | NP_001093111.1, NM_001099641.2 [P16305-1] NP_032094.2, NM_008068.3 [P16305-2] XP_006532260.1, XM_006532197.3 |
3D structure databases
AlphaFoldDBi | P16305 |
SMRi | P16305 |
ModBasei | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-2981, GABA-A receptor, alpha-6/beta-3/gamma-2 CPX-2986, GABA-A receptor, alpha-6/beta-3/delta CPX-2987, GABA-A receptor, alpha-6/beta-2/delta |
STRINGi | 10090.ENSMUSP00000126114 |
Chemistry databases
ChEMBLi | CHEMBL2094133 |
DrugCentrali | P16305 |
PTM databases
GlyConnecti | 2437, 2 N-Linked glycans (2 sites) [P16305-3] |
GlyGeni | P16305, 3 sites |
iPTMneti | P16305 |
PhosphoSitePlusi | P16305 |
Proteomic databases
MaxQBi | P16305 |
PaxDbi | P16305 |
PeptideAtlasi | P16305 |
PRIDEi | P16305 |
ProteomicsDBi | 273421 [P16305-1] 273422 [P16305-2] 273423 [P16305-3] 273424 [P16305-4] |
Protocols and materials databases
ABCDi | P16305, 2 sequenced antibodies |
Antibodypediai | 28560, 209 antibodies from 32 providers |
DNASUi | 14399 |
Genome annotation databases
Ensembli | ENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428 [P16305-2] ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428 [P16305-3] ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428 [P16305-1] |
GeneIDi | 14399 |
KEGGi | mmu:14399 |
UCSCi | uc007img.2, mouse [P16305-2] uc007imh.2, mouse [P16305-1] |
Organism-specific databases
CTDi | 2559 |
MGIi | MGI:95618, Gabra6 |
VEuPathDBi | HostDB:ENSMUSG00000020428 |
Phylogenomic databases
eggNOGi | KOG3642, Eukaryota |
GeneTreei | ENSGT00940000156722 |
HOGENOMi | CLU_010920_2_2_1 |
InParanoidi | P16305 |
OMAi | YIILWVE |
OrthoDBi | 1057372at2759 |
PhylomeDBi | P16305 |
TreeFami | TF315453 |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 14399, 4 hits in 71 CRISPR screens |
PROi | PR:P16305 |
RNActi | P16305, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020428, Expressed in cerebellum lobe and 62 other tissues |
Genevisiblei | P16305, MM |
Family and domain databases
Gene3Di | 1.20.58.390, 1 hit 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR001390, GABAAa_rcpt IPR005436, GABBAa6_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR038050, Neuro_actylchol_rec IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01079, GABAARALPHA PR01619, GABAARALPHA6 PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRA6_MOUSE | |
Accessioni | P16305Primary (citable) accession number: P16305 Secondary accession number(s): Q5SUU5 Q9R0V5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families