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UniProtKB - P16305 (GBRA6_MOUSE)

Entry version 187 (25 May 2022)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

Gamma-aminobutyric acid receptor subunit alpha-6

Gene

Gabra6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-977443, GABA receptor activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit alpha-6
Alternative name(s):
GABA(A) receptor subunit alpha-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gabra6
Synonyms:Gabra-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:95618, Gabra6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000020428

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 242ExtracellularCuratedAdd BLAST223
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei243 – 264HelicalCuratedAdd BLAST22
Transmembranei269 – 290HelicalCuratedAdd BLAST22
Transmembranei301 – 324HelicalCuratedAdd BLAST24
Topological domaini325 – 419CytoplasmicCuratedAdd BLAST95
Transmembranei420 – 441HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2094133

DrugCentral

More...DrugCentrali		P16305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000044820 – 453Gamma-aminobutyric acid receptor subunit alpha-6Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi156 ↔ 170By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei375PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16305

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16305

PeptideAtlas

More...PeptideAtlasi		P16305

PRoteomics IDEntifications database

More...PRIDEi		P16305

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		273421 [P16305-1]
273422 [P16305-2]
273423 [P16305-3]
273424 [P16305-4]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2437, 2 N-Linked glycans (2 sites) [P16305-3]

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16305, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16305

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Only found in cerebellar granule cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020428, Expressed in cerebellum lobe and 62 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16305, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2981, GABA-A receptor, alpha-6/beta-3/gamma-2
CPX-2986, GABA-A receptor, alpha-6/beta-3/delta
CPX-2987, GABA-A receptor, alpha-6/beta-2/delta

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000126114

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16305, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P16305

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16305

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily. [View classification]Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3642, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010920_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16305

Identification of Orthologs from Complete Genome Data

More...OMAi		YIILWVE

Database of Orthologous Groups

More...OrthoDBi		1057372at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16305

TreeFam database of animal gene trees

More...TreeFami		TF315453

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.390, 1 hit
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006028, GABAA/Glycine_rcpt
IPR001390, GABAAa_rcpt
IPR005436, GABBAa6_rcpt
IPR006202, Neur_chan_lig-bd
IPR036734, Neur_chan_lig-bd_sf
IPR006201, Neur_channel
IPR036719, Neuro-gated_channel_TM_sf
IPR038050, Neuro_actylchol_rec
IPR006029, Neurotrans-gated_channel_TM
IPR018000, Neurotransmitter_ion_chnl_CS

The PANTHER Classification System

More...PANTHERi		PTHR18945, PTHR18945, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02931, Neur_chan_LBD, 1 hit
PF02932, Neur_chan_memb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01079, GABAARALPHA
PR01619, GABAARALPHA6
PR00253, GABAARECEPTR
PR00252, NRIONCHANNEL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63712, SSF63712, 1 hit
SSF90112, SSF90112, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00860, LIC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00236, NEUROTR_ION_CHANNEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P16305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLLLPWLFI ILWLENAQAQ LEDEGNFYSE NVSRILDNLL EGYDNRLRPG 
        60         70         80         90        100
FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFKGPAEI 
       110        120        130        140        150
LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRLMQ NGTILYTMRL 
       160        170        180        190        200
TINADCPMRL VNFPMDGHAC PLKFGSYAYP KTEIIYTWKK GPLYSVEVPE 
       210        220        230        240        250
ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP 
       260        270        280        290        300
CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA 
       310        320        330        340        350
TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QSQKAERQAQ TAATPPVAKS 
       360        370        380        390        400
KASESLQAEI VVHSDSKYHL KKRISSLTLP IVPSSEASKA LSRTPILKST 
       410        420        430        440        450
PVSPPLLLPA TGGTSKIDQY SRILFPVAFA GFNLVYWIVY LSKDTMEVSS 

TVE
Length:453
Mass (Da):51,106
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iACCDF38AE8D4695D
GO
Isoform 2 (identifier: P16305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-85: Missing.

Show »
Length:443
Mass (Da):49,789
Checksum:i688CF66DC6503652
GO
Isoform 3 (identifier: P16305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVLLLPWLFIILW → MRNMKDLEDFSR

Show »
Length:452
Mass (Da):50,991
Checksum:i2381E676A8F3C780
GO
Isoform 4 (identifier: P16305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVLLLPWLFIILW → MRNMKDLEDFSR
     76-85: Missing.

Show »
Length:442
Mass (Da):49,673
Checksum:iDF2F09AF5E35C766
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357Q → E in CAA36244 (PubMed:2167378).Curated1
Sequence conflicti357Q → E in AAD52001 (Ref. 2) Curated1
Sequence conflicti357Q → E in AAD52002 (Ref. 2) Curated1
Sequence conflicti357Q → E in AAD52003 (Ref. 2) Curated1
Sequence conflicti357Q → E in AAD52004 (Ref. 2) Curated1
Sequence conflicti357Q → E in AAG28024 (Ref. 3) Curated1
Sequence conflicti357Q → E in AAG28025 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0000851 – 13MVLLL…FIILW → MRNMKDLEDFSR in isoform 3 and isoform 4. CuratedAdd BLAST13
Alternative sequenceiVSP_00008676 – 85Missing in isoform 2 and isoform 4. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X51986 mRNA Translation: CAA36244.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52001.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52002.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52003.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52004.1
AF256197 mRNA Translation: AAG28024.1
AF256198 mRNA Translation: AAG28025.1
AK135145 mRNA Translation: BAE22438.1
AL645823 Genomic DNA No translation available.
BC145158 mRNA Translation: AAI45159.1
BC145702 mRNA Translation: AAI45703.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24554.1 [P16305-2]
CCDS48769.1 [P16305-1]
CCDS88145.1 [P16305-3]

Protein sequence database of the Protein Information Resource

More...PIRi		S11396

NCBI Reference Sequences

More...RefSeqi		NP_001093111.1, NM_001099641.2 [P16305-1]
NP_032094.2, NM_008068.3 [P16305-2]
XP_006532260.1, XM_006532197.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428 [P16305-2]
ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428 [P16305-3]
ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428 [P16305-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14399

UCSC genome browser

More...UCSCi		uc007img.2, mouse [P16305-2]
uc007imh.2, mouse [P16305-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51986 mRNA Translation: CAA36244.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52001.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52002.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52003.1
U77411, U77409, U77410 Genomic DNA Translation: AAD52004.1
AF256197 mRNA Translation: AAG28024.1
AF256198 mRNA Translation: AAG28025.1
AK135145 mRNA Translation: BAE22438.1
AL645823 Genomic DNA No translation available.
BC145158 mRNA Translation: AAI45159.1
BC145702 mRNA Translation: AAI45703.1
CCDSiCCDS24554.1 [P16305-2]
CCDS48769.1 [P16305-1]
CCDS88145.1 [P16305-3]
PIRiS11396
RefSeqiNP_001093111.1, NM_001099641.2 [P16305-1]
NP_032094.2, NM_008068.3 [P16305-2]
XP_006532260.1, XM_006532197.3

3D structure databases

AlphaFoldDBiP16305
SMRiP16305
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2981, GABA-A receptor, alpha-6/beta-3/gamma-2
CPX-2986, GABA-A receptor, alpha-6/beta-3/delta
CPX-2987, GABA-A receptor, alpha-6/beta-2/delta
STRINGi10090.ENSMUSP00000126114

Chemistry databases

ChEMBLiCHEMBL2094133
DrugCentraliP16305

PTM databases

GlyConnecti2437, 2 N-Linked glycans (2 sites) [P16305-3]
GlyGeniP16305, 3 sites
iPTMnetiP16305
PhosphoSitePlusiP16305

Proteomic databases

MaxQBiP16305
PaxDbiP16305
PeptideAtlasiP16305
PRIDEiP16305
ProteomicsDBi273421 [P16305-1]
273422 [P16305-2]
273423 [P16305-3]
273424 [P16305-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P16305, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28560, 209 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		14399

Genome annotation databases

EnsembliENSMUST00000020703; ENSMUSP00000020703; ENSMUSG00000020428 [P16305-2]
ENSMUST00000109286; ENSMUSP00000104909; ENSMUSG00000020428 [P16305-3]
ENSMUST00000155218; ENSMUSP00000126114; ENSMUSG00000020428 [P16305-1]
GeneIDi14399
KEGGimmu:14399
UCSCiuc007img.2, mouse [P16305-2]
uc007imh.2, mouse [P16305-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2559
MGIiMGI:95618, Gabra6
VEuPathDBiHostDB:ENSMUSG00000020428

Phylogenomic databases

eggNOGiKOG3642, Eukaryota
GeneTreeiENSGT00940000156722
HOGENOMiCLU_010920_2_2_1
InParanoidiP16305
OMAiYIILWVE
OrthoDBi1057372at2759
PhylomeDBiP16305
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-MMU-977443, GABA receptor activation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14399, 4 hits in 71 CRISPR screens

Protein Ontology

More...PROi		PR:P16305
RNActiP16305, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020428, Expressed in cerebellum lobe and 62 other tissues
GenevisibleiP16305, MM

Family and domain databases

Gene3Di1.20.58.390, 1 hit
2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028, GABAA/Glycine_rcpt
IPR001390, GABAAa_rcpt
IPR005436, GABBAa6_rcpt
IPR006202, Neur_chan_lig-bd
IPR036734, Neur_chan_lig-bd_sf
IPR006201, Neur_channel
IPR036719, Neuro-gated_channel_TM_sf
IPR038050, Neuro_actylchol_rec
IPR006029, Neurotrans-gated_channel_TM
IPR018000, Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945, PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931, Neur_chan_LBD, 1 hit
PF02932, Neur_chan_memb, 1 hit
PRINTSiPR01079, GABAARALPHA
PR01619, GABAARALPHA6
PR00253, GABAARECEPTR
PR00252, NRIONCHANNEL
SUPFAMiSSF63712, SSF63712, 1 hit
SSF90112, SSF90112, 1 hit
TIGRFAMsiTIGR00860, LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236, NEUROTR_ION_CHANNEL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBRA6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16305
Secondary accession number(s): Q5SUU5
, Q9R0V3, Q9R0V4, Q9R0V5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: May 25, 2022
This is version 187 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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