UniProtKB - P16297 (IL2RB_MOUSE)
Protein
Interleukin-2 receptor subunit beta
Gene
Il2rb
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).By similarity
GO - Molecular functioni
- interleukin-15 receptor activity Source: UniProtKB
- interleukin-2 binding Source: MGI
- interleukin-2 receptor activity Source: MGI
GO - Biological processi
- cytokine-mediated signaling pathway Source: MGI
- interleukin-15-mediated signaling pathway Source: UniProtKB
- natural killer cell activation Source: MGI
- negative regulation of apoptotic process Source: MGI
- positive regulation of phagocytosis Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
Reactomei | R-MMU-5673001 RAF/MAP kinase cascade R-MMU-8983432 Interleukin-15 signaling R-MMU-9020558 Interleukin-2 signaling R-MMU-912526 Interleukin receptor SHC signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-2 receptor subunit betaShort name: IL-2 receptor subunit beta Short name: IL-2R subunit beta Short name: IL-2RB Alternative name(s): High affinity IL-2 receptor subunit beta p70-75 CD_antigen: CD122 |
Gene namesi | Name:Il2rb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96550 Il2rb |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Other locations
- Cell surface By similarity
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: Reactome
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 240 | ExtracellularSequence analysisAdd BLAST | 214 | |
Transmembranei | 241 – 268 | HelicalSequence analysisAdd BLAST | 28 | |
Topological domaini | 269 – 539 | CytoplasmicSequence analysisAdd BLAST | 271 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Add BLAST | 26 | |
ChainiPRO_0000010879 | 27 – 539 | Interleukin-2 receptor subunit betaAdd BLAST | 513 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 30 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 36 ↔ 46 | By similarity | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 74 ↔ 86 | By similarity | ||
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 216 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P16297 |
PaxDbi | P16297 |
PRIDEi | P16297 |
PTM databases
iPTMneti | P16297 |
PhosphoSitePlusi | P16297 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000068227 Expressed in 41 organ(s), highest expression level in lymph node |
Genevisiblei | P16297 MM |
Interactioni
Subunit structurei
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation (By similarity).By similarity
GO - Molecular functioni
- interleukin-2 binding Source: MGI
Protein-protein interaction databases
IntActi | P16297, 1 interactor |
STRINGi | 10090.ENSMUSP00000086820 |
Structurei
3D structure databases
ProteinModelPortali | P16297 |
SMRi | P16297 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 235 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 101 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 221 – 225 | WSXWS motif | 5 | |
Motifi | 281 – 289 | Box 1 motif | 9 |
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410II5H Eukaryota ENOG410YXT9 LUCA |
GeneTreei | ENSGT00510000049239 |
HOGENOMi | HOG000038003 |
HOVERGENi | HBG052110 |
InParanoidi | P16297 |
KOi | K05069 |
OMAi | SWACNLI |
OrthoDBi | 1322475at2759 |
PhylomeDBi | P16297 |
TreeFami | TF337874 |
Family and domain databases
CDDi | cd00063 FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold |
SUPFAMi | SSF49265 SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16297-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATIALPWSL SLYVFLLLLA TPWASAAVKN CSHLECFYNS RANVSCMWSH
60 70 80 90 100
EEALNVTTCH VHAKSNLRHW NKTCELTLVR QASWACNLIL GSFPESQSLT
110 120 130 140 150
SVDLLDINVV CWEEKGWRRV KTCDFHPFDN LRLVAPHSLQ VLHIDTQRCN
160 170 180 190 200
ISWKVSQVSH YIEPYLEFEA RRRLLGHSWE DASVLSLKQR QQWLFLEMLI
210 220 230 240 250
PSTSYEVQVR VKAQRNNTGT WSPWSQPLTF RTRPADPMKE ILPMSWLRYL
260 270 280 290 300
LLVLGCFSGF FSCVYILVKC RYLGPWLKTV LKCHIPDPSE FFSQLSSQHG
310 320 330 340 350
GDLQKWLSSP VPLSFFSPSG PAPEISPLEV LDGDSKAVQL LLLQKDSAPL
360 370 380 390 400
PSPSGHSQAS CFTNQGYFFF HLPNALEIES CQVYFTYDPC VEEEVEEDGS
410 420 430 440 450
RLPEGSPHPP LLPLAGEQDD YCAFPPRDDL LLFSPSLSTP NTAYGGSRAP
460 470 480 490 500
EERSPLSLHE GLPSLASRDL MGLQRPLERM PEGDGEGLSA NSSGEQASVP
510 520 530
EGNLHGQDQD RGQGPILTLN TDAYLSLQEL QAQDSVHLI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28052 mRNA Translation: AAA39283.1 AK017288 mRNA Translation: BAB30674.1 AK157572 mRNA Translation: BAE34125.1 |
CCDSi | CCDS27616.1 |
PIRi | A35052 |
RefSeqi | NP_032394.1, NM_008368.4 XP_006520540.1, XM_006520477.3 XP_006520541.1, XM_006520478.3 XP_006520542.1, XM_006520479.2 XP_006520543.1, XM_006520480.3 XP_006520544.1, XM_006520481.2 |
UniGenei | Mm.35287 Mm.384038 |
Genome annotation databases
Ensembli | ENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227 ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227 |
GeneIDi | 16185 |
KEGGi | mmu:16185 |
UCSCi | uc007wpk.2 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28052 mRNA Translation: AAA39283.1 AK017288 mRNA Translation: BAB30674.1 AK157572 mRNA Translation: BAE34125.1 |
CCDSi | CCDS27616.1 |
PIRi | A35052 |
RefSeqi | NP_032394.1, NM_008368.4 XP_006520540.1, XM_006520477.3 XP_006520541.1, XM_006520478.3 XP_006520542.1, XM_006520479.2 XP_006520543.1, XM_006520480.3 XP_006520544.1, XM_006520481.2 |
UniGenei | Mm.35287 Mm.384038 |
3D structure databases
ProteinModelPortali | P16297 |
SMRi | P16297 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | P16297, 1 interactor |
STRINGi | 10090.ENSMUSP00000086820 |
PTM databases
iPTMneti | P16297 |
PhosphoSitePlusi | P16297 |
Proteomic databases
EPDi | P16297 |
PaxDbi | P16297 |
PRIDEi | P16297 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000089398; ENSMUSP00000086820; ENSMUSG00000068227 ENSMUST00000163494; ENSMUSP00000127006; ENSMUSG00000068227 |
GeneIDi | 16185 |
KEGGi | mmu:16185 |
UCSCi | uc007wpk.2 mouse |
Organism-specific databases
CTDi | 3560 |
MGIi | MGI:96550 Il2rb |
Phylogenomic databases
eggNOGi | ENOG410II5H Eukaryota ENOG410YXT9 LUCA |
GeneTreei | ENSGT00510000049239 |
HOGENOMi | HOG000038003 |
HOVERGENi | HBG052110 |
InParanoidi | P16297 |
KOi | K05069 |
OMAi | SWACNLI |
OrthoDBi | 1322475at2759 |
PhylomeDBi | P16297 |
TreeFami | TF337874 |
Enzyme and pathway databases
Reactomei | R-MMU-5673001 RAF/MAP kinase cascade R-MMU-8983432 Interleukin-15 signaling R-MMU-9020558 Interleukin-2 signaling R-MMU-912526 Interleukin receptor SHC signaling |
Miscellaneous databases
PROi | PR:P16297 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068227 Expressed in 41 organ(s), highest expression level in lymph node |
Genevisiblei | P16297 MM |
Family and domain databases
CDDi | cd00063 FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR003531 Hempt_rcpt_S_F1_CS IPR013783 Ig-like_fold |
SUPFAMi | SSF49265 SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853 FN3, 1 hit PS01355 HEMATOPO_REC_S_F1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | IL2RB_MOUSE | |
Accessioni | P16297Primary (citable) accession number: P16297 Secondary accession number(s): Q3TZT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | February 13, 2019 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot