F9 - Coagulation factor IX precursor - Mus musculus (Mouse)

Functionⁱ

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca²⁺ ions, phospholipids, and factor VIIIa.By similarity

Catalytic activityⁱ

Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	47	Calcium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	48	Calcium 2By similarity	1
Metal bindingⁱ	53	Calcium 1; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	53	Calcium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	54	Calcium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	54	Calcium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	61	Calcium 4 or magnesium 1; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	63	Calcium 1; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	63	Calcium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	63	Calcium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	66	Calcium 4 or magnesium 1; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	67	Calcium 1; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	72	Calcium 5 or magnesium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	73	Calcium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	73	Calcium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	76	Calcium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	76	Calcium 5 or magnesium 2; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	82	Calcium 6 or magnesium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	86	Calcium 6 or magnesium 3; via 4-carboxyglutamateBy similarity	1
Metal bindingⁱ	93	Calcium 7By similarity	1
Metal bindingⁱ	94	Calcium 7; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	96	Calcium 7By similarity	1
Metal bindingⁱ	110	Calcium 7By similarity	1
Metal bindingⁱ	111	Calcium 7; via carbonyl oxygenBy similarity	1
Active siteⁱ	277	Charge relay systemBy similarity	1
Metal bindingⁱ	291	Calcium 8By similarity	1
Metal bindingⁱ	293	Calcium 8; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	298	Calcium 8By similarity	1
Metal bindingⁱ	301	Calcium 8By similarity	1
Active siteⁱ	325	Charge relay systemBy similarity	1
Active siteⁱ	421	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

calcium ion binding Source: UniProtKB
endopeptidase activity Source: UniProtKB
peptidase activity
Source: MGI
Inferred from direct assayⁱ
- 15178576
serine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15178576
proteolysis Source: MGI
zymogen activation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease
Biological process	Blood coagulation, Hemostasis
Ligand	Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140834 Extrinsic Pathway of Fibrin Clot Formation R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation R-MMU-159740 Gamma-carboxylation of protein precursors R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Reactomeⁱ

R-MMU-140834 Extrinsic Pathway of Fibrin Clot Formation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-159740 Gamma-carboxylation of protein precursors
R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.214

MEROPSⁱ

S01.214

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Coagulation factor IX (EC:3.4.21.22By similarity) Alternative name(s): Christmas factor Cleaved into the following 2 chains: Coagulation factor IXa light chain Coagulation factor IXa heavy chain
Gene namesⁱ	Name:F9 Synonyms:Cf9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:88384 F9

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST	28
PropeptideⁱPRO_0000027760	29 – 46	By similarityAdd BLAST	18
ChainⁱPRO_0000027761	47 – 471	Coagulation factor IXAdd BLAST	425
ChainⁱPRO_0000027762	47 – 192	Coagulation factor IXa light chainAdd BLAST	146
PropeptideⁱPRO_0000027763	193 – 236	Activation peptideBy similarityAdd BLAST	44
ChainⁱPRO_0000027764	237 – 471	Coagulation factor IXa heavy chainAdd BLAST	235

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	54	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	61	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	63	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Disulfide bondⁱ	64 ↔ 69	By similarity
Modified residueⁱ	66	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	67	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	72	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	73	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	76	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	79	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Modified residueⁱ	82	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Glycosylationⁱ	85	O-linked (GalNAc...) threonineBy similarity	1
Modified residueⁱ	86	4-carboxyglutamatePROSITE-ProRule annotationBy similarity	1
Disulfide bondⁱ	97 ↔ 108	By similarity
Glycosylationⁱ	99	O-linked (Glc...) serine; alternateBy similarity	1
Glycosylationⁱ	99	O-linked (Xyl...) serine; alternateBy similarity	1
Disulfide bondⁱ	102 ↔ 117	By similarity
Modified residueⁱ	110	(3R)-3-hydroxyaspartateBy similarity	1
Modified residueⁱ	114	PhosphoserineBy similarity	1
Disulfide bondⁱ	119 ↔ 128	By similarity
Disulfide bondⁱ	134 ↔ 145	By similarity
Disulfide bondⁱ	141 ↔ 155	By similarity
Disulfide bondⁱ	157 ↔ 170	By similarity
Disulfide bondⁱ	178 ↔ 345	Interchain (between light and heavy chains)By similarity
Modified residueⁱ	202	SulfotyrosineBy similarity	1
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	205	PhosphoserineBy similarity	1
Modified residueⁱ	206	Phosphothreonine; alternateBy similarity	1
Glycosylationⁱ	206	O-linked (GalNAc...) threonine; alternateBy similarity	1
Glycosylationⁱ	223	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	225	O-linked (GalNAc...) threonineBy similarity	1
Glycosylationⁱ	235	O-linked (GalNAc...) threonineBy similarity	1
Disulfide bondⁱ	262 ↔ 278	By similarity
Disulfide bondⁱ	392 ↔ 406	By similarity
Disulfide bondⁱ	417 ↔ 445	By similarity

Post-translational modificationⁱ

Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.By similarity

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Predominantly O-glucosylated at Ser-99 by POGLUT1 in vitro.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	192 – 193	Cleavage; by factor XIaBy similarity		2
Siteⁱ	236 – 237	Cleavage; by factor XIaBy similarity		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16294
PaxDbⁱ	P16294
PRIDEⁱ	P16294
TopDownProteomicsⁱ	P16294

PTM databases

iPTMnetⁱ	P16294
PhosphoSitePlusⁱ	P16294

Expressionⁱ

Tissue specificityⁱ

Detected in liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000031138 Expressed in 26 organ(s), highest expression level in liver
CleanExⁱ	MM_F9
Genevisibleⁱ	P16294 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of a light chain and a heavy chain; disulfide-linked. Interacts with SERPINC1.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033477

STRINGⁱ

10090.ENSMUSP00000033477

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P16294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	47 – 92	GlaPROSITE-ProRule annotationAdd BLAST	46
Domainⁱ	93 – 129	EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	130 – 171	EGF-like 2PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	237 – 469	Peptidase S1PROSITE-ProRule annotationAdd BLAST	233

Domainⁱ

Calcium binds to the gamma-carboxyglutamic acid (Gla) residues in the Gla domain. Calcium can also bind, with stronger affinity, to another site beyond the Gla domain. Under physiological ion concentrations, Ca²⁺ is displaced by Mg²⁺ from some of the gammaglutamate residues in the N-terminal Gla domain. This leads to a subtle conformation change that may affect the interaction with its binding protein.By similarity

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118890
HOGENOMⁱ	HOG000251821
HOVERGENⁱ	HBG013304
InParanoidⁱ	P16294
KEGG Orthology (KO) More...KOⁱ	K01321
OMAⁱ	SYECWCQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5
PhylomeDBⁱ	P16294
TreeFamⁱ	TF327329

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR035694 Coagulation_factor_IX IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR44064:SF4 PTHR44064:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P16294-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKHLNTVMAE SPALITIFLL GYLLSTECAV FLDRENATKI LTRPKRYNSG 
        60         70         80         90        100
KLEEFVRGNL ERECIEERCS FEEAREVFEN TEKTTEFWKQ YVDGDQCESN 
       110        120        130        140        150
PCLNGGICKD DISSYECWCQ VGFEGRNCEL DATCNIKNGR CKQFCKNSPD 
       160        170        180        190        200
NKVICSCTEG YQLAEDQKSC EPTVPFPCGR ASISYSSKKI TRAETVFSNM 
       210        220        230        240        250
DYENSTEAVF IQDDITDGAI LNNVTESSES LNDFTRVVGG ENAKPGQIPW 
       260        270        280        290        300
QVILNGEIEA FCGGAIINEK WIVTAAHCLK PGDKIEVVAG EYNIDKKEDT 
       310        320        330        340        350
EQRRNVIRTI PHHQYNATIN KYSHDIALLE LDKPLILNSY VTPICVANRE 
       360        370        380        390        400
YTNIFLKFGS GYVSGWGKVF NKGRQASILQ YLRVPLVDRA TCLRSTTFTI 
       410        420        430        440        450
YNNMFCAGYR EGGKDSCEGD SGGPHVTEVE GTSFLTGIIS WGEECAMKGK 
       460        470 
YGIYTKVSRY VNWIKEKTKL T

Length:471

Mass (Da):52,978

Last modified:January 9, 2007 - v3

Checksum:ⁱ05E08E86622397E2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	375	Q → H in AAA37629 (PubMed:2323576).Curated		1
Sequence conflictⁱ	400	I → T in AAA37629 (PubMed:2323576).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK149372 mRNA Translation: BAE28840.1 M23109 mRNA Translation: AAA37629.1 M26236 mRNA Translation: AAA37630.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30158.1
PIRⁱ	JQ0419
NCBI Reference Sequences More...RefSeqⁱ	NP_001292726.1, NM_001305797.1 NP_032005.1, NM_007979.2
UniGeneⁱ	Mm.391283

Genome annotation databases

Ensemblⁱ	ENSMUST00000033477; ENSMUSP00000033477; ENSMUSG00000031138
GeneIDⁱ	14071
KEGGⁱ	mmu:14071
UCSC genome browser More...UCSCⁱ	uc009thw.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16294	F9 protein (Fragment)		MOUSE		470	UniRef100_P16294

Protein	Similar proteins		Species	Score	Length	Source
P16294	Coagulation factor IX		RAT		462	UniRef90_P16294
F9 protein (Fragment)		MOUSE		470
Coagulation factor X-like protein		CRIGR		464
UPI00042AAE7B		PERMB		471
UPI000A31A02C		MUSCR		471
+4

Protein	Similar proteins		Species	Score	Length	Source
P16294	Coagulation factor IX	)	HUMAN		461	UniRef50_P00740
Coagulation factor IX		PANTR		461
Coagulation factor IX		RAT		462
Coagulation factor IX (Fragment)		CAVPO		285
Coagulation factor IX (Fragment)	)	PIG		409
+293

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK149372 mRNA Translation: BAE28840.1 M23109 mRNA Translation: AAA37629.1 M26236 mRNA Translation: AAA37630.1
CCDSⁱ	CCDS30158.1
PIRⁱ	JQ0419
RefSeqⁱ	NP_001292726.1, NM_001305797.1 NP_032005.1, NM_007979.2
UniGeneⁱ	Mm.391283

3D structure databases

ProteinModelPortalⁱ	P16294
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000033477

STRINGⁱ

10090.ENSMUSP00000033477

Protein family/group databases

MEROPSⁱ	S01.214

MEROPSⁱ

S01.214

PTM databases

iPTMnetⁱ	P16294
PhosphoSitePlusⁱ	P16294

Proteomic databases

MaxQBⁱ	P16294
PaxDbⁱ	P16294
PRIDEⁱ	P16294
TopDownProteomicsⁱ	P16294

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033477; ENSMUSP00000033477; ENSMUSG00000031138
GeneIDⁱ	14071
KEGGⁱ	mmu:14071
UCSCⁱ	uc009thw.2 mouse

Organism-specific databases

CTDⁱ	2158
MGIⁱ	MGI:88384 F9

Phylogenomic databases

eggNOGⁱ	ENOG410IGPV Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00760000118890
HOGENOMⁱ	HOG000251821
HOVERGENⁱ	HBG013304
InParanoidⁱ	P16294
KOⁱ	K01321
OMAⁱ	SYECWCQ
OrthoDBⁱ	EOG091G0AH5
PhylomeDBⁱ	P16294
TreeFamⁱ	TF327329

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140834 Extrinsic Pathway of Fibrin Clot Formation R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation R-MMU-159740 Gamma-carboxylation of protein precursors R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Reactomeⁱ

R-MMU-140834 Extrinsic Pathway of Fibrin Clot Formation
R-MMU-140837 Intrinsic Pathway of Fibrin Clot Formation
R-MMU-159740 Gamma-carboxylation of protein precursors
R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P16294
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031138 Expressed in 26 organ(s), highest expression level in liver
CleanExⁱ	MM_F9
Genevisibleⁱ	P16294 MM

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	4.10.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR017857 Coagulation_fac-like_Gla_dom IPR035694 Coagulation_factor_IX IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR035972 GLA-like_dom_SF IPR000294 GLA_domain IPR012224 Pept_S1A_FX IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR44064:SF4 PTHR44064:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00008 EGF, 1 hit PF00594 Gla, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001143 Factor_X, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN PR00001 GLABLOOD
SMARTⁱ	View protein in SMART SM00181 EGF, 2 hits SM00179 EGF_CA, 1 hit SM00069 GLA, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57630 SSF57630, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS00022 EGF_1, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 1 hit PS01187 EGF_CA, 1 hit PS00011 GLA_1, 1 hit PS50998 GLA_2, 1 hit PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA9_MOUSE
Accessionⁱ	P16294Primary (citable) accession number: P16294 Secondary accession number(s): Q3UES1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 9, 2007
	Last modified:	November 7, 2018
	This is version 195 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - P16294 (FA9_MOUSE)

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Coagulation factor IX

F9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ