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UniProtKB - P16292 (FA9_RABIT)
Protein
Coagulation factor IX
Gene
F9
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa.
By similarityCatalytic activityi
- Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.By similarity EC:3.4.21.22
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 89 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 103 | CalciumBy similarity | 1 | |
Metal bindingi | 105 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 108 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 110 | CalciumBy similarity | 1 | |
Metal bindingi | 113 | CalciumBy similarity | 1 | |
Active sitei | 137 | Charge relay systemBy similarity | 1 | |
Active sitei | 233 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- endopeptidase activity Source: UniProtKB
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- blood coagulation Source: UniProtKB
- proteolysis Source: UniProtKB
- zymogen activation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium, Metal-binding |
Protein family/group databases
MEROPSi | S01.214 |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor IX (EC:3.4.21.22By similarity)Alternative name(s): Christmas factor |
Gene namesi | Name:F9 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088684 | ‹1 – ›275 | Coagulation factor IXAdd BLAST | ›275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | SulfotyrosineBy similarity | 1 | |
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 27 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 47 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Disulfide bondi | 74 ↔ 90 | By similarity | ||
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 204 ↔ 218 | By similarity | ||
Disulfide bondi | 229 ↔ 257 | By similarity |
Post-translational modificationi
Activated by factor XIa, which excises the activation peptide. The propeptide can also be removed by snake venom protease.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 13 – 14 | Cleavage; by factor XIaBy similarity | 2 | |
Sitei | 48 – 49 | Cleavage; by factor XIaBy similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, SulfationProteomic databases
PRIDEi | P16292 |
Interactioni
Subunit structurei
Heterodimer of a light chain and a heavy chain; disulfide-linked.
Interacts with SERPINC1.
By similarityProtein-protein interaction databases
STRINGi | 9986.ENSOCUP00000004537 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – ›275 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | ›227 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | ENOG502QUEV, Eukaryota |
InParanoidi | P16292 |
OMAi | SCTEGYQ |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR035694, Coagulation_factor_IX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF31, PTHR24278:SF31, 1 hit |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Fragment.
P16292-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GVSVSHASKK ITRATTIFSN TEYENFTEAE TIRGNVTQRS QSSDDFTRIV
60 70 80 90 100
GGENAKPGQF PWQVLLNGKV EAFCGGSIIN EKWVVTAAHC IKPDDNITVV
110 120 130 140 150
AGEYNIQETE NTEQKRNVIR IIPYHKYNAT INKYNHDIAL LELDKPLTLN
160 170 180 190 200
SYVTPICIAN REYTNIFLNF GSGYVSGWGR VFNRGRQASI LQYLRVPFVD
210 220 230 240 250
RATCLRSTKF TIYNNMFCAG FDVGGKDSCE GDSGGPHVTE VEGTSFLTGI
260 270
ISWGEECAIK GKYGVYTRVS WYVNW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 275 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26234 mRNA Translation: AAA31251.1 |
PIRi | I46712 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M26234 mRNA Translation: AAA31251.1 |
PIRi | I46712 |
3D structure databases
SMRi | P16292 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000004537 |
Protein family/group databases
MEROPSi | S01.214 |
Proteomic databases
PRIDEi | P16292 |
Phylogenomic databases
eggNOGi | ENOG502QUEV, Eukaryota |
InParanoidi | P16292 |
OMAi | SCTEGYQ |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR035694, Coagulation_factor_IX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF31, PTHR24278:SF31, 1 hit |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FA9_RABIT | |
Accessioni | P16292Primary (citable) accession number: P16292 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families