UniProtKB - P16284 (PECA1_HUMAN)
Platelet endothelial cell adhesion molecule
PECAM1
Functioni
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- angiogenesis Source: Ensembl
- bicellular tight junction assembly Source: ARUK-UCL
- cell-cell adhesion Source: ARUK-UCL
- cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
- cell recognition Source: ProtInc
- cell surface receptor signaling pathway Source: GO_Central
- diapedesis Source: UniProtKB
- endothelial cell-matrix adhesion Source: Ensembl
- endothelial cell migration Source: Ensembl
- endothelial cell morphogenesis Source: Ensembl
- establishment of endothelial barrier Source: ARUK-UCL
- extracellular matrix organization Source: Reactome
- glomerular endothelium development Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- leukocyte cell-cell adhesion Source: UniProtKB
- leukocyte migration Source: Reactome
- maintenance of blood-brain barrier Source: ARUK-UCL
- monocyte extravasation Source: ARUK-UCL
- neutrophil degranulation Source: Reactome
- neutrophil extravasation Source: UniProtKB
- phagocytosis Source: UniProtKB
- platelet degranulation Source: Reactome
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- positive regulation of protein localization to cell-cell junction Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: ARUK-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- Rho protein signal transduction Source: Ensembl
- signal transduction Source: ProtInc
- wound healing Source: Ensembl
Keywordsi
Biological process | Cell adhesion, Phagocytosis |
Enzyme and pathway databases
PathwayCommonsi | P16284 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-210990, PECAM1 interactions R-HSA-216083, Integrin cell surface interactions R-HSA-432142, Platelet sensitization by LDL R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P16284 |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet endothelial cell adhesion moleculeShort name: PECAM-1 Alternative name(s): EndoCAM GPIIA' PECA1 CD_antigen: CD31 |
Gene namesi | Name:PECAM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8823, PECAM1 |
MIMi | 173445, gene |
neXtProti | NX_P16284 |
VEuPathDBi | HostDB:ENSG00000261371.5 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Note: Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation.1 Publication
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Other locations
- Membrane raft 2 Publications
- Cell junction 1 Publication
Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.1 Publication
Other locations
- Cell junction 1 Publication
Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell-cell contact zone Source: Ensembl
- cell-cell junction Source: ARUK-UCL
- membrane raft Source: UniProtKB-SubCell
- platelet alpha granule membrane Source: Reactome
- protein-containing complex Source: ARUK-UCL
- secretory granule membrane Source: Reactome
- smooth muscle contractile fiber Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 601 | ExtracellularSequence analysisAdd BLAST | 574 | |
Transmembranei | 602 – 620 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 621 – 738 | CytoplasmicSequence analysisAdd BLAST | 118 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 52 | N → Q: Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-84 and Q-151. 1 Publication | 1 | |
Mutagenesisi | 74 | L → E: Reduced homophilic cell adhesion; when associated with E-112; E-188 and E-190. 1 Publication | 1 | |
Mutagenesisi | 84 | N → Q: Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-52 and Q-151. 1 Publication | 1 | |
Mutagenesisi | 89 | K → A: Lacks homophilic binding ability and is distributed over the entire plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 112 | I → E: Reduced homophilic cell adhesion; when associated with E-74; E-188 and E-190. 1 Publication | 1 | |
Mutagenesisi | 151 | N → Q: Probable loss of N-glycosylation. No effect on homophilic cell adhesion; when associated with Q-52 and Q-84. 1 Publication | 1 | |
Mutagenesisi | 188 | F → E: Reduced homophilic cell adhesion; when associated with E-74; E-112 and E-190. 1 Publication | 1 | |
Mutagenesisi | 190 | I → E: Reduced homophilic cell adhesion; when associated with E-74; E-112 and E-188. 1 Publication | 1 | |
Mutagenesisi | 622 | C → A: 6-fold decrease in association with membrane microdomains. 1 Publication | 1 | |
Mutagenesisi | 690 | Y → F: No effect on Tyr-713 phosphorylation. Inhibits targeted recycling of PECAM1 from the lateral border recycling compartment (LBRC) around transmigrating monocytes. Decreases phosphorylation. No effect on interaction with PTPN11. Loss of phosphorylation and loss of binding to PTPN11; when associated with F-713. 3 Publications | 1 | |
Mutagenesisi | 713 | Y → F: Loss of Tyr-690 phosphorylation. Does not inhibit targeted recycling of PECAM1 from the lateral border recycling compartment (LBRC) around transmigrating monocytes. Decreases phosphorylation. Loss of interaction with PTPN11. Loss of phosphorylation and loss of binding to PTPN11; when associated with F-690. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 5175 |
OpenTargetsi | ENSG00000261371 |
PharmGKBi | PA33167 |
Miscellaneous databases
Pharosi | P16284, Tbio |
Genetic variation databases
BioMutai | PECAM1 |
DMDMi | 129747 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Add BLAST | 27 | |
ChainiPRO_0000014895 | 28 – 738 | Platelet endothelial cell adhesion moleculeAdd BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 57 ↔ 109 | PROSITE-ProRule annotationCombined sources2 Publications | ||
Glycosylationi | 84 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineCombined sources2 Publications | 1 | |
Disulfide bondi | 152 ↔ 206 | PROSITE-ProRule annotationCombined sources2 Publications | ||
Disulfide bondi | 256 ↔ 304 | PROSITE-ProRule annotation | ||
Glycosylationi | 301 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 320 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 344 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 347 ↔ 386 | PROSITE-ProRule annotation | ||
Glycosylationi | 356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 431 ↔ 476 | PROSITE-ProRule annotation | ||
Glycosylationi | 453 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 523 ↔ 572 | PROSITE-ProRule annotation | ||
Glycosylationi | 551 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Lipidationi | 622 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 690 | Phosphotyrosine; by FER2 Publications | 1 | |
Modified residuei | 713 | Phosphotyrosine; by FER3 Publications | 1 | |
Modified residuei | 729 | Phosphoserine1 Publication | 1 | |
Modified residuei | 734 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
CPTACi | CPTAC-2602 |
EPDi | P16284 |
jPOSTi | P16284 |
MassIVEi | P16284 |
PeptideAtlasi | P16284 |
PRIDEi | P16284 |
ProteomicsDBi | 53335 [P16284-1] 53336 [P16284-2] 53337 [P16284-3] 53338 [P16284-4] 53339 [P16284-5] 53340 [P16284-6] |
TopDownProteomicsi | P16284-1 [P16284-1] |
2D gel databases
UCD-2DPAGEi | P16284 |
PTM databases
GlyConnecti | 1610, 12 N-Linked glycans (5 sites) |
GlyGeni | P16284, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | P16284 |
PhosphoSitePlusi | P16284 |
SwissPalmi | P16284 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000261371, Expressed in tendon of biceps brachii and 248 other tissues |
ExpressionAtlasi | P16284, baseline and differential |
Interactioni
Subunit structurei
Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302).
Forms a complex with BDKRB2 and GNAQ (PubMed:18672896).
Interacts with BDKRB2 and GNAQ (PubMed:18672896).
Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684).
Interacts with FER (By similarity).
Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca2+-dependent; the interaction is direct (PubMed:17580308).
By similarity6 PublicationsBinary interactionsi
P16284
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 111201, 23 interactors |
IntActi | P16284, 94 interactors |
MINTi | P16284 |
STRINGi | 9606.ENSP00000457421 |
Miscellaneous databases
RNActi | P16284, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P16284 |
SMRi | P16284 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16284 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 121 | Ig-like C2-type 1Add BLAST | 87 | |
Domaini | 145 – 233 | Ig-like C2-type 2Add BLAST | 89 | |
Domaini | 236 – 315 | Ig-like C2-type 3Add BLAST | 80 | |
Domaini | 328 – 401 | Ig-like C2-type 4Add BLAST | 74 | |
Domaini | 424 – 493 | Ig-like C2-type 5Add BLAST | 70 | |
Domaini | 499 – 591 | Ig-like C2-type 6Add BLAST | 93 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 709 – 729 | Membrane-bound segment which detaches upon phosphorylation1 PublicationAdd BLAST | 21 | |
Regioni | 721 – 738 | May play a role in cytoprotective signalingAdd BLAST | 18 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 688 – 693 | ITIM motif 11 Publication | 6 | |
Motifi | 711 – 716 | ITIM motif 21 Publication | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW63, Eukaryota |
GeneTreei | ENSGT01000000214398 |
InParanoidi | P16284 |
OMAi | PIYFTIE |
OrthoDBi | 419506at2759 |
PhylomeDBi | P16284 |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR040878, Ig_C17orf99 IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF17736, Ig_C17orf99, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQPRWAQGAT MWLGVLLTLL LCSSLEGQEN SFTINSVDMK SLPDWTVQNG
60 70 80 90 100
KNLTLQCFAD VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR
110 120 130 140 150
IYDSGTYKCT VIVNNKEKTT AEYQVLVEGV PSPRVTLDKK EAIQGGIVRV
160 170 180 190 200
NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE KNSRDQNFVI LEFPVEEQDR
210 220 230 240 250
VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI SPTGMIMEGA
260 270 280 290 300
QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG
310 320 330 340 350
NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP
360 370 380 390 400
GAPPANFTIQ KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV
410 420 430 440 450
QIVVCEMLSQ PRISYDAQFE VIKGQTIEVR CESISGTLPI SYQLLKTSKV
460 470 480 490 500
LENSTKNSND PAVFKDNPTE DVEYQCVADN CHSHAKMLSE VLRVKVIAPV
510 520 530 540 550
DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK EGKPFYQMTS
560 570 580 590 600
NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK
610 620 630 640 650
KGLIAVVIIG VIIALLIIAA KCYFLRKAKA KQMPVEMSRP AVPLLNSNNE
660 670 680 690 700
KMSDPNMEAN SHYGHNDDVR NHAMKPINDN KEPLNSDVQY TEVQVSSAES
710 720 730
HKDLGKKDTE TVYSEVRKAV PDAVESRYSR TEGSLDGT
The sequence of this isoform differs from the canonical sequence as follows:
664-681: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
682-702: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
703-721: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
703-729: Missing.
730-738: RTEGSLDGT → ENGRLP
The sequence of this isoform differs from the canonical sequence as follows:
722-729: Missing.
730-738: RTEGSLDGT → ENGRLP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A075B727 | A0A075B727_HUMAN | Platelet endothelial cell adhesion ... | PECAM1 | 230 | Annotation score: | ||
A0A075B737 | A0A075B737_HUMAN | Platelet endothelial cell adhesion ... | PECAM1 | 134 | Annotation score: | ||
A0A075B728 | A0A075B728_HUMAN | Platelet endothelial cell adhesion ... | PECAM1 | 183 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | A → T in BAF83381 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 8 – 12 | GATMW → ADV (PubMed:2351935).Curated | 5 | |
Sequence conflicti | 80 | V → M in AAK84009 (PubMed:17212705).Curated | 1 | |
Sequence conflicti | 97 | P → L in AAK84011 (PubMed:17212705).Curated | 1 | |
Sequence conflicti | 329 | E → K in AAF91460 (PubMed:17212705).Curated | 1 | |
Sequence conflicti | 430 | R → H in AAF91451 (PubMed:17212705).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013145 | 125 | V → L4 PublicationsCorresponds to variant dbSNP:rs281865545EnsemblClinVar. | 1 | |
Natural variantiVAR_059402 | 304 | C → Y. Corresponds to variant dbSNP:rs7209607Ensembl. | 1 | |
Natural variantiVAR_059403 | 563 | S → I. Corresponds to variant dbSNP:rs12953EnsemblClinVar. | 1 | |
Natural variantiVAR_059404 | 563 | S → N7 PublicationsCorresponds to variant dbSNP:rs12953EnsemblClinVar. | 1 | |
Natural variantiVAR_059405 | 670 | R → G6 PublicationsCorresponds to variant dbSNP:rs1131012EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011806 | 664 – 681 | Missing in isoform Delta12. CuratedAdd BLAST | 18 | |
Alternative sequenceiVSP_011807 | 682 – 702 | Missing in isoform Delta13. CuratedAdd BLAST | 21 | |
Alternative sequenceiVSP_011808 | 703 – 729 | Missing in isoform Delta14-15. CuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_011809 | 703 – 721 | Missing in isoform Delta14. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_011810 | 722 – 729 | Missing in isoform Delta15. Curated | 8 | |
Alternative sequenceiVSP_011811 | 730 – 738 | RTEGSLDGT → ENGRLP in isoform Delta14-15 and isoform Delta15. Curated | 9 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000563924; ENSP00000457421; ENSG00000261371 [P16284-1] |
GeneIDi | 5175 |
KEGGi | hsa:5175 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia CD31 entry |
Functional Glycomics Gateway - Glycan Binding PECAM-1 |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KY5 | NMR | - | A | 686-738 | [»] | |
5C14 | X-ray | 2.80 | A/B | 28-229 | [»] | |
5GNI | X-ray | 3.01 | A/B | 28-232 | [»] | |
BMRBi | P16284 | |||||
SMRi | P16284 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111201, 23 interactors |
IntActi | P16284, 94 interactors |
MINTi | P16284 |
STRINGi | 9606.ENSP00000457421 |
PTM databases
GlyConnecti | 1610, 12 N-Linked glycans (5 sites) |
GlyGeni | P16284, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | P16284 |
PhosphoSitePlusi | P16284 |
SwissPalmi | P16284 |
Genetic variation databases
BioMutai | PECAM1 |
DMDMi | 129747 |
2D gel databases
UCD-2DPAGEi | P16284 |
Proteomic databases
CPTACi | CPTAC-2602 |
EPDi | P16284 |
jPOSTi | P16284 |
MassIVEi | P16284 |
PeptideAtlasi | P16284 |
PRIDEi | P16284 |
ProteomicsDBi | 53335 [P16284-1] 53336 [P16284-2] 53337 [P16284-3] 53338 [P16284-4] 53339 [P16284-5] 53340 [P16284-6] |
TopDownProteomicsi | P16284-1 [P16284-1] |
Protocols and materials databases
Antibodypediai | 58161, 3742 antibodies |
DNASUi | 5175 |
Genome annotation databases
Ensembli | ENST00000563924; ENSP00000457421; ENSG00000261371 [P16284-1] |
GeneIDi | 5175 |
KEGGi | hsa:5175 |
Organism-specific databases
CTDi | 5175 |
DisGeNETi | 5175 |
GeneCardsi | PECAM1 |
HGNCi | HGNC:8823, PECAM1 |
MIMi | 173445, gene |
neXtProti | NX_P16284 |
OpenTargetsi | ENSG00000261371 |
PharmGKBi | PA33167 |
VEuPathDBi | HostDB:ENSG00000261371.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW63, Eukaryota |
GeneTreei | ENSGT01000000214398 |
InParanoidi | P16284 |
OMAi | PIYFTIE |
OrthoDBi | 419506at2759 |
PhylomeDBi | P16284 |
Enzyme and pathway databases
PathwayCommonsi | P16284 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-210990, PECAM1 interactions R-HSA-216083, Integrin cell surface interactions R-HSA-432142, Platelet sensitization by LDL R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P16284 |
Miscellaneous databases
BioGRID-ORCSi | 5175, 3 hits in 92 CRISPR screens |
ChiTaRSi | PECAM1, human |
EvolutionaryTracei | P16284 |
GeneWikii | CD31 |
GenomeRNAii | 5175 |
Pharosi | P16284, Tbio |
PROi | PR:P16284 |
RNActi | P16284, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000261371, Expressed in tendon of biceps brachii and 248 other tissues |
ExpressionAtlasi | P16284, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 4 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR040878, Ig_C17orf99 IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF17736, Ig_C17orf99, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 5 hits SM00408, IGc2, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PECA1_HUMAN | |
Accessioni | P16284Primary (citable) accession number: P16284 Secondary accession number(s): A0A075B738 Q9NQT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references