UniProtKB - P16283 (B3A3_MOUSE)
Anion exchange protein 3
Slc4a3
Functioni
Plasma membrane anion exchange protein.
GO - Molecular functioni
- anion:anion antiporter activity Source: MGI
- bicarbonate transmembrane transporter activity Source: MGI
- enzyme binding Source: MGI
- inorganic anion exchanger activity Source: InterPro
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- bicarbonate transport Source: MGI
- cardiac conduction Source: MGI
- ion homeostasis Source: GO_Central
- regulation of intracellular pH Source: MGI
- transmembrane transport Source: GO_Central
Keywordsi
Biological process | Anion exchange, Antiport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-425381, Bicarbonate transporters |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange protein 3Short name: AE 3 Short name: Anion exchanger 3 Alternative name(s): Neuronal band 3-like protein Solute carrier family 4 member 3 |
Gene namesi | Name:Slc4a3 Synonyms:Ae3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109350, Slc4a3 |
VEuPathDBi | HostDB:ENSMUSG00000006576 |
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 707 | CytoplasmicAdd BLAST | 707 | |
Transmembranei | 708 – 730 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 736 – 773 | HelicalSequence analysisAdd BLAST | 38 | |
Transmembranei | 793 – 815 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 825 – 846 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 888 – 905 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 906 – 920 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 921 – 941 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 975 – 997 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1023 – 1044 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1078 – 1123 | HelicalSequence analysisAdd BLAST | 46 | |
Transmembranei | 1150 – 1186 | HelicalSequence analysisAdd BLAST | 37 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079220 | 1 – 1227 | Anion exchange protein 3Add BLAST | 1227 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 170 | PhosphoserineCombined sources | 1 | |
Modified residuei | 175 | PhosphoserineBy similarity | 1 | |
Modified residuei | 198 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | Omega-N-methylarginineCombined sources | 1 | |
Glycosylationi | 868 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1160 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
MaxQBi | P16283 |
PaxDbi | P16283 |
PeptideAtlasi | P16283 |
PRIDEi | P16283 |
ProteomicsDBi | 273521 [P16283-1] 273522 [P16283-2] 273523 [P16283-3] |
PTM databases
GlyGeni | P16283, 1 site |
iPTMneti | P16283 |
PhosphoSitePlusi | P16283 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000006576, Expressed in heart and 290 other tissues |
Genevisiblei | P16283, MM |
Interactioni
GO - Molecular functioni
- enzyme binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000116747 |
Miscellaneous databases
RNActi | P16283, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 256 | DisorderedSequence analysisAdd BLAST | 256 | |
Regioni | 286 – 312 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 428 – 497 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 708 – 1227 | Membrane (anion exchange)Add BLAST | 520 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 23 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 62 – 77 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 98 – 113 | Basic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 131 – 151 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 191 – 224 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 435 – 453 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 479 – 497 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1172, Eukaryota |
GeneTreei | ENSGT00940000159765 |
HOGENOMi | CLU_002289_1_0_1 |
InParanoidi | P16283 |
OMAi | IMSDQIR |
PhylomeDBi | P16283 |
TreeFami | TF313630 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002979, Anion_exchange_3 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt-like_TM_dom IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF15, PTHR11453:SF15, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01189, ANIONEXHNGR3 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANGVIPPPG GASPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRPPP
110 120 130 140 150
TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPLPPGP PQKAKFSIGS DEDDSPGLPV KAPCAKALPS VGLQSDQSPQ
210 220 230 240 250
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV
260 270 280 290 300
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL
310 320 330 340 350
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV
360 370 380 390 400
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE
410 420 430 440 450
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG
460 470 480 490 500
NHHPTPSHGP DGAVPTMADD QGEPAPLWPH DPDAKEKPLH MPGGDGHRGK
510 520 530 540 550
SLKLLEKIPE DAEATVVLVG CVPFLEQPAA AFVRLSEAVL LESVLEVPVP
560 570 580 590 600
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI
610 620 630 640 650
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG
660 670 680 690 700
YAAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR
710 720 730 740 750
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG
760 770 780 790 800
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV
810 820 830 840 850
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP
860 870 880 890 900
LLPFYPPDEA LETGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL
910 920 930 940 950
IAFFLRKFRN SRFLGGKARR IIGDFGIPIS ILVMVLVDYS ITDTYTQKLT
960 970 980 990 1000
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ
1010 1020 1030 1040 1050
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT
1060 1070 1080 1090 1100
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI
1110 1120 1130 1140 1150
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM
1160 1170 1180 1190 1200
HLFTCIQLGC IALLWVVKST AASLAFPFLL LLTVPLRRCL LPRLFQDREL
1210 1220
QALDSEDAEP NFDEDGQDEY NELHMPV
The sequence of this isoform differs from the canonical sequence as follows:
381-391: AALLDLEQTTL → RAFWAGNESLL
392-1227: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
487-503: KPLHMPGGDGHRGKSLK → FCVLRSPSPCLGETVTEGKA
504-1227: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6Q7T0 | F6Q7T0_MOUSE | Anion exchange protein 3 | Slc4a3 | 207 | Annotation score: | ||
F8WHM3 | F8WHM3_MOUSE | Anion exchange protein 3 | Slc4a3 | 573 | Annotation score: | ||
F6S265 | F6S265_MOUSE | Anion exchange protein 3 | Slc4a3 | 81 | Annotation score: | ||
D3Z5A2 | D3Z5A2_MOUSE | Anion exchange protein 3 | Slc4a3 | 227 | Annotation score: | ||
D3YWK8 | D3YWK8_MOUSE | Anion exchange protein 3 | Slc4a3 | 104 | Annotation score: | ||
D3Z3U9 | D3Z3U9_MOUSE | Anion exchange protein 3 | Slc4a3 | 95 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 530 | A → G in AAA37184 (PubMed:2686841).Curated | 1 | |
Sequence conflicti | 812 | S → T in AAA37184 (PubMed:2686841).Curated | 1 | |
Sequence conflicti | 1150 – 1151 | MH → ID in AAA37184 (PubMed:2686841).Curated | 2 | |
Sequence conflicti | 1187 – 1188 | RR → SG in AAA37184 (PubMed:2686841).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000464 | 381 – 391 | AALLDLEQTTL → RAFWAGNESLL in isoform 311-AE3. CuratedAdd BLAST | 11 | |
Alternative sequenceiVSP_000465 | 392 – 1227 | Missing in isoform 311-AE3. CuratedAdd BLAST | 836 | |
Alternative sequenceiVSP_000466 | 487 – 503 | KPLHM…GKSLK → FCVLRSPSPCLGETVTEGKA in isoform 14-AE3. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_000467 | 504 – 1227 | Missing in isoform 14-AE3. CuratedAdd BLAST | 724 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28383 mRNA Translation: AAA37184.1 S69314 mRNA Translation: AAB30140.1 AF294651 Genomic DNA Translation: AAG25582.1 CH466548 Genomic DNA Translation: EDL00426.1 |
CCDSi | CCDS15080.1 [P16283-1] |
PIRi | A33638 |
RefSeqi | NP_033234.2, NM_009208.3 [P16283-1] XP_006496512.1, XM_006496449.3 XP_006496513.1, XM_006496450.3 [P16283-1] XP_006496514.1, XM_006496451.3 [P16283-1] XP_006496515.1, XM_006496452.3 XP_006496516.1, XM_006496453.2 [P16283-1] |
Genome annotation databases
Ensembli | ENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576 [P16283-1] |
GeneIDi | 20536 |
KEGGi | mmu:20536 |
UCSCi | uc007bpv.2, mouse [P16283-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M28383 mRNA Translation: AAA37184.1 S69314 mRNA Translation: AAB30140.1 AF294651 Genomic DNA Translation: AAG25582.1 CH466548 Genomic DNA Translation: EDL00426.1 |
CCDSi | CCDS15080.1 [P16283-1] |
PIRi | A33638 |
RefSeqi | NP_033234.2, NM_009208.3 [P16283-1] XP_006496512.1, XM_006496449.3 XP_006496513.1, XM_006496450.3 [P16283-1] XP_006496514.1, XM_006496451.3 [P16283-1] XP_006496515.1, XM_006496452.3 XP_006496516.1, XM_006496453.2 [P16283-1] |
3D structure databases
AlphaFoldDBi | P16283 |
SMRi | P16283 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000116747 |
PTM databases
GlyGeni | P16283, 1 site |
iPTMneti | P16283 |
PhosphoSitePlusi | P16283 |
Proteomic databases
MaxQBi | P16283 |
PaxDbi | P16283 |
PeptideAtlasi | P16283 |
PRIDEi | P16283 |
ProteomicsDBi | 273521 [P16283-1] 273522 [P16283-2] 273523 [P16283-3] |
Protocols and materials databases
Antibodypediai | 52538, 31 antibodies from 13 providers |
DNASUi | 20536 |
Genome annotation databases
Ensembli | ENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576 [P16283-1] |
GeneIDi | 20536 |
KEGGi | mmu:20536 |
UCSCi | uc007bpv.2, mouse [P16283-1] |
Organism-specific databases
CTDi | 6508 |
MGIi | MGI:109350, Slc4a3 |
VEuPathDBi | HostDB:ENSMUSG00000006576 |
Phylogenomic databases
eggNOGi | KOG1172, Eukaryota |
GeneTreei | ENSGT00940000159765 |
HOGENOMi | CLU_002289_1_0_1 |
InParanoidi | P16283 |
OMAi | IMSDQIR |
PhylomeDBi | P16283 |
TreeFami | TF313630 |
Enzyme and pathway databases
Reactomei | R-MMU-425381, Bicarbonate transporters |
Miscellaneous databases
BioGRID-ORCSi | 20536, 2 hits in 71 CRISPR screens |
ChiTaRSi | Slc4a3, mouse |
PROi | PR:P16283 |
RNActi | P16283, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000006576, Expressed in heart and 290 other tissues |
Genevisiblei | P16283, MM |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002979, Anion_exchange_3 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt-like_TM_dom IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF15, PTHR11453:SF15, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01189, ANIONEXHNGR3 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B3A3_MOUSE | |
Accessioni | P16283Primary (citable) accession number: P16283 Secondary accession number(s): Q9ERP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families