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UniProtKB - P16283 (B3A3_MOUSE)

Entry version 158 (08 May 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Anion exchange protein 3

Gene

Slc4a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plasma membrane anion exchange protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-425381 Bicarbonate transporters

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
Neuronal band 3-like protein
Solute carrier family 4 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc4a3
Synonyms:Ae3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:109350 Slc4a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 707CytoplasmicAdd BLAST707
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei708 – 730HelicalSequence analysisAdd BLAST23
Transmembranei736 – 773HelicalSequence analysisAdd BLAST38
Transmembranei793 – 815HelicalSequence analysisAdd BLAST23
Transmembranei825 – 846HelicalSequence analysisAdd BLAST22
Transmembranei888 – 905HelicalSequence analysisAdd BLAST18
Topological domaini906 – 920CytoplasmicSequence analysisAdd BLAST15
Transmembranei921 – 941HelicalSequence analysisAdd BLAST21
Transmembranei975 – 997HelicalSequence analysisAdd BLAST23
Transmembranei1023 – 1044HelicalSequence analysisAdd BLAST22
Transmembranei1078 – 1123HelicalSequence analysisAdd BLAST46
Transmembranei1150 – 1186HelicalSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792201 – 1227Anion exchange protein 3Add BLAST1227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei167PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei175PhosphoserineBy similarity1
Modified residuei198PhosphoserineCombined sources1
Modified residuei294Omega-N-methylarginineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi868N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1160S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16283

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16283

PeptideAtlas

More...PeptideAtlasi		P16283

PRoteomics IDEntifications database

More...PRIDEi		P16283

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16283

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16283

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neuronal.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000006576 Expressed in 261 organ(s), highest expression level in heart

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16283 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16283 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P16283, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000116747

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16283

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni708 – 1227Membrane (anion exchange)Add BLAST520

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi135 – 145Poly-GluAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000280683

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16283

KEGG Orthology (KO)

More...KOi		K13856

Identification of Orthologs from Complete Genome Data

More...OMAi		CIQLACI

Database of Orthologous Groups

More...OrthoDBi		265068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16283

TreeFam database of animal gene trees

More...TreeFami		TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001717 Anion_exchange
IPR002979 Anion_exchange_3
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...PANTHERi		PTHR11453 PTHR11453, 1 hit
PTHR11453:SF15 PTHR11453:SF15, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00165 ANIONEXCHNGR
PR01189 ANIONEXHNGR3
PR01231 HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00834 ae, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform FL-AE3 (identifier: P16283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLGPD VEEEDDDLGK TLAVSRFGDL 
        60         70         80         90        100
ISKTPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRPPP 
       110        120        130        140        150
TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGAEEEEEE EEEEEGESEA 
       160        170        180        190        200
EPVEPLPPGP PQKAKFSIGS DEDDSPGLPV KAPCAKALPS VGLQSDQSPQ 
       210        220        230        240        250
RSGSSPSPRA RASRISTEKS RPWSPSASYD LRERLCPGSA LGNPGPEQRV 
       260        270        280        290        300
PTDEAEAQML GSADLDDMKS HRLEDNPGVR RHLVKKPSRI QGGRGSPSGL 
       310        320        330        340        350
APILRRKKKK KKLDRRPHEV FVELNELMLD RSQEPHWRET ARWIKFEEDV 
       360        370        380        390        400
EEETERWGKP HVASLSFRSL LELRRTIAQG AALLDLEQTT LPGIAHLVVE 
       410        420        430        440        450
TMIVSDQIRP EDRASVLRTL LLKHSHPNDD KDSGFFPRNP SSSSVNSVLG 
       460        470        480        490        500
NHHPTPSHGP DGAVPTMADD QGEPAPLWPH DPDAKEKPLH MPGGDGHRGK 
       510        520        530        540        550
SLKLLEKIPE DAEATVVLVG CVPFLEQPAA AFVRLSEAVL LESVLEVPVP 
       560        570        580        590        600
VRFLFVMLGP SHTSTDYHEL GRSIATLMSD KLFHEAAYQA DDRQDLLGAI 
       610        620        630        640        650
SEFLDGSIVI PPSEVEGRDL LRSVAAFQRE LLRKRREREQ TKVEMTTRGG 
       660        670        680        690        700
YAAPGKELSL EMGGSEATSE DDPLQRTGSV FGGLVRDVKR RYPHYPSDLR 
       710        720        730        740        750
DALHSQCVAA VLFIYFAALS PAITFGGLLG EKTEGLMGVS ELIVSTAVLG 
       760        770        780        790        800
VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWLV 
       810        820        830        840        850
VFVLALVAAE GSFLVRYISP FTQEIFAFLI SLIFIYETFH KLYKVFTEHP 
       860        870        880        890        900
LLPFYPPDEA LETGLELNSS ALPPTEGPPG PRNQPNTALL SLILMLGTFL 
       910        920        930        940        950
IAFFLRKFRN SRFLGGKARR IIGDFGIPIS ILVMVLVDYS ITDTYTQKLT 
       960        970        980        990       1000
VPTGLSVTSP HKRTWFIPPL GSARPFPPWM MVAAAVPALL VLILIFMETQ 
      1010       1020       1030       1040       1050
ITALIVSQKA RRLLKGSGFH LDLLLIGSLG GLCGLFGLPW LTAATVRSVT 
      1060       1070       1080       1090       1100
HVNALTVMRT AIAPGDKPQI QEVREQRVTG VLIASLVGLS IVMGAVLRRI 
      1110       1120       1130       1140       1150
PLAVLFGIFL YMGVTSLSGI QLSQRLLLIF MPAKHHPEQP YVTKVKTWRM 
      1160       1170       1180       1190       1200
HLFTCIQLGC IALLWVVKST AASLAFPFLL LLTVPLRRCL LPRLFQDREL 
      1210       1220 
QALDSEDAEP NFDEDGQDEY NELHMPV
Length:1,227
Mass (Da):135,373
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68BC64B72E5FDC55
GO
Isoform 311-AE3 (identifier: P16283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-391: AALLDLEQTTL → RAFWAGNESLL
     392-1227: Missing.

Show »
Length:391
Mass (Da):43,470
Checksum:i3489399BE07290D5
GO
Isoform 14-AE3 (identifier: P16283-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     487-503: KPLHMPGGDGHRGKSLK → FCVLRSPSPCLGETVTEGKA
     504-1227: Missing.

Show »
Length:506
Mass (Da):55,695
Checksum:iB9749CF90C91B695
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHM3F8WHM3_MOUSE
Anion exchange protein 3
Slc4a3
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5A2D3Z5A2_MOUSE
Anion exchange protein 3
Slc4a3
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q7T0F6Q7T0_MOUSE
Anion exchange protein 3
Slc4a3
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWK8D3YWK8_MOUSE
Anion exchange protein 3
Slc4a3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S265F6S265_MOUSE
Anion exchange protein 3
Slc4a3
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3U9D3Z3U9_MOUSE
Anion exchange protein 3
Slc4a3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti530A → G in AAA37184 (PubMed:2686841).Curated1
Sequence conflicti812S → T in AAA37184 (PubMed:2686841).Curated1
Sequence conflicti1150 – 1151MH → ID in AAA37184 (PubMed:2686841).Curated2
Sequence conflicti1187 – 1188RR → SG in AAA37184 (PubMed:2686841).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000464381 – 391AALLDLEQTTL → RAFWAGNESLL in isoform 311-AE3. CuratedAdd BLAST11
Alternative sequenceiVSP_000465392 – 1227Missing in isoform 311-AE3. CuratedAdd BLAST836
Alternative sequenceiVSP_000466487 – 503KPLHM…GKSLK → FCVLRSPSPCLGETVTEGKA in isoform 14-AE3. CuratedAdd BLAST17
Alternative sequenceiVSP_000467504 – 1227Missing in isoform 14-AE3. CuratedAdd BLAST724

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M28383 mRNA Translation: AAA37184.1
S69314 mRNA Translation: AAB30140.1
AF294651 Genomic DNA Translation: AAG25582.1
CH466548 Genomic DNA Translation: EDL00426.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS15080.1 [P16283-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A33638

NCBI Reference Sequences

More...RefSeqi		NP_033234.2, NM_009208.3 [P16283-1]
XP_006496512.1, XM_006496449.3
XP_006496513.1, XM_006496450.3 [P16283-1]
XP_006496514.1, XM_006496451.3 [P16283-1]
XP_006496515.1, XM_006496452.3
XP_006496516.1, XM_006496453.2 [P16283-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576 [P16283-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20536

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20536

UCSC genome browser

More...UCSCi		uc007bpv.2 mouse [P16283-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28383 mRNA Translation: AAA37184.1
S69314 mRNA Translation: AAB30140.1
AF294651 Genomic DNA Translation: AAG25582.1
CH466548 Genomic DNA Translation: EDL00426.1
CCDSiCCDS15080.1 [P16283-1]
PIRiA33638
RefSeqiNP_033234.2, NM_009208.3 [P16283-1]
XP_006496512.1, XM_006496449.3
XP_006496513.1, XM_006496450.3 [P16283-1]
XP_006496514.1, XM_006496451.3 [P16283-1]
XP_006496515.1, XM_006496452.3
XP_006496516.1, XM_006496453.2 [P16283-1]

3D structure databases

SMRiP16283
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16283, 1 interactor
STRINGi10090.ENSMUSP00000116747

PTM databases

iPTMnetiP16283
PhosphoSitePlusiP16283

Proteomic databases

MaxQBiP16283
PaxDbiP16283
PeptideAtlasiP16283
PRIDEiP16283

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124341; ENSMUSP00000116747; ENSMUSG00000006576 [P16283-1]
GeneIDi20536
KEGGimmu:20536
UCSCiuc007bpv.2 mouse [P16283-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6508
MGIiMGI:109350 Slc4a3

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000159765
HOGENOMiHOG000280683
InParanoidiP16283
KOiK13856
OMAiCIQLACI
OrthoDBi265068at2759
PhylomeDBiP16283
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-MMU-425381 Bicarbonate transporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Slc4a3 mouse

Protein Ontology

More...PROi		PR:P16283

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000006576 Expressed in 261 organ(s), highest expression level in heart
ExpressionAtlasiP16283 baseline and differential
GenevisibleiP16283 MM

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717 Anion_exchange
IPR002979 Anion_exchange_3
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PTHR11453:SF15 PTHR11453:SF15, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR00165 ANIONEXCHNGR
PR01189 ANIONEXHNGR3
PR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit
PROSITEiView protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3A3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16283
Secondary accession number(s): Q9ERP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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