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Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-196783 Coenzyme A biosynthesis

Protein family/group databases

TCDBi2.A.29.12.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Graves disease autoantigen
Short name:
GDA
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
Gene namesi
Name:SLC25A16
Synonyms:GDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000122912.14
HGNCiHGNC:10986 SLC25A16
MIMi139080 gene
neXtProtiNX_P16260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8034
OpenTargetsiENSG00000122912
PharmGKBiPA35862

Polymorphism and mutation databases

BioMutaiSLC25A16
DMDMi215274156

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906161 – 332Graves disease carrier proteinAdd BLAST332

Proteomic databases

EPDiP16260
MaxQBiP16260
PaxDbiP16260
PeptideAtlasiP16260
PRIDEiP16260
ProteomicsDBi53331

PTM databases

iPTMnetiP16260
PhosphoSitePlusiP16260

Expressioni

Gene expression databases

BgeeiENSG00000122912
CleanExiHS_GDA
HS_SLC25A16
ExpressionAtlasiP16260 baseline and differential
GenevisibleiP16260 HS

Organism-specific databases

HPAiHPA036243
HPA044580

Interactioni

Protein-protein interaction databases

BioGridi113727, 29 interactors
STRINGi9606.ENSP00000265870

Structurei

3D structure databases

ProteinModelPortaliP16260
SMRiP16260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 120Solcar 1Add BLAST87
Repeati128 – 216Solcar 2Add BLAST89
Repeati238 – 328Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752 Eukaryota
ENOG410ZRF1 LUCA
GeneTreeiENSGT00920000149156
HOGENOMiHOG000165726
HOVERGENiHBG104402
InParanoidiP16260
KOiK15084
OMAiKMWREEG
OrthoDBiEOG091G0C8S
PhylomeDBiP16260
TreeFamiTF314806

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P16260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTL ITTKLGISGH VHRLMAGSMA GMTAVICTYP
160 170 180 190 200
LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA KEGGFFGFYR GLMPTILGMA
210 220 230 240 250
PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT HVNLLCGGVA
260 270 280 290 300
GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
310 320 330
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
Length:332
Mass (Da):36,224
Last modified:November 25, 2008 - v3
Checksum:i71C2C3D413F80246
GO

Sequence cautioni

The sequence AAA36329 differs from that shown. Reason: Frameshift at position 320.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21Q → G in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti44G → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti149 – 151YPL → DPV in AAA36329 (PubMed:2575220).Curated3
Sequence conflicti167S → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti227R → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti251G → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti290V → D in AAA36329 (PubMed:2575220).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA Translation: AAA36329.1 Frameshift.
AK290255 mRNA Translation: BAF82944.1
AL713888 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54298.1
BC030266 mRNA Translation: AAH30266.1
CCDSiCCDS7280.1
PIRiA40141
RefSeqiNP_689920.1, NM_152707.3
XP_011538513.1, XM_011540211.2
UniGeneiHs.180408

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912
GeneIDi8034
KEGGihsa:8034
UCSCiuc001joi.4 human

Similar proteinsi

Entry informationi

Entry nameiGDC_HUMAN
AccessioniPrimary (citable) accession number: P16260
Secondary accession number(s): Q8N2U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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