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Entry version 183 (02 Dec 2020)
Sequence version 3 (25 Nov 2008)
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Protein

Graves disease carrier protein

Gene

SLC25A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the accumulation of coenzyme A in the mitochondrial matrix.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P16260

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196783, Coenzyme A biosynthesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.29.12.3, the mitochondrial carrier (mc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Graves disease carrier protein
Short name:
GDC
Alternative name(s):
Graves disease autoantigen
Short name:
GDA
Mitochondrial solute carrier protein homolog
Solute carrier family 25 member 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC25A16
Synonyms:GDA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000122912.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10986, SLC25A16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
139080, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei244 – 264Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei299 – 319Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8034

Open Targets

More...
OpenTargetsi
ENSG00000122912

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35862

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P16260, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC25A16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274156

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000906161 – 332Graves disease carrier proteinAdd BLAST332

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P16260

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16260

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P16260

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P16260

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16260

PeptideAtlas

More...
PeptideAtlasi
P16260

PRoteomics IDEntifications database

More...
PRIDEi
P16260

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53331

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16260

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16260

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16260

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122912, Expressed in adipose tissue and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16260, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16260, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000122912, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113727, 31 interactors

Protein interaction database and analysis system

More...
IntActi
P16260, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000476815

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P16260, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16260

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati34 – 120Solcar 1Add BLAST87
Repeati128 – 216Solcar 2Add BLAST89
Repeati238 – 328Solcar 3Add BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0752, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157520

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015166_10_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16260

Identification of Orthologs from Complete Genome Data

More...
OMAi
AKMWREE

Database of Orthologous Groups

More...
OrthoDBi
1173026at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16260

TreeFam database of animal gene trees

More...
TreeFami
TF314806

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002167, Graves_DC
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00153, Mito_carr, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00928, GRAVESDC
PR00926, MITOCARRIER

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103506, SSF103506, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50920, SOLCAR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P16260-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAATAAAAL AAADPPPAMP QAAGAGGPTT RRDFYWLRSF LAGGIAGCCA
60 70 80 90 100
KTTVAPLDRV KVLLQAHNHH YKHLGVFSAL RAVPQKEGFL GLYKGNGAMM
110 120 130 140 150
IRIFPYGAIQ FMAFEHYKTL ITTKLGISGH VHRLMAGSMA GMTAVICTYP
160 170 180 190 200
LDMVRVRLAF QVKGEHSYTG IIHAFKTIYA KEGGFFGFYR GLMPTILGMA
210 220 230 240 250
PYAGVSFFTF GTLKSVGLSH APTLLGRPSS DNPNVLVLKT HVNLLCGGVA
260 270 280 290 300
GAIAQTISYP FDVTRRRMQL GTVLPEFEKC LTMRDTMKYV YGHHGIRKGL
310 320 330
YRGLSLNYIR CIPSQAVAFT TYELMKQFFH LN
Length:332
Mass (Da):36,224
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71C2C3D413F80246
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ24V9GZ24_HUMAN
Graves disease carrier protein
SLC25A16
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY06V9GY06_HUMAN
Graves disease carrier protein
SLC25A16
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYA5V9GYA5_HUMAN
Graves disease carrier protein
SLC25A16
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYB8V9GYB8_HUMAN
Graves disease carrier protein
SLC25A16
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36329 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti21Q → G in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti44G → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti149 – 151YPL → DPV in AAA36329 (PubMed:2575220).Curated3
Sequence conflicti167S → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti227R → S in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti251G → R in AAA36329 (PubMed:2575220).Curated1
Sequence conflicti290V → D in AAA36329 (PubMed:2575220).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31659 mRNA Translation: AAA36329.1 Frameshift.
AK290255 mRNA Translation: BAF82944.1
AL713888 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54298.1
BC030266 mRNA Translation: AAH30266.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7280.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40141

NCBI Reference Sequences

More...
RefSeqi
NP_689920.1, NM_152707.3
XP_011538513.1, XM_011540211.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000609923; ENSP00000476815; ENSG00000122912

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8034

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8034

UCSC genome browser

More...
UCSCi
uc001joi.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31659 mRNA Translation: AAA36329.1 Frameshift.
AK290255 mRNA Translation: BAF82944.1
AL713888 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54298.1
BC030266 mRNA Translation: AAH30266.1
CCDSiCCDS7280.1
PIRiA40141
RefSeqiNP_689920.1, NM_152707.3
XP_011538513.1, XM_011540211.2

3D structure databases

SMRiP16260
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113727, 31 interactors
IntActiP16260, 13 interactors
STRINGi9606.ENSP00000476815

Protein family/group databases

TCDBi2.A.29.12.3, the mitochondrial carrier (mc) family

PTM databases

iPTMnetiP16260
PhosphoSitePlusiP16260
SwissPalmiP16260

Polymorphism and mutation databases

BioMutaiSLC25A16
DMDMi215274156

Proteomic databases

EPDiP16260
jPOSTiP16260
MassIVEiP16260
MaxQBiP16260
PaxDbiP16260
PeptideAtlasiP16260
PRIDEiP16260
ProteomicsDBi53331

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28525, 70 antibodies

The DNASU plasmid repository

More...
DNASUi
8034

Genome annotation databases

EnsembliENST00000609923; ENSP00000476815; ENSG00000122912
GeneIDi8034
KEGGihsa:8034
UCSCiuc001joi.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8034
DisGeNETi8034
EuPathDBiHostDB:ENSG00000122912.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC25A16
HGNCiHGNC:10986, SLC25A16
HPAiENSG00000122912, Low tissue specificity
MIMi139080, gene
neXtProtiNX_P16260
OpenTargetsiENSG00000122912
PharmGKBiPA35862

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0752, Eukaryota
GeneTreeiENSGT00940000157520
HOGENOMiCLU_015166_10_1_1
InParanoidiP16260
OMAiAKMWREE
OrthoDBi1173026at2759
PhylomeDBiP16260
TreeFamiTF314806

Enzyme and pathway databases

PathwayCommonsiP16260
ReactomeiR-HSA-196783, Coenzyme A biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8034, 3 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC25A16, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8034
PharosiP16260, Tbio

Protein Ontology

More...
PROi
PR:P16260
RNActiP16260, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122912, Expressed in adipose tissue and 224 other tissues
ExpressionAtlasiP16260, baseline and differential
GenevisibleiP16260, HS

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002167, Graves_DC
IPR002067, Mit_carrier
IPR018108, Mitochondrial_sb/sol_carrier
IPR023395, Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153, Mito_carr, 3 hits
PRINTSiPR00928, GRAVESDC
PR00926, MITOCARRIER
SUPFAMiSSF103506, SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920, SOLCAR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16260
Secondary accession number(s): Q8N2U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: December 2, 2020
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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