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Entry version 157 (13 Nov 2019)
Sequence version 2 (01 Nov 1995)
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Protein

Sodium/pantothenate symporter

Gene

panF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the sodium-dependent uptake of extracellular pantothenate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:PANF-MONOMER
ECOL316407:JW3226-MONOMER
MetaCyc:PANF-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.21.1.1 the solute:sodium symporter (sss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/pantothenate symporter
Alternative name(s):
Pantothenate permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:panF
Ordered Locus Names:b3258, JW3226
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2CytoplasmicSequence analysis2
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 42PeriplasmicSequence analysisAdd BLAST19
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 123PeriplasmicSequence analysisAdd BLAST29
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 161CytoplasmicSequence analysisAdd BLAST17
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 232PeriplasmicSequence analysisAdd BLAST50
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 272CytoplasmicSequence analysisAdd BLAST19
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 305PeriplasmicSequence analysisAdd BLAST12
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 368CytoplasmicSequence analysisAdd BLAST42
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 391PeriplasmicSequence analysis2
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 423CytoplasmicSequence analysisAdd BLAST11
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445PeriplasmicSequence analysis1
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 483CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001054021 – 483Sodium/pantothenate symporterAdd BLAST483

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16256

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16256

PRoteomics IDEntifications database

More...
PRIDEi
P16256

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4262451, 174 interactors

Database of interacting proteins

More...
DIPi
DIP-10439N

STRING: functional protein association networks

More...
STRINGi
511145.b3258

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108IA2 Bacteria
COG4145 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000281958

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16256

KEGG Orthology (KO)

More...
KOi
K14392

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16256

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10327 SLC5sbd_PanF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR011849 Na/pantothenate_symporter
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02119 panF, 1 hit
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P16256-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLEVILPLV AYLVVVFGIS VYAMRKRSTG TFLNEYFLGS RSMGGIVLAM
60 70 80 90 100
TLTATYISAS SFIGGPGAAY KYGLGWVLLA MIQLPAVWLS LGILGKKFAI
110 120 130 140 150
LARRYNAVTL NDMLFARYQS RLLVWLASLS LLVAFVGAMT VQFIGGARLL
160 170 180 190 200
ETAAGIPYET GLLIFGISIA LYTAFGGFRA SVLNDTMQGL VMLIGTVVLL
210 220 230 240 250
IGVVHAAGGL SNAVQTLQTI DPQLVTPQGA DDILSPAFMT SFWVLVCFGV
260 270 280 290 300
IGLPHTAVRC ISYKDSKAVH RGIIIGTIVV AILMFGMHLA GALGRAVIPD
310 320 330 340 350
LTVPDLVIPT LMVKVLPPFA AGIFLAAPMA AIMSTINAQL LQSSATIIKD
360 370 380 390 400
LYLNIRPDQM QNETRLKRMS AVITLVLGAL LLLAAWKPPE MIIWLNLLAF
410 420 430 440 450
GGLEAVFLWP LVLGLYWERA NAKGALSAMI VGGVLYAVLA TLNIQYLGFH
460 470 480
PIVPSLLLSL LAFLVGNRFG TSVPQATVLT TDK
Length:483
Mass (Da):51,717
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F607C043ECAB1F8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA23747 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAA58061 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179 – 206RASVL…GVVHA → APAAERHHARACDADWHRCA AYWRSTC in AAA24276 (PubMed:2193919).CuratedAdd BLAST28
Sequence conflicti254P → A in AAA24276 (PubMed:2193919).Curated1
Sequence conflicti302T → H in AAA24276 (PubMed:2193919).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M30953 Genomic DNA Translation: AAA24276.1
U18997 Genomic DNA Translation: AAA58061.1 Different initiation.
U00096 Genomic DNA Translation: AAC76290.2
AP009048 Genomic DNA Translation: BAE77299.1
M83198 Genomic DNA Translation: AAA23747.1 Different initiation.
S67010 Genomic DNA Translation: AAB28768.1

NCBI Reference Sequences

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RefSeqi
NP_417724.4, NC_000913.3
WP_001175728.1, NZ_SSZK01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76290; AAC76290; b3258
BAE77299; BAE77299; BAE77299

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947752

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3226
eco:b3258

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3357

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30953 Genomic DNA Translation: AAA24276.1
U18997 Genomic DNA Translation: AAA58061.1 Different initiation.
U00096 Genomic DNA Translation: AAC76290.2
AP009048 Genomic DNA Translation: BAE77299.1
M83198 Genomic DNA Translation: AAA23747.1 Different initiation.
S67010 Genomic DNA Translation: AAB28768.1
RefSeqiNP_417724.4, NC_000913.3
WP_001175728.1, NZ_SSZK01000034.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4262451, 174 interactors
DIPiDIP-10439N
STRINGi511145.b3258

Protein family/group databases

TCDBi2.A.21.1.1 the solute:sodium symporter (sss) family

Proteomic databases

jPOSTiP16256
PaxDbiP16256
PRIDEiP16256

Genome annotation databases

EnsemblBacteriaiAAC76290; AAC76290; b3258
BAE77299; BAE77299; BAE77299
GeneIDi947752
KEGGiecj:JW3226
eco:b3258
PATRICifig|511145.12.peg.3357

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0679

Phylogenomic databases

eggNOGiENOG4108IA2 Bacteria
COG4145 LUCA
HOGENOMiHOG000281958
InParanoidiP16256
KOiK14392
PhylomeDBiP16256

Enzyme and pathway databases

BioCyciEcoCyc:PANF-MONOMER
ECOL316407:JW3226-MONOMER
MetaCyc:PANF-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P16256

Family and domain databases

CDDicd10327 SLC5sbd_PanF, 1 hit
Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR011849 Na/pantothenate_symporter
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR02119 panF, 1 hit
TIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPANF_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16256
Secondary accession number(s): P76679, Q2M8V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1995
Last modified: November 13, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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