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Protein

Cuticle collagen 3A3

Gene

3A3

Organism
Haemonchus contortus (Barber pole worm)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.

Miscellaneous

This protein shows 4 potential triple-helical regions, which contain glycine as every third amino acid.
In all nematode cuticle collagens, the polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cuticle collagen 3A3
Gene namesi
Name:3A3
OrganismiHaemonchus contortus (Barber pole worm)
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchus

Subcellular locationi

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001276071 – 295Cuticle collagen 3A3Add BLAST295

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 127Triple-helical regionAdd BLAST30
Regioni147 – 203Triple-helical regionAdd BLAST57
Regioni212 – 277Triple-helical regionAdd BLAST66

Sequence similaritiesi

Belongs to the cuticular collagen family.Curated

Keywords - Domaini

Collagen, Repeat

Family and domain databases

InterProiView protein in InterPro
IPR002486 Col_cuticle_N
IPR008160 Collagen
PfamiView protein in Pfam
PF01484 Col_cuticle_N, 1 hit
PF01391 Collagen, 1 hit
SMARTiView protein in SMART
SM01088 Col_cuticle_N, 1 hit

Sequencei

Sequence statusi: Complete.

P16253-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVIDHRIKA YRFVAYAAVG FSVVAVLSVC VTLPIVYNYV HYVRKSLHKE
60 70 80 90 100
ASLCKISTNS VWDDVTVLRL AHFGNRTARQ AITSSEENGG CESCCRPGPP
110 120 130 140 150
GPPGPPGRPG RPGRPGAPGL PGVPGLPPPD GSCEPVSIPP CAECPAGPPG
160 170 180 190 200
PPGKPGPPGD PGEDGQPGPP GQDGIPGQQG TKGPPGPPGI PGKPGESGEV
210 220 230 240 250
GEDAECEPVA PGDQGPPGEP GPEGPPGEPG LQGPVGMPGQ VGQKGESGSD
260 270 280 290
GQLDFDGSPG RPGPPGPPGR PGEPGICPKY CAIDGGIFFE DGTRR
Length:295
Mass (Da):29,618
Last modified:August 1, 1990 - v1
Checksum:i85355A431B6D3311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32821 mRNA Translation: AAA29174.1
M32820 Genomic DNA Translation: AAA29173.1
PIRiA44984

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32821 mRNA Translation: AAA29174.1
M32820 Genomic DNA Translation: AAA29173.1
PIRiA44984

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002486 Col_cuticle_N
IPR008160 Collagen
PfamiView protein in Pfam
PF01484 Col_cuticle_N, 1 hit
PF01391 Collagen, 1 hit
SMARTiView protein in SMART
SM01088 Col_cuticle_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCUC3A_HAECO
AccessioniPrimary (citable) accession number: P16253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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