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Entry version 177 (07 Oct 2020)
Sequence version 1 (01 Apr 1990)
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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

Lhcgr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-375281, Hormone ligand-binding receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lhcgr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3007, Lhcgr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 362ExtracellularSequence analysisAdd BLAST336
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei363 – 390Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini391 – 399CytoplasmicSequence analysis9
Transmembranei400 – 422Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini423 – 443ExtracellularSequence analysisAdd BLAST21
Transmembranei444 – 466Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini467 – 486CytoplasmicSequence analysisAdd BLAST20
Transmembranei487 – 509Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini510 – 529ExtracellularSequence analysisAdd BLAST20
Transmembranei530 – 551Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini552 – 574CytoplasmicSequence analysisAdd BLAST23
Transmembranei575 – 598Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini599 – 609ExtracellularSequence analysisAdd BLAST11
Transmembranei610 – 631Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini632 – 700CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi409D → N: Significant reduction of binding. 1 Publication1
Mutagenesisi436D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi455E → Q: No change in binding or cAMP production. 1 Publication1
Mutagenesisi582D → N: No change in binding or cAMP production. 1 Publication1
Mutagenesisi647C → A: Trapped intracellularly and does not appear to become mature; when associated with A-648. 1 Publication1
Mutagenesisi648C → A: Trapped intracellularly and does not appear to become mature; when associated with A-647. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2456

DrugCentral

More...
DrugCentrali
P16235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 262 PublicationsAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001278327 – 700Lutropin-choriogonadotropic hormone receptorAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei335SulfotyrosineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi443 ↔ 518PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi647S-palmitoyl cysteine1 Publication1
Lipidationi648S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P16235

PRoteomics IDEntifications database

More...
PRIDEi
P16235

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P16235, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16235

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16235

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16235

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000022481

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16235

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 150LRR 1Add BLAST25
Repeati152 – 175LRR 2Add BLAST24
Repeati176 – 200LRR 3Add BLAST25
Repeati202 – 224LRR 4Add BLAST23
Repeati225 – 248LRR 5Add BLAST24
Repeati250 – 271LRR 6Add BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2087, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16235

KEGG Orthology (KO)

More...
KOi
K04248

Database of Orthologous Groups

More...
OrthoDBi
257031at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16235

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002131, Gphrmn_rcpt_fam
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR002273, LSH_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit
PF13306, LRR_5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00373, GLYCHORMONER
PR00237, GPCRRHODOPSN
PR01144, LSHRECEPTOR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P16235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRRVPALRQ LLVLAVLLLK PSQLQSRELS GSRCPEPCDC APDGALRCPG
60 70 80 90 100
PRAGLARLSL TYLPVKVIPS QAFRGLNEVV KIEISQSDSL ERIEANAFDN
110 120 130 140 150
LLNLSELLIQ NTKNLLYIEP GAFTNLPRLK YLSICNTGIR TLPDVTKISS
160 170 180 190 200
SEFNFILEIC DNLHITTIPG NAFQGMNNES VTLKLYGNGF EEVQSHAFNG
210 220 230 240 250
TTLISLELKE NIYLEKMHSG AFQGATGPSI LDISSTKLQA LPSHGLESIQ
260 270 280 290 300
TLIALSSYSL KTLPSKEKFT SLLVATLTYP SHCCAFRNLP KKEQNFSFSI
310 320 330 340 350
FENFSKQCES TVRKADNETL YSAIFEENEL SGWDYDYGFC SPKTLQCAPE
360 370 380 390 400
PDAFNPCEDI MGYAFLRVLI WLINILAIFG NLTVLFVLLT SRYKLTVPRF
410 420 430 440 450
LMCNLSFADF CMGLYLLLIA SVDSQTKGQY YNHAIDWQTG SGCGAAGFFT
460 470 480 490 500
VFASELSVYT LTVITLERWH TITYAVQLDQ KLRLRHAIPI MLGGWLFSTL
510 520 530 540 550
IATMPLVGIS NYMKVSICLP MDVESTLSQV YILSILILNV VAFVVICACY
560 570 580 590 600
IRIYFAVQNP ELTAPNKDTK IAKKMAILIF TDFTCMAPIS FFAISAAFKV
610 620 630 640 650
PLITVTNSKI LLVLFYPVNS CANPFLYAIF TKAFQRDFLL LLSRFGCCKR
660 670 680 690 700
RAELYRRKEF SAYTSNCKNG FPGASKPSQA TLKLSTVHCQ QPIPPRALTH
Length:700
Mass (Da):78,036
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31807E73BAC94F1F
GO
Isoform 1759 (identifier: P16235-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-157: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:316
Mass (Da):34,776
Checksum:i7B2268943600064C
GO
Isoform 1834 (identifier: P16235-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:341
Mass (Da):37,514
Checksum:iF07ADCB07BB0A074
GO
Isoform 1950 (identifier: P16235-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-132: Missing.

Show »
Length:650
Mass (Da):72,318
Checksum:i9674879D3BB793AD
GO
Isoform 2075 (identifier: P16235-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-251: DISSTKLQALPSHGLESIQT → PCRATGWSPFRRSSPCLPTH
     252-700: Missing.

Show »
Length:251
Mass (Da):27,595
Checksum:i0CF9CC2BA3EEBD33
GO
Isoform C1 (identifier: P16235-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-294: Q → P
     295-700: Missing.

Show »
Length:294
Mass (Da):32,243
Checksum:i6BCDFA656F66B8F3
GO
Isoform C2 (identifier: P16235-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-700: Missing.

Show »
Length:183
Mass (Da):20,132
Checksum:i0F4579BC254CAF7F
GO
Isoform EA2 (identifier: P16235-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.

Show »
Length:638
Mass (Da):71,246
Checksum:i2A51B16A0ABAABA5
GO
Isoform EB (identifier: P16235-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     321-342: YSAIFEENELSGWDYDYGFCSP → LHGALPAAHCLRGLPNKRPVL
     343-700: Missing.

Show »
Length:279
Mass (Da):30,724
Checksum:iC20FE7913916C1EC
GO
Isoform B1 (identifier: P16235-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-293: Missing.
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:305
Mass (Da):33,721
Checksum:iA6F021436A24B636
GO
Isoform B3 (identifier: P16235-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-367: QNFSFSIFEN...EDIMGYAFLR → IFHFPFLKTS...ILWAMPSLGS
     368-700: Missing.

Show »
Length:367
Mass (Da):40,511
Checksum:i49B1FC6213C166FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMG6F1LMG6_RAT
Lutropin-choriogonadotropic hormone...
Lhcgr LHCGR
700Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33R → L AA sequence (PubMed:2925659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti82I → M in isoform 1950. 1
Natural varianti179E → G in isoform 1759. 1
Natural varianti233I → T in isoform 1950. 1
Natural varianti646G → S in isoform 1950. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00196883 – 132Missing in isoform 1950. CuratedAdd BLAST50
Alternative sequenceiVSP_001969133 – 157Missing in isoform 1759. CuratedAdd BLAST25
Alternative sequenceiVSP_001970184 – 700Missing in isoform C2. CuratedAdd BLAST517
Alternative sequenceiVSP_001972232 – 293Missing in isoform EA2, isoform EB and isoform B1. CuratedAdd BLAST62
Alternative sequenceiVSP_001971232 – 251DISST…ESIQT → PCRATGWSPFRRSSPCLPTH in isoform 2075. CuratedAdd BLAST20
Alternative sequenceiVSP_001973252 – 700Missing in isoform 2075. CuratedAdd BLAST449
Alternative sequenceiVSP_001974294 – 367QNFSF…YAFLR → IFHFPFLKTSPNNAKAQLEK QITRRFIPPSLRRMNSVAGI MIMASVHPRHSNVLQNQMLS TPVKILWAMPSLGS in isoform B1 and isoform B3. CuratedAdd BLAST74
Alternative sequenceiVSP_001975294Q → P in isoform C1. Curated1
Alternative sequenceiVSP_001976295 – 700Missing in isoform C1. CuratedAdd BLAST406
Alternative sequenceiVSP_001977321 – 342YSAIF…GFCSP → LHGALPAAHCLRGLPNKRPV L in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST22
Alternative sequenceiVSP_001978343 – 700Missing in isoform 1834, isoform 1759 and isoform EB. CuratedAdd BLAST358
Alternative sequenceiVSP_001979368 – 700Missing in isoform B1 and isoform B3. CuratedAdd BLAST333

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M26199 mRNA Translation: AAA41528.1
M61212, M61211 Genomic DNA Translation: AAA41527.1
S40803 S40798 Genomic DNA Translation: AAB22680.1
S40795 S40920 Genomic DNA Translation: AAB22681.1
S40803 S40798 Genomic DNA Translation: AAB22682.2
S40803 S40798 Genomic DNA Translation: AAB22683.1
S40803 S40798 Genomic DNA Translation: AAB22684.2
M68928 M68927 Genomic DNA Translation: AAA41529.1
AH004953 Genomic DNA Translation: AAB42193.1

Protein sequence database of the Protein Information Resource

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PIRi
A49744
I57668
I77461

NCBI Reference Sequences

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RefSeqi
NP_037110.1, NM_012978.1 [P16235-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
25477

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:25477

UCSC genome browser

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UCSCi
RGD:3007, rat [P16235-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence-structure-function-analysis of glycoprotein hormone receptors

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26199 mRNA Translation: AAA41528.1
M61212, M61211 Genomic DNA Translation: AAA41527.1
S40803 S40798 Genomic DNA Translation: AAB22680.1
S40795 S40920 Genomic DNA Translation: AAB22681.1
S40803 S40798 Genomic DNA Translation: AAB22682.2
S40803 S40798 Genomic DNA Translation: AAB22683.1
S40803 S40798 Genomic DNA Translation: AAB22684.2
M68928 M68927 Genomic DNA Translation: AAA41529.1
AH004953 Genomic DNA Translation: AAB42193.1
PIRiA49744
I57668
I77461
RefSeqiNP_037110.1, NM_012978.1 [P16235-1]

3D structure databases

SMRiP16235
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022481

Chemistry databases

BindingDBiP16235
ChEMBLiCHEMBL2456
DrugCentraliP16235

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniP16235, 6 sites
iPTMnetiP16235
PhosphoSitePlusiP16235
SwissPalmiP16235

Proteomic databases

PaxDbiP16235
PRIDEiP16235

Genome annotation databases

GeneIDi25477
KEGGirno:25477
UCSCiRGD:3007, rat [P16235-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3973
RGDi3007, Lhcgr

Phylogenomic databases

eggNOGiKOG2087, Eukaryota
InParanoidiP16235
KOiK04248
OrthoDBi257031at2759
PhylomeDBiP16235

Enzyme and pathway databases

ReactomeiR-RNO-375281, Hormone ligand-binding receptors

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P16235

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
IPR002131, Gphrmn_rcpt_fam
IPR026906, LRR_5
IPR032675, LRR_dom_sf
IPR002273, LSH_rcpt
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PF13306, LRR_5, 2 hits
PRINTSiPR00373, GLYCHORMONER
PR00237, GPCRRHODOPSN
PR01144, LSHRECEPTOR
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLSHR_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16235
Secondary accession number(s): P70646
, Q63807, Q63808, Q63809, Q6LDI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 7, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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