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Protein

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

ACADS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms.By similarity

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei161Substrate; via carbonyl oxygen1
Binding sitei297FAD; shared with dimeric partner1 Publication1
Binding sitei308FAD1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei392Proton acceptorBy similarity1
Binding sitei393Substrate; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi152 – 161FAD1 Publication10
Nucleotide bindingi185 – 187FAD1 Publication3
Nucleotide bindingi365 – 369FAD; shared with dimeric partner1 Publication5
Nucleotide bindingi394 – 396FAD1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acyl-CoA dehydrogenase activity Source: BHF-UCL
  • butyryl-CoA dehydrogenase activity Source: GO_Central
  • flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04619-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P16219

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00660

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001403

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
Short name:
SCAD
Alternative name(s):
Butyryl-CoA dehydrogenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACADS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122971.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:90 ACADS

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606885 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16219

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Acyl-CoA dehydrogenase short-chain deficiency (ACADSD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error of mitochondrial fatty acid beta-oxidation resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in adults.
See also OMIM:201470
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00031046R → W in ACADSD. Corresponds to variant dbSNP:rs121908003EnsemblClinVar.1
Natural variantiVAR_01356590G → S in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908005EnsemblClinVar.1
Natural variantiVAR_00031192G → C in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs121908004EnsemblClinVar.1
Natural variantiVAR_013566104Missing in ACADSD; no detectable activity. 1 Publication1
Natural variantiVAR_000312107R → C in ACADSD. Corresponds to variant dbSNP:rs61732144EnsemblClinVar.1
Natural variantiVAR_000314177W → R in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs57443665EnsemblClinVar.1
Natural variantiVAR_013568192A → V in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28940874EnsemblClinVar.1
Natural variantiVAR_013569325R → W in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908006EnsemblClinVar.1
Natural variantiVAR_013570353S → L in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28941773EnsemblClinVar.1
Natural variantiVAR_013571380R → W in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28940875EnsemblClinVar.1
Natural variantiVAR_000316383R → C in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs28940872EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
35

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ACADS

MalaCards human disease database

More...
MalaCardsi
ACADS
MIMi201470 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000122971

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
26792 Short chain acyl-CoA dehydrogenase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24426

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03059 Acetoacetyl-Coenzyme A
DB03147 Flavin adenine dinucleotide
DB00157 NADH

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACADS

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000049825 – 412Short-chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphothreonineBy similarity1
Modified residuei51N6-acetyllysine; alternateBy similarity1
Modified residuei51N6-succinyllysine; alternateBy similarity1
Modified residuei72N6-acetyllysineBy similarity1
Modified residuei129N6-acetyllysine; alternateBy similarity1
Modified residuei129N6-succinyllysine; alternateBy similarity1
Modified residuei208N6-acetyllysineBy similarity1
Modified residuei262N6-acetyllysine; alternateBy similarity1
Modified residuei262N6-succinyllysine; alternateBy similarity1
Modified residuei306N6-acetyllysine; alternateBy similarity1
Modified residuei306N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P16219

MaxQB - The MaxQuant DataBase

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MaxQBi
P16219

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16219

PeptideAtlas

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PeptideAtlasi
P16219

PRoteomics IDEntifications database

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PRIDEi
P16219

ProteomicsDB human proteome resource

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ProteomicsDBi
53323

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P16219

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P16219

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P16219

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122971 Expressed in 186 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACADS

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16219 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16219 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB019284
HPA004799
HPA022271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106553, 14 interactors

Protein interaction database and analysis system

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IntActi
P16219, 2 interactors

Molecular INTeraction database

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MINTi
P16219

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000242592

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16219

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16219

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16219

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni269 – 272Substrate binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0139 Eukaryota
COG1960 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158866

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000131659

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000224

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16219

KEGG Orthology (KO)

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KOi
K00248

Identification of Orthologs from Complete Genome Data

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OMAi
QKQQWIT

Database of Orthologous Groups

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OrthoDBi
EOG091G04BS

Database for complete collections of gene phylogenies

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PhylomeDBi
P16219

TreeFam database of animal gene trees

More...
TreeFami
TF105019

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.540.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P16219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAALLARAS GPARRALCPR AWRQLHTIYQ SVELPETHQM LLQTCRDFAE
60 70 80 90 100
KELFPIAAQV DKEHLFPAAQ VKKMGGLGLL AMDVPEELGG AGLDYLAYAI
110 120 130 140 150
AMEEISRGCA STGVIMSVNN SLYLGPILKF GSKEQKQAWV TPFTSGDKIG
160 170 180 190 200
CFALSEPGNG SDAGAASTTA RAEGDSWVLN GTKAWITNAW EASAAVVFAS
210 220 230 240 250
TDRALQNKGI SAFLVPMPTP GLTLGKKEDK LGIRGSSTAN LIFEDCRIPK
260 270 280 290 300
DSILGEPGMG FKIAMQTLDM GRIGIASQAL GIAQTALDCA VNYAENRMAF
310 320 330 340 350
GAPLTKLQVI QFKLADMALA LESARLLTWR AAMLKDNKKP FIKEAAMAKL
360 370 380 390 400
AASEAATAIS HQAIQILGGM GYVTEMPAER HYRDARITEI YEGTSEIQRL
410
VIAGHLLRSY RS
Length:412
Mass (Da):44,297
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E946ADFC3DA3C0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PE82E9PE82_HUMAN
Short-chain-specific acyl-CoA dehyd...
ACADS
408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00031046R → W in ACADSD. Corresponds to variant dbSNP:rs121908003EnsemblClinVar.1
Natural variantiVAR_01356590G → S in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908005EnsemblClinVar.1
Natural variantiVAR_00031192G → C in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs121908004EnsemblClinVar.1
Natural variantiVAR_013566104Missing in ACADSD; no detectable activity. 1 Publication1
Natural variantiVAR_000312107R → C in ACADSD. Corresponds to variant dbSNP:rs61732144EnsemblClinVar.1
Natural variantiVAR_013567171R → W 69% of wild-type activity; confers susceptibility to ethylmalonicaciduria. 2 PublicationsCorresponds to variant dbSNP:rs1800556EnsemblClinVar.1
Natural variantiVAR_000314177W → R in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs57443665EnsemblClinVar.1
Natural variantiVAR_013568192A → V in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28940874EnsemblClinVar.1
Natural variantiVAR_000315209G → S 86% of wild-type activity; confers susceptibility to ethylmalonicaciduria. 2 PublicationsCorresponds to variant dbSNP:rs1799958EnsemblClinVar.1
Natural variantiVAR_013569325R → W in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908006EnsemblClinVar.1
Natural variantiVAR_013570353S → L in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28941773EnsemblClinVar.1
Natural variantiVAR_013571380R → W in ACADSD; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs28940875EnsemblClinVar.1
Natural variantiVAR_000316383R → C in ACADSD. 1 PublicationCorresponds to variant dbSNP:rs28940872EnsemblClinVar.1
Natural variantiVAR_033458383R → H. Corresponds to variant dbSNP:rs35233375EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M26393 mRNA Translation: AAA60307.1
Z80345, Z80347 Genomic DNA Translation: CAB02492.1
U83992, U83991 Genomic DNA Translation: AAD00552.1
BC025963 mRNA Translation: AAH25963.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9207.1

Protein sequence database of the Protein Information Resource

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PIRi
A30605

NCBI Reference Sequences

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RefSeqi
NP_000008.1, NM_000017.3
NP_001289483.1, NM_001302554.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.507076

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000242592; ENSP00000242592; ENSG00000122971

Database of genes from NCBI RefSeq genomes

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GeneIDi
35

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:35

UCSC genome browser

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UCSCi
uc001tza.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Butyryl-CoA dehydrogenase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26393 mRNA Translation: AAA60307.1
Z80345, Z80347 Genomic DNA Translation: CAB02492.1
U83992, U83991 Genomic DNA Translation: AAD00552.1
BC025963 mRNA Translation: AAH25963.1
CCDSiCCDS9207.1
PIRiA30605
RefSeqiNP_000008.1, NM_000017.3
NP_001289483.1, NM_001302554.1
UniGeneiHs.507076

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VIGX-ray1.90A/B/C/D/E/F/G/H30-412[»]
ProteinModelPortaliP16219
SMRiP16219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106553, 14 interactors
IntActiP16219, 2 interactors
MINTiP16219
STRINGi9606.ENSP00000242592

Chemistry databases

DrugBankiDB03059 Acetoacetyl-Coenzyme A
DB03147 Flavin adenine dinucleotide
DB00157 NADH
SwissLipidsiSLP:000001403

PTM databases

iPTMnetiP16219
PhosphoSitePlusiP16219

Polymorphism and mutation databases

BioMutaiACADS
DMDMi113019

2D gel databases

DOSAC-COBS-2DPAGEiP16219
SWISS-2DPAGEiP16219
UCD-2DPAGEiP16219

Proteomic databases

EPDiP16219
MaxQBiP16219
PaxDbiP16219
PeptideAtlasiP16219
PRIDEiP16219
ProteomicsDBi53323

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
35
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242592; ENSP00000242592; ENSG00000122971
GeneIDi35
KEGGihsa:35
UCSCiuc001tza.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
35
DisGeNETi35
EuPathDBiHostDB:ENSG00000122971.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ACADS
GeneReviewsiACADS
HGNCiHGNC:90 ACADS
HPAiCAB019284
HPA004799
HPA022271
MalaCardsiACADS
MIMi201470 phenotype
606885 gene
neXtProtiNX_P16219
OpenTargetsiENSG00000122971
Orphaneti26792 Short chain acyl-CoA dehydrogenase deficiency
PharmGKBiPA24426

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0139 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00940000158866
HOGENOMiHOG000131659
HOVERGENiHBG000224
InParanoidiP16219
KOiK00248
OMAiQKQQWIT
OrthoDBiEOG091G04BS
PhylomeDBiP16219
TreeFamiTF105019

Enzyme and pathway databases

UniPathwayi
UPA00660

BioCyciMetaCyc:HS04619-MONOMER
ReactomeiR-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA
SABIO-RKiP16219

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACADS human
EvolutionaryTraceiP16219

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
35

Protein Ontology

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PROi
PR:P16219

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122971 Expressed in 186 organ(s), highest expression level in right lobe of liver
CleanExiHS_ACADS
ExpressionAtlasiP16219 baseline and differential
GenevisibleiP16219 HS

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACADS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16219
Secondary accession number(s): P78331
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: December 5, 2018
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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