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Protein

Neuromedin-K receptor

Gene

Tacr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

GO - Molecular functioni

  • tachykinin receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-380095 Tachykinin receptors bind tachykinins
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-K receptor
Short name:
NKR
Alternative name(s):
NK-3 receptor
Short name:
NK-3R
Neurokinin B receptor
Tachykinin receptor 3
Gene namesi
Name:Tacr3
Synonyms:Tac3r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3810 Tacr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71ExtracellularSequence analysisAdd BLAST71
Transmembranei72 – 94Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini95 – 104CytoplasmicSequence analysis10
Transmembranei105 – 126Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini127 – 146ExtracellularSequence analysisAdd BLAST20
Transmembranei147 – 168Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini169 – 188CytoplasmicSequence analysisAdd BLAST20
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini210 – 232ExtracellularSequence analysisAdd BLAST23
Transmembranei233 – 257Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini258 – 286CytoplasmicSequence analysisAdd BLAST29
Transmembranei287 – 308Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini309 – 321ExtracellularSequence analysisAdd BLAST13
Transmembranei322 – 346Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini347 – 452CytoplasmicSequence analysisAdd BLAST106

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3154
GuidetoPHARMACOLOGYi362

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699021 – 452Neuromedin-K receptorAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 220PROSITE-ProRule annotation
Lipidationi361S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP16177

PTM databases

PhosphoSitePlusiP16177

Expressioni

Gene expression databases

BgeeiENSRNOG00000009372 Expressed in 5 organ(s), highest expression level in brain
GenevisibleiP16177 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012473

Chemistry databases

BindingDBiP16177

Structurei

3D structure databases

ProteinModelPortaliP16177
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219 Eukaryota
ENOG410XSC5 LUCA
GeneTreeiENSGT00920000148949
HOGENOMiHOG000013018
HOVERGENiHBG103412
InParanoidiP16177
KOiK04224
OMAiVMTFAIC
OrthoDBiEOG091G0WYG
PhylomeDBiP16177
TreeFamiTF315303

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001681 Neurokn_rcpt
IPR001013 NK3_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01026 NEUROKININ3R
PR00244 NEUROKININR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P16177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVPRGENW TDGTVEVGTH TGNLSSALGV TEWLALQAGN FSSALGLPAT
60 70 80 90 100
TQAPSQVRAN LTNQFVQPSW RIALWSLAYG LVVAVAVFGN LIVIWIILAH
110 120 130 140 150
KRMRTVTNYF LVNLAFSDAS VAAFNTLINF IYGLHSEWYF GANYCRFQNF
160 170 180 190 200
FPITAVFASI YSMTAIAVDR YMAIIDPLKP RLSATATKIV IGSIWILAFL
210 220 230 240 250
LAFPQCLYSK IKVMPGRTLC YVQWPEGPKQ HFTYHIIVII LVYCFPLLIM
260 270 280 290 300
GVTYTIVGIT LWGGEIPGDT CDKYHEQLKA KRKVVKMMII VVVTFAICWL
310 320 330 340 350
PYHVYFILTA IYQQLNRWKY IQQVYLASFW LAMSSTMYNP IIYCCLNKRF
360 370 380 390 400
RAGFKRAFRW CPFIQVSSYD ELELKTTRFH PTRQSSLYTV SRMESVTVLF
410 420 430 440 450
DPNDGDPTKS SRKKRAVPRD PSANGCSHRG SKSASTTSSF ISSPYTSVDE

YS
Length:452
Mass (Da):51,107
Last modified:April 1, 1990 - v1
Checksum:i51D8EFC94F34CCAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05189 mRNA Translation: AAA41688.1
PIRiA34916
RefSeqiNP_058749.1, NM_017053.1
UniGeneiRn.9702

Genome annotation databases

EnsembliENSRNOT00000012473; ENSRNOP00000012473; ENSRNOG00000009372
GeneIDi24808
KEGGirno:24808

Similar proteinsi

Entry informationi

Entry nameiNK3R_RAT
AccessioniPrimary (citable) accession number: P16177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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