UniProtKB - P16176 (TGFB1_XENLA)
Transforming growth factor beta-1 proprotein
tgfb1
Functioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of microglia differentiation Source: UniProtKB
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-1 proproteinAlternative name(s): TGF-beta-51 Publication Cleaved into the following 2 chains: |
Gene namesi | Name:tgfb1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-865765, tgfb1.L |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: InterPro
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000445549 | 22 – 270 | Latency-associated peptideBy similarityAdd BLAST | 249 | |
ChainiPRO_0000033777 | 271 – 382 | Transforming growth factor beta-1By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 | Interchain (with C-? in LTBP1 TB3 domain); in inactive formBy similarity | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 123 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 166 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 215 | Interchain (with C-217)By similarity | ||
Disulfide bondi | 217 | Interchain (with C-215)By similarity | ||
Disulfide bondi | 277 ↔ 286 | By similarity | ||
Disulfide bondi | 285 ↔ 348 | By similarity | ||
Disulfide bondi | 314 ↔ 379 | By similarity | ||
Disulfide bondi | 318 ↔ 381 | By similarity | ||
Disulfide bondi | 347 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PRIDEi | P16176 |
Interactioni
Subunit structurei
Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide:
Interacts with Transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains (TGF-beta-1) in a latent state; each Latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Transforming growth factor beta-1: Homodimer; disulfide-linked. Transforming growth factor beta-1:
Interacts with TGF-beta receptors (tgfbr1 and tgfbr2), leading to signal transduction.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 65 | Straightjacket domainBy similarityAdd BLAST | 44 | |
Regioni | 66 – 263 | Arm domainBy similarityAdd BLAST | 198 | |
Regioni | 218 – 242 | Bowtie tailBy similarityAdd BLAST | 25 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 234 – 236 | Cell attachment siteSequence analysis | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
OMAi | MAKEPEP |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MEVLWMLLVL LVLHLSSLAM SLSTCKAVDM EEVRKRRIEA IRGQILSKLK
60 70 80 90 100
LDKTPDVDSE KMTVPSEAIF LYNSTLEVIR EKATREEEHV GHDQNIQDYY
110 120 130 140 150
AKQVYRFESI TELEDHEFKF KFNASHVREN VGMNSLLHHA ELRMYKKQTD
160 170 180 190 200
KNMDQRMELF WKYQENGTTH SRYLESKYIT PVTDDEWMSF DVTKTVNEWL
210 220 230 240 250
KRAEENEQFG LQPACKCPTP QAKDIDIEGF PALRGDLASL SSKENTKPYL
260 270 280 290 300
MITSMPAERI DTVTSSRKKR GVGQEYCFGN NGPNCCVKPL YINFRKDLGW
310 320 330 340 350
KWIHEPKGYE ANYCLGNCPY IWSMDTQYSK VLSLYNQNNP GASISPCCVP
360 370 380
DVLEPLPIIY YVGRTAKVEQ LSNMVVRSCN CS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05180 mRNA Translation: AAA49968.1 AF009335 , AF009331, AF009332, AF009333, AF009334 Genomic DNA Translation: AAB64441.1 BC129720 mRNA Translation: AAI29721.1 |
PIRi | A34929, B61036 |
RefSeqi | NP_001081330.1, NM_001087861.1 |
Genome annotation databases
GeneIDi | 397778 |
KEGGi | xla:397778 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05180 mRNA Translation: AAA49968.1 AF009335 , AF009331, AF009332, AF009333, AF009334 Genomic DNA Translation: AAB64441.1 BC129720 mRNA Translation: AAI29721.1 |
PIRi | A34929, B61036 |
RefSeqi | NP_001081330.1, NM_001087861.1 |
3D structure databases
SMRi | P16176 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P16176 |
Genome annotation databases
GeneIDi | 397778 |
KEGGi | xla:397778 |
Organism-specific databases
CTDi | 397778 |
Xenbasei | XB-GENE-865765, tgfb1.L |
Phylogenomic databases
OMAi | MAKEPEP |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB1_XENLA | |
Accessioni | P16176Primary (citable) accession number: P16176 Secondary accession number(s): A1L2V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |