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Entry version 213 (08 May 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Ankyrin-1

Gene

ANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.1 Publication
Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447038 NrCAM interactions
R-HSA-447041 CHL1 interactions
R-HSA-447043 Neurofascin interactions
R-HSA-6807878 COPI-mediated anterograde transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.28.1.2 the ankyrin (ankyrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin-1
Short name:
ANK-1
Alternative name(s):
Ankyrin-R
Erythrocyte ankyrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK1
Synonyms:ANK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:492 ANK1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612641 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16157

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spherocytosis 1 (SPH1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spherocytosis, a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH1 is characterized by severe hemolytic anemia. Inheritance can be autosomal dominant or autosomal recessive. Patients with homozygous mutations have a more severe disorder.
See also OMIM:182900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054991276L → R in SPH1. 1 Publication1
Natural variantiVAR_000596463V → I in SPH1. 1 PublicationCorresponds to variant dbSNP:rs140085544Ensembl.1
Natural variantiVAR_0549921054I → T in SPH1. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1824T → P: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication1
Mutagenesisi1826K → E: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication1
Mutagenesisi1829R → G: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication1
Mutagenesisi1830K → E: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication1

Keywords - Diseasei

Disease mutation, Elliptocytosis, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
286

MalaCards human disease database

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MalaCardsi
ANK1
MIMi182900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000029534

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251066 8p11.2 deletion syndrome
822 Hereditary spherocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24798

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116241246

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000668831 – 1881Ankyrin-1Add BLAST1881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei105(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei233(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei429PhosphoserineCombined sources1
Modified residuei431(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei464(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei629(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei662(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei695(3S)-3-hydroxyaspartate; by HIF1AN; partial1 Publication1
Modified residuei728(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei759PhosphoserineCombined sources1
Modified residuei761(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei781PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei961PhosphothreonineBy similarity1
Modified residuei1073PhosphotyrosineBy similarity1
Modified residuei1082PhosphoserineBy similarity1
Modified residuei1378PhosphothreonineCombined sources1
Modified residuei1380PhosphothreonineCombined sources1
Modified residuei1390PhosphoserineBy similarity1
Modified residuei1392PhosphoserineBy similarity1
Modified residuei1396PhosphoserineCombined sources1
Modified residuei1400PhosphothreonineBy similarity1
Modified residuei1428PhosphoserineCombined sources1
Modified residuei1486PhosphoserineCombined sources1
Modified residuei1523PhosphoserineCombined sources1
Modified residuei1533PhosphoserineCombined sources1
Modified residuei1617PhosphoserineBy similarity1
Modified residuei1666PhosphoserineCombined sources1
Modified residuei1671PhosphoserineCombined sources1
Modified residuei1686PhosphoserineCombined sources1
Modified residuei1690PhosphoserineCombined sources1
Modified residuei1696PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Regulated by phosphorylation.
Palmitoylated.
Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region. Hydroxylation seems to increase the conformational stability of this region and may also modulate protein-protein interactions mediated by the ANK repeat region.1 Publication

Keywords - PTMi

Hydroxylation, Lipoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P16157

MaxQB - The MaxQuant DataBase

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MaxQBi
P16157

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16157

PeptideAtlas

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PeptideAtlasi
P16157

PRoteomics IDEntifications database

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PRIDEi
P16157

ProteomicsDB human proteome resource

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ProteomicsDBi
53299
53300 [P16157-10]
53301 [P16157-11]
53302 [P16157-12]
53303 [P16157-13]
53304 [P16157-14]
53305 [P16157-15]
53306 [P16157-16]
53307 [P16157-17]
53308 [P16157-18]
53309 [P16157-19]
53310 [P16157-2]
53311 [P16157-20]
53312 [P16157-21]
53313 [P16157-3]
53314 [P16157-4]
53315 [P16157-5]
53316 [P16157-6]
53317 [P16157-7]
53318 [P16157-8]
53319 [P16157-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16157

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16157

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P16157

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000029534 Expressed in 165 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16157 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16157 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004842
HPA056953

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with a number of integral membrane proteins and cytoskeletal proteins. Interacts (via N-terminus) with SPTB/spectrin (beta chain). Interacts (via N-terminus ANK repeats) with SLC4A1/erythrocyte membrane protein band 3 (via cytoplasmic N-terminus). Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin. Interacts with HIF1AN.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
OBSCNQ5VST9-38EBI-941819,EBI-941921

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106783, 24 interactors

Protein interaction database and analysis system

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IntActi
P16157, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11881
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N11X-ray2.70A402-827[»]
2YQFNMR-A1394-1497[»]
2YVIX-ray1.92A1394-1497[»]
3F59X-ray2.00A/B/C/D911-1068[»]
3KBTX-ray2.75C/D911-1068[»]
3KBUX-ray2.75C/D911-1068[»]
3UD1X-ray2.00A/B/C911-1233[»]
3UD2X-ray2.21A/B/C911-1233[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16157

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16157

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati44 – 73ANK 1Add BLAST30
Repeati77 – 106ANK 2Add BLAST30
Repeati110 – 139ANK 3Add BLAST30
Repeati143 – 172ANK 4Add BLAST30
Repeati174 – 201ANK 5Add BLAST28
Repeati205 – 234ANK 6Add BLAST30
Repeati238 – 267ANK 7Add BLAST30
Repeati271 – 300ANK 8Add BLAST30
Repeati304 – 333ANK 9Add BLAST30
Repeati337 – 366ANK 10Add BLAST30
Repeati370 – 399ANK 11Add BLAST30
Repeati403 – 432ANK 12Add BLAST30
Repeati436 – 465ANK 13Add BLAST30
Repeati469 – 498ANK 14Add BLAST30
Repeati502 – 531ANK 15Add BLAST30
Repeati535 – 564ANK 16Add BLAST30
Repeati568 – 597ANK 17Add BLAST30
Repeati601 – 630ANK 18Add BLAST30
Repeati634 – 663ANK 19Add BLAST30
Repeati667 – 696ANK 20Add BLAST30
Repeati700 – 729ANK 21Add BLAST30
Repeati733 – 762ANK 22Add BLAST30
Repeati766 – 795ANK 23Add BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini913 – 1068ZU5 1PROSITE-ProRule annotationAdd BLAST156
Domaini1070 – 1216ZU5 2PROSITE-ProRule annotationAdd BLAST147
Domaini1403 – 1487DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82789 kDa domainAdd BLAST827
Regioni1234 – 1362UPA domainBy similarityAdd BLAST129
Regioni1383 – 188155 kDa regulatory domainAdd BLAST499

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3.
The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters.
The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin (By similarity).By similarity

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4177 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000237351

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16157

KEGG Orthology (KO)

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KOi
K10380

Identification of Orthologs from Complete Genome Data

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OMAi
DRADMKM

Database of Orthologous Groups

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OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P16157

TreeFam database of animal gene trees

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TreeFami
TF351263

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 8 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (23+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 23 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 23 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Er1 (identifier: P16157-1) [UniParc]FASTAAdd to basket
Also known as: 1, 2.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH
60 70 80 90 100
LASKEGHVKM VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY
110 120 130 140 150
GANVNAQSQK GFTPLYMAAQ ENHLEVVKFL LENGANQNVA TEDGFTPLAV
160 170 180 190 200
ALQQGHENVV AHLINYGTKG KVRLPALHIA ARNDDTRTAA VLLQNDPNPD
210 220 230 240 250
VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI TPLHIASRRG
260 270 280 290 300
NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA
310 320 330 340 350
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH
360 370 380 390 400
HRVAKVLLDK GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV
410 420 430 440 450
TESGLTPLHV ASFMGHLPIV KNLLQRGASP NVSNVKVETP LHMAARAGHT
460 470 480 490 500
EVAKYLLQNK AKVNAKAKDD QTPLHCAARI GHTNMVKLLL ENNANPNLAT
510 520 530 540 550
TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL HVAAKYGKVR
560 570 580 590 600
VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW
610 620 630 640 650
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM
660 670 680 690 700
VALLLSKQAN GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM
710 720 730 740 750
GYTPLHVASH YGNIKLVKFL LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV
760 770 780 790 800
TLLLKNGASP NEVSSDGTTP LAIAKRLGYI SVTDVLKVVT DETSFVLVSD
810 820 830 840 850
KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE KELLDFVPKL
860 870 880 890 900
DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD
910 920 930 940 950
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT
960 970 980 990 1000
CRLVKPQKLS TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG
1010 1020 1030 1040 1050
RGDRELVVLR SENGSVWKEH RSRYGESYLD QILNGMDEEL GSLEELEKKR
1060 1070 1080 1090 1100
VCRIITTDFP LYFVIMSRLC QDYDTIGPEG GSLKSKLVPL VQATFPENAV
1110 1120 1130 1140 1150
TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK FHRPIGLRIP
1160 1170 1180 1190 1200
LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC
1210 1220 1230 1240 1250
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND
1260 1270 1280 1290 1300
PREGRLRCYC MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN
1310 1320 1330 1340 1350
LVPVKKAAQQ RSFHFQSFRE NRLAMPVKVR DSSREPGGSL SFLRKAMKYE
1360 1370 1380 1390 1400
DTQHILCHLN ITMPPCAKGS GAEDRRRTPT PLALRYSILS ESTPGSLSGT
1410 1420 1430 1440 1450
EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP NSLLEQSVAL
1460 1470 1480 1490 1500
LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT
1510 1520 1530 1540 1550
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI
1560 1570 1580 1590 1600
PLAATEHDTM LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW
1610 1620 1630 1640 1650
KLEGALSEEP RGPELGSLEL VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL
1660 1670 1680 1690 1700
PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ ARITHSPTVS QVTERSQDRL
1710 1720 1730 1740 1750
QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE GLEPGGSQEY
1760 1770 1780 1790 1800
EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN
1810 1820 1830 1840 1850
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT
1860 1870 1880
VEGPLEDPSE LEVDIDYFMK HSKDHTSTPN P
Note: Major erythrocyte-specific isoform. Produced by alternative promoter usage.
Length:1,881
Mass (Da):206,265
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49466F6F915019EC
GO
Isoform Er2 (identifier: P16157-4) [UniParc]FASTAAdd to basket
Also known as: 2, 2.2

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.

Note: Predominant form of minor erythrocyte-specific isoforms. Produced by alternative splicing of isoform Er1.
Show »
Length:1,719
Mass (Da):188,999
Checksum:i407D614678AF8EE0
GO
Isoform Er3 (identifier: P16157-5) [UniParc]FASTAAdd to basket
Also known as: 3

The sequence of this isoform differs from the canonical sequence as follows:
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,856
Mass (Da):203,405
Checksum:iFEC7837B2E7711B8
GO
Isoform Er4 (identifier: P16157-6) [UniParc]FASTAAdd to basket
Also known as: 4

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1849-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,694
Mass (Da):186,139
Checksum:iBB17E7510AE1067A
GO
Isoform Er5 (identifier: P16157-3) [UniParc]FASTAAdd to basket
Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,880
Mass (Da):206,026
Checksum:i3153959168D8D91D
GO
Isoform Er6 (identifier: P16157-7) [UniParc]FASTAAdd to basket
Also known as: 6

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,718
Mass (Da):188,760
Checksum:i9A5DBC78974FD512
GO
Isoform Er7 (identifier: P16157-8) [UniParc]FASTAAdd to basket
Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,834
Mass (Da):200,915
Checksum:iB3735FA102F08B3D
GO
Isoform Er8 (identifier: P16157-9) [UniParc]FASTAAdd to basket
Also known as: 8

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1827-1873: Missing.

Show »
Length:1,672
Mass (Da):183,649
Checksum:i195930085EF487B7
GO
Isoform Er9 (identifier: P16157-10) [UniParc]FASTAAdd to basket
Also known as: 9

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,806
Mass (Da):197,752
Checksum:iA50828175CF6AD01
GO
Isoform Er10 (identifier: P16157-11) [UniParc]FASTAAdd to basket
Also known as: 10

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,644
Mass (Da):180,487
Checksum:i21DC6E7730722E51
GO
Isoform Er11 (identifier: P16157-12) [UniParc]FASTAAdd to basket
Also known as: 11

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,905
Mass (Da):208,886
Checksum:i22CA0F47329C69FA
GO
Isoform Er12 (identifier: P16157-13) [UniParc]FASTAAdd to basket
Also known as: 12

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,743
Mass (Da):191,620
Checksum:iAA2C9A6353D00A2C
GO
Isoform Er13 (identifier: P16157-14) [UniParc]FASTAAdd to basket
Also known as: 13

The sequence of this isoform differs from the canonical sequence as follows:
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,983
Mass (Da):217,479
Checksum:i94434C72B761D98D
GO
Isoform Er14 (identifier: P16157-15) [UniParc]FASTAAdd to basket
Also known as: 14

The sequence of this isoform differs from the canonical sequence as follows:
     1514-1675: Missing.
     1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,821
Mass (Da):200,214
Checksum:i748E485DAAC8FAAC
GO
Isoform Er15 (identifier: P16157-16) [UniParc]FASTAAdd to basket
Also known as: 15

The sequence of this isoform differs from the canonical sequence as follows:
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,858
Mass (Da):203,536
Checksum:i1DFB26BFA488DCC4
GO
Isoform Er16 (identifier: P16157-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1513-1874: Missing.
     1875-1875: H → D

Note: Produced by alternative splicing of isoform Er1.
Show »
Length:1,519
Mass (Da):166,480
Checksum:i1D71CA896F1FDD7F
GO
Isoform Mu17 (identifier: P16157-17) [UniParc]FASTAAdd to basket
Also known as: ank1.5, muscle-specific 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative promoter usage.Curated
Show »
Length:155
Mass (Da):17,615
Checksum:i55C5EA3888044FFB
GO
Isoform Mu18 (identifier: P16157-18) [UniParc]FASTAAdd to basket
Also known as: ank1.6, muscle-specific 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.
Show »
Length:133
Mass (Da):15,125
Checksum:iC987D8EF586B6704
GO
Isoform Mu19 (identifier: P16157-19) [UniParc]FASTAAdd to basket
Also known as: muscle-specific 3

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1799-1873: Missing.

Note: Produced by alternative splicing of isoform Mu17.
Show »
Length:81
Mass (Da):9,342
Checksum:i6A4EA54308E3B04B
GO
Isoform Mu20 (identifier: P16157-20) [UniParc]FASTAAdd to basket
Also known as: muscle-specific 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...LCFVLKHIHQ
     1799-1881: GNEFQNIPGE...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ

Note: Produced by alternative splicing of isoform Mu17.
Show »
Length:74
Mass (Da):8,374
Checksum:iFA79EF4284FBDDEB
GO
Isoform Br21 (identifier: P16157-21) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MPYSVGFRE → MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK
     820-820: E → EGTAHITIM
     1849-1873: Missing.

Note: No experimental confirmation available. Produced by alternative splicing of isoform Er1.
Show »
Length:1,897
Mass (Da):208,239
Checksum:i82682973D1A52BA2
GO
Isoform 22 (identifier: P16157-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
     1826-1872: Missing.

Note: Produced by alternative splicing.
Show »
Length:109
Mass (Da):12,504
Checksum:iCA36067BFBD7B9A4
GO
Isoform 23 (identifier: P16157-23) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1725: Missing.
     1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK

Show »
Length:156
Mass (Da):17,854
Checksum:iCE82F91038B0C57A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBS0H0YBS0_HUMAN
Ankyrin-1
ANK1
1,040Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JN86C9JN86_HUMAN
Ankyrin-1
ANK1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PK32Q6PK32_HUMAN
ANK1 protein
ANK1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAY8H0YAY8_HUMAN
Ankyrin-1
ANK1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4B0A0A2R8Y4B0_HUMAN
Ankyrin-1
ANK1
553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB47805 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230A → S in AAA51732 (PubMed:1689849).Curated1
Sequence conflicti801K → L in AAB47805 (PubMed:9235914).Curated1
Sequence conflicti845D → R AA sequence (PubMed:2137557).Curated1
Sequence conflicti902I → T in AAB47805 (PubMed:9235914).Curated1
Isoform Mu17 (identifier: P16157-17)
Sequence conflicti63T → P in AAC01950 (PubMed:9430667).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00059521R → T. 1
Natural variantiVAR_054991276L → R in SPH1. 1 Publication1
Natural variantiVAR_035605332D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_000596463V → I in SPH1. 1 PublicationCorresponds to variant dbSNP:rs140085544Ensembl.1
Natural variantiVAR_000597619R → H in Brueggen. Corresponds to variant dbSNP:rs2304877EnsemblClinVar.1
Natural variantiVAR_028769733L → I. Corresponds to variant dbSNP:rs11778936Ensembl.1
Natural variantiVAR_000598750V → A1 Publication1
Natural variantiVAR_061012832R → Q. Corresponds to variant dbSNP:rs34523608EnsemblClinVar.1
Natural variantiVAR_000599845D → E. 1
Natural variantiVAR_026411991V → L1 PublicationCorresponds to variant dbSNP:rs758454168Ensembl.1
Natural variantiVAR_0549921054I → T in SPH1. 1 Publication1
Natural variantiVAR_0482631075T → I4 PublicationsCorresponds to variant dbSNP:rs35213384EnsemblClinVar.1
Natural variantiVAR_0287701126A → P. Corresponds to variant dbSNP:rs504465Ensembl.1
Natural variantiVAR_0287711192T → P. Corresponds to variant dbSNP:rs486770Ensembl.1
Natural variantiVAR_0006011286E → D1 Publication1
Natural variantiVAR_0287721325M → V. Corresponds to variant dbSNP:rs10093583EnsemblClinVar.1
Natural variantiVAR_0006001392S → T. 1
Natural variantiVAR_0287731546V → I1 PublicationCorresponds to variant dbSNP:rs1060130EnsemblClinVar.1
Natural variantiVAR_0006021592D → N in Duesseldorf. Corresponds to variant dbSNP:rs1457291305Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0184401 – 1725Missing in isoform Mu17, isoform Mu18, isoform Mu19, isoform Mu20, isoform 22 and isoform 23. 2 PublicationsAdd BLAST1725
Alternative sequenceiVSP_0184391 – 9MPYSVGFRE → MAQAAKQLKKIKDIEAQALQ EQKEKEESNRKRRNRSRDRK KK in isoform Br21. 1 Publication9
Alternative sequenceiVSP_018441820E → EGTAHITIM in isoform Br21. 1 Publication1
Alternative sequenceiVSP_0002641513 – 1874Missing in isoform Er16. 1 PublicationAdd BLAST362
Alternative sequenceiVSP_0184421514 – 1675Missing in isoform Er2, isoform Er4, isoform Er6, isoform Er8, isoform Er10, isoform Er12 and isoform Er14. 1 PublicationAdd BLAST162
Alternative sequenceiVSP_0184431726 – 1798TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQELDKELGESEGLSDDEET ISTRVVRRRVFLK in isoform Mu17, isoform Mu18, isoform Mu19, isoform 22 and isoform 23. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0184441726 – 1798TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQ in isoform Mu20. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0184461799 – 1881GNEFQ…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Mu20. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_0184451799 – 1873Missing in isoform Er9, isoform Er10 and isoform Mu19. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_0454391826 – 1872Missing in isoform 22. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0184481827 – 1881IIRKV…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er15 and isoform Mu18. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_0184471827 – 1873Missing in isoform Er7 and isoform Er8. CuratedAdd BLAST47
Alternative sequenceiVSP_0184491849 – 1873Missing in isoform Er3, isoform Er4 and isoform Br21. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0002661850 – 1881TVEGP…STPNP → ELRGSGLQPDLIEGRKGAQI VKRASLKRGKQ in isoform Er5, isoform Er6 and isoform Mu17. 3 PublicationsAdd BLAST32
Alternative sequenceiVSP_0184501874 – 1881DHTSTPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er11 and isoform Er12. Curated8
Alternative sequenceiVSP_0184511874 – 1881DHTSTPNP → VLRRPRPWGTQRHHCCLALP GRLHDTSLHSPLYELSLQSL FSLVGSVSAPPCRSFRSSAC VLPVFAICPAFCLCCCLQVE LRGSGLQPDLIEGRKGAQIV KRASLKRGKQ in isoform Er13 and isoform Er14. Curated8
Alternative sequenceiVSP_0002651875H → D in isoform Er16. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16609 mRNA Translation: CAA34610.1
X16609 mRNA Translation: CAA34611.1
M28880 mRNA Translation: AAA51732.1
U50133
, U50092, U50093, U50094, U50095, U50096, U50097, U50098, U50099, U50100, U50101, U50102, U50103, U50104, U50105, U50106, U50107, U50108, U50109, U50110, U50111, U50112, U50113, U50114, U50115, U50116, U50117, U50118, U50119, U50120, U50121, U50122, U50123, U50124, U50125, U50126, U50127, U50128, U50129, U50130, U50131, U50132 Genomic DNA Translation: AAB47805.1 Sequence problems.
AF005213 mRNA Translation: AAC01950.1
AB209418 mRNA Translation: BAD92655.1
AK223578 mRNA Translation: BAD97298.1
AC027702 Genomic DNA No translation available.
AC113133 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63243.1
CH471080 Genomic DNA Translation: EAW63244.1
BC030957 mRNA Translation: AAH30957.1
BC117121 mRNA Translation: AAI17122.1
BC014467 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47849.1 [P16157-21]
CCDS55227.1 [P16157-23]
CCDS6119.1 [P16157-1]
CCDS6120.1 [P16157-22]
CCDS6121.1 [P16157-3]
CCDS6122.1 [P16157-17]

Protein sequence database of the Protein Information Resource

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PIRi
A35049
S08275 SJHUK

NCBI Reference Sequences

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RefSeqi
NP_000028.3, NM_000037.3 [P16157-3]
NP_001135917.1, NM_001142445.1 [P16157-23]
NP_001135918.1, NM_001142446.1 [P16157-21]
NP_065208.2, NM_020475.2 [P16157-5]
NP_065209.2, NM_020476.2 [P16157-1]
NP_065210.2, NM_020477.2 [P16157-4]
NP_065211.2, NM_020478.4 [P16157-17]
NP_065213.2, NM_020480.4 [P16157-22]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265709; ENSP00000265709; ENSG00000029534 [P16157-21]
ENST00000289734; ENSP00000289734; ENSG00000029534 [P16157-3]
ENST00000314214; ENSP00000319123; ENSG00000029534 [P16157-17]
ENST00000347528; ENSP00000339620; ENSG00000029534 [P16157-1]
ENST00000348036; ENSP00000297744; ENSG00000029534 [P16157-22]
ENST00000522543; ENSP00000430368; ENSG00000029534 [P16157-23]

Database of genes from NCBI RefSeq genomes

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GeneIDi
286

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:286

UCSC genome browser

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UCSCi
uc003xoc.4 human [P16157-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Ankyrin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16609 mRNA Translation: CAA34610.1
X16609 mRNA Translation: CAA34611.1
M28880 mRNA Translation: AAA51732.1
U50133
, U50092, U50093, U50094, U50095, U50096, U50097, U50098, U50099, U50100, U50101, U50102, U50103, U50104, U50105, U50106, U50107, U50108, U50109, U50110, U50111, U50112, U50113, U50114, U50115, U50116, U50117, U50118, U50119, U50120, U50121, U50122, U50123, U50124, U50125, U50126, U50127, U50128, U50129, U50130, U50131, U50132 Genomic DNA Translation: AAB47805.1 Sequence problems.
AF005213 mRNA Translation: AAC01950.1
AB209418 mRNA Translation: BAD92655.1
AK223578 mRNA Translation: BAD97298.1
AC027702 Genomic DNA No translation available.
AC113133 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63243.1
CH471080 Genomic DNA Translation: EAW63244.1
BC030957 mRNA Translation: AAH30957.1
BC117121 mRNA Translation: AAI17122.1
BC014467 mRNA No translation available.
CCDSiCCDS47849.1 [P16157-21]
CCDS55227.1 [P16157-23]
CCDS6119.1 [P16157-1]
CCDS6120.1 [P16157-22]
CCDS6121.1 [P16157-3]
CCDS6122.1 [P16157-17]
PIRiA35049
S08275 SJHUK
RefSeqiNP_000028.3, NM_000037.3 [P16157-3]
NP_001135917.1, NM_001142445.1 [P16157-23]
NP_001135918.1, NM_001142446.1 [P16157-21]
NP_065208.2, NM_020475.2 [P16157-5]
NP_065209.2, NM_020476.2 [P16157-1]
NP_065210.2, NM_020477.2 [P16157-4]
NP_065211.2, NM_020478.4 [P16157-17]
NP_065213.2, NM_020480.4 [P16157-22]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N11X-ray2.70A402-827[»]
2YQFNMR-A1394-1497[»]
2YVIX-ray1.92A1394-1497[»]
3F59X-ray2.00A/B/C/D911-1068[»]
3KBTX-ray2.75C/D911-1068[»]
3KBUX-ray2.75C/D911-1068[»]
3UD1X-ray2.00A/B/C911-1233[»]
3UD2X-ray2.21A/B/C911-1233[»]
SMRiP16157
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106783, 24 interactors
IntActiP16157, 11 interactors
STRINGi9606.ENSP00000265709

Protein family/group databases

TCDBi8.A.28.1.2 the ankyrin (ankyrin) family

PTM databases

iPTMnetiP16157
PhosphoSitePlusiP16157

Polymorphism and mutation databases

BioMutaiANK1
DMDMi116241246

Proteomic databases

jPOSTiP16157
MaxQBiP16157
PaxDbiP16157
PeptideAtlasiP16157
PRIDEiP16157
ProteomicsDBi53299
53300 [P16157-10]
53301 [P16157-11]
53302 [P16157-12]
53303 [P16157-13]
53304 [P16157-14]
53305 [P16157-15]
53306 [P16157-16]
53307 [P16157-17]
53308 [P16157-18]
53309 [P16157-19]
53310 [P16157-2]
53311 [P16157-20]
53312 [P16157-21]
53313 [P16157-3]
53314 [P16157-4]
53315 [P16157-5]
53316 [P16157-6]
53317 [P16157-7]
53318 [P16157-8]
53319 [P16157-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
286
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265709; ENSP00000265709; ENSG00000029534 [P16157-21]
ENST00000289734; ENSP00000289734; ENSG00000029534 [P16157-3]
ENST00000314214; ENSP00000319123; ENSG00000029534 [P16157-17]
ENST00000347528; ENSP00000339620; ENSG00000029534 [P16157-1]
ENST00000348036; ENSP00000297744; ENSG00000029534 [P16157-22]
ENST00000522543; ENSP00000430368; ENSG00000029534 [P16157-23]
GeneIDi286
KEGGihsa:286
UCSCiuc003xoc.4 human [P16157-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
286
DisGeNETi286

GeneCards: human genes, protein and diseases

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GeneCardsi
ANK1
HGNCiHGNC:492 ANK1
HPAiHPA004842
HPA056953
MalaCardsiANK1
MIMi182900 phenotype
612641 gene
neXtProtiNX_P16157
OpenTargetsiENSG00000029534
Orphaneti251066 8p11.2 deletion syndrome
822 Hereditary spherocytosis
PharmGKBiPA24798

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4177 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155760
HOGENOMiHOG000237351
InParanoidiP16157
KOiK10380
OMAiDRADMKM
OrthoDBi1376537at2759
PhylomeDBiP16157
TreeFamiTF351263

Enzyme and pathway databases

ReactomeiR-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-447038 NrCAM interactions
R-HSA-447041 CHL1 interactions
R-HSA-447043 Neurofascin interactions
R-HSA-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANK1 human
EvolutionaryTraceiP16157

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
286
PMAP-CutDBiP16157

Protein Ontology

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PROi
PR:P16157

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000029534 Expressed in 165 organ(s), highest expression level in muscle of leg
ExpressionAtlasiP16157 baseline and differential
GenevisibleiP16157 HS

Family and domain databases

CDDicd00204 ANK, 6 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR040745 Ankyrin_UPA
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR000906 ZU5_dom
PfamiView protein in Pfam
PF00023 Ank, 2 hits
PF12796 Ank_2, 8 hits
PF00531 Death, 1 hit
PF17809 UPA_2, 1 hit
PF00791 ZU5, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 23 hits
SM00005 DEATH, 1 hit
SM00218 ZU5, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 20 hits
PS50017 DEATH_DOMAIN, 1 hit
PS51145 ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16157
Secondary accession number(s): A0PJN8
, A6NJ23, E5RFL7, O43400, Q13768, Q53ER1, Q59FP2, Q8N604, Q99407
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 213 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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