UniProtKB - P16157 (ANK1_HUMAN)
Ankyrin-1
ANK1
Functioni
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
- cytoskeletal anchor activity Source: BHF-UCL
- enzyme binding Source: UniProtKB
- ion channel binding Source: GO_Central
- protein phosphatase binding Source: ARUK-UCL
- spectrin binding Source: ARUK-UCL
- structural constituent of cytoskeleton Source: ProtInc
- structural molecule activity Source: UniProtKB
GO - Biological processi
- cytoskeleton organization Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: BHF-UCL
- exocytosis Source: UniProtKB
- maintenance of epithelial cell apical/basal polarity Source: UniProtKB
- positive regulation of organelle organization Source: Ensembl
- protein localization to plasma membrane Source: BHF-UCL
- signal transduction Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | P16157 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-447038, NrCAM interactions R-HSA-447041, CHL1 interactions R-HSA-447043, Neurofascin interactions R-HSA-6807878, COPI-mediated anterograde transport |
Protein family/group databases
TCDBi | 8.A.28.1.2, the ankyrin (ankyrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Ankyrin-1Short name: ANK-1 Alternative name(s): Ankyrin-R Erythrocyte ankyrin |
Gene namesi | Name:ANK1 Synonyms:ANK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:492, ANK1 |
MIMi | 612641, gene |
neXtProti | NX_P16157 |
VEuPathDBi | HostDB:ENSG00000029534.19 |
Subcellular locationi
Cytoskeleton
Note: Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.
Other locations
- Sarcoplasmic reticulum Curated
Other locations
- Sarcoplasmic reticulum Curated
Other locations
- Sarcoplasmic reticulum Curated
Cytoskeleton
- cytoskeleton Source: UniProtKB
- spectrin-associated cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- sarcoplasmic reticulum Source: UniProtKB-SubCell
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- axolemma Source: Ensembl
- basolateral plasma membrane Source: UniProtKB
- cytoplasmic side of plasma membrane Source: ARUK-UCL
- plasma membrane Source: BHF-UCL
- postsynaptic membrane Source: Ensembl
- sarcolemma Source: Ensembl
Other locations
- M band Source: UniProtKB-SubCell
- neuron projection Source: GO_Central
- Z disc Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Membrane, Sarcoplasmic reticulumPathology & Biotechi
Involvement in diseasei
Spherocytosis 1 (SPH1)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054991 | 276 | L → R in SPH1. 1 Publication | 1 | |
Natural variantiVAR_000596 | 463 | V → I in SPH1. 1 PublicationCorresponds to variant dbSNP:rs140085544EnsemblClinVar. | 1 | |
Natural variantiVAR_054992 | 1054 | I → T in SPH1. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1824 | T → P: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication | 1 | |
Mutagenesisi | 1826 | K → E: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication | 1 | |
Mutagenesisi | 1829 | R → G: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication | 1 | |
Mutagenesisi | 1830 | K → E: Abolishes interaction with OBSCN (in isoform Mu17). 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Elliptocytosis, Hereditary hemolytic anemiaOrganism-specific databases
DisGeNETi | 286 |
MalaCardsi | ANK1 |
MIMi | 182900, phenotype |
OpenTargetsi | ENSG00000029534 |
Orphaneti | 251066, 8p11.2 deletion syndrome 822, Hereditary spherocytosis |
PharmGKBi | PA24798 |
Miscellaneous databases
Pharosi | P16157, Tbio |
Genetic variation databases
BioMutai | ANK1 |
DMDMi | 116241246 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066883 | 1 – 1881 | Ankyrin-1Add BLAST | 1881 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 105 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 233 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 429 | PhosphoserineCombined sources | 1 | |
Modified residuei | 431 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 464 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 629 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 662 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 695 | (3S)-3-hydroxyaspartate; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 728 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 759 | PhosphoserineCombined sources | 1 | |
Modified residuei | 761 | (3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication | 1 | |
Modified residuei | 781 | PhosphoserineCombined sources | 1 | |
Modified residuei | 817 | PhosphoserineCombined sources | 1 | |
Modified residuei | 834 | PhosphoserineCombined sources | 1 | |
Modified residuei | 856 | PhosphoserineCombined sources | 1 | |
Modified residuei | 961 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1073 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1082 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1378 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1380 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1390 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1392 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1396 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1400 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1428 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1486 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1523 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1533 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1617 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1666 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1671 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1686 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1690 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1696 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Hydroxylation, Lipoprotein, PhosphoproteinProteomic databases
jPOSTi | P16157 |
MassIVEi | P16157 |
MaxQBi | P16157 |
PaxDbi | P16157 |
PeptideAtlasi | P16157 |
PRIDEi | P16157 |
ProteomicsDBi | 15386 53299 [P16157-1] 53300 [P16157-10] 53301 [P16157-11] 53302 [P16157-12] 53303 [P16157-13] 53304 [P16157-14] 53305 [P16157-15] 53306 [P16157-16] 53307 [P16157-17] 53308 [P16157-18] 53309 [P16157-19] 53310 [P16157-2] 53311 [P16157-20] 53312 [P16157-21] 53313 [P16157-3] 53314 [P16157-4] 53315 [P16157-5] 53316 [P16157-6] 53317 [P16157-7] 53318 [P16157-8] 53319 [P16157-9] 62 62447 |
PTM databases
GlyConnecti | 2881, 1 O-Linked glycan (4 sites) |
iPTMneti | P16157 |
MetOSitei | P16157 |
PhosphoSitePlusi | P16157 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000029534, Expressed in skeletal muscle tissue and 181 other tissues |
ExpressionAtlasi | P16157, baseline and differential |
Genevisiblei | P16157, HS |
Organism-specific databases
HPAi | ENSG00000029534, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts with a number of integral membrane proteins and cytoskeletal proteins.
Interacts (via N-terminus) with SPTB/spectrin (beta chain).
Interacts (via N-terminus ANK repeats) with SLC4A1/erythrocyte membrane protein band 3 (via cytoplasmic N-terminus).
Also interacts with TTN/titin. Isoform Mu17 interacts with OBSCN isoform 3/obscurin.
Interacts with HIF1AN.
4 PublicationsBinary interactionsi
Hide detailsP16157
With | #Exp. | IntAct |
---|---|---|
OBSCN - isoform 3 [Q5VST9-3] | 3 | EBI-941686,EBI-941921 |
Isoform Mu17 [P16157-17]
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
- enzyme binding Source: UniProtKB
- ion channel binding Source: GO_Central
- protein phosphatase binding Source: ARUK-UCL
- spectrin binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 106783, 37 interactors |
IntActi | P16157, 20 interactors |
STRINGi | 9606.ENSP00000265709 |
Miscellaneous databases
RNActi | P16157, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P16157 |
SMRi | P16157 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16157 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 44 – 73 | ANK 1Add BLAST | 30 | |
Repeati | 77 – 106 | ANK 2Add BLAST | 30 | |
Repeati | 110 – 139 | ANK 3Add BLAST | 30 | |
Repeati | 143 – 172 | ANK 4Add BLAST | 30 | |
Repeati | 174 – 201 | ANK 5Add BLAST | 28 | |
Repeati | 205 – 234 | ANK 6Add BLAST | 30 | |
Repeati | 238 – 267 | ANK 7Add BLAST | 30 | |
Repeati | 271 – 300 | ANK 8Add BLAST | 30 | |
Repeati | 304 – 333 | ANK 9Add BLAST | 30 | |
Repeati | 337 – 366 | ANK 10Add BLAST | 30 | |
Repeati | 370 – 399 | ANK 11Add BLAST | 30 | |
Repeati | 403 – 432 | ANK 12Add BLAST | 30 | |
Repeati | 436 – 465 | ANK 13Add BLAST | 30 | |
Repeati | 469 – 498 | ANK 14Add BLAST | 30 | |
Repeati | 502 – 531 | ANK 15Add BLAST | 30 | |
Repeati | 535 – 564 | ANK 16Add BLAST | 30 | |
Repeati | 568 – 597 | ANK 17Add BLAST | 30 | |
Repeati | 601 – 630 | ANK 18Add BLAST | 30 | |
Repeati | 634 – 663 | ANK 19Add BLAST | 30 | |
Repeati | 667 – 696 | ANK 20Add BLAST | 30 | |
Repeati | 700 – 729 | ANK 21Add BLAST | 30 | |
Repeati | 733 – 762 | ANK 22Add BLAST | 30 | |
Repeati | 766 – 795 | ANK 23Add BLAST | 30 | |
Domaini | 913 – 1068 | ZU5 1PROSITE-ProRule annotationAdd BLAST | 156 | |
Domaini | 1070 – 1216 | ZU5 2PROSITE-ProRule annotationAdd BLAST | 147 | |
Domaini | 1403 – 1487 | DeathPROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 827 | 89 kDa domainAdd BLAST | 827 | |
Regioni | 1234 – 1362 | UPA domainBy similarityAdd BLAST | 129 | |
Regioni | 1383 – 1881 | 55 kDa regulatory domainAdd BLAST | 499 |
Domaini
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000155760 |
HOGENOMi | CLU_1694857_0_0_1 |
InParanoidi | P16157 |
OMAi | AQHILCH |
OrthoDBi | 1011028at2759 |
PhylomeDBi | P16157 |
TreeFami | TF351263 |
Family and domain databases
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 9 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
s (23+)i Sequence
Sequence statusi: Complete.
This entry describes 23 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 23 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH
60 70 80 90 100
LASKEGHVKM VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY
110 120 130 140 150
GANVNAQSQK GFTPLYMAAQ ENHLEVVKFL LENGANQNVA TEDGFTPLAV
160 170 180 190 200
ALQQGHENVV AHLINYGTKG KVRLPALHIA ARNDDTRTAA VLLQNDPNPD
210 220 230 240 250
VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI TPLHIASRRG
260 270 280 290 300
NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA
310 320 330 340 350
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH
360 370 380 390 400
HRVAKVLLDK GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV
410 420 430 440 450
TESGLTPLHV ASFMGHLPIV KNLLQRGASP NVSNVKVETP LHMAARAGHT
460 470 480 490 500
EVAKYLLQNK AKVNAKAKDD QTPLHCAARI GHTNMVKLLL ENNANPNLAT
510 520 530 540 550
TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL HVAAKYGKVR
560 570 580 590 600
VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW
610 620 630 640 650
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM
660 670 680 690 700
VALLLSKQAN GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM
710 720 730 740 750
GYTPLHVASH YGNIKLVKFL LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV
760 770 780 790 800
TLLLKNGASP NEVSSDGTTP LAIAKRLGYI SVTDVLKVVT DETSFVLVSD
810 820 830 840 850
KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE KELLDFVPKL
860 870 880 890 900
DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD
910 920 930 940 950
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT
960 970 980 990 1000
CRLVKPQKLS TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG
1010 1020 1030 1040 1050
RGDRELVVLR SENGSVWKEH RSRYGESYLD QILNGMDEEL GSLEELEKKR
1060 1070 1080 1090 1100
VCRIITTDFP LYFVIMSRLC QDYDTIGPEG GSLKSKLVPL VQATFPENAV
1110 1120 1130 1140 1150
TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK FHRPIGLRIP
1160 1170 1180 1190 1200
LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC
1210 1220 1230 1240 1250
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND
1260 1270 1280 1290 1300
PREGRLRCYC MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN
1310 1320 1330 1340 1350
LVPVKKAAQQ RSFHFQSFRE NRLAMPVKVR DSSREPGGSL SFLRKAMKYE
1360 1370 1380 1390 1400
DTQHILCHLN ITMPPCAKGS GAEDRRRTPT PLALRYSILS ESTPGSLSGT
1410 1420 1430 1440 1450
EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP NSLLEQSVAL
1460 1470 1480 1490 1500
LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT
1510 1520 1530 1540 1550
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI
1560 1570 1580 1590 1600
PLAATEHDTM LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW
1610 1620 1630 1640 1650
KLEGALSEEP RGPELGSLEL VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL
1660 1670 1680 1690 1700
PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ ARITHSPTVS QVTERSQDRL
1710 1720 1730 1740 1750
QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE GLEPGGSQEY
1760 1770 1780 1790 1800
EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN
1810 1820 1830 1840 1850
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT
1860 1870 1880
VEGPLEDPSE LEVDIDYFMK HSKDHTSTPN P
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1849-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1849-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1827-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1827-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1799-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1799-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1874-1881: DHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1514-1675: Missing.
1874-1881: DHTSTPNP → VLRRPRPWGT...KRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1513-1874: Missing.
1875-1875: H → D
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
1850-1881: TVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP → ELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
1827-1881: IIRKVVRQID...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
1799-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...LCFVLKHIHQ
1799-1881: GNEFQNIPGE...SKDHTSTPNP → VELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
The sequence of this isoform differs from the canonical sequence as follows:
1-9: MPYSVGFRE → MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKK
820-820: E → EGTAHITIM
1849-1873: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
1826-1872: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1725: Missing.
1726-1798: TQGPHSFQGT...AKNTFTQVVQ → MWTFVTQLLV...RVVRRRVFLK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBS0 | H0YBS0_HUMAN | Ankyrin-1 | ANK1 | 1,040 | Annotation score: | ||
H0YAY8 | H0YAY8_HUMAN | Ankyrin-1 | ANK1 | 177 | Annotation score: | ||
A0A2R8Y4B0 | A0A2R8Y4B0_HUMAN | Ankyrin-1 | ANK1 | 553 | Annotation score: | ||
Q6PK32 | Q6PK32_HUMAN | ANK1 protein | ANK1 | 131 | Annotation score: | ||
C9JN86 | C9JN86_HUMAN | Ankyrin-1 | ANK1 | 113 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 230 | A → S in AAA51732 (PubMed:1689849).Curated | 1 | ||
Sequence conflicti | 801 | K → L in AAB47805 (PubMed:9235914).Curated | 1 | ||
Sequence conflicti | 845 | D → R AA sequence (PubMed:2137557).Curated | 1 | ||
Sequence conflicti | 902 | I → T in AAB47805 (PubMed:9235914).Curated | 1 | ||
Isoform Mu17 (identifier: P16157-17) | |||||
Sequence conflicti | 63 | T → P in AAC01950 (PubMed:9430667).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_000595 | 21 | R → T. | 1 | |
Natural variantiVAR_054991 | 276 | L → R in SPH1. 1 Publication | 1 | |
Natural variantiVAR_035605 | 332 | D → H in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_000596 | 463 | V → I in SPH1. 1 PublicationCorresponds to variant dbSNP:rs140085544EnsemblClinVar. | 1 | |
Natural variantiVAR_000597 | 619 | R → H in Brueggen. Corresponds to variant dbSNP:rs2304877EnsemblClinVar. | 1 | |
Natural variantiVAR_028769 | 733 | L → I. Corresponds to variant dbSNP:rs11778936Ensembl. | 1 | |
Natural variantiVAR_000598 | 750 | V → A1 Publication | 1 | |
Natural variantiVAR_061012 | 832 | R → Q. Corresponds to variant dbSNP:rs34523608EnsemblClinVar. | 1 | |
Natural variantiVAR_000599 | 845 | D → E. | 1 | |
Natural variantiVAR_026411 | 991 | V → L1 PublicationCorresponds to variant dbSNP:rs758454168Ensembl. | 1 | |
Natural variantiVAR_054992 | 1054 | I → T in SPH1. 1 Publication | 1 | |
Natural variantiVAR_048263 | 1075 | T → I4 PublicationsCorresponds to variant dbSNP:rs35213384EnsemblClinVar. | 1 | |
Natural variantiVAR_028770 | 1126 | A → P. Corresponds to variant dbSNP:rs504465Ensembl. | 1 | |
Natural variantiVAR_028771 | 1192 | T → P. Corresponds to variant dbSNP:rs486770Ensembl. | 1 | |
Natural variantiVAR_000601 | 1286 | E → D1 Publication | 1 | |
Natural variantiVAR_028772 | 1325 | M → V. Corresponds to variant dbSNP:rs10093583EnsemblClinVar. | 1 | |
Natural variantiVAR_000600 | 1392 | S → T. | 1 | |
Natural variantiVAR_028773 | 1546 | V → I1 PublicationCorresponds to variant dbSNP:rs1060130EnsemblClinVar. | 1 | |
Natural variantiVAR_000602 | 1592 | D → N in Duesseldorf. Corresponds to variant dbSNP:rs1457291305Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018440 | 1 – 1725 | Missing in isoform Mu17, isoform Mu18, isoform Mu19, isoform Mu20, isoform 22 and isoform 23. 2 PublicationsAdd BLAST | 1725 | |
Alternative sequenceiVSP_018439 | 1 – 9 | MPYSVGFRE → MAQAAKQLKKIKDIEAQALQ EQKEKEESNRKRRNRSRDRK KK in isoform Br21. 1 Publication | 9 | |
Alternative sequenceiVSP_018441 | 820 | E → EGTAHITIM in isoform Br21. 1 Publication | 1 | |
Alternative sequenceiVSP_000264 | 1513 – 1874 | Missing in isoform Er16. 1 PublicationAdd BLAST | 362 | |
Alternative sequenceiVSP_018442 | 1514 – 1675 | Missing in isoform Er2, isoform Er4, isoform Er6, isoform Er8, isoform Er10, isoform Er12 and isoform Er14. 1 PublicationAdd BLAST | 162 | |
Alternative sequenceiVSP_018443 | 1726 – 1798 | TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQELDKELGESEGLSDDEET ISTRVVRRRVFLK in isoform Mu17, isoform Mu18, isoform Mu19, isoform 22 and isoform 23. 2 PublicationsAdd BLAST | 73 | |
Alternative sequenceiVSP_018444 | 1726 – 1798 | TQGPH…TQVVQ → MWTFVTQLLVTLVLLSFFLV SCQNVMHIVRGSLCFVLKHI HQ in isoform Mu20. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_018446 | 1799 – 1881 | GNEFQ…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Mu20. 1 PublicationAdd BLAST | 83 | |
Alternative sequenceiVSP_018445 | 1799 – 1873 | Missing in isoform Er9, isoform Er10 and isoform Mu19. 1 PublicationAdd BLAST | 75 | |
Alternative sequenceiVSP_045439 | 1826 – 1872 | Missing in isoform 22. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_018448 | 1827 – 1881 | IIRKV…STPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er15 and isoform Mu18. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_018447 | 1827 – 1873 | Missing in isoform Er7 and isoform Er8. CuratedAdd BLAST | 47 | |
Alternative sequenceiVSP_018449 | 1849 – 1873 | Missing in isoform Er3, isoform Er4 and isoform Br21. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_000266 | 1850 – 1881 | TVEGP…STPNP → ELRGSGLQPDLIEGRKGAQI VKRASLKRGKQ in isoform Er5, isoform Er6 and isoform Mu17. 3 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_018450 | 1874 – 1881 | DHTSTPNP → VELRGSGLQPDLIEGRKGAQ IVKRASLKRGKQ in isoform Er11 and isoform Er12. Curated | 8 | |
Alternative sequenceiVSP_018451 | 1874 – 1881 | DHTSTPNP → VLRRPRPWGTQRHHCCLALP GRLHDTSLHSPLYELSLQSL FSLVGSVSAPPCRSFRSSAC VLPVFAICPAFCLCCCLQVE LRGSGLQPDLIEGRKGAQIV KRASLKRGKQ in isoform Er13 and isoform Er14. Curated | 8 | |
Alternative sequenceiVSP_000265 | 1875 | H → D in isoform Er16. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000265709; ENSP00000265709; ENSG00000029534 [P16157-21] ENST00000289734; ENSP00000289734; ENSG00000029534 [P16157-3] ENST00000314214; ENSP00000319123; ENSG00000029534 [P16157-17] ENST00000347528; ENSP00000339620; ENSG00000029534 [P16157-1] ENST00000348036; ENSP00000297744; ENSG00000029534 [P16157-22] ENST00000522543; ENSP00000430368; ENSG00000029534 [P16157-23] |
GeneIDi | 286 |
KEGGi | hsa:286 |
UCSCi | uc003xoc.4, human [P16157-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Ankyrin entry |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N11 | X-ray | 2.70 | A | 402-827 | [»] | |
2YQF | NMR | - | A | 1394-1497 | [»] | |
2YVI | X-ray | 1.92 | A | 1394-1497 | [»] | |
3F59 | X-ray | 2.00 | A/B/C/D | 911-1068 | [»] | |
3KBT | X-ray | 2.75 | C/D | 911-1068 | [»] | |
3KBU | X-ray | 2.75 | C/D | 911-1068 | [»] | |
3UD1 | X-ray | 2.00 | A/B/C | 911-1233 | [»] | |
3UD2 | X-ray | 2.21 | A/B/C | 911-1233 | [»] | |
BMRBi | P16157 | |||||
SMRi | P16157 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106783, 37 interactors |
IntActi | P16157, 20 interactors |
STRINGi | 9606.ENSP00000265709 |
Protein family/group databases
TCDBi | 8.A.28.1.2, the ankyrin (ankyrin) family |
PTM databases
GlyConnecti | 2881, 1 O-Linked glycan (4 sites) |
iPTMneti | P16157 |
MetOSitei | P16157 |
PhosphoSitePlusi | P16157 |
Genetic variation databases
BioMutai | ANK1 |
DMDMi | 116241246 |
Proteomic databases
jPOSTi | P16157 |
MassIVEi | P16157 |
MaxQBi | P16157 |
PaxDbi | P16157 |
PeptideAtlasi | P16157 |
PRIDEi | P16157 |
ProteomicsDBi | 15386 53299 [P16157-1] 53300 [P16157-10] 53301 [P16157-11] 53302 [P16157-12] 53303 [P16157-13] 53304 [P16157-14] 53305 [P16157-15] 53306 [P16157-16] 53307 [P16157-17] 53308 [P16157-18] 53309 [P16157-19] 53310 [P16157-2] 53311 [P16157-20] 53312 [P16157-21] 53313 [P16157-3] 53314 [P16157-4] 53315 [P16157-5] 53316 [P16157-6] 53317 [P16157-7] 53318 [P16157-8] 53319 [P16157-9] 62 62447 |
Protocols and materials databases
ABCDi | P16157, 3 sequenced antibodies |
Antibodypediai | 4229, 434 antibodies |
DNASUi | 286 |
Genome annotation databases
Ensembli | ENST00000265709; ENSP00000265709; ENSG00000029534 [P16157-21] ENST00000289734; ENSP00000289734; ENSG00000029534 [P16157-3] ENST00000314214; ENSP00000319123; ENSG00000029534 [P16157-17] ENST00000347528; ENSP00000339620; ENSG00000029534 [P16157-1] ENST00000348036; ENSP00000297744; ENSG00000029534 [P16157-22] ENST00000522543; ENSP00000430368; ENSG00000029534 [P16157-23] |
GeneIDi | 286 |
KEGGi | hsa:286 |
UCSCi | uc003xoc.4, human [P16157-1] |
Organism-specific databases
CTDi | 286 |
DisGeNETi | 286 |
GeneCardsi | ANK1 |
HGNCi | HGNC:492, ANK1 |
HPAi | ENSG00000029534, Group enriched (skeletal muscle, tongue) |
MalaCardsi | ANK1 |
MIMi | 182900, phenotype 612641, gene |
neXtProti | NX_P16157 |
OpenTargetsi | ENSG00000029534 |
Orphaneti | 251066, 8p11.2 deletion syndrome 822, Hereditary spherocytosis |
PharmGKBi | PA24798 |
VEuPathDBi | HostDB:ENSG00000029534.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4177, Eukaryota |
GeneTreei | ENSGT00940000155760 |
HOGENOMi | CLU_1694857_0_0_1 |
InParanoidi | P16157 |
OMAi | AQHILCH |
OrthoDBi | 1011028at2759 |
PhylomeDBi | P16157 |
TreeFami | TF351263 |
Enzyme and pathway databases
PathwayCommonsi | P16157 |
Reactomei | R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-447038, NrCAM interactions R-HSA-447041, CHL1 interactions R-HSA-447043, Neurofascin interactions R-HSA-6807878, COPI-mediated anterograde transport |
Miscellaneous databases
BioGRID-ORCSi | 286, 6 hits in 994 CRISPR screens |
ChiTaRSi | ANK1, human |
EvolutionaryTracei | P16157 |
GeneWikii | ANK1 |
GenomeRNAii | 286 |
Pharosi | P16157, Tbio |
PROi | PR:P16157 |
RNActi | P16157, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000029534, Expressed in skeletal muscle tissue and 181 other tissues |
ExpressionAtlasi | P16157, baseline and differential |
Genevisiblei | P16157, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 9 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANK1_HUMAN | |
Accessioni | P16157Primary (citable) accession number: P16157 Secondary accession number(s): A0PJN8 Q99407 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 228 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references