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Protein

Toxin A

Gene

toxA

Organism
Clostridioides difficile (Peptoclostridium difficile)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei655PROSITE-ProRule annotation1
Active sitei700NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEnterotoxin, Hydrolase, Protease, Thiol protease, Toxin

Enzyme and pathway databases

BRENDAi2.4.1.B62 13625
3.1.4.B4 13625

Protein family/group databases

CAZyiGT44 Glycosyltransferase Family 44
MEROPSiC80.002
TCDBi1.C.57.1.2 the clostridial cytotoxin (cct) family
UniLectiniP16154

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin A (EC:3.4.22.-)
Gene namesi
Name:toxA
Synonyms:tcdA
OrganismiClostridioides difficile (Peptoclostridium difficile)
Taxonomic identifieri1496 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3580504

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726341 – 2710Toxin AAdd BLAST2710

Proteomic databases

PRIDEiP16154

Structurei

Secondary structure

12710
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP16154
SMRiP16154
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16154

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini569 – 776Peptidase C80PROSITE-ProRule annotationAdd BLAST208
Repeati1810 – 1829Cell wall-binding 1Add BLAST20
Repeati1851 – 1870Cell wall-binding 2Add BLAST20
Repeati1872 – 1891Cell wall-binding 3Add BLAST20
Repeati1923 – 1942Cell wall-binding 4Add BLAST20
Repeati1943 – 1962Cell wall-binding 5Add BLAST20
Repeati1964 – 1983Cell wall-binding 6Add BLAST20
Repeati1985 – 2004Cell wall-binding 7Add BLAST20
Repeati2006 – 2025Cell wall-binding 8Add BLAST20
Repeati2057 – 2076Cell wall-binding 9Add BLAST20
Repeati2077 – 2096Cell wall-binding 10Add BLAST20
Repeati2098 – 2117Cell wall-binding 11Add BLAST20
Repeati2119 – 2138Cell wall-binding 12Add BLAST20
Repeati2140 – 2159Cell wall-binding 13Add BLAST20
Repeati2191 – 2210Cell wall-binding 14Add BLAST20
Repeati2211 – 2230Cell wall-binding 15Add BLAST20
Repeati2232 – 2251Cell wall-binding 16Add BLAST20
Repeati2252 – 2271Cell wall-binding 17Add BLAST20
Repeati2305 – 2324Cell wall-binding 18Add BLAST20
Repeati2325 – 2344Cell wall-binding 19Add BLAST20
Repeati2346 – 2365Cell wall-binding 20Add BLAST20
Repeati2367 – 2386Cell wall-binding 21Add BLAST20
Repeati2388 – 2407Cell wall-binding 22Add BLAST20
Repeati2439 – 2458Cell wall-binding 23Add BLAST20
Repeati2459 – 2478Cell wall-binding 24Add BLAST20
Repeati2480 – 2499Cell wall-binding 25Add BLAST20
Repeati2501 – 2520Cell wall-binding 26Add BLAST20
Repeati2552 – 2571Cell wall-binding 27Add BLAST20
Repeati2572 – 2591Cell wall-binding 28Add BLAST20
Repeati2593 – 2612Cell wall-binding 29Add BLAST20
Repeati2643 – 2662Cell wall-binding 30Add BLAST20
Repeati2663 – 2682Cell wall-binding 31Add BLAST20
Repeati2685 – 2704Cell wall-binding 32Add BLAST20

Domaini

The C-terminal part of toxin A consists of a 833 AA repetitive structure. This part of toxin A is composed of five different oligopeptides.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105SFK Bacteria
ENOG4111U22 LUCA

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473 CW_binding_1, 12 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 32 hits

Sequencei

Sequence statusi: Complete.

P16154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLISKEELI KLAYSIRPRE NEYKTILTNL DEYNKLTTNN NENKYLQLKK
60 70 80 90 100
LNESIDVFMN KYKTSSRNRA LSNLKKDILK EVILIKNSNT SPVEKNLHFV
110 120 130 140 150
WIGGEVSDIA LEYIKQWADI NAEYNIKLWY DSEAFLVNTL KKAIVESSTT
160 170 180 190 200
EALQLLEEEI QNPQFDNMKF YKKRMEFIYD RQKRFINYYK SQINKPTVPT
210 220 230 240 250
IDDIIKSHLV SEYNRDETVL ESYRTNSLRK INSNHGIDIR ANSLFTEQEL
260 270 280 290 300
LNIYSQELLN RGNLAAASDI VRLLALKNFG GVYLDVDMLP GIHSDLFKTI
310 320 330 340 350
SRPSSIGLDR WEMIKLEAIM KYKKYINNYT SENFDKLDQQ LKDNFKLIIE
360 370 380 390 400
SKSEKSEIFS KLENLNVSDL EIKIAFALGS VINQALISKQ GSYLTNLVIE
410 420 430 440 450
QVKNRYQFLN QHLNPAIESD NNFTDTTKIF HDSLFNSATA ENSMFLTKIA
460 470 480 490 500
PYLQVGFMPE ARSTISLSGP GAYASAYYDF INLQENTIEK TLKASDLIEF
510 520 530 540 550
KFPENNLSQL TEQEINSLWS FDQASAKYQF EKYVRDYTGG SLSEDNGVDF
560 570 580 590 600
NKNTALDKNY LLNNKIPSNN VEEAGSKNYV HYIIQLQGDD ISYEATCNLF
610 620 630 640 650
SKNPKNSIII QRNMNESAKS YFLSDDGESI LELNKYRIPE RLKNKEKVKV
660 670 680 690 700
TFIGHGKDEF NTSEFARLSV DSLSNEISSF LDTIKLDISP KNVEVNLLGC
710 720 730 740 750
NMFSYDFNVE ETYPGKLLLS IMDKITSTLP DVNKNSITIG ANQYEVRINS
760 770 780 790 800
EGRKELLAHS GKWINKEEAI MSDLSSKEYI FFDSIDNKLK AKSKNIPGLA
810 820 830 840 850
SISEDIKTLL LDASVSPDTK FILNNLKLNI ESSIGDYIYY EKLEPVKNII
860 870 880 890 900
HNSIDDLIDE FNLLENVSDE LYELKKLNNL DEKYLISFED ISKNNSTYSV
910 920 930 940 950
RFINKSNGES VYVETEKEIF SKYSEHITKE ISTIKNSIIT DVNGNLLDNI
960 970 980 990 1000
QLDHTSQVNT LNAAFFIQSL IDYSSNKDVL NDLSTSVKVQ LYAQLFSTGL
1010 1020 1030 1040 1050
NTIYDSIQLV NLISNAVNDT INVLPTITEG IPIVSTILDG INLGAAIKEL
1060 1070 1080 1090 1100
LDEHDPLLKK ELEAKVGVLA INMSLSIAAT VASIVGIGAE VTIFLLPIAG
1110 1120 1130 1140 1150
ISAGIPSLVN NELILHDKAT SVVNYFNHLS ESKKYGPLKT EDDKILVPID
1160 1170 1180 1190 1200
DLVISEIDFN NNSIKLGTCN ILAMEGGSGH TVTGNIDHFF SSPSISSHIP
1210 1220 1230 1240 1250
SLSIYSAIGI ETENLDFSKK IMMLPNAPSR VFWWETGAVP GLRSLENDGT
1260 1270 1280 1290 1300
RLLDSIRDLY PGKFYWRFYA FFDYAITTLK PVYEDTNIKI KLDKDTRNFI
1310 1320 1330 1340 1350
MPTITTNEIR NKLSYSFDGA GGTYSLLLSS YPISTNINLS KDDLWIFNID
1360 1370 1380 1390 1400
NEVREISIEN GTIKKGKLIK DVLSKIDINK NKLIIGNQTI DFSGDIDNKD
1410 1420 1430 1440 1450
RYIFLTCELD DKISLIIEIN LVAKSYSLLL SGDKNYLISN LSNTIEKINT
1460 1470 1480 1490 1500
LGLDSKNIAY NYTDESNNKY FGAISKTSQK SIIHYKKDSK NILEFYNDST
1510 1520 1530 1540 1550
LEFNSKDFIA EDINVFMKDD INTITGKYYV DNNTDKSIDF SISLVSKNQV
1560 1570 1580 1590 1600
KVNGLYLNES VYSSYLDFVK NSDGHHNTSN FMNLFLDNIS FWKLFGFENI
1610 1620 1630 1640 1650
NFVIDKYFTL VGKTNLGYVE FICDNNKNID IYFGEWKTSS SKSTIFSGNG
1660 1670 1680 1690 1700
RNVVVEPIYN PDTGEDISTS LDFSYEPLYG IDRYINKVLI APDLYTSLIN
1710 1720 1730 1740 1750
INTNYYSNEY YPEIIVLNPN TFHKKVNINL DSSSFEYKWS TEGSDFILVR
1760 1770 1780 1790 1800
YLEESNKKIL QKIRIKGILS NTQSFNKMSI DFKDIKKLSL GYIMSNFKSF
1810 1820 1830 1840 1850
NSENELDRDH LGFKIIDNKT YYYDEDSKLV KGLININNSL FYFDPIEFNL
1860 1870 1880 1890 1900
VTGWQTINGK KYYFDINTGA ALTSYKIING KHFYFNNDGV MQLGVFKGPD
1910 1920 1930 1940 1950
GFEYFAPANT QNNNIEGQAI VYQSKFLTLN GKKYYFDNNS KAVTGWRIIN
1960 1970 1980 1990 2000
NEKYYFNPNN AIAAVGLQVI DNNKYYFNPD TAIISKGWQT VNGSRYYFDT
2010 2020 2030 2040 2050
DTAIAFNGYK TIDGKHFYFD SDCVVKIGVF STSNGFEYFA PANTYNNNIE
2060 2070 2080 2090 2100
GQAIVYQSKF LTLNGKKYYF DNNSKAVTGL QTIDSKKYYF NTNTAEAATG
2110 2120 2130 2140 2150
WQTIDGKKYY FNTNTAEAAT GWQTIDGKKY YFNTNTAIAS TGYTIINGKH
2160 2170 2180 2190 2200
FYFNTDGIMQ IGVFKGPNGF EYFAPANTDA NNIEGQAILY QNEFLTLNGK
2210 2220 2230 2240 2250
KYYFGSDSKA VTGWRIINNK KYYFNPNNAI AAIHLCTINN DKYYFSYDGI
2260 2270 2280 2290 2300
LQNGYITIER NNFYFDANNE SKMVTGVFKG PNGFEYFAPA NTHNNNIEGQ
2310 2320 2330 2340 2350
AIVYQNKFLT LNGKKYYFDN DSKAVTGWQT IDGKKYYFNL NTAEAATGWQ
2360 2370 2380 2390 2400
TIDGKKYYFN LNTAEAATGW QTIDGKKYYF NTNTFIASTG YTSINGKHFY
2410 2420 2430 2440 2450
FNTDGIMQIG VFKGPNGFEY FAPANTDANN IEGQAILYQN KFLTLNGKKY
2460 2470 2480 2490 2500
YFGSDSKAVT GLRTIDGKKY YFNTNTAVAV TGWQTINGKK YYFNTNTSIA
2510 2520 2530 2540 2550
STGYTIISGK HFYFNTDGIM QIGVFKGPDG FEYFAPANTD ANNIEGQAIR
2560 2570 2580 2590 2600
YQNRFLYLHD NIYYFGNNSK AATGWVTIDG NRYYFEPNTA MGANGYKTID
2610 2620 2630 2640 2650
NKNFYFRNGL PQIGVFKGSN GFEYFAPANT DANNIEGQAI RYQNRFLHLL
2660 2670 2680 2690 2700
GKIYYFGNNS KAVTGWQTIN GKVYYFMPDT AMAAAGGLFE IDGVIYFFGV
2710
DGVKAPGIYG
Length:2,710
Mass (Da):308,056
Last modified:February 1, 1996 - v2
Checksum:i0A6E52CE84C14421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51797 Genomic DNA Translation: CAA36094.1
M30307 Genomic DNA Translation: AAA23283.1
X92982 Genomic DNA Translation: CAA63564.1
PIRiA37052
RefSeqiWP_009902072.1, NZ_MPFS01000075.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51797 Genomic DNA Translation: CAA36094.1
M30307 Genomic DNA Translation: AAA23283.1
X92982 Genomic DNA Translation: CAA63564.1
PIRiA37052
RefSeqiWP_009902072.1, NZ_MPFS01000075.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F6EX-ray1.85A2583-2709[»]
2G7CX-ray2.00A/B2456-2710[»]
2QJ6X-ray2.50A/B2387-2706[»]
3HO6X-ray1.60A/B543-809[»]
4DMVX-ray1.50A1-541[»]
4DMWX-ray2.50A1-541[»]
4R04X-ray3.26A1-1832[»]
5UMIX-ray3.23C2461-2710[»]
5UQKX-ray1.85A1-544[»]
5UQLX-ray1.97A1-544[»]
ProteinModelPortaliP16154
SMRiP16154
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL3580504

Protein family/group databases

CAZyiGT44 Glycosyltransferase Family 44
MEROPSiC80.002
TCDBi1.C.57.1.2 the clostridial cytotoxin (cct) family
UniLectiniP16154

Proteomic databases

PRIDEiP16154

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105SFK Bacteria
ENOG4111U22 LUCA

Enzyme and pathway databases

BRENDAi2.4.1.B62 13625
3.1.4.B4 13625

Miscellaneous databases

EvolutionaryTraceiP16154

Family and domain databases

Gene3Di3.40.50.11050, 1 hit
InterProiView protein in InterPro
IPR018337 Cell_wall/Cho-bd_repeat
IPR020974 CPD_dom
IPR038383 CPD_dom_sf
IPR029044 Nucleotide-diphossugar_trans
IPR024770 TcdA/TcdB_cat
IPR024772 TcdA/TcdB_N
IPR024769 TcdA/TcdB_pore_forming
PfamiView protein in Pfam
PF01473 CW_binding_1, 12 hits
PF11713 Peptidase_C80, 1 hit
PF12919 TcdA_TcdB, 1 hit
PF12920 TcdA_TcdB_pore, 1 hit
PF12918 TcdB_N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
PROSITEiView protein in PROSITE
PS51771 CGT_MARTX_CPD, 1 hit
PS51170 CW, 32 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTOXA_CLODI
AccessioniPrimary (citable) accession number: P16154
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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