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Protein

Carbonyl reductase [NADPH] 1

Gene

CBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by quercetin, rutenin and its derivatives.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 µM for S-nitrosoglutathione2 Publications
  2. KM=22 µM for menadione2 Publications
  3. KM=309 µM for prostaglandin E22 Publications
  4. KM=173 µM for daunorubicin2 Publications
  5. KM=247 µM for NADPH2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90NADP; via carbonyl oxygen3 Publications1
    Binding sitei106Glutathione1
    Binding sitei140Substrate1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei194Proton acceptor1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 34NADP3 PublicationsAdd BLAST25
    Nucleotide bindingi63 – 64NADP3 Publications2
    Nucleotide bindingi194 – 198NADP3 Publications5
    Nucleotide bindingi231 – 233NADP3 Publications3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.1.1.184 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P16152

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Carbonyl reductase [NADPH] 1 (EC:1.1.1.184)
    Alternative name(s):
    15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197)
    NADPH-dependent carbonyl reductase 1
    Prostaglandin 9-ketoreductase
    Prostaglandin-E(2) 9-reductase (EC:1.1.1.189)
    Short chain dehydrogenase/reductase family 21C member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CBR1
    Synonyms:CBR, CRN, SDR21C1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000159228.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:1548 CBR1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    114830 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P16152

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    873

    Open Targets

    More...
    OpenTargetsi
    ENSG00000159228

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA26121

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5586

    Drug and drug target database

    More...
    DrugBanki
    DB00414 Acetohexamide
    DB00997 Doxorubicin
    DB00502 Haloperidol
    DB01046 Lubiprostone
    DB05197 Sofalcone
    DB04844 Tetrabenazine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1383

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CBR1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    118519

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000546022 – 277Carbonyl reductase [NADPH] 1Add BLAST276

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
    Modified residuei2PhosphoserineBy similarity1
    Modified residuei30PhosphoserineBy similarity1
    Modified residuei239N6-1-carboxyethyl lysine1 Publication1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P16152

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P16152

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P16152

    PeptideAtlas

    More...
    PeptideAtlasi
    P16152

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P16152

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    53298

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P16152-1 [P16152-1]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00295386

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    P16152

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P16152

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P16152

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P16152

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000159228 Expressed in 227 organ(s), highest expression level in duodenum

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_CBR1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P16152 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P16152 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA018433

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.3 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    107319, 39 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-33136N

    Protein interaction database and analysis system

    More...
    IntActi
    P16152, 30 interactors

    Molecular INTeraction database

    More...
    MINTi
    P16152

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000290349

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P16152

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1277
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P16152

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P16152

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P16152

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni95 – 97Glutathione binding3
    Regioni193 – 194Glutathione binding2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1208 Eukaryota
    COG1028 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00510000046499

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG001909

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P16152

    KEGG Orthology (KO)

    More...
    KOi
    K00079

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GTENSME

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0V7L

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P16152

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329359

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00106 adh_short, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00081 GDHRDH
    PR00080 SDRFAMILY

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51735 SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P16152-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL
    60 70 80 90 100
    QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP
    110 120 130 140 150
    TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC
    160 170 180 190 200
    SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG
    210 220 230 240 250
    VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET
    260 270
    PVYLALLPPD AEGPHGQFVS EKRVEQW
    Length:277
    Mass (Da):30,375
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A5A495EB4F4EC3
    GO
    Isoform 2 (identifier: P16152-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         133-173: GRVVNVSSIM...TEEELVGLMN → ASCVLSAWSC...ICRCLTLGPF
         174-277: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:173
    Mass (Da):18,762
    Checksum:i0D3547831C072133
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A8MTM1A8MTM1_HUMAN
    Carbonyl reductase [NADPH] 1
    CBR1
    222Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PQ63E9PQ63_HUMAN
    Carbonyl reductase [NADPH] 1
    CBR1
    178Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05905388V → I Reduced affinity for NADPH and reduced activity towards daunorubicin and prostaglandin E2. 1 PublicationCorresponds to variant dbSNP:rs1143663Ensembl.1
    Natural variantiVAR_031706131P → S1 PublicationCorresponds to variant dbSNP:rs41557318Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054796133 – 173GRVVN…VGLMN → ASCVLSAWSCLSQNPSGGKS KPLAWFTEMSIICRCLTLGP F in isoform 2. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_054797174 – 277Missing in isoform 2. 1 PublicationAdd BLAST104

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J04056 mRNA Translation: AAA52070.1
    M62420 Genomic DNA Translation: AAA17881.1
    AB003151 Genomic DNA Translation: BAA33498.1
    AP000688 Genomic DNA Translation: BAA89424.1
    AB124848 mRNA Translation: BAE45940.1
    BT019843 mRNA Translation: AAV38646.1
    CR541708 mRNA Translation: CAG46509.1
    AK294142 mRNA Translation: BAG57468.1
    AK314879 mRNA Translation: BAG37394.1
    EF141836 Genomic DNA Translation: ABK97430.1
    AP001724 Genomic DNA Translation: BAA95508.1
    CH471079 Genomic DNA Translation: EAX09754.1
    CH471079 Genomic DNA Translation: EAX09755.1
    BC002511 mRNA Translation: AAH02511.1
    BC015640 mRNA Translation: AAH15640.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13641.1 [P16152-1]
    CCDS68202.1 [P16152-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A61271 RDHUCB

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001273718.1, NM_001286789.1 [P16152-2]
    NP_001748.1, NM_001757.3 [P16152-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.88778

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
    ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    873

    KEGG: Kyoto Encyclopedia of Genes and Genomes

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    KEGGi
    hsa:873

    UCSC genome browser

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    UCSCi
    uc002yvb.3 human [P16152-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J04056 mRNA Translation: AAA52070.1
    M62420 Genomic DNA Translation: AAA17881.1
    AB003151 Genomic DNA Translation: BAA33498.1
    AP000688 Genomic DNA Translation: BAA89424.1
    AB124848 mRNA Translation: BAE45940.1
    BT019843 mRNA Translation: AAV38646.1
    CR541708 mRNA Translation: CAG46509.1
    AK294142 mRNA Translation: BAG57468.1
    AK314879 mRNA Translation: BAG37394.1
    EF141836 Genomic DNA Translation: ABK97430.1
    AP001724 Genomic DNA Translation: BAA95508.1
    CH471079 Genomic DNA Translation: EAX09754.1
    CH471079 Genomic DNA Translation: EAX09755.1
    BC002511 mRNA Translation: AAH02511.1
    BC015640 mRNA Translation: AAH15640.1
    CCDSiCCDS13641.1 [P16152-1]
    CCDS68202.1 [P16152-2]
    PIRiA61271 RDHUCB
    RefSeqiNP_001273718.1, NM_001286789.1 [P16152-2]
    NP_001748.1, NM_001757.3 [P16152-1]
    UniGeneiHs.88778

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1WMAX-ray1.24A2-277[»]
    2PFGX-ray1.54A2-277[»]
    3BHIX-ray2.27A2-277[»]
    3BHJX-ray1.77A2-277[»]
    3BHMX-ray1.80A2-277[»]
    4Z3DX-ray1.80A/B/C/D2-277[»]
    ProteinModelPortaliP16152
    SMRiP16152
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107319, 39 interactors
    DIPiDIP-33136N
    IntActiP16152, 30 interactors
    MINTiP16152
    STRINGi9606.ENSP00000290349

    Chemistry databases

    BindingDBiP16152
    ChEMBLiCHEMBL5586
    DrugBankiDB00414 Acetohexamide
    DB00997 Doxorubicin
    DB00502 Haloperidol
    DB01046 Lubiprostone
    DB05197 Sofalcone
    DB04844 Tetrabenazine
    GuidetoPHARMACOLOGYi1383

    PTM databases

    iPTMnetiP16152
    PhosphoSitePlusiP16152
    SwissPalmiP16152

    Polymorphism and mutation databases

    BioMutaiCBR1
    DMDMi118519

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00295386
    UCD-2DPAGEiP16152

    Proteomic databases

    EPDiP16152
    MaxQBiP16152
    PaxDbiP16152
    PeptideAtlasiP16152
    PRIDEiP16152
    ProteomicsDBi53298
    TopDownProteomicsiP16152-1 [P16152-1]

    Protocols and materials databases

    The DNASU plasmid repository

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    DNASUi
    873
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
    ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]
    GeneIDi873
    KEGGihsa:873
    UCSCiuc002yvb.3 human [P16152-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

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    CTDi
    873
    DisGeNETi873
    EuPathDBiHostDB:ENSG00000159228.12

    GeneCards: human genes, protein and diseases

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    GeneCardsi
    CBR1
    HGNCiHGNC:1548 CBR1
    HPAiHPA018433
    MIMi114830 gene
    neXtProtiNX_P16152
    OpenTargetsiENSG00000159228
    PharmGKBiPA26121

    GenAtlas: human gene database

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    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1208 Eukaryota
    COG1028 LUCA
    GeneTreeiENSGT00510000046499
    HOVERGENiHBG001909
    InParanoidiP16152
    KOiK00079
    OMAiGTENSME
    OrthoDBiEOG091G0V7L
    PhylomeDBiP16152
    TreeFamiTF329359

    Enzyme and pathway databases

    BRENDAi1.1.1.184 2681
    ReactomeiR-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    SABIO-RKiP16152

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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    ChiTaRSi
    CBR1 human
    EvolutionaryTraceiP16152

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    CBR1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    873

    Protein Ontology

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    PROi
    PR:P16152

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000159228 Expressed in 227 organ(s), highest expression level in duodenum
    CleanExiHS_CBR1
    ExpressionAtlasiP16152 baseline and differential
    GenevisibleiP16152 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291 NAD(P)-bd_dom_sf
    IPR020904 Sc_DH/Rdtase_CS
    IPR002347 SDR_fam
    PfamiView protein in Pfam
    PF00106 adh_short, 1 hit
    PRINTSiPR00081 GDHRDH
    PR00080 SDRFAMILY
    SUPFAMiSSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061 ADH_SHORT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBR1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16152
    Secondary accession number(s): B2RBZ7, B4DFK7, Q3LHW8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: December 5, 2018
    This is version 204 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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