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UniProtKB - P16152 (CBR1_HUMAN)

Entry version 222 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Carbonyl reductase [NADPH] 1

Gene

CBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231).

Can convert prostaglandin E to prostaglandin F2-alpha (By similarity).

Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).

By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by quercetin, rutenin and its derivatives.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 µM for S-nitrosoglutathione2 Publications
  2. KM=22 µM for menadione2 Publications
  3. KM=309 µM for prostaglandin E22 Publications
  4. KM=450 µM for prostaglandin E11 Publication
  5. KM=4 mM for phenylglyoxal1 Publication
  6. KM=1.6 mM for 4-nitrobenzaldehyde1 Publication
  7. KM=17 µM for ubiquinone-11 Publication
  8. KM=173 µM for daunorubicin2 Publications
  9. KM=247 µM for NADPH2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90NADP; via carbonyl oxygen3 Publications1
Binding sitei106Glutathione1
Binding sitei140Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei194Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 34NADP3 PublicationsAdd BLAST25
Nucleotide bindingi63 – 64NADP3 Publications2
Nucleotide bindingi194 – 198NADP3 Publications5
Nucleotide bindingi231 – 233NADP3 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.184, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16152

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P16152

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbonyl reductase [NADPH] 1Curated (EC:1.1.1.184)
Alternative name(s):
15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.196By similarity, EC:1.1.1.1971 Publication)
20-beta-hydroxysteroid dehydrogenase
NADPH-dependent carbonyl reductase 1
Prostaglandin 9-ketoreductase1 Publication
Short name:
PG-9-KR1 Publication
Prostaglandin-E(2) 9-reductaseBy similarity (EC:1.1.1.189By similarity)
Short chain dehydrogenase/reductase family 21C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CBR1Imported
Synonyms:CBR, CRN, SDR21C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1548, CBR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114830, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16152

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000159228

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		873

Open Targets

More...OpenTargetsi		ENSG00000159228

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26121

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16152, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5586

Drug and drug target database

More...DrugBanki		DB03556, 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400
DB04463, 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol
DB00414, Acetohexamide
DB06263, Amrubicin
DB11672, Curcumin
DB14635, Curcumin sulfate
DB12161, Deutetrabenazine
DB00997, Doxorubicin
DB01039, Fenofibrate
DB00502, Haloperidol
DB03394, Heptaethylene glycol
DB09212, Loxoprofen
DB01046, Lubiprostone
DB00776, Oxcarbazepine
DB04216, Quercetin
DB02709, Resveratrol
DB01698, Rutin
DB05197, Sofalcone
DB04844, Tetrabenazine

DrugCentral

More...DrugCentrali		P16152

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1383

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CBR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		118519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000546022 – 277Carbonyl reductase [NADPH] 1Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei239N6-1-carboxyethyl lysine1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-329
CPTAC-330

Encyclopedia of Proteome Dynamics

More...EPDi		P16152

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16152

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16152

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16152

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16152

PeptideAtlas

More...PeptideAtlasi		P16152

PRoteomics IDEntifications database

More...PRIDEi		P16152

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4051
53298 [P16152-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P16152-1 [P16152-1]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00295386

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P16152

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16152, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16152

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P16152

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16152

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P16152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000159228, Expressed in duodenum and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16152, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16152, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000159228, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107319, 67 interactors

Database of interacting proteins

More...DIPi		DIP-33136N

Protein interaction database and analysis system

More...IntActi		P16152, 38 interactors

Molecular INTeraction database

More...MINTi		P16152

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000290349

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P16152

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16152, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16152

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni95 – 97Glutathione binding3
Regioni193 – 194Glutathione binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1208, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000046499

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010194_9_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16152

Identification of Orthologs from Complete Genome Data

More...OMAi		YWANDSV

Database of Orthologous Groups

More...OrthoDBi		1259665at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16152

TreeFam database of animal gene trees

More...TreeFami		TF329359

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106, adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081, GDHRDH
PR00080, SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00061, ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16152-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL 
        60         70         80         90        100
QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP 
       110        120        130        140        150
TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC 
       160        170        180        190        200
SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG 
       210        220        230        240        250
VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET 
       260        270 
PVYLALLPPD AEGPHGQFVS EKRVEQW
Length:277
Mass (Da):30,375
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A5A495EB4F4EC3
GO
Isoform 2 (identifier: P16152-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-173: GRVVNVSSIM...TEEELVGLMN → ASCVLSAWSC...ICRCLTLGPF
     174-277: Missing.

Show »
Length:173
Mass (Da):18,762
Checksum:i0D3547831C072133
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MTM1A8MTM1_HUMAN
Carbonyl reductase [NADPH] 1
CBR1
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ63E9PQ63_HUMAN
Carbonyl reductase [NADPH] 1
CBR1
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05905388V → I Reduced affinity for NADPH and reduced activity towards daunorubicin and prostaglandin E2. 2 PublicationsCorresponds to variant dbSNP:rs1143663Ensembl.1
Natural variantiVAR_031706131P → S1 PublicationCorresponds to variant dbSNP:rs41557318Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054796133 – 173GRVVN…VGLMN → ASCVLSAWSCLSQNPSGGKS KPLAWFTEMSIICRCLTLGP F in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_054797174 – 277Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04056 mRNA Translation: AAA52070.1
M62420 Genomic DNA Translation: AAA17881.1
AB003151 Genomic DNA Translation: BAA33498.1
AP000688 Genomic DNA Translation: BAA89424.1
AB124848 mRNA Translation: BAE45940.1
BT019843 mRNA Translation: AAV38646.1
CR541708 mRNA Translation: CAG46509.1
AK294142 mRNA Translation: BAG57468.1
AK314879 mRNA Translation: BAG37394.1
EF141836 Genomic DNA Translation: ABK97430.1
AP001724 Genomic DNA Translation: BAA95508.1
CH471079 Genomic DNA Translation: EAX09754.1
CH471079 Genomic DNA Translation: EAX09755.1
BC002511 mRNA Translation: AAH02511.1
BC015640 mRNA Translation: AAH15640.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13641.1 [P16152-1]
CCDS68202.1 [P16152-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A61271, RDHUCB

NCBI Reference Sequences

More...RefSeqi		NP_001273718.1, NM_001286789.1 [P16152-2]
NP_001748.1, NM_001757.3 [P16152-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		873

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:873

UCSC genome browser

More...UCSCi		uc002yvb.3, human [P16152-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04056 mRNA Translation: AAA52070.1
M62420 Genomic DNA Translation: AAA17881.1
AB003151 Genomic DNA Translation: BAA33498.1
AP000688 Genomic DNA Translation: BAA89424.1
AB124848 mRNA Translation: BAE45940.1
BT019843 mRNA Translation: AAV38646.1
CR541708 mRNA Translation: CAG46509.1
AK294142 mRNA Translation: BAG57468.1
AK314879 mRNA Translation: BAG37394.1
EF141836 Genomic DNA Translation: ABK97430.1
AP001724 Genomic DNA Translation: BAA95508.1
CH471079 Genomic DNA Translation: EAX09754.1
CH471079 Genomic DNA Translation: EAX09755.1
BC002511 mRNA Translation: AAH02511.1
BC015640 mRNA Translation: AAH15640.1
CCDSiCCDS13641.1 [P16152-1]
CCDS68202.1 [P16152-2]
PIRiA61271, RDHUCB
RefSeqiNP_001273718.1, NM_001286789.1 [P16152-2]
NP_001748.1, NM_001757.3 [P16152-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WMAX-ray1.24A2-277[»]
2PFGX-ray1.54A2-277[»]
3BHIX-ray2.27A2-277[»]
3BHJX-ray1.77A2-277[»]
3BHMX-ray1.80A2-277[»]
4Z3DX-ray1.80A/B/C/D2-277[»]
SMRiP16152
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107319, 67 interactors
DIPiDIP-33136N
IntActiP16152, 38 interactors
MINTiP16152
STRINGi9606.ENSP00000290349

Chemistry databases

BindingDBiP16152
ChEMBLiCHEMBL5586
DrugBankiDB03556, 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400
DB04463, 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol
DB00414, Acetohexamide
DB06263, Amrubicin
DB11672, Curcumin
DB14635, Curcumin sulfate
DB12161, Deutetrabenazine
DB00997, Doxorubicin
DB01039, Fenofibrate
DB00502, Haloperidol
DB03394, Heptaethylene glycol
DB09212, Loxoprofen
DB01046, Lubiprostone
DB00776, Oxcarbazepine
DB04216, Quercetin
DB02709, Resveratrol
DB01698, Rutin
DB05197, Sofalcone
DB04844, Tetrabenazine
DrugCentraliP16152
GuidetoPHARMACOLOGYi1383

PTM databases

GlyGeniP16152, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP16152
MetOSiteiP16152
PhosphoSitePlusiP16152
SwissPalmiP16152

Genetic variation databases

BioMutaiCBR1
DMDMi118519

2D gel databases

REPRODUCTION-2DPAGEiIPI00295386
UCD-2DPAGEiP16152

Proteomic databases

CPTACiCPTAC-329
CPTAC-330
EPDiP16152
jPOSTiP16152
MassIVEiP16152
MaxQBiP16152
PaxDbiP16152
PeptideAtlasiP16152
PRIDEiP16152
ProteomicsDBi4051
53298 [P16152-1]
TopDownProteomicsiP16152-1 [P16152-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8245, 477 antibodies

The DNASU plasmid repository

More...DNASUi		873

Genome annotation databases

EnsembliENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]
GeneIDi873
KEGGihsa:873
UCSCiuc002yvb.3, human [P16152-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		873
DisGeNETi873

GeneCards: human genes, protein and diseases

More...GeneCardsi		CBR1
HGNCiHGNC:1548, CBR1
HPAiENSG00000159228, Tissue enhanced (intestine)
MIMi114830, gene
neXtProtiNX_P16152
OpenTargetsiENSG00000159228
PharmGKBiPA26121
VEuPathDBiHostDB:ENSG00000159228

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1208, Eukaryota
GeneTreeiENSGT00510000046499
HOGENOMiCLU_010194_9_0_1
InParanoidiP16152
OMAiYWANDSV
OrthoDBi1259665at2759
PhylomeDBiP16152
TreeFamiTF329359

Enzyme and pathway databases

BRENDAi1.1.1.184, 2681
PathwayCommonsiP16152
ReactomeiR-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiP16152

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		873, 4 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CBR1, human
EvolutionaryTraceiP16152

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CBR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		873
PharosiP16152, Tchem

Protein Ontology

More...PROi		PR:P16152
RNActiP16152, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000159228, Expressed in duodenum and 238 other tissues
ExpressionAtlasiP16152, baseline and differential
GenevisibleiP16152, HS

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PRINTSiPR00081, GDHRDH
PR00080, SDRFAMILY
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061, ADH_SHORT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16152
Secondary accession number(s): B2RBZ7, B4DFK7, Q3LHW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 222 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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