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UniProtKB - P16152 (CBR1_HUMAN)

Entry version 218 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Carbonyl reductase [NADPH] 1

Gene

CBR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by quercetin, rutenin and its derivatives.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 µM for S-nitrosoglutathione2 Publications
  2. KM=22 µM for menadione2 Publications
  3. KM=309 µM for prostaglandin E22 Publications
  4. KM=450 µM for prostaglandin E11 Publication
  5. KM=4 mM for phenylglyoxal1 Publication
  6. KM=1.6 mM for 4-nitrobenzaldehyde1 Publication
  7. KM=17 µM for ubiquinone-11 Publication
  8. KM=173 µM for daunorubicin2 Publications
  9. KM=247 µM for NADPH2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90NADP; via carbonyl oxygen3 Publications1
    Binding sitei106Glutathione1
    Binding sitei140Substrate1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei194Proton acceptor1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi10 – 34NADP3 PublicationsAdd BLAST25
    Nucleotide bindingi63 – 64NADP3 Publications2
    Nucleotide bindingi194 – 198NADP3 Publications5
    Nucleotide bindingi231 – 233NADP3 Publications3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandNADP

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		1.1.1.184, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P16152

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P16152

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Carbonyl reductase [NADPH] 1Curated (EC:1.1.1.184)
    Alternative name(s):
    15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.196By similarity, EC:1.1.1.1971 Publication)
    20-beta-hydroxysteroid dehydrogenase
    NADPH-dependent carbonyl reductase 1
    Prostaglandin 9-ketoreductase1 Publication
    Short name:
    PG-9-KR1 Publication
    Prostaglandin-E(2) 9-reductaseBy similarity (EC:1.1.1.189By similarity)
    Short chain dehydrogenase/reductase family 21C member 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CBR1Imported
    Synonyms:CBR, CRN, SDR21C1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000159228.12

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:1548, CBR1

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		114830, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P16152

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		873

    Open Targets

    More...    OpenTargetsi    		ENSG00000159228

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA26121

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P16152, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL5586

    Drug and drug target database

    More...    DrugBanki    		DB03556, 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400
    DB04463, 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol
    DB00414, Acetohexamide
    DB06263, Amrubicin
    DB11672, Curcumin
    DB14635, Curcumin sulfate
    DB12161, Deutetrabenazine
    DB00997, Doxorubicin
    DB01039, Fenofibrate
    DB00502, Haloperidol
    DB03394, Heptaethylene glycol
    DB09212, Loxoprofen
    DB01046, Lubiprostone
    DB00776, Oxcarbazepine
    DB04216, Quercetin
    DB02709, Resveratrol
    DB01698, Rutin
    DB05197, Sofalcone
    DB04844, Tetrabenazine

    DrugCentral

    More...    DrugCentrali    		P16152

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		1383

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		CBR1

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		118519

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000546022 – 277Carbonyl reductase [NADPH] 1Add BLAST276

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
    Modified residuei2PhosphoserineBy similarity1
    Modified residuei30PhosphoserineBy similarity1
    Modified residuei239N6-1-carboxyethyl lysine1 Publication1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...    CPTACi    		CPTAC-329
    CPTAC-330

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P16152

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P16152

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P16152

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P16152

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P16152

    PeptideAtlas

    More...    PeptideAtlasi    		P16152

    PRoteomics IDEntifications database

    More...    PRIDEi    		P16152

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		4051
    53298 [P16152-1]

    Consortium for Top Down Proteomics

    More...    TopDownProteomicsi    		P16152-1 [P16152-1]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...    REPRODUCTION-2DPAGEi    		IPI00295386

    University College Dublin 2-DE Proteome Database

    More...    UCD-2DPAGEi    		P16152

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P16152

    MetOSite database of methionine sulfoxide sites

    More...    MetOSitei    		P16152

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P16152

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		P16152

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in kidney (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000159228, Expressed in duodenum and 237 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P16152, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P16152, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000159228, Tissue enhanced (intestine)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    3 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		107319, 53 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-33136N

    Protein interaction database and analysis system

    More...    IntActi    		P16152, 38 interactors

    Molecular INTeraction database

    More...    MINTi    		P16152

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000290349

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P16152

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P16152, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1277
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P16152

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		P16152

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni95 – 97Glutathione binding3
    Regioni193 – 194Glutathione binding2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1208, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00510000046499

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_010194_9_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P16152

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		IRVTNAM

    Database of Orthologous Groups

    More...    OrthoDBi    		1259665at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P16152

    TreeFam database of animal gene trees

    More...    TreeFami    		TF329359

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR036291, NAD(P)-bd_dom_sf
    IPR020904, Sc_DH/Rdtase_CS
    IPR002347, SDR_fam

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00106, adh_short, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00081, GDHRDH
    PR00080, SDRFAMILY

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51735, SSF51735, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00061, ADH_SHORT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P16152-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL 
            60         70         80         90        100
    QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP 
           110        120        130        140        150
    TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC 
           160        170        180        190        200
    SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG 
           210        220        230        240        250
    VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET 
           260        270 
    PVYLALLPPD AEGPHGQFVS EKRVEQW
    Length:277
    Mass (Da):30,375
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A5A495EB4F4EC3
    GO
    Isoform 2 (identifier: P16152-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         133-173: GRVVNVSSIM...TEEELVGLMN → ASCVLSAWSC...ICRCLTLGPF
         174-277: Missing.

    Show »
    Length:173
    Mass (Da):18,762
    Checksum:i0D3547831C072133
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A8MTM1A8MTM1_HUMAN
    Carbonyl reductase [NADPH] 1
    CBR1
    		222Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PQ63E9PQ63_HUMAN
    Carbonyl reductase [NADPH] 1
    CBR1
    		178Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05905388V → I Reduced affinity for NADPH and reduced activity towards daunorubicin and prostaglandin E2. 2 PublicationsCorresponds to variant dbSNP:rs1143663Ensembl.1
    Natural variantiVAR_031706131P → S1 PublicationCorresponds to variant dbSNP:rs41557318Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054796133 – 173GRVVN…VGLMN → ASCVLSAWSCLSQNPSGGKS KPLAWFTEMSIICRCLTLGP F in isoform 2. 1 PublicationAdd BLAST41
    Alternative sequenceiVSP_054797174 – 277Missing in isoform 2. 1 PublicationAdd BLAST104

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		J04056 mRNA Translation: AAA52070.1
    M62420 Genomic DNA Translation: AAA17881.1
    AB003151 Genomic DNA Translation: BAA33498.1
    AP000688 Genomic DNA Translation: BAA89424.1
    AB124848 mRNA Translation: BAE45940.1
    BT019843 mRNA Translation: AAV38646.1
    CR541708 mRNA Translation: CAG46509.1
    AK294142 mRNA Translation: BAG57468.1
    AK314879 mRNA Translation: BAG37394.1
    EF141836 Genomic DNA Translation: ABK97430.1
    AP001724 Genomic DNA Translation: BAA95508.1
    CH471079 Genomic DNA Translation: EAX09754.1
    CH471079 Genomic DNA Translation: EAX09755.1
    BC002511 mRNA Translation: AAH02511.1
    BC015640 mRNA Translation: AAH15640.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS13641.1 [P16152-1]
    CCDS68202.1 [P16152-2]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		A61271, RDHUCB

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001273718.1, NM_001286789.1 [P16152-2]
    NP_001748.1, NM_001757.3 [P16152-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
    ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		873

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:873

    UCSC genome browser

    More...    UCSCi    		uc002yvb.3, human [P16152-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		J04056 mRNA Translation: AAA52070.1
    M62420 Genomic DNA Translation: AAA17881.1
    AB003151 Genomic DNA Translation: BAA33498.1
    AP000688 Genomic DNA Translation: BAA89424.1
    AB124848 mRNA Translation: BAE45940.1
    BT019843 mRNA Translation: AAV38646.1
    CR541708 mRNA Translation: CAG46509.1
    AK294142 mRNA Translation: BAG57468.1
    AK314879 mRNA Translation: BAG37394.1
    EF141836 Genomic DNA Translation: ABK97430.1
    AP001724 Genomic DNA Translation: BAA95508.1
    CH471079 Genomic DNA Translation: EAX09754.1
    CH471079 Genomic DNA Translation: EAX09755.1
    BC002511 mRNA Translation: AAH02511.1
    BC015640 mRNA Translation: AAH15640.1
    CCDSiCCDS13641.1 [P16152-1]
    CCDS68202.1 [P16152-2]
    PIRiA61271, RDHUCB
    RefSeqiNP_001273718.1, NM_001286789.1 [P16152-2]
    NP_001748.1, NM_001757.3 [P16152-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1WMAX-ray1.24A2-277[»]
    2PFGX-ray1.54A2-277[»]
    3BHIX-ray2.27A2-277[»]
    3BHJX-ray1.77A2-277[»]
    3BHMX-ray1.80A2-277[»]
    4Z3DX-ray1.80A/B/C/D2-277[»]
    SMRiP16152
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi107319, 53 interactors
    DIPiDIP-33136N
    IntActiP16152, 38 interactors
    MINTiP16152
    STRINGi9606.ENSP00000290349

    Chemistry databases

    BindingDBiP16152
    ChEMBLiCHEMBL5586
    DrugBankiDB03556, 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400
    DB04463, 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol
    DB00414, Acetohexamide
    DB06263, Amrubicin
    DB11672, Curcumin
    DB14635, Curcumin sulfate
    DB12161, Deutetrabenazine
    DB00997, Doxorubicin
    DB01039, Fenofibrate
    DB00502, Haloperidol
    DB03394, Heptaethylene glycol
    DB09212, Loxoprofen
    DB01046, Lubiprostone
    DB00776, Oxcarbazepine
    DB04216, Quercetin
    DB02709, Resveratrol
    DB01698, Rutin
    DB05197, Sofalcone
    DB04844, Tetrabenazine
    DrugCentraliP16152
    GuidetoPHARMACOLOGYi1383

    PTM databases

    iPTMnetiP16152
    MetOSiteiP16152
    PhosphoSitePlusiP16152
    SwissPalmiP16152

    Polymorphism and mutation databases

    BioMutaiCBR1
    DMDMi118519

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00295386
    UCD-2DPAGEiP16152

    Proteomic databases

    CPTACiCPTAC-329
    CPTAC-330
    EPDiP16152
    jPOSTiP16152
    MassIVEiP16152
    MaxQBiP16152
    PaxDbiP16152
    PeptideAtlasiP16152
    PRIDEiP16152
    ProteomicsDBi4051
    53298 [P16152-1]
    TopDownProteomicsiP16152-1 [P16152-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		8245, 449 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		873

    Genome annotation databases

    EnsembliENST00000290349; ENSP00000290349; ENSG00000159228 [P16152-1]
    ENST00000530908; ENSP00000434613; ENSG00000159228 [P16152-2]
    GeneIDi873
    KEGGihsa:873
    UCSCiuc002yvb.3, human [P16152-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		873
    DisGeNETi873
    EuPathDBiHostDB:ENSG00000159228.12

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		CBR1
    HGNCiHGNC:1548, CBR1
    HPAiENSG00000159228, Tissue enhanced (intestine)
    MIMi114830, gene
    neXtProtiNX_P16152
    OpenTargetsiENSG00000159228
    PharmGKBiPA26121

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1208, Eukaryota
    GeneTreeiENSGT00510000046499
    HOGENOMiCLU_010194_9_0_1
    InParanoidiP16152
    OMAiIRVTNAM
    OrthoDBi1259665at2759
    PhylomeDBiP16152
    TreeFamiTF329359

    Enzyme and pathway databases

    BRENDAi1.1.1.184, 2681
    PathwayCommonsiP16152
    ReactomeiR-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    SABIO-RKiP16152

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		873, 2 hits in 843 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		CBR1, human
    EvolutionaryTraceiP16152

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		CBR1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		873
    PharosiP16152, Tchem

    Protein Ontology

    More...    PROi    		PR:P16152
    RNActiP16152, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000159228, Expressed in duodenum and 237 other tissues
    ExpressionAtlasiP16152, baseline and differential
    GenevisibleiP16152, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR036291, NAD(P)-bd_dom_sf
    IPR020904, Sc_DH/Rdtase_CS
    IPR002347, SDR_fam
    PfamiView protein in Pfam
    PF00106, adh_short, 1 hit
    PRINTSiPR00081, GDHRDH
    PR00080, SDRFAMILY
    SUPFAMiSSF51735, SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00061, ADH_SHORT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBR1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16152
    Secondary accession number(s): B2RBZ7, B4DFK7, Q3LHW8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: December 2, 2020
    This is version 218 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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