SPN

Functionⁱ

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4⁺ T-cells and to a lesser extent by CD8⁺ T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).By similarity2 Publications

CD43 cytoplasmic tail: Protects cells from apoptotic signals, promoting cell survival.By similarity

GO - Molecular functionⁱ

heat shock protein binding
Source: CAFA
Inferred from physical interactionⁱ
- 20633027
Hsp70 protein binding
Source: CAFA
Inferred from physical interactionⁱ
- 20633027
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 1683685

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular defense response
Source: ProtInc
Traceable author statementⁱ
- 1683685
chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 10753822
defense response to bacterium
Source: MGI
Inferred from direct assayⁱ
- 10899905
establishment or maintenance of cell polarity
Source: ProtInc
Traceable author statementⁱ
- 10753822
immune response
Source: ProtInc
Traceable author statementⁱ
- 2023632
interferon-gamma production
Source: UniProtKB
Inferred from direct assayⁱ
- 18036228
leukocyte migration Source: Reactome
leukocyte tethering or rolling Source: UniProtKB
negative regulation of cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 10753822
negative regulation of T cell proliferation Source: UniProtKB
positive regulation of T cell migration Source: UniProtKB
positive regulation of tumor necrosis factor biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 10899905
regulation of T cell migration Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2023632
T-helper 1 cell lineage commitment
Source: UniProtKB
Inferred from direct assayⁱ
- 18036228

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-210991 Basigin interactions

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210991 Basigin interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukosialin Alternative name(s): GPL1151 Publication Galactoglycoprotein Short name: GALGP Leukocyte sialoglycoprotein Sialophorin CD_antigen: CD43 Cleaved into the following chain: CD43 cytoplasmic tail1 Publication Short name: CD43-ct1 Publication Short name: CD43ct1 Publication
Gene namesⁱ	Name:SPN Synonyms:CD43
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197471.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11249 SPN
MIMⁱ	182160 gene
neXtProtⁱ	NX_P16150

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 253	ExtracellularSequence analysisAdd BLAST	234
Transmembraneⁱ	254 – 276	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	277 – 400	CytoplasmicSequence analysisAdd BLAST	124

Keywords - Cellular componentⁱ

Cell projection, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6693
Open Targets More...OpenTargetsⁱ	ENSG00000197471
PharmGKBⁱ	PA36079

Polymorphism and mutation databases

BioMutaⁱ	SPN
DMDMⁱ	126213

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST	19
ChainⁱPRO_0000021588	20 – 400	LeukosialinAdd BLAST	381
ChainⁱPRO_0000443406	277 – 400	CD43 cytoplasmic tailBy similarityAdd BLAST	124

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	22	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	26	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	28	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	29	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	35	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	36	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	37	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	41	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	42	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	46	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	47	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	48	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	50	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	58	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	69	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	99	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	103	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	109	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	113	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	114	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	136	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	137	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	173	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	178	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	239	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	291	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	336	PhosphoserineCombined sources	1
Modified residueⁱ	341	PhosphothreonineCombined sources	1
Modified residueⁱ	351	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	355	Phosphoserine; by PKC/PRKCQCombined sources	1
Modified residueⁱ	368	PhosphoserineCombined sources	1
Modified residueⁱ	379	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.1 Publication

Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes.By similarity

Has a high content of sialic acid and O-linked carbohydrate structures.

Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus.2 Publications

CD43 cytoplasmic tail: Sumoylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P16150
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P16150
PaxDbⁱ	P16150
PeptideAtlas More...PeptideAtlasⁱ	P16150
PRIDEⁱ	P16150
ProteomicsDBⁱ	53297

PTM databases

GlyConnectⁱ	340
iPTMnetⁱ	P16150
PhosphoSitePlusⁱ	P16150
UniCarbKBⁱ	P16150

Miscellaneous databases

PMAP-CutDBⁱ	P16150

PMAP-CutDBⁱ

P16150

Expressionⁱ

Tissue specificityⁱ

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Gene expression databases

Bgeeⁱ	ENSG00000197471 Expressed in 208 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_SPN
ExpressionAtlasⁱ	P16150 baseline and differential
Genevisibleⁱ	P16150 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002666 HPA055244

HPAⁱ

CAB002666
HPA055244

Interactionⁱ

Subunit structureⁱ

Interacts with HIPK2 via the cytoplasmic domain. Interacts with SIGLEC1, RDX, EZR and MSN.By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112571, 13 interactors
IntActⁱ	P16150, 9 interactors
STRINGⁱ	9606.ENSP00000353238

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P16150
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	278 – 308	Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST		31

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J161 Eukaryota ENOG410YXQE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017626
HOGENOMⁱ	HOG000294199
HOVERGENⁱ	HBG006258
InParanoidⁱ	P16150
KEGG Orthology (KO) More...KOⁱ	K06477
OMAⁱ	TGPPVTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MEV
PhylomeDBⁱ	P16150
TreeFamⁱ	TF337688

Family and domain databases

InterProⁱ	View protein in InterPro IPR038829 Leukosialin
PANTHERⁱ	PTHR35265 PTHR35265, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P16150-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT 
        60         70         80         90        100
SDPKADSTGD QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI 
       110        120        130        140        150
KMSSVPQETP HATSHPAVPI TANSLGSHTV TGGTITTNSP ETSSRTSGAP 
       160        170        180        190        200
VTTAASSLET SRGTSGPPLT MATVSLETSK GTSGPPVTMA TDSLETSTGT 
       210        220        230        240        250
TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA STVPFRNPDE 
       260        270        280        290        300
NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 
       310        320        330        340        350
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK 
       360        370        380        390        400
SRQGSLAMEE LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP

Length:400

Mass (Da):40,322

Last modified:April 1, 1990 - v1

Checksum:ⁱC9C9AB8435D5E1FE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JUK7	C9JUK7_HUMAN		Leukosialin Leukosialin	SPN	355	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051091	22	T → I. Corresponds to variant dbSNP:rs2229653Ensembl.		1
Natural variantⁱVAR_051092	93	T → A. Corresponds to variant dbSNP:rs2229654Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04168 mRNA Translation: AAA59510.1 J04536 mRNA Translation: AAB59540.1 X52075 Genomic DNA Translation: CAA36294.1 M61827 Genomic DNA Translation: AAA51949.1 AK292626 mRNA Translation: BAF85315.1 AK313750 mRNA Translation: BAG36490.1 CH471238 Genomic DNA Translation: EAW80015.1 BC012350 mRNA Translation: AAH12350.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10650.1
PIRⁱ	A39822
NCBI Reference Sequences More...RefSeqⁱ	NP_001025459.1, NM_001030288.2 NP_003114.1, NM_003123.4
UniGeneⁱ	Hs.632188

Genome annotation databases

Ensemblⁱ	ENST00000360121; ENSP00000353238; ENSG00000197471 ENST00000395389; ENSP00000378787; ENSG00000197471 ENST00000563039; ENSP00000455266; ENSG00000197471
GeneIDⁱ	6693
KEGGⁱ	hsa:6693
UCSC genome browser More...UCSCⁱ	uc002dtm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P16150	Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a		HUMAN		400	UniRef100_P16150
Leukosialin (Fragment)		HUMAN		355

Protein	Similar proteins		Species	Score	Length	Source
P16150	Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a		HUMAN		400	UniRef90_P16150
SPN isoform 1		PANTR		418
Sialophorin		PONAB		400
Uncharacterized protein		PANPA		400
Uncharacterized protein		NOMLE		400
+6

Protein	Similar proteins		Species	Score	Length	Source
P16150	Leukosialin	)	MOUSE		395	UniRef50_P15702
Uncharacterized protein		MACNE		405
Sialophorin		CHLSB		408
Uncharacterized protein		MACFA		405
Uncharacterized protein		MANLE		405
+39

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04168 mRNA Translation: AAA59510.1 J04536 mRNA Translation: AAB59540.1 X52075 Genomic DNA Translation: CAA36294.1 M61827 Genomic DNA Translation: AAA51949.1 AK292626 mRNA Translation: BAF85315.1 AK313750 mRNA Translation: BAG36490.1 CH471238 Genomic DNA Translation: EAW80015.1 BC012350 mRNA Translation: AAH12350.1
CCDSⁱ	CCDS10650.1
PIRⁱ	A39822
RefSeqⁱ	NP_001025459.1, NM_001030288.2 NP_003114.1, NM_003123.4
UniGeneⁱ	Hs.632188

3D structure databases

ProteinModelPortalⁱ	P16150
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112571, 13 interactors
IntActⁱ	P16150, 9 interactors
STRINGⁱ	9606.ENSP00000353238

PTM databases

GlyConnectⁱ	340
iPTMnetⁱ	P16150
PhosphoSitePlusⁱ	P16150
UniCarbKBⁱ	P16150

Polymorphism and mutation databases

BioMutaⁱ	SPN
DMDMⁱ	126213

Proteomic databases

EPDⁱ	P16150
MaxQBⁱ	P16150
PaxDbⁱ	P16150
PeptideAtlasⁱ	P16150
PRIDEⁱ	P16150
ProteomicsDBⁱ	53297

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6693
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000360121; ENSP00000353238; ENSG00000197471 ENST00000395389; ENSP00000378787; ENSG00000197471 ENST00000563039; ENSP00000455266; ENSG00000197471
GeneIDⁱ	6693
KEGGⁱ	hsa:6693
UCSCⁱ	uc002dtm.5 human

Organism-specific databases

CTDⁱ	6693
DisGeNETⁱ	6693
EuPathDBⁱ	HostDB:ENSG00000197471.11
GeneCardsⁱ	SPN
HGNCⁱ	HGNC:11249 SPN
HPAⁱ	CAB002666 HPA055244
MIMⁱ	182160 gene
neXtProtⁱ	NX_P16150
OpenTargetsⁱ	ENSG00000197471
PharmGKBⁱ	PA36079
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J161 Eukaryota ENOG410YXQE LUCA
GeneTreeⁱ	ENSGT00390000017626
HOGENOMⁱ	HOG000294199
HOVERGENⁱ	HBG006258
InParanoidⁱ	P16150
KOⁱ	K06477
OMAⁱ	TGPPVTM
OrthoDBⁱ	EOG091G0MEV
PhylomeDBⁱ	P16150
TreeFamⁱ	TF337688

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-210991 Basigin interactions

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210991 Basigin interactions

Miscellaneous databases

GeneWikiⁱ	CD43
PMAP-CutDBⁱ	P16150
Protein Ontology More...PROⁱ	PR:P16150
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197471 Expressed in 208 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_SPN
ExpressionAtlasⁱ	P16150 baseline and differential
Genevisibleⁱ	P16150 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR038829 Leukosialin
PANTHERⁱ	PTHR35265 PTHR35265, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LEUK_HUMAN
Accessionⁱ	P16150Primary (citable) accession number: P16150 Secondary accession number(s): A8K9B1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	April 1, 1990
	Last modified:	September 12, 2018
	This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P16150 (LEUK_HUMAN)

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Leukosialin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ