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UniProtKB - P16150 (LEUK_HUMAN)

Entry version 188 (02 Jun 2021)
Sequence version 1 (01 Apr 1990)
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Protein

Leukosialin

Gene

SPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity).

Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4+ T-cells and to a lesser extent by CD8+ T-cells (PubMed:18036228).

Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034).

Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).

By similarity2 Publications

Protects cells from apoptotic signals, promoting cell survival.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16150

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-210991, Basigin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukosialin
Alternative name(s):
GPL1151 Publication
Galactoglycoprotein
Short name:
GALGP
Leukocyte sialoglycoprotein
Sialophorin
CD_antigen: CD43
Cleaved into the following chain:
CD43 cytoplasmic tail1 Publication
Short name:
CD43-ct1 Publication
Short name:
CD43ct1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPN
Synonyms:CD43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11249, SPN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182160, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16150

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197471.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 253ExtracellularSequence analysisAdd BLAST234
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei254 – 276HelicalSequence analysisAdd BLAST23
Topological domaini277 – 400CytoplasmicSequence analysisAdd BLAST124

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6693

Open Targets

More...OpenTargetsi		ENSG00000197471

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36079

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16150, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPN

Domain mapping of disease mutations (DMDM)

More...DMDMi		126213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002158820 – 400LeukosialinAdd BLAST381
ChainiPRO_0000443406277 – 400CD43 cytoplasmic tailBy similarityAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21O-linked (GalNAc...) threonine1 Publication1
Glycosylationi22O-linked (GalNAc...) threonine1 Publication1
Glycosylationi26O-linked (GalNAc...) threonine1 Publication1
Glycosylationi28O-linked (GalNAc...) threonine1 Publication1
Glycosylationi29O-linked (GalNAc...) serine1 Publication1
Glycosylationi35O-linked (GalNAc...) serine1 Publication1
Glycosylationi36O-linked (GalNAc...) threonine1 Publication1
Glycosylationi37O-linked (GalNAc...) serine1 Publication1
Glycosylationi41O-linked (GalNAc...) serine1 Publication1
Glycosylationi42O-linked (GalNAc...) serine1 Publication1
Glycosylationi46O-linked (GalNAc...) threonine1 Publication1
Glycosylationi47O-linked (GalNAc...) threonine1 Publication1
Glycosylationi48O-linked (GalNAc...) serine1 Publication1
Glycosylationi50O-linked (GalNAc...) threonine1 Publication1
Glycosylationi58O-linked (GalNAc...) threonine1 Publication1
Glycosylationi69O-linked (GalNAc...) threonine1 Publication1
Glycosylationi99O-linked (GalNAc...) serine1 Publication1
Glycosylationi103O-linked (GalNAc...) serine1 Publication1
Glycosylationi109O-linked (GalNAc...) threonine1 Publication1
Glycosylationi113O-linked (GalNAc...) threonine1 Publication1
Glycosylationi114O-linked (GalNAc...) serine1 Publication1
Glycosylationi136O-linked (GalNAc...) threonine1 Publication1
Glycosylationi137O-linked (GalNAc...) threonine1 Publication1
Glycosylationi173O-linked (GalNAc...) threonine1 Publication1
Glycosylationi178O-linked (GalNAc...) threonine1 Publication1
Glycosylationi239N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei291PhosphoserineCombined sources1 Publication1
Modified residuei336PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei351PhosphoserineCombined sources1 Publication1
Modified residuei355Phosphoserine; by PKC/PRKCQCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.1 Publication
Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes.By similarity
Has a high content of sialic acid and O-linked carbohydrate structures.
Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus.2 Publications
Sumoylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P16150

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16150

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16150

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16150

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16150

PeptideAtlas

More...PeptideAtlasi		P16150

PRoteomics IDEntifications database

More...PRIDEi		P16150

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53297

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		340, 11 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16150, 28 sites, 8 O-linked glycans (27 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16150

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16150

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197471, Expressed in buccal mucosa cell and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16150, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16150, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197471, Group enriched (blood, bone marrow, lung, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIPK2 via the cytoplasmic domain.

Interacts with SIGLEC1, RDX, EZR and MSN.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112571, 22 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P16150

Protein interaction database and analysis system

More...IntActi		P16150, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353238

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16150, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 224DisorderedSequence analysisAdd BLAST204
Regioni278 – 308Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST31
Regioni320 – 400DisorderedSequence analysisAdd BLAST81

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SBHY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038831_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16150

Identification of Orthologs from Complete Genome Data

More...OMAi		RRKSHQG

Database of Orthologous Groups

More...OrthoDBi		1178463at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16150

TreeFam database of animal gene trees

More...TreeFami		TF337688

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038829, Leukosialin

The PANTHER Classification System

More...PANTHERi		PTHR35265, PTHR35265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P16150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT 
        60         70         80         90        100
SDPKADSTGD QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI 
       110        120        130        140        150
KMSSVPQETP HATSHPAVPI TANSLGSHTV TGGTITTNSP ETSSRTSGAP 
       160        170        180        190        200
VTTAASSLET SRGTSGPPLT MATVSLETSK GTSGPPVTMA TDSLETSTGT 
       210        220        230        240        250
TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA STVPFRNPDE 
       260        270        280        290        300
NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV 
       310        320        330        340        350
DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK 
       360        370        380        390        400
SRQGSLAMEE LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP
Length:400
Mass (Da):40,322
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9C9AB8435D5E1FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUK7C9JUK7_HUMAN
Leukosialin
SPN
355Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05109122T → I. Corresponds to variant dbSNP:rs2229653EnsemblClinVar.1
Natural variantiVAR_05109293T → A. Corresponds to variant dbSNP:rs2229654EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04168 mRNA Translation: AAA59510.1
J04536 mRNA Translation: AAB59540.1
X52075 Genomic DNA Translation: CAA36294.1
M61827 Genomic DNA Translation: AAA51949.1
AK292626 mRNA Translation: BAF85315.1
AK313750 mRNA Translation: BAG36490.1
CH471238 Genomic DNA Translation: EAW80015.1
BC012350 mRNA Translation: AAH12350.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10650.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39822

NCBI Reference Sequences

More...RefSeqi		NP_001025459.1, NM_001030288.2
NP_003114.1, NM_003123.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360121; ENSP00000353238; ENSG00000197471
ENST00000395389; ENSP00000378787; ENSG00000197471
ENST00000563039; ENSP00000455266; ENSG00000197471
ENST00000652691; ENSP00000498852; ENSG00000197471

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6693

UCSC genome browser

More...UCSCi		uc002dtm.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04168 mRNA Translation: AAA59510.1
J04536 mRNA Translation: AAB59540.1
X52075 Genomic DNA Translation: CAA36294.1
M61827 Genomic DNA Translation: AAA51949.1
AK292626 mRNA Translation: BAF85315.1
AK313750 mRNA Translation: BAG36490.1
CH471238 Genomic DNA Translation: EAW80015.1
BC012350 mRNA Translation: AAH12350.1
CCDSiCCDS10650.1
PIRiA39822
RefSeqiNP_001025459.1, NM_001030288.2
NP_003114.1, NM_003123.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112571, 22 interactors
CORUMiP16150
IntActiP16150, 12 interactors
STRINGi9606.ENSP00000353238

PTM databases

GlyConnecti340, 11 O-Linked glycans
GlyGeniP16150, 28 sites, 8 O-linked glycans (27 sites)
iPTMnetiP16150
PhosphoSitePlusiP16150

Genetic variation databases

BioMutaiSPN
DMDMi126213

Proteomic databases

EPDiP16150
jPOSTiP16150
MassIVEiP16150
MaxQBiP16150
PaxDbiP16150
PeptideAtlasiP16150
PRIDEiP16150
ProteomicsDBi53297

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3627, 2185 antibodies

The DNASU plasmid repository

More...DNASUi		6693

Genome annotation databases

EnsembliENST00000360121; ENSP00000353238; ENSG00000197471
ENST00000395389; ENSP00000378787; ENSG00000197471
ENST00000563039; ENSP00000455266; ENSG00000197471
ENST00000652691; ENSP00000498852; ENSG00000197471
GeneIDi6693
KEGGihsa:6693
UCSCiuc002dtm.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6693
DisGeNETi6693

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPN
HGNCiHGNC:11249, SPN
HPAiENSG00000197471, Group enriched (blood, bone marrow, lung, lymphoid tissue)
MIMi182160, gene
neXtProtiNX_P16150
OpenTargetsiENSG00000197471
PharmGKBiPA36079
VEuPathDBiHostDB:ENSG00000197471.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SBHY, Eukaryota
GeneTreeiENSGT00390000017626
HOGENOMiCLU_038831_0_1_1
InParanoidiP16150
OMAiRRKSHQG
OrthoDBi1178463at2759
PhylomeDBiP16150
TreeFamiTF337688

Enzyme and pathway databases

PathwayCommonsiP16150
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-210991, Basigin interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6693, 9 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPN, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD43

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6693
PharosiP16150, Tbio

Protein Ontology

More...PROi		PR:P16150
RNActiP16150, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197471, Expressed in buccal mucosa cell and 220 other tissues
ExpressionAtlasiP16150, baseline and differential
GenevisibleiP16150, HS

Family and domain databases

InterProiView protein in InterPro
IPR038829, Leukosialin
PANTHERiPTHR35265, PTHR35265, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEUK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16150
Secondary accession number(s): A8K9B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 2, 2021
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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