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UniProtKB - P16112 (PGCA_HUMAN)

Entry version 222 (29 Sep 2021)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Aggrecan core protein

Gene

ACAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2381Calcium 1By similarity1
Metal bindingi2385Calcium 1By similarity1
Metal bindingi2385Calcium 3By similarity1
Metal bindingi2405Calcium 2By similarity1
Metal bindingi2407Calcium 2By similarity1
Metal bindingi2408Calcium 1By similarity1
Metal bindingi2414Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi2414Calcium 2By similarity1
Metal bindingi2415Calcium 1By similarity1
Metal bindingi2415Calcium 3By similarity1
Metal bindingi2428Calcium 2By similarity1
Metal bindingi2429Calcium 2By similarity1
Metal bindingi2429Calcium 2; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16112

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-2022857, Keratan sulfate degradation
R-HSA-3000178, ECM proteoglycans
R-HSA-3656225, Defective CHST6 causes MCDC1
R-HSA-3656243, Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P16112

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aggrecan core protein
Alternative name(s):
Cartilage-specific proteoglycan core protein
Short name:
CSPCP
Chondroitin sulfate proteoglycan core protein 1
Short name:
Chondroitin sulfate proteoglycan 1
Cleaved into the following chain:
Aggrecan core protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACAN
Synonyms:AGC1, CSPG1, MSK16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:319, ACAN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		155760, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16112

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000157766

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloepiphyseal dysplasia type Kimberley (SEDK)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSpondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
Related information in OMIM
Spondyloepimetaphyseal dysplasia, aggrecan type (SEMDAG)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0630532381D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568Ensembl.1
Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by short stature, advanced bone maturation, early-onset osteoarthritis, and mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disk disease and osteochondritis dissecans. Osteochondritis dissecans is defined as a separation of cartilage and subchondral bone from the surrounding tissue.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637652418V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl.1

Keywords - Diseasei

Disease variant, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		176

MalaCards human disease database

More...MalaCardsi		ACAN
MIMi165800, phenotype
608361, phenotype
612813, phenotype

Open Targets

More...OpenTargetsi		ENSG00000157766

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		251262, Familial osteochondritis dissecans
435804, Short stature-advanced bone age-early-onset osteoarthritis syndrome
171866, Spondyloepimetaphyseal dysplasia, aggrecan type
93283, Spondyloepiphyseal dysplasia, Kimberley type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24616

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16112, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02255, Ilomastat

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACAN

Domain mapping of disease mutations (DMDM)

More...DMDMi		129886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001750517 – 2530Aggrecan core proteinAdd BLAST2514
ChainiPRO_0000017506393 – 2530Aggrecan core protein 2Add BLAST2138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 133By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 246By similarity
Disulfide bondi199 ↔ 220By similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 348By similarity
Disulfide bondi297 ↔ 318By similarity
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371O-linked (Xyl...) (keratan sulfate) threonine1 Publication1
Glycosylationi376O-linked (Xyl...) (keratan sulfate) threonine1 Publication1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 571By similarity
Disulfide bondi524 ↔ 545By similarity
Disulfide bondi598 ↔ 673By similarity
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 643By similarity
Glycosylationi658N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2013N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2283 ↔ 2293By similarity
Disulfide bondi2288 ↔ 2302By similarity
Disulfide bondi2304 ↔ 2313By similarity
Disulfide bondi2320 ↔ 2331By similarity
Disulfide bondi2348 ↔ 2440By similarity
Disulfide bondi2416 ↔ 2432By similarity
Disulfide bondi2447 ↔ 2490By similarity
Disulfide bondi2476 ↔ 2503By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei392 – 393Cleavage; by aggrecanase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16112

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16112

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16112

PeptideAtlas

More...PeptideAtlasi		P16112

PRoteomics IDEntifications database

More...PRIDEi		P16112

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		17235
19009
40179
53288 [P16112-1]
53289 [P16112-2]
53290 [P16112-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2002, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16112, 82 sites, 5 N-linked glycans (1 site), 10 O-linked glycans (73 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16112

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16112

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to cartilages.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression was detected in chondrocytes throughout the developing skeleton.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157766, Expressed in tibia and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16112, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FBLN1 (By similarity).

Interacts with COMP.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P16112, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000387356

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16112, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16112

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 147Ig-like V-typeAdd BLAST114
Domaini153 – 248Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini254 – 350Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini478 – 573Link 3PROSITE-ProRule annotationAdd BLAST96
Domaini579 – 675Link 4PROSITE-ProRule annotationAdd BLAST97
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati773 – 7781-16
Repeati779 – 7841-26
Repeati785 – 7901-36
Repeati791 – 7961-46
Repeati797 – 8021-56
Repeati803 – 8081-66
Repeati809 – 8141-7; approximate6
Repeati815 – 8201-8; approximate6
Repeati821 – 8261-96
Repeati827 – 8321-10; approximate6
Repeati833 – 8381-116
Repeati839 – 8441-126
Repeati942 – 9602-1Add BLAST19
Repeati961 – 9792-2Add BLAST19
Repeati980 – 9982-3Add BLAST19
Repeati999 – 10172-4Add BLAST19
Repeati1018 – 10362-5Add BLAST19
Repeati1037 – 10552-6Add BLAST19
Repeati1056 – 10742-7Add BLAST19
Repeati1075 – 10932-8Add BLAST19
Repeati1094 – 11122-9Add BLAST19
Repeati1113 – 11312-10Add BLAST19
Repeati1132 – 11502-11Add BLAST19
Repeati1151 – 11692-12Add BLAST19
Repeati1170 – 11882-13Add BLAST19
Repeati1189 – 12072-14Add BLAST19
Repeati1208 – 12262-15Add BLAST19
Repeati1227 – 12452-16Add BLAST19
Repeati1246 – 12642-17Add BLAST19
Repeati1265 – 12832-18Add BLAST19
Repeati1284 – 13022-19Add BLAST19
Repeati1303 – 13212-20Add BLAST19
Repeati1322 – 13402-21Add BLAST19
Repeati1341 – 13592-22Add BLAST19
Repeati1360 – 13782-23Add BLAST19
Repeati1379 – 13972-24Add BLAST19
Repeati1398 – 14162-25Add BLAST19
Repeati1417 – 14352-26Add BLAST19
Repeati1436 – 14542-27Add BLAST19
Repeati1455 – 14732-28Add BLAST19
Repeati1475 – 14932-29Add BLAST19
Repeati1494 – 15122-30Add BLAST19
Repeati1513 – 15312-31Add BLAST19
Repeati1533 – 15512-32Add BLAST19
Repeati1553 – 15722-33; approximateAdd BLAST20
Repeati1574 – 15922-34Add BLAST19
Repeati1594 – 16122-35Add BLAST19
Domaini2279 – 2314EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini2327 – 2441C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini2445 – 2505SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni48 – 141G1-AAdd BLAST94
Regioni152 – 247G1-BAdd BLAST96
Regioni253 – 349G1-B'Add BLAST97
Regioni477 – 571G2-BAdd BLAST95
Regioni578 – 673G2-B'Add BLAST96
Regioni677 – 849KSAdd BLAST173
Regioni734 – 979DisorderedSequence analysisAdd BLAST246
Regioni773 – 84412 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]Add BLAST72
Regioni852 – 1612CS-1Add BLAST761
Regioni942 – 161235 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]-[GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-GAdd BLAST671
Regioni1499 – 1526DisorderedSequence analysisAdd BLAST28
Regioni1543 – 1649DisorderedSequence analysisAdd BLAST107
Regioni1613 – 2277CS-2Add BLAST665
Regioni1687 – 1772DisorderedSequence analysisAdd BLAST86
Regioni1784 – 1827DisorderedSequence analysisAdd BLAST44
Regioni1883 – 1902DisorderedSequence analysisAdd BLAST20
Regioni1948 – 1977DisorderedSequence analysisAdd BLAST30
Regioni2048 – 2204DisorderedSequence analysisAdd BLAST157
Regioni2249 – 2281DisorderedSequence analysisAdd BLAST33
Regioni2278 – 2530G3Add BLAST253
Regioni2510 – 2530DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi765 – 785Polar residuesSequence analysisAdd BLAST21
Compositional biasi792 – 808Pro residuesSequence analysisAdd BLAST17
Compositional biasi898 – 913Polar residuesSequence analysisAdd BLAST16
Compositional biasi1615 – 1629Polar residuesSequence analysisAdd BLAST15
Compositional biasi1709 – 1723Polar residuesSequence analysisAdd BLAST15
Compositional biasi1739 – 1772Polar residuesSequence analysisAdd BLAST34
Compositional biasi1812 – 1827Polar residuesSequence analysisAdd BLAST16
Compositional biasi2048 – 2077Polar residuesSequence analysisAdd BLAST30
Compositional biasi2093 – 2107Polar residuesSequence analysisAdd BLAST15
Compositional biasi2126 – 2159Polar residuesSequence analysisAdd BLAST34
Compositional biasi2166 – 2204Polar residuesSequence analysisAdd BLAST39
Compositional biasi2513 – 2530Basic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUX8, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155971

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16112

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16112

TreeFam database of animal gene trees

More...TreeFami		TF332134

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.100.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 5 hits
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit
PS01241, LINK_1, 4 hits
PS50963, LINK_2, 4 hits
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16112-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP 
        60         70         80         90        100
CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY 
       110        120        130        140        150
QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV 
       160        170        180        190        200
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD 
       210        220        230        240        250
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE 
       260        270        280        290        300
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG 
       310        320        330        340        350
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT 
       360        370        380        390        400
GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT 
       410        420        430        440        450
VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL 
       460        470        480        490        500
GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC 
       510        520        530        540        550
LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD 
       560        570        580        590        600
SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES 
       610        620        630        640        650
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV 
       660        670        680        690        700
RTVYLYPNQT GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW 
       710        720        730        740        750
IVTQVVPGVA AVPVEEETTA VPSGETTAIL EFTTEPENQT EWEPAYTPVG 
       760        770        780        790        800
TSPLPGILPT WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS 
       810        820        830        840        850
PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS 
       860        870        880        890        900
WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD 
       910        920        930        940        950
SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG 
       960        970        980        990       1000
VGDLSGLPSG EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV 
      1010       1020       1030       1040       1050
LETTAPGVED ISGLPSGEVL ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS 
      1060       1070       1080       1090       1100
GLPSGEVLET TAPGVEDISG LPSGEVLETT APGVEDISGL PSGEVLETAA 
      1110       1120       1130       1140       1150
PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG 
      1160       1170       1180       1190       1200
EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED 
      1210       1220       1230       1240       1250
ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET 
      1260       1270       1280       1290       1300
AAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP 
      1310       1320       1330       1340       1350
SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV 
      1360       1370       1380       1390       1400
EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED ISGLPSGEVL 
      1410       1420       1430       1440       1450
ETTAPGVEEI SGLPSGEVLE TTAPGVDEIS GLPSGEVLET TAPGVEEISG 
      1460       1470       1480       1490       1500
LPSGEVLETS TSAVGDLSGL PSGGEVLEIS VSGVEDISGL PSGEVVETSA 
      1510       1520       1530       1540       1550
SGIEDVSELP SGEGLETSAS GVEDLSRLPS GEEVLEISAS GFGDLSGLPS 
      1560       1570       1580       1590       1600
GGEGLETSAS EVGTDLSGLP SGREGLETSA SGAEDLSGLP SGKEDLVGSA 
      1610       1620       1630       1640       1650
SGDLDLGKLP SGTLGSGQAP ETSGLPSGFS GEYSGVDLGS GPPSGLPDFS 
      1660       1670       1680       1690       1700
GLPSGFPTVS LVDSTLVEVV TASTASELEG RGTIGISGAG EISGLPSSEL 
      1710       1720       1730       1740       1750
DISGRASGLP SGTELSGQAS GSPDVSGEIP GLFGVSGQPS GFPDTSGETS 
      1760       1770       1780       1790       1800
GVTELSGLSS GQPGISGEAS GVLYGTSQPF GITDLSGETS GVPDLSGQPS 
      1810       1820       1830       1840       1850
GLPGFSGATS GVPDLVSGTT SGSGESSGIT FVDTSLVEVA PTTFKEEEGL 
      1860       1870       1880       1890       1900
GSVELSGLPS GEADLSGKSG MVDVSGQFSG TVDSSGFTSQ TPEFSGLPSG 
      1910       1920       1930       1940       1950
IAEVSGESSR AEIGSSLPSG AYYGSGTPSS FPTVSLVDRT LVESVTQAPT 
      1960       1970       1980       1990       2000
AQEAGEGPSG ILELSGAHSG APDMSGEHSG FLDLSGLQSG LIEPSGEPPG 
      2010       2020       2030       2040       2050
TPYFSGDFAS TTNVSGESSV AMGTSGEASG LPEVTLITSE FVEGVTEPTI 
      2060       2070       2080       2090       2100
SQELGQRPPV THTPQLFESS GKVSTAGDIS GATPVLPGSG VEVSSVPESS 
      2110       2120       2130       2140       2150
SETSAYPEAG FGASAAPEAS REDSGSPDLS ETTSAFHEAN LERSSGLGVS 
      2160       2170       2180       2190       2200
GSTLTFQEGE ASAAPEVSGE STTTSDVGTE APGLPSATPT ASGDRTEISG 
      2210       2220       2230       2240       2250
DLSGHTSQLG VVISTSIPES EWTQQTQRPA ETHLEIESSS LLYSGEETHT 
      2260       2270       2280       2290       2300
VETATSPTDA SIPASPEWKR ESESTAAAPA RSCAEEPCGA GTCKETEGHV 
      2310       2320       2330       2340       2350
ICLCPPGYTG EHCNIDQEVC EEGWNKYQGH CYRHFPDRET WVDAERRCRE 
      2360       2370       2380       2390       2400
QQSHLSSIVT PEEQEFVNNN AQDYQWIGLN DRTIEGDFRW SDGHPMQFEN 
      2410       2420       2430       2440       2450
WRPNQPDNFF AAGEDCVVMI WHEKGEWNDV PCNYHLPFTC KKGTVACGEP 
      2460       2470       2480       2490       2500
PVVEHARTFG QKKDRYEINS LVRYQCTEGF VQRHMPTIRC QPSGHWEEPQ 
      2510       2520       2530
ITCTDPTTYK RRLQKRSSRH PRRSRPSTAH
Length:2,530
Mass (Da):261,329
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C809F6DE829956B
GO
Isoform 2 (identifier: P16112-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2278-2315: Missing.

Show »
Length:2,492
Mass (Da):257,441
Checksum:i8473F19E0104B24D
GO
Isoform 3 (identifier: P16112-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2278-2315: Missing.
     2445-2506: VACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDP → A

Show »
Length:2,431
Mass (Da):250,372
Checksum:iE9A15851313D2B30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMF1H0YMF1_HUMAN
Aggrecan core protein
ACAN
2,568Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW97A0A5K1VW97_HUMAN
Aggrecan core protein
ACAN
2,530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PID9Q6PID9_HUMAN
Aggrecan
ACAN
721Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK70H0YK70_HUMAN
Aggrecan core protein
ACAN
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti285 – 286QL → HV in AAA62824 (PubMed:1985970).Curated2
Sequence conflicti501 – 502LR → PG in AAA62824 (PubMed:1985970).Curated2
Sequence conflicti605Missing in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti767A → E in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti848V → E in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti999 – 1017Missing in AAI50625 (PubMed:15489334).CuratedAdd BLAST19
Sequence conflicti1075 – 1188Missing in AAA62824 (PubMed:1985970).CuratedAdd BLAST114
Sequence conflicti1548L → V in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti2043E → A in CAA35463 (PubMed:8611178).Curated1
Sequence conflicti2185P → A in AAA35726 (PubMed:2789216).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056152102D → E. Corresponds to variant dbSNP:rs16942318Ensembl.1
Natural variantiVAR_056153275R → Q. Corresponds to variant dbSNP:rs34949187EnsemblClinVar.1
Natural variantiVAR_080159864P → L1 PublicationCorresponds to variant dbSNP:rs3743398Ensembl.1
Natural variantiVAR_080160913P → T1 PublicationCorresponds to variant dbSNP:rs35430524Ensembl.1
Natural variantiVAR_080161930S → I1 PublicationCorresponds to variant dbSNP:rs938608Ensembl.1
Natural variantiVAR_080162939S → T1 PublicationCorresponds to variant dbSNP:rs938609Ensembl.1
Natural variantiVAR_0801631080T → A1 PublicationCorresponds to variant dbSNP:rs373544100Ensembl.1
Natural variantiVAR_0801641403T → A1 PublicationCorresponds to variant dbSNP:rs12899191Ensembl.1
Natural variantiVAR_0801651508E → A1 PublicationCorresponds to variant dbSNP:rs2882676EnsemblClinVar.1
Natural variantiVAR_0801661765I → V2 PublicationsCorresponds to variant dbSNP:rs4932439Ensembl.1
Natural variantiVAR_0561542058P → L. Corresponds to variant dbSNP:rs35061438Ensembl.1
Natural variantiVAR_0801672079I → V3 PublicationsCorresponds to variant dbSNP:rs1042630Ensembl.1
Natural variantiVAR_0561552120S → R. Corresponds to variant dbSNP:rs34153007Ensembl.1
Natural variantiVAR_0801682373D → E1 PublicationCorresponds to variant dbSNP:rs3817428Ensembl.1
Natural variantiVAR_0630532381D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568Ensembl.1
Natural variantiVAR_0637652418V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl.1
Natural variantiVAR_0801692500Q → R2 PublicationsCorresponds to variant dbSNP:rs1126823Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0030742278 – 2315Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_0030752445 – 2506VACGE…TCTDP → A in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M55172 mRNA Translation: AAA62824.1
AC103982 Genomic DNA No translation available.
BC150624 mRNA Translation: AAI50625.1
X80278 mRNA No translation available.
S74659 Genomic DNA Translation: AAC60643.2
X17406 mRNA Translation: CAA35463.1
J05062 mRNA Translation: AAA35726.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53970.1 [P16112-1]
CCDS53971.1 [P16112-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A39086

NCBI Reference Sequences

More...RefSeqi		NP_001126.3, NM_001135.3 [P16112-3]
NP_037359.3, NM_013227.3 [P16112-1]
XP_011519616.1, XM_011521314.1 [P16112-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3]
ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1]
ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		176

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:176

UCSC genome browser

More...UCSCi		uc010upo.1, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Aggrecan

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55172 mRNA Translation: AAA62824.1
AC103982 Genomic DNA No translation available.
BC150624 mRNA Translation: AAI50625.1
X80278 mRNA No translation available.
S74659 Genomic DNA Translation: AAC60643.2
X17406 mRNA Translation: CAA35463.1
J05062 mRNA Translation: AAA35726.1
CCDSiCCDS53970.1 [P16112-1]
CCDS53971.1 [P16112-3]
PIRiA39086
RefSeqiNP_001126.3, NM_001135.3 [P16112-3]
NP_037359.3, NM_013227.3 [P16112-1]
XP_011519616.1, XM_011521314.1 [P16112-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MD4X-ray1.95C89-103[»]
SMRiP16112
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP16112, 3 interactors
STRINGi9606.ENSP00000387356

Chemistry databases

DrugBankiDB02255, Ilomastat

PTM databases

GlyConnecti2002, 3 N-Linked glycans (1 site)
GlyGeniP16112, 82 sites, 5 N-linked glycans (1 site), 10 O-linked glycans (73 sites)
iPTMnetiP16112
PhosphoSitePlusiP16112

Genetic variation databases

BioMutaiACAN
DMDMi129886

Proteomic databases

jPOSTiP16112
MassIVEiP16112
PaxDbiP16112
PeptideAtlasiP16112
PRIDEiP16112
ProteomicsDBi17235
19009
40179
53288 [P16112-1]
53289 [P16112-2]
53290 [P16112-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4288, 543 antibodies

The DNASU plasmid repository

More...DNASUi		176

Genome annotation databases

EnsembliENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3]
ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1]
ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2]
GeneIDi176
KEGGihsa:176
UCSCiuc010upo.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		176
DisGeNETi176

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACAN
HGNCiHGNC:319, ACAN
MalaCardsiACAN
MIMi155760, gene
165800, phenotype
608361, phenotype
612813, phenotype
neXtProtiNX_P16112
OpenTargetsiENSG00000157766
Orphaneti251262, Familial osteochondritis dissecans
435804, Short stature-advanced bone age-early-onset osteoarthritis syndrome
171866, Spondyloepimetaphyseal dysplasia, aggrecan type
93283, Spondyloepiphyseal dysplasia, Kimberley type
PharmGKBiPA24616
VEuPathDBiHostDB:ENSG00000157766

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUX8, Eukaryota
GeneTreeiENSGT00940000155971
InParanoidiP16112
PhylomeDBiP16112
TreeFamiTF332134

Enzyme and pathway databases

PathwayCommonsiP16112
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-2022854, Keratan sulfate biosynthesis
R-HSA-2022857, Keratan sulfate degradation
R-HSA-3000178, ECM proteoglycans
R-HSA-3656225, Defective CHST6 causes MCDC1
R-HSA-3656243, Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
SIGNORiP16112

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		176, 7 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACAN, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		176
PharosiP16112, Tbio

Protein Ontology

More...PROi		PR:P16112
RNActiP16112, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157766, Expressed in tibia and 180 other tissues
ExpressionAtlasiP16112, baseline and differential

Family and domain databases

CDDicd00033, CCP, 1 hit
cd03588, CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 5 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033987, CSPG_CTLD
IPR016187, CTDL_fold
IPR000742, EGF-like_dom
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR013106, Ig_V-set
IPR000538, Link_dom
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
PF00084, Sushi, 1 hit
PF07686, V-set, 1 hit
PF00193, Xlink, 4 hits
PRINTSiPR01265, LINKMODULE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00034, CLECT, 1 hit
SM00181, EGF, 1 hit
SM00409, IG, 1 hit
SM00406, IGv, 1 hit
SM00445, LINK, 4 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF56436, SSF56436, 5 hits
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit
PS01241, LINK_1, 4 hits
PS50963, LINK_2, 4 hits
PS50923, SUSHI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGCA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16112
Secondary accession number(s): B9EK55
, E7ENV9, E7EX88, H0YM81, Q13650, Q9UCD3, Q9UCP4, Q9UCP5, Q9UDE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: March 28, 2018
Last modified: September 29, 2021
This is version 222 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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