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UniProtKB - P16112 (PGCA_HUMAN)

Protein

Aggrecan core protein

Gene

ACAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2381Calcium 1By similarity1
Metal bindingi2385Calcium 1By similarity1
Metal bindingi2385Calcium 3By similarity1
Metal bindingi2405Calcium 2By similarity1
Metal bindingi2407Calcium 2By similarity1
Metal bindingi2408Calcium 1By similarity1
Metal bindingi2414Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi2414Calcium 2By similarity1
Metal bindingi2415Calcium 1By similarity1
Metal bindingi2415Calcium 3By similarity1
Metal bindingi2428Calcium 2By similarity1
Metal bindingi2429Calcium 2By similarity1
Metal bindingi2429Calcium 2; via carbonyl oxygenBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
SIGNORiP16112

Names & Taxonomyi

Protein namesi
Recommended name:
Aggrecan core protein
Alternative name(s):
Cartilage-specific proteoglycan core protein
Short name:
CSPCP
Chondroitin sulfate proteoglycan core protein 1
Short name:
Chondroitin sulfate proteoglycan 1
Cleaved into the following chain:
Aggrecan core protein 2
Gene namesi
Name:ACAN
Synonyms:AGC1, CSPG1, MSK16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000157766.15
HGNCiHGNC:319 ACAN
MIMi155760 gene
neXtProtiNX_P16112

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Spondyloepiphyseal dysplasia type Kimberley (SEDK)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
See also OMIM:608361
Spondyloepimetaphyseal dysplasia, aggrecan type (SEMDAG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.
See also OMIM:612813
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0630532381D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568EnsemblClinVar.1
Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by short stature, advanced bone maturation, early-onset osteoarthritis, and mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disk disease and osteochondritis dissecans. Osteochondritis dissecans is defined as a separation of cartilage and subchondral bone from the surrounding tissue.
See also OMIM:165800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0637652418V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi176
MalaCardsiACAN
MIMi165800 phenotype
608361 phenotype
612813 phenotype
OpenTargetsiENSG00000157766
Orphaneti251262 Familial osteochondritis dissecans
171866 Spondyloepimetaphyseal dysplasia, aggrecan type
93283 Spondyloepiphyseal dysplasia, Kimberley type
PharmGKBiPA24616

Chemistry databases

DrugBankiDB02255 GM6001

Polymorphism and mutation databases

DMDMi129886

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
ChainiPRO_000001750517 – 2530Aggrecan core proteinAdd BLAST2514
ChainiPRO_0000017506393 – 2530Aggrecan core protein 2Add BLAST2138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 133By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi175 ↔ 246By similarity
Disulfide bondi199 ↔ 220By similarity
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 348By similarity
Disulfide bondi297 ↔ 318By similarity
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371O-linked (Xyl...) (keratan sulfate) threonine1 Publication1
Glycosylationi376O-linked (Xyl...) (keratan sulfate) threonine1 Publication1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 571By similarity
Disulfide bondi524 ↔ 545By similarity
Disulfide bondi598 ↔ 673By similarity
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 643By similarity
Glycosylationi658N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2013N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2283 ↔ 2293By similarity
Disulfide bondi2288 ↔ 2302By similarity
Disulfide bondi2304 ↔ 2313By similarity
Disulfide bondi2320 ↔ 2331By similarity
Disulfide bondi2348 ↔ 2440By similarity
Disulfide bondi2416 ↔ 2432By similarity
Disulfide bondi2447 ↔ 2490By similarity
Disulfide bondi2476 ↔ 2503By similarity

Post-translational modificationi

Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei392 – 393Cleavage; by aggrecanase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PeptideAtlasiP16112
PRIDEiP16112
ProteomicsDBi53288
53289 [P16112-2]
53290 [P16112-3]

PTM databases

iPTMnetiP16112
PhosphoSitePlusiP16112

Miscellaneous databases

PMAP-CutDBiP16112

Expressioni

Tissue specificityi

Restricted to cartilages.1 Publication

Developmental stagei

Expression was detected in chondrocytes throughout the developing skeleton.

Gene expression databases

BgeeiENSG00000157766 Expressed in 160 organ(s), highest expression level in tibia
CleanExiHS_ACAN

Organism-specific databases

HPAiHPA038241
HPA038242

Interactioni

Subunit structurei

Interacts with FBLN1 (By similarity). Interacts with COMP.By similarity1 Publication

Protein-protein interaction databases

IntActiP16112, 1 interactor
STRINGi9606.ENSP00000387356

Structurei

3D structure databases

ProteinModelPortaliP16112
SMRiP16112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 147Ig-like V-typeAdd BLAST114
Domaini153 – 248Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini254 – 350Link 2PROSITE-ProRule annotationAdd BLAST97
Domaini478 – 573Link 3PROSITE-ProRule annotationAdd BLAST96
Domaini579 – 675Link 4PROSITE-ProRule annotationAdd BLAST97
Repeati773 – 7781-16
Repeati779 – 7841-26
Repeati785 – 7901-36
Repeati791 – 7961-46
Repeati797 – 8021-56
Repeati803 – 8081-66
Repeati809 – 8141-7; approximate6
Repeati815 – 8201-8; approximate6
Repeati821 – 8261-96
Repeati827 – 8321-10; approximate6
Repeati833 – 8381-116
Repeati839 – 8441-126
Repeati942 – 9602-1Add BLAST19
Repeati961 – 9792-2Add BLAST19
Repeati980 – 9982-3Add BLAST19
Repeati999 – 10172-4Add BLAST19
Repeati1018 – 10362-5Add BLAST19
Repeati1037 – 10552-6Add BLAST19
Repeati1056 – 10742-7Add BLAST19
Repeati1075 – 10932-8Add BLAST19
Repeati1094 – 11122-9Add BLAST19
Repeati1113 – 11312-10Add BLAST19
Repeati1132 – 11502-11Add BLAST19
Repeati1151 – 11692-12Add BLAST19
Repeati1170 – 11882-13Add BLAST19
Repeati1189 – 12072-14Add BLAST19
Repeati1208 – 12262-15Add BLAST19
Repeati1227 – 12452-16Add BLAST19
Repeati1246 – 12642-17Add BLAST19
Repeati1265 – 12832-18Add BLAST19
Repeati1284 – 13022-19Add BLAST19
Repeati1303 – 13212-20Add BLAST19
Repeati1322 – 13402-21Add BLAST19
Repeati1341 – 13592-22Add BLAST19
Repeati1360 – 13782-23Add BLAST19
Repeati1379 – 13972-24Add BLAST19
Repeati1398 – 14162-25Add BLAST19
Repeati1417 – 14352-26Add BLAST19
Repeati1436 – 14542-27Add BLAST19
Repeati1455 – 14732-28Add BLAST19
Repeati1475 – 14932-29Add BLAST19
Repeati1494 – 15122-30Add BLAST19
Repeati1513 – 15312-31Add BLAST19
Repeati1533 – 15512-32Add BLAST19
Repeati1553 – 15722-33; approximateAdd BLAST20
Repeati1574 – 15922-34Add BLAST19
Repeati1594 – 16122-35Add BLAST19
Domaini2279 – 2314EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini2327 – 2441C-type lectinPROSITE-ProRule annotationAdd BLAST115
Domaini2445 – 2505SushiPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 141G1-AAdd BLAST94
Regioni152 – 247G1-BAdd BLAST96
Regioni253 – 349G1-B'Add BLAST97
Regioni477 – 571G2-BAdd BLAST95
Regioni578 – 673G2-B'Add BLAST96
Regioni677 – 849KSAdd BLAST173
Regioni773 – 84412 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]Add BLAST72
Regioni852 – 1612CS-1Add BLAST761
Regioni942 – 161235 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]-[GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-GAdd BLAST671
Regioni1613 – 2277CS-2Add BLAST665
Regioni2278 – 2530G3Add BLAST253

Domaini

Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.

Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJP2 Eukaryota
ENOG410XRES LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000168421
HOVERGENiHBG007982
InParanoidiP16112
KOiK06792
OMAiDTNETYD
PhylomeDBiP16112
TreeFamiTF332134

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 5 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 4 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 4 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 5 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 4 hits
PS50963 LINK_2, 4 hits
PS50923 SUSHI, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16112-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP 
        60         70         80         90        100
CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY 
       110        120        130        140        150
QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV 
       160        170        180        190        200
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD 
       210        220        230        240        250
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE 
       260        270        280        290        300
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG 
       310        320        330        340        350
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT 
       360        370        380        390        400
GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT 
       410        420        430        440        450
VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL 
       460        470        480        490        500
GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC 
       510        520        530        540        550
LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD 
       560        570        580        590        600
SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES 
       610        620        630        640        650
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV 
       660        670        680        690        700
RTVYLYPNQT GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW 
       710        720        730        740        750
IVTQVVPGVA AVPVEEETTA VPSGETTAIL EFTTEPENQT EWEPAYTPVG 
       760        770        780        790        800
TSPLPGILPT WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS 
       810        820        830        840        850
PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS 
       860        870        880        890        900
WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD 
       910        920        930        940        950
SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG 
       960        970        980        990       1000
VGDLSGLPSG EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV 
      1010       1020       1030       1040       1050
LETTAPGVED ISGLPSGEVL ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS 
      1060       1070       1080       1090       1100
GLPSGEVLET TAPGVEDISG LPSGEVLETT APGVEDISGL PSGEVLETAA 
      1110       1120       1130       1140       1150
PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG 
      1160       1170       1180       1190       1200
EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED 
      1210       1220       1230       1240       1250
ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET 
      1260       1270       1280       1290       1300
AAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP 
      1310       1320       1330       1340       1350
SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV 
      1360       1370       1380       1390       1400
EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED ISGLPSGEVL 
      1410       1420       1430       1440       1450
ETTAPGVEEI SGLPSGEVLE TTAPGVDEIS GLPSGEVLET TAPGVEEISG 
      1460       1470       1480       1490       1500
LPSGEVLETS TSAVGDLSGL PSGGEVLEIS VSGVEDISGL PSGEVVETSA 
      1510       1520       1530       1540       1550
SGIEDVSELP SGEGLETSAS GVEDLSRLPS GEEVLEISAS GFGDLSGLPS 
      1560       1570       1580       1590       1600
GGEGLETSAS EVGTDLSGLP SGREGLETSA SGAEDLSGLP SGKEDLVGSA 
      1610       1620       1630       1640       1650
SGDLDLGKLP SGTLGSGQAP ETSGLPSGFS GEYSGVDLGS GPPSGLPDFS 
      1660       1670       1680       1690       1700
GLPSGFPTVS LVDSTLVEVV TASTASELEG RGTIGISGAG EISGLPSSEL 
      1710       1720       1730       1740       1750
DISGRASGLP SGTELSGQAS GSPDVSGEIP GLFGVSGQPS GFPDTSGETS 
      1760       1770       1780       1790       1800
GVTELSGLSS GQPGISGEAS GVLYGTSQPF GITDLSGETS GVPDLSGQPS 
      1810       1820       1830       1840       1850
GLPGFSGATS GVPDLVSGTT SGSGESSGIT FVDTSLVEVA PTTFKEEEGL 
      1860       1870       1880       1890       1900
GSVELSGLPS GEADLSGKSG MVDVSGQFSG TVDSSGFTSQ TPEFSGLPSG 
      1910       1920       1930       1940       1950
IAEVSGESSR AEIGSSLPSG AYYGSGTPSS FPTVSLVDRT LVESVTQAPT 
      1960       1970       1980       1990       2000
AQEAGEGPSG ILELSGAHSG APDMSGEHSG FLDLSGLQSG LIEPSGEPPG 
      2010       2020       2030       2040       2050
TPYFSGDFAS TTNVSGESSV AMGTSGEASG LPEVTLITSE FVEGVTEPTI 
      2060       2070       2080       2090       2100
SQELGQRPPV THTPQLFESS GKVSTAGDIS GATPVLPGSG VEVSSVPESS 
      2110       2120       2130       2140       2150
SETSAYPEAG FGASAAPEAS REDSGSPDLS ETTSAFHEAN LERSSGLGVS 
      2160       2170       2180       2190       2200
GSTLTFQEGE ASAAPEVSGE STTTSDVGTE APGLPSATPT ASGDRTEISG 
      2210       2220       2230       2240       2250
DLSGHTSQLG VVISTSIPES EWTQQTQRPA ETHLEIESSS LLYSGEETHT 
      2260       2270       2280       2290       2300
VETATSPTDA SIPASPEWKR ESESTAAAPA RSCAEEPCGA GTCKETEGHV 
      2310       2320       2330       2340       2350
ICLCPPGYTG EHCNIDQEVC EEGWNKYQGH CYRHFPDRET WVDAERRCRE 
      2360       2370       2380       2390       2400
QQSHLSSIVT PEEQEFVNNN AQDYQWIGLN DRTIEGDFRW SDGHPMQFEN 
      2410       2420       2430       2440       2450
WRPNQPDNFF AAGEDCVVMI WHEKGEWNDV PCNYHLPFTC KKGTVACGEP 
      2460       2470       2480       2490       2500
PVVEHARTFG QKKDRYEINS LVRYQCTEGF VQRHMPTIRC QPSGHWEEPQ 
      2510       2520       2530
ITCTDPTTYK RRLQKRSSRH PRRSRPSTAH
Length:2,530
Mass (Da):261,329
Last modified:March 28, 2018 - v3
Checksum:i3C809F6DE829956B
GO
Isoform 2 (identifier: P16112-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2278-2315: Missing.

Show »
Length:2,492
Mass (Da):257,441
Checksum:i8473F19E0104B24D
GO
Isoform 3 (identifier: P16112-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2278-2315: Missing.
     2445-2506: VACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDP → A

Show »
Length:2,431
Mass (Da):250,372
Checksum:iE9A15851313D2B30
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMF1H0YMF1_HUMAN
Aggrecan core protein
ACAN
2,568Annotation score:
Q6PID9Q6PID9_HUMAN
Aggrecan
ACAN
721Annotation score:
A0A087X1T7A0A087X1T7_HUMAN
Aggrecan core protein
ACAN
2,473Annotation score:
H0YK70H0YK70_HUMAN
Aggrecan core protein
ACAN
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285 – 286QL → HV in AAA62824 (PubMed:1985970).Curated2
Sequence conflicti501 – 502LR → PG in AAA62824 (PubMed:1985970).Curated2
Sequence conflicti605Missing in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti767A → E in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti848V → E in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti999 – 1017Missing in AAI50625 (PubMed:15489334).CuratedAdd BLAST19
Sequence conflicti1075 – 1188Missing in AAA62824 (PubMed:1985970).CuratedAdd BLAST114
Sequence conflicti1548L → V in AAA62824 (PubMed:1985970).Curated1
Sequence conflicti2043E → A in CAA35463 (PubMed:8611178).Curated1
Sequence conflicti2185P → A in AAA35726 (PubMed:2789216).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056152102D → E. Corresponds to variant dbSNP:rs16942318Ensembl.1
Natural variantiVAR_056153275R → Q. Corresponds to variant dbSNP:rs34949187Ensembl.1
Natural variantiVAR_080159864P → L1 PublicationCorresponds to variant dbSNP:rs3743398Ensembl.1
Natural variantiVAR_080160913P → T1 PublicationCorresponds to variant dbSNP:rs35430524Ensembl.1
Natural variantiVAR_080161930S → I1 PublicationCorresponds to variant dbSNP:rs938608Ensembl.1
Natural variantiVAR_080162939S → T1 PublicationCorresponds to variant dbSNP:rs938609Ensembl.1
Natural variantiVAR_0801631080T → A1 PublicationCorresponds to variant dbSNP:rs373544100Ensembl.1
Natural variantiVAR_0801641403T → A1 PublicationCorresponds to variant dbSNP:rs12899191Ensembl.1
Natural variantiVAR_0801651508E → A1 PublicationCorresponds to variant dbSNP:rs2882676EnsemblClinVar.1
Natural variantiVAR_0801661765I → V2 PublicationsCorresponds to variant dbSNP:rs4932439Ensembl.1
Natural variantiVAR_0561542058P → L. Corresponds to variant dbSNP:rs35061438Ensembl.1
Natural variantiVAR_0801672079I → V3 PublicationsCorresponds to variant dbSNP:rs1042630Ensembl.1
Natural variantiVAR_0561552120S → R. Corresponds to variant dbSNP:rs34153007Ensembl.1
Natural variantiVAR_0801682373D → E1 PublicationCorresponds to variant dbSNP:rs3817428Ensembl.1
Natural variantiVAR_0630532381D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568EnsemblClinVar.1
Natural variantiVAR_0637652418V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl.1
Natural variantiVAR_0801692500Q → R2 PublicationsCorresponds to variant dbSNP:rs1126823Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0030742278 – 2315Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_0030752445 – 2506VACGE…TCTDP → A in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55172 mRNA Translation: AAA62824.1
AC103982 Genomic DNA No translation available.
BC150624 mRNA Translation: AAI50625.1
X80278 mRNA No translation available.
S74659 Genomic DNA Translation: AAC60643.2
X17406 mRNA Translation: CAA35463.1
J05062 mRNA Translation: AAA35726.1
CCDSiCCDS53970.1 [P16112-1]
CCDS53971.1 [P16112-3]
PIRiA39086
RefSeqiNP_001126.3, NM_001135.3 [P16112-3]
NP_037359.3, NM_013227.3 [P16112-1]
XP_011519616.1, XM_011521314.1 [P16112-2]
UniGeneiHs.2159
Hs.616395

Genome annotation databases

EnsembliENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3]
ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1]
ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2]
ENST00000561243; ENSP00000453342; ENSG00000157766 [P16112-1]
GeneIDi176
KEGGihsa:176
UCSCiuc010upo.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Aggrecan

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55172 mRNA Translation: AAA62824.1
AC103982 Genomic DNA No translation available.
BC150624 mRNA Translation: AAI50625.1
X80278 mRNA No translation available.
S74659 Genomic DNA Translation: AAC60643.2
X17406 mRNA Translation: CAA35463.1
J05062 mRNA Translation: AAA35726.1
CCDSiCCDS53970.1 [P16112-1]
CCDS53971.1 [P16112-3]
PIRiA39086
RefSeqiNP_001126.3, NM_001135.3 [P16112-3]
NP_037359.3, NM_013227.3 [P16112-1]
XP_011519616.1, XM_011521314.1 [P16112-2]
UniGeneiHs.2159
Hs.616395

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MD4X-ray1.95C89-103[»]
ProteinModelPortaliP16112
SMRiP16112
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16112, 1 interactor
STRINGi9606.ENSP00000387356

Chemistry databases

DrugBankiDB02255 GM6001

PTM databases

iPTMnetiP16112
PhosphoSitePlusiP16112

Polymorphism and mutation databases

DMDMi129886

Proteomic databases

PeptideAtlasiP16112
PRIDEiP16112
ProteomicsDBi53288
53289 [P16112-2]
53290 [P16112-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3]
ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1]
ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2]
ENST00000561243; ENSP00000453342; ENSG00000157766 [P16112-1]
GeneIDi176
KEGGihsa:176
UCSCiuc010upo.1 human

Organism-specific databases

CTDi176
DisGeNETi176
EuPathDBiHostDB:ENSG00000157766.15
GeneCardsiACAN
H-InvDBiHIX0026812
HGNCiHGNC:319 ACAN
HPAiHPA038241
HPA038242
MalaCardsiACAN
MIMi155760 gene
165800 phenotype
608361 phenotype
612813 phenotype
neXtProtiNX_P16112
OpenTargetsiENSG00000157766
Orphaneti251262 Familial osteochondritis dissecans
171866 Spondyloepimetaphyseal dysplasia, aggrecan type
93283 Spondyloepiphyseal dysplasia, Kimberley type
PharmGKBiPA24616
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJP2 Eukaryota
ENOG410XRES LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000168421
HOVERGENiHBG007982
InParanoidiP16112
KOiK06792
OMAiDTNETYD
PhylomeDBiP16112
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
SIGNORiP16112

Miscellaneous databases

ChiTaRSiACAN human
GenomeRNAii176
PMAP-CutDBiP16112
PROiPR:P16112
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157766 Expressed in 160 organ(s), highest expression level in tibia
CleanExiHS_ACAN

Family and domain databases

CDDicd00033 CCP, 1 hit
cd03588 CLECT_CSPGs, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 5 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033987 CSPG_CTLD
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 4 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 4 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 5 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 4 hits
PS50963 LINK_2, 4 hits
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGCA_HUMAN
AccessioniPrimary (citable) accession number: P16112
Secondary accession number(s): B9EK55
, E7ENV9, E7EX88, H0YM81, Q13650, Q9UCD3, Q9UCP4, Q9UCP5, Q9UDE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 202 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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