UniProtKB - P16112 (PGCA_HUMAN)
Protein
Aggrecan core protein
Gene
ACAN
Organism
Homo sapiens (Human)
Status
Functioni
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 2381 | Calcium 1By similarity | 1 | |
Metal bindingi | 2385 | Calcium 1By similarity | 1 | |
Metal bindingi | 2385 | Calcium 3By similarity | 1 | |
Metal bindingi | 2405 | Calcium 2By similarity | 1 | |
Metal bindingi | 2407 | Calcium 2By similarity | 1 | |
Metal bindingi | 2408 | Calcium 1By similarity | 1 | |
Metal bindingi | 2414 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 2414 | Calcium 2By similarity | 1 | |
Metal bindingi | 2415 | Calcium 1By similarity | 1 | |
Metal bindingi | 2415 | Calcium 3By similarity | 1 | |
Metal bindingi | 2428 | Calcium 2By similarity | 1 | |
Metal bindingi | 2429 | Calcium 2By similarity | 1 | |
Metal bindingi | 2429 | Calcium 2; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- extracellular matrix structural constituent Source: UniProtKB
- hyaluronic acid binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: InterPro
- central nervous system development Source: GO_Central
- extracellular matrix organization Source: Reactome
- keratan sulfate biosynthetic process Source: Reactome
- keratan sulfate catabolic process Source: Reactome
- proteolysis Source: UniProtKB
- skeletal system development Source: GO_Central
Keywordsi
Ligand | Calcium, Lectin, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P16112 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-2022854, Keratan sulfate biosynthesis R-HSA-2022857, Keratan sulfate degradation R-HSA-3000178, ECM proteoglycans R-HSA-3656225, Defective CHST6 causes MCDC1 R-HSA-3656243, Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656244, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) |
SIGNORi | P16112 |
Names & Taxonomyi
Protein namesi | Recommended name: Aggrecan core proteinAlternative name(s): Cartilage-specific proteoglycan core protein Short name: CSPCP Chondroitin sulfate proteoglycan core protein 1 Short name: Chondroitin sulfate proteoglycan 1 Cleaved into the following chain: |
Gene namesi | Name:ACAN Synonyms:AGC1, CSPG1, MSK16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:319, ACAN |
MIMi | 155760, gene |
neXtProti | NX_P16112 |
VEuPathDBi | HostDB:ENSG00000157766.15 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
- extracellular region Source: Reactome
Golgi apparatus
- Golgi lumen Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Spondyloepiphyseal dysplasia type Kimberley (SEDK)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSpondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.
Related information in OMIMSpondyloepimetaphyseal dysplasia, aggrecan type (SEMDAG)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063053 | 2381 | D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568Ensembl. | 1 |
Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans (SSOAOD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disease characterized by short stature, advanced bone maturation, early-onset osteoarthritis, and mild dysmorphic features consisting of midface hypoplasia, brachydactyly, broad great toes, and lumbar lordosis. Other features include intervertebral disk disease and osteochondritis dissecans. Osteochondritis dissecans is defined as a separation of cartilage and subchondral bone from the surrounding tissue.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063765 | 2418 | V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl. | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 176 |
MalaCardsi | ACAN |
MIMi | 165800, phenotype 608361, phenotype 612813, phenotype |
OpenTargetsi | ENSG00000157766 |
Orphaneti | 251262, Familial osteochondritis dissecans 435804, Short stature-advanced bone age-early-onset osteoarthritis syndrome 171866, Spondyloepimetaphyseal dysplasia, aggrecan type 93283, Spondyloepiphyseal dysplasia, Kimberley type |
PharmGKBi | PA24616 |
Miscellaneous databases
Pharosi | P16112, Tbio |
Chemistry databases
DrugBanki | DB02255, Ilomastat |
Genetic variation databases
BioMutai | ACAN |
DMDMi | 129886 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | 1 PublicationAdd BLAST | 16 | |
ChainiPRO_0000017505 | 17 – 2530 | Aggrecan core proteinAdd BLAST | 2514 | |
ChainiPRO_0000017506 | 393 – 2530 | Aggrecan core protein 2Add BLAST | 2138 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 133 | By similarity | ||
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 175 ↔ 246 | By similarity | ||
Disulfide bondi | 199 ↔ 220 | By similarity | ||
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 273 ↔ 348 | By similarity | ||
Disulfide bondi | 297 ↔ 318 | By similarity | ||
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 371 | O-linked (Xyl...) (keratan sulfate) threonine1 Publication | 1 | |
Glycosylationi | 376 | O-linked (Xyl...) (keratan sulfate) threonine1 Publication | 1 | |
Glycosylationi | 387 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 434 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 500 ↔ 571 | By similarity | ||
Disulfide bondi | 524 ↔ 545 | By similarity | ||
Disulfide bondi | 598 ↔ 673 | By similarity | ||
Glycosylationi | 602 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 622 ↔ 643 | By similarity | ||
Glycosylationi | 658 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 738 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 2013 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2283 ↔ 2293 | By similarity | ||
Disulfide bondi | 2288 ↔ 2302 | By similarity | ||
Disulfide bondi | 2304 ↔ 2313 | By similarity | ||
Disulfide bondi | 2320 ↔ 2331 | By similarity | ||
Disulfide bondi | 2348 ↔ 2440 | By similarity | ||
Disulfide bondi | 2416 ↔ 2432 | By similarity | ||
Disulfide bondi | 2447 ↔ 2490 | By similarity | ||
Disulfide bondi | 2476 ↔ 2503 | By similarity |
Post-translational modificationi
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 392 – 393 | Cleavage; by aggrecanase | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
jPOSTi | P16112 |
MassIVEi | P16112 |
PaxDbi | P16112 |
PeptideAtlasi | P16112 |
PRIDEi | P16112 |
ProteomicsDBi | 17235 19009 40179 53288 [P16112-1] 53289 [P16112-2] 53290 [P16112-3] |
PTM databases
GlyConnecti | 2002, 3 N-Linked glycans (1 site) |
GlyGeni | P16112, 81 sites, 2 N-linked glycans (1 site), 7 O-linked glycans (72 sites) |
iPTMneti | P16112 |
PhosphoSitePlusi | P16112 |
Expressioni
Tissue specificityi
Restricted to cartilages.1 Publication
Developmental stagei
Expression was detected in chondrocytes throughout the developing skeleton.
Gene expression databases
Bgeei | ENSG00000157766, Expressed in tibia and 179 other tissues |
ExpressionAtlasi | P16112, baseline and differential |
Interactioni
Subunit structurei
Interacts with FBLN1 (By similarity).
Interacts with COMP.
By similarity1 PublicationBinary interactionsi
P16112
With | #Exp. | IntAct |
---|---|---|
APP [P05067] | 3 | EBI-9076211,EBI-77613 |
Protein-protein interaction databases
IntActi | P16112, 3 interactors |
MINTi | P16112 |
STRINGi | 9606.ENSP00000387356 |
Miscellaneous databases
RNActi | P16112, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 147 | Ig-like V-typeAdd BLAST | 114 | |
Domaini | 153 – 248 | Link 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 254 – 350 | Link 2PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 478 – 573 | Link 3PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 579 – 675 | Link 4PROSITE-ProRule annotationAdd BLAST | 97 | |
Repeati | 773 – 778 | 1-1 | 6 | |
Repeati | 779 – 784 | 1-2 | 6 | |
Repeati | 785 – 790 | 1-3 | 6 | |
Repeati | 791 – 796 | 1-4 | 6 | |
Repeati | 797 – 802 | 1-5 | 6 | |
Repeati | 803 – 808 | 1-6 | 6 | |
Repeati | 809 – 814 | 1-7; approximate | 6 | |
Repeati | 815 – 820 | 1-8; approximate | 6 | |
Repeati | 821 – 826 | 1-9 | 6 | |
Repeati | 827 – 832 | 1-10; approximate | 6 | |
Repeati | 833 – 838 | 1-11 | 6 | |
Repeati | 839 – 844 | 1-12 | 6 | |
Repeati | 942 – 960 | 2-1Add BLAST | 19 | |
Repeati | 961 – 979 | 2-2Add BLAST | 19 | |
Repeati | 980 – 998 | 2-3Add BLAST | 19 | |
Repeati | 999 – 1017 | 2-4Add BLAST | 19 | |
Repeati | 1018 – 1036 | 2-5Add BLAST | 19 | |
Repeati | 1037 – 1055 | 2-6Add BLAST | 19 | |
Repeati | 1056 – 1074 | 2-7Add BLAST | 19 | |
Repeati | 1075 – 1093 | 2-8Add BLAST | 19 | |
Repeati | 1094 – 1112 | 2-9Add BLAST | 19 | |
Repeati | 1113 – 1131 | 2-10Add BLAST | 19 | |
Repeati | 1132 – 1150 | 2-11Add BLAST | 19 | |
Repeati | 1151 – 1169 | 2-12Add BLAST | 19 | |
Repeati | 1170 – 1188 | 2-13Add BLAST | 19 | |
Repeati | 1189 – 1207 | 2-14Add BLAST | 19 | |
Repeati | 1208 – 1226 | 2-15Add BLAST | 19 | |
Repeati | 1227 – 1245 | 2-16Add BLAST | 19 | |
Repeati | 1246 – 1264 | 2-17Add BLAST | 19 | |
Repeati | 1265 – 1283 | 2-18Add BLAST | 19 | |
Repeati | 1284 – 1302 | 2-19Add BLAST | 19 | |
Repeati | 1303 – 1321 | 2-20Add BLAST | 19 | |
Repeati | 1322 – 1340 | 2-21Add BLAST | 19 | |
Repeati | 1341 – 1359 | 2-22Add BLAST | 19 | |
Repeati | 1360 – 1378 | 2-23Add BLAST | 19 | |
Repeati | 1379 – 1397 | 2-24Add BLAST | 19 | |
Repeati | 1398 – 1416 | 2-25Add BLAST | 19 | |
Repeati | 1417 – 1435 | 2-26Add BLAST | 19 | |
Repeati | 1436 – 1454 | 2-27Add BLAST | 19 | |
Repeati | 1455 – 1473 | 2-28Add BLAST | 19 | |
Repeati | 1475 – 1493 | 2-29Add BLAST | 19 | |
Repeati | 1494 – 1512 | 2-30Add BLAST | 19 | |
Repeati | 1513 – 1531 | 2-31Add BLAST | 19 | |
Repeati | 1533 – 1551 | 2-32Add BLAST | 19 | |
Repeati | 1553 – 1572 | 2-33; approximateAdd BLAST | 20 | |
Repeati | 1574 – 1592 | 2-34Add BLAST | 19 | |
Repeati | 1594 – 1612 | 2-35Add BLAST | 19 | |
Domaini | 2279 – 2314 | EGF-likePROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2327 – 2441 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 2445 – 2505 | SushiPROSITE-ProRule annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 141 | G1-AAdd BLAST | 94 | |
Regioni | 152 – 247 | G1-BAdd BLAST | 96 | |
Regioni | 253 – 349 | G1-B'Add BLAST | 97 | |
Regioni | 477 – 571 | G2-BAdd BLAST | 95 | |
Regioni | 578 – 673 | G2-B'Add BLAST | 96 | |
Regioni | 677 – 849 | KSAdd BLAST | 173 | |
Regioni | 773 – 844 | 12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]Add BLAST | 72 | |
Regioni | 852 – 1612 | CS-1Add BLAST | 761 | |
Regioni | 942 – 1612 | 35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]-[GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-GAdd BLAST | 671 | |
Regioni | 1613 – 2277 | CS-2Add BLAST | 665 | |
Regioni | 2278 – 2530 | G3Add BLAST | 253 |
Domaini
Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.
Sequence similaritiesi
Belongs to the aggrecan/versican proteoglycan family.Curated
Keywords - Domaini
EGF-like domain, Immunoglobulin domain, Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502QUX8, Eukaryota |
GeneTreei | ENSGT00940000155971 |
InParanoidi | P16112 |
OMAi | CKKGTAT |
PhylomeDBi | P16112 |
TreeFami | TF332134 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit cd03588, CLECT_CSPGs, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 5 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033987, CSPG_CTLD IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 4 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 4 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 5 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit PS01241, LINK_1, 4 hits PS50963, LINK_2, 4 hits PS50923, SUSHI, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P16112-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTTLLWVFVT LRVITAAVTV ETSDHDNSLS VSIPQPSPLR VLLGTSLTIP
60 70 80 90 100
CYFIDPMHPV TTAPSTAPLA PRIKWSRVSK EKEVVLLVAT EGRVRVNSAY
110 120 130 140 150
QDKVSLPNYP AIPSDATLEV QSLRSNDSGV YRCEVMHGIE DSEATLEVVV
160 170 180 190 200
KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD
210 220 230 240 250
AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE
260 270 280 290 300
MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QAGMDMCSAG
310 320 330 340 350
WLADRSVRYP ISKARPNCGG NLLGVRTVYV HANQTGYPDP SSRYDAICYT
360 370 380 390 400
GEDFVDIPEN FFGVGGEEDI TVQTVTWPDM ELPLPRNITE GEARGSVILT
410 420 430 440 450
VKPIFEVSPS PLEPEEPFTF APEIGATAFA EVENETGEAT RPWGFPTPGL
460 470 480 490 500
GPATAFTSED LVVQVTAVPG QPHLPGGVVF HYRPGPTRYS LTFEEAQQAC
510 520 530 540 550
LRTGAVIASP EQLQAAYEAG YEQCDAGWLR DQTVRYPIVS PRTPCVGDKD
560 570 580 590 600
SSPGVRTYGV RPSTETYDVY CFVDRLEGEV FFATRLEQFT FQEALEFCES
610 620 630 640 650
HNATLATTGQ LYAAWSRGLD KCYAGWLADG SLRYPIVTPR PACGGDKPGV
660 670 680 690 700
RTVYLYPNQT GLPDPLSRHH AFCFRGISAV PSPGEEEGGT PTSPSGVEEW
710 720 730 740 750
IVTQVVPGVA AVPVEEETTA VPSGETTAIL EFTTEPENQT EWEPAYTPVG
760 770 780 790 800
TSPLPGILPT WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS
810 820 830 840 850
PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS
860 870 880 890 900
WTELPSSGEE SGAPDVSGDF TGSGDVSGHL DFSGQLSGDR ASGLPSGDLD
910 920 930 940 950
SSGLTSTVGS GLPVESGLPS GDEERIEWPS TPTVGELPSG AEILEGSASG
960 970 980 990 1000
VGDLSGLPSG EVLETSASGV GDLSGLPSGE VLETTAPGVE DISGLPSGEV
1010 1020 1030 1040 1050
LETTAPGVED ISGLPSGEVL ETTAPGVEDI SGLPSGEVLE TTAPGVEDIS
1060 1070 1080 1090 1100
GLPSGEVLET TAPGVEDISG LPSGEVLETT APGVEDISGL PSGEVLETAA
1110 1120 1130 1140 1150
PGVEDISGLP SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG
1160 1170 1180 1190 1200
EVLETAAPGV EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED
1210 1220 1230 1240 1250
ISGLPSGEVL ETAAPGVEDI SGLPSGEVLE TAAPGVEDIS GLPSGEVLET
1260 1270 1280 1290 1300
AAPGVEDISG LPSGEVLETA APGVEDISGL PSGEVLETAA PGVEDISGLP
1310 1320 1330 1340 1350
SGEVLETAAP GVEDISGLPS GEVLETAAPG VEDISGLPSG EVLETAAPGV
1360 1370 1380 1390 1400
EDISGLPSGE VLETAAPGVE DISGLPSGEV LETAAPGVED ISGLPSGEVL
1410 1420 1430 1440 1450
ETTAPGVEEI SGLPSGEVLE TTAPGVDEIS GLPSGEVLET TAPGVEEISG
1460 1470 1480 1490 1500
LPSGEVLETS TSAVGDLSGL PSGGEVLEIS VSGVEDISGL PSGEVVETSA
1510 1520 1530 1540 1550
SGIEDVSELP SGEGLETSAS GVEDLSRLPS GEEVLEISAS GFGDLSGLPS
1560 1570 1580 1590 1600
GGEGLETSAS EVGTDLSGLP SGREGLETSA SGAEDLSGLP SGKEDLVGSA
1610 1620 1630 1640 1650
SGDLDLGKLP SGTLGSGQAP ETSGLPSGFS GEYSGVDLGS GPPSGLPDFS
1660 1670 1680 1690 1700
GLPSGFPTVS LVDSTLVEVV TASTASELEG RGTIGISGAG EISGLPSSEL
1710 1720 1730 1740 1750
DISGRASGLP SGTELSGQAS GSPDVSGEIP GLFGVSGQPS GFPDTSGETS
1760 1770 1780 1790 1800
GVTELSGLSS GQPGISGEAS GVLYGTSQPF GITDLSGETS GVPDLSGQPS
1810 1820 1830 1840 1850
GLPGFSGATS GVPDLVSGTT SGSGESSGIT FVDTSLVEVA PTTFKEEEGL
1860 1870 1880 1890 1900
GSVELSGLPS GEADLSGKSG MVDVSGQFSG TVDSSGFTSQ TPEFSGLPSG
1910 1920 1930 1940 1950
IAEVSGESSR AEIGSSLPSG AYYGSGTPSS FPTVSLVDRT LVESVTQAPT
1960 1970 1980 1990 2000
AQEAGEGPSG ILELSGAHSG APDMSGEHSG FLDLSGLQSG LIEPSGEPPG
2010 2020 2030 2040 2050
TPYFSGDFAS TTNVSGESSV AMGTSGEASG LPEVTLITSE FVEGVTEPTI
2060 2070 2080 2090 2100
SQELGQRPPV THTPQLFESS GKVSTAGDIS GATPVLPGSG VEVSSVPESS
2110 2120 2130 2140 2150
SETSAYPEAG FGASAAPEAS REDSGSPDLS ETTSAFHEAN LERSSGLGVS
2160 2170 2180 2190 2200
GSTLTFQEGE ASAAPEVSGE STTTSDVGTE APGLPSATPT ASGDRTEISG
2210 2220 2230 2240 2250
DLSGHTSQLG VVISTSIPES EWTQQTQRPA ETHLEIESSS LLYSGEETHT
2260 2270 2280 2290 2300
VETATSPTDA SIPASPEWKR ESESTAAAPA RSCAEEPCGA GTCKETEGHV
2310 2320 2330 2340 2350
ICLCPPGYTG EHCNIDQEVC EEGWNKYQGH CYRHFPDRET WVDAERRCRE
2360 2370 2380 2390 2400
QQSHLSSIVT PEEQEFVNNN AQDYQWIGLN DRTIEGDFRW SDGHPMQFEN
2410 2420 2430 2440 2450
WRPNQPDNFF AAGEDCVVMI WHEKGEWNDV PCNYHLPFTC KKGTVACGEP
2460 2470 2480 2490 2500
PVVEHARTFG QKKDRYEINS LVRYQCTEGF VQRHMPTIRC QPSGHWEEPQ
2510 2520 2530
ITCTDPTTYK RRLQKRSSRH PRRSRPSTAH
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMF1 | H0YMF1_HUMAN | Aggrecan core protein | ACAN | 2,568 | Annotation score: | ||
A0A087X1T7 | A0A087X1T7_HUMAN | Aggrecan core protein | ACAN | 2,473 | Annotation score: | ||
Q6PID9 | Q6PID9_HUMAN | Aggrecan | ACAN | 721 | Annotation score: | ||
A0A5K1VW97 | A0A5K1VW97_HUMAN | Aggrecan core protein | ACAN | 2,054 | Annotation score: | ||
H0YK70 | H0YK70_HUMAN | Aggrecan core protein | ACAN | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 285 – 286 | QL → HV in AAA62824 (PubMed:1985970).Curated | 2 | |
Sequence conflicti | 501 – 502 | LR → PG in AAA62824 (PubMed:1985970).Curated | 2 | |
Sequence conflicti | 605 | Missing in AAA62824 (PubMed:1985970).Curated | 1 | |
Sequence conflicti | 767 | A → E in AAA62824 (PubMed:1985970).Curated | 1 | |
Sequence conflicti | 848 | V → E in AAA62824 (PubMed:1985970).Curated | 1 | |
Sequence conflicti | 999 – 1017 | Missing in AAI50625 (PubMed:15489334).CuratedAdd BLAST | 19 | |
Sequence conflicti | 1075 – 1188 | Missing in AAA62824 (PubMed:1985970).CuratedAdd BLAST | 114 | |
Sequence conflicti | 1548 | L → V in AAA62824 (PubMed:1985970).Curated | 1 | |
Sequence conflicti | 2043 | E → A in CAA35463 (PubMed:8611178).Curated | 1 | |
Sequence conflicti | 2185 | P → A in AAA35726 (PubMed:2789216).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056152 | 102 | D → E. Corresponds to variant dbSNP:rs16942318Ensembl. | 1 | |
Natural variantiVAR_056153 | 275 | R → Q. Corresponds to variant dbSNP:rs34949187EnsemblClinVar. | 1 | |
Natural variantiVAR_080159 | 864 | P → L1 PublicationCorresponds to variant dbSNP:rs3743398Ensembl. | 1 | |
Natural variantiVAR_080160 | 913 | P → T1 PublicationCorresponds to variant dbSNP:rs35430524Ensembl. | 1 | |
Natural variantiVAR_080161 | 930 | S → I1 PublicationCorresponds to variant dbSNP:rs938608Ensembl. | 1 | |
Natural variantiVAR_080162 | 939 | S → T1 PublicationCorresponds to variant dbSNP:rs938609Ensembl. | 1 | |
Natural variantiVAR_080163 | 1080 | T → A1 PublicationCorresponds to variant dbSNP:rs373544100Ensembl. | 1 | |
Natural variantiVAR_080164 | 1403 | T → A1 PublicationCorresponds to variant dbSNP:rs12899191Ensembl. | 1 | |
Natural variantiVAR_080165 | 1508 | E → A1 PublicationCorresponds to variant dbSNP:rs2882676EnsemblClinVar. | 1 | |
Natural variantiVAR_080166 | 1765 | I → V2 PublicationsCorresponds to variant dbSNP:rs4932439Ensembl. | 1 | |
Natural variantiVAR_056154 | 2058 | P → L. Corresponds to variant dbSNP:rs35061438Ensembl. | 1 | |
Natural variantiVAR_080167 | 2079 | I → V3 PublicationsCorresponds to variant dbSNP:rs1042630Ensembl. | 1 | |
Natural variantiVAR_056155 | 2120 | S → R. Corresponds to variant dbSNP:rs34153007Ensembl. | 1 | |
Natural variantiVAR_080168 | 2373 | D → E1 PublicationCorresponds to variant dbSNP:rs3817428Ensembl. | 1 | |
Natural variantiVAR_063053 | 2381 | D → N in SEMDAG; creates a functional N-glycosylation site; does not adversely affect protein trafficking and secretion. 1 PublicationCorresponds to variant dbSNP:rs121913568Ensembl. | 1 | |
Natural variantiVAR_063765 | 2418 | V → M in SSOAOD. 1 PublicationCorresponds to variant dbSNP:rs779794758Ensembl. | 1 | |
Natural variantiVAR_080169 | 2500 | Q → R2 PublicationsCorresponds to variant dbSNP:rs1126823Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003074 | 2278 – 2315 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 38 | |
Alternative sequenceiVSP_003075 | 2445 – 2506 | VACGE…TCTDP → A in isoform 3. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55172 mRNA Translation: AAA62824.1 AC103982 Genomic DNA No translation available. BC150624 mRNA Translation: AAI50625.1 X80278 mRNA No translation available. S74659 Genomic DNA Translation: AAC60643.2 X17406 mRNA Translation: CAA35463.1 J05062 mRNA Translation: AAA35726.1 |
CCDSi | CCDS53970.1 [P16112-1] CCDS53971.1 [P16112-3] |
PIRi | A39086 |
RefSeqi | NP_001126.3, NM_001135.3 [P16112-3] NP_037359.3, NM_013227.3 [P16112-1] XP_011519616.1, XM_011521314.1 [P16112-2] |
Genome annotation databases
Ensembli | ENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3] ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1] ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2] |
GeneIDi | 176 |
KEGGi | hsa:176 |
UCSCi | uc010upo.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Aggrecan |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55172 mRNA Translation: AAA62824.1 AC103982 Genomic DNA No translation available. BC150624 mRNA Translation: AAI50625.1 X80278 mRNA No translation available. S74659 Genomic DNA Translation: AAC60643.2 X17406 mRNA Translation: CAA35463.1 J05062 mRNA Translation: AAA35726.1 |
CCDSi | CCDS53970.1 [P16112-1] CCDS53971.1 [P16112-3] |
PIRi | A39086 |
RefSeqi | NP_001126.3, NM_001135.3 [P16112-3] NP_037359.3, NM_013227.3 [P16112-1] XP_011519616.1, XM_011521314.1 [P16112-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4MD4 | X-ray | 1.95 | C | 89-103 | [»] | |
SMRi | P16112 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P16112, 3 interactors |
MINTi | P16112 |
STRINGi | 9606.ENSP00000387356 |
Chemistry databases
DrugBanki | DB02255, Ilomastat |
PTM databases
GlyConnecti | 2002, 3 N-Linked glycans (1 site) |
GlyGeni | P16112, 81 sites, 2 N-linked glycans (1 site), 7 O-linked glycans (72 sites) |
iPTMneti | P16112 |
PhosphoSitePlusi | P16112 |
Genetic variation databases
BioMutai | ACAN |
DMDMi | 129886 |
Proteomic databases
jPOSTi | P16112 |
MassIVEi | P16112 |
PaxDbi | P16112 |
PeptideAtlasi | P16112 |
PRIDEi | P16112 |
ProteomicsDBi | 17235 19009 40179 53288 [P16112-1] 53289 [P16112-2] 53290 [P16112-3] |
Protocols and materials databases
Antibodypediai | 4288, 531 antibodies |
Genome annotation databases
Ensembli | ENST00000352105; ENSP00000341615; ENSG00000157766 [P16112-3] ENST00000439576; ENSP00000387356; ENSG00000157766 [P16112-1] ENST00000559004; ENSP00000453499; ENSG00000157766 [P16112-2] |
GeneIDi | 176 |
KEGGi | hsa:176 |
UCSCi | uc010upo.1, human |
Organism-specific databases
CTDi | 176 |
DisGeNETi | 176 |
GeneCardsi | ACAN |
HGNCi | HGNC:319, ACAN |
MalaCardsi | ACAN |
MIMi | 155760, gene 165800, phenotype 608361, phenotype 612813, phenotype |
neXtProti | NX_P16112 |
OpenTargetsi | ENSG00000157766 |
Orphaneti | 251262, Familial osteochondritis dissecans 435804, Short stature-advanced bone age-early-onset osteoarthritis syndrome 171866, Spondyloepimetaphyseal dysplasia, aggrecan type 93283, Spondyloepiphyseal dysplasia, Kimberley type |
PharmGKBi | PA24616 |
VEuPathDBi | HostDB:ENSG00000157766.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUX8, Eukaryota |
GeneTreei | ENSGT00940000155971 |
InParanoidi | P16112 |
OMAi | CKKGTAT |
PhylomeDBi | P16112 |
TreeFami | TF332134 |
Enzyme and pathway databases
PathwayCommonsi | P16112 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-2022854, Keratan sulfate biosynthesis R-HSA-2022857, Keratan sulfate degradation R-HSA-3000178, ECM proteoglycans R-HSA-3656225, Defective CHST6 causes MCDC1 R-HSA-3656243, Defective ST3GAL3 causes MCT12 and EIEE15 R-HSA-3656244, Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) |
SIGNORi | P16112 |
Miscellaneous databases
BioGRID-ORCSi | 176, 6 hits in 873 CRISPR screens |
ChiTaRSi | ACAN, human |
GenomeRNAii | 176 |
Pharosi | P16112, Tbio |
PROi | PR:P16112 |
RNActi | P16112, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157766, Expressed in tibia and 179 other tissues |
ExpressionAtlasi | P16112, baseline and differential |
Family and domain databases
CDDi | cd00033, CCP, 1 hit cd03588, CLECT_CSPGs, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 5 hits |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR033987, CSPG_CTLD IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit PF00084, Sushi, 1 hit PF07686, V-set, 1 hit PF00193, Xlink, 4 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00034, CLECT, 1 hit SM00181, EGF, 1 hit SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 4 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 5 hits SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00615, C_TYPE_LECTIN_1, 1 hit PS50041, C_TYPE_LECTIN_2, 1 hit PS00022, EGF_1, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit PS01241, LINK_1, 4 hits PS50963, LINK_2, 4 hits PS50923, SUSHI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGCA_HUMAN | |
Accessioni | P16112Primary (citable) accession number: P16112 Secondary accession number(s): B9EK55 Q9UDE0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 219 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families