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Protein

P-selectin

Gene

SELP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi121CalciumCombined sources1 Publication1
Metal bindingi123CalciumCombined sources1 Publication1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei123CarbohydrateCombined sources1 Publication1
Metal bindingi124CalciumCombined sources1
Binding sitei133CarbohydrateCombined sources1 Publication1
Metal bindingi146CalciumCombined sources1 Publication1
Binding sitei146CarbohydrateCombined sources1 Publication1
Metal bindingi147CalciumCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: UniProtKB
  • fucose binding Source: BHF-UCL
  • glycosphingolipid binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • lipopolysaccharide binding Source: BHF-UCL
  • oligosaccharide binding Source: UniProtKB
  • sialic acid binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-202733 Cell surface interactions at the vascular wall

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16109

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P16109

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P-selectin
Alternative name(s):
CD62 antigen-like family member P
Granule membrane protein 140
Short name:
GMP-1401 Publication
Leukocyte-endothelial cell adhesion molecule 3
Short name:
LECAM3
Platelet activation dependent granule-external membrane protein
Short name:
PADGEM
CD_antigen: CD62P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SELP
Synonyms:GMRP, GRMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174175.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10721 SELP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173610 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini42 – 771ExtracellularSequence analysisAdd BLAST730
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei772 – 795HelicalSequence analysisAdd BLAST24
Topological domaini796 – 830CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
See also OMIM:601367

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi129E → D: Impairs interaction with SELPLG. Abolishes cell rolling on glycan ligands. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6403

MalaCards human disease database

More...
MalaCardsi
SELP
MIMi173610 gene+phenotype
601367 phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35643

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5378

Drug and drug target database

More...
DrugBanki
DB06779 Dalteparin
DB01109 Heparin
DB03721 N-acetyl-alpha-neuraminic acid
DB08813 Nadroparin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SELP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274139

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 41Add BLAST41
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001749842 – 830P-selectinAdd BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 158Combined sources1 Publication
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 150Combined sources1 Publication
Disulfide bondi163 ↔ 174Combined sources1 Publication
Disulfide bondi168 ↔ 183Combined sources1 Publication
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 194Combined sources1 Publication
Disulfide bondi200 ↔ 244By similarity
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi219N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 257By similarity
Disulfide bondi262 ↔ 306By similarity
Disulfide bondi292 ↔ 319By similarity
Disulfide bondi324 ↔ 368By similarity
Disulfide bondi354 ↔ 381By similarity
Disulfide bondi386 ↔ 430By similarity
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi416 ↔ 443By similarity
Disulfide bondi448 ↔ 492By similarity
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi478 ↔ 505By similarity
Disulfide bondi510 ↔ 554By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi540 ↔ 567By similarity
Disulfide bondi572 ↔ 616By similarity
Disulfide bondi602 ↔ 629By similarity
Disulfide bondi642 ↔ 686By similarity
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 699By similarity
Disulfide bondi704 ↔ 748By similarity
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi723N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi734 ↔ 761By similarity
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi807S-palmitoyl cysteine; alternate1 Publication1
Lipidationi807S-stearoyl cysteine; alternate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16109

PeptideAtlas

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PeptideAtlasi
P16109

PRoteomics IDEntifications database

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PRIDEi
P16109

ProteomicsDB human proteome resource

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ProteomicsDBi
53287

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16109

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16109

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16109

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174175 Expressed in 136 organ(s), highest expression level in adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_SELP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P16109 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P16109 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002145
HPA002655
HPA005990

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SNX17. Interacts with SELPLG/PSGL1 and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of SELPLG and PODXL2, and specific tyrosine sulfation on SELPLG.7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SELPLGQ142424EBI-1030170,EBI-1030190

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112303, 9 interactors

Database of interacting proteins

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DIPi
DIP-37667N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P16109

Protein interaction database and analysis system

More...
IntActi
P16109, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263686

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1830
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16109

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16109

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P16109

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 158C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini159 – 195EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini198 – 259Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini260 – 321Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini322 – 383Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini384 – 445Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini446 – 507Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini508 – 569Sushi 6PROSITE-ProRule annotationAdd BLAST62
Domaini570 – 631Sushi 7PROSITE-ProRule annotationAdd BLAST62
Domaini640 – 701Sushi 8PROSITE-ProRule annotationAdd BLAST62
Domaini702 – 763Sushi 9PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni821 – 830Interaction with SNX1710

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi818 – 821Endocytosis signalCurated4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS44 Eukaryota
ENOG410Y5JF LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236254

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052375

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P16109

KEGG Orthology (KO)

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KOi
K06496

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00VV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16109

TreeFam database of animal gene trees

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TreeFami
TF326910

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 9 hits
cd03592 CLECT_selectins_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00343 SELECTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 9 hits
SM00034 CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P16109-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA
60 70 80 90 100
YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT
110 120 130 140 150
WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC
160 170 180 190 200
LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC
210 220 230 240 250
GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW
260 270 280 290 300
TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
310 320 330 340 350
PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC
360 370 380 390 400
KFECQPGYRV RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS
410 420 430 440 450
PSLRAFQYDT NCSFRCAEGF MLRGADIVRC DNLGQWTAPA PVCQALQCQD
460 470 480 490 500
LPVPNEARVN CSHPFGAFRY QSVCSFTCNE GLLLVGASVL QCLATGNWNS
510 520 530 540 550
VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC DEGYSLSGPE
560 570 580 590 600
RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF
610 620 630 640 650
SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGL QCPALTTPGQ
660 670 680 690 700
GTMYCRHHPG TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR
710 720 730 740 750
AVKCSELHVN KPIAMNCSNL WGNFSYGSIC SFHCLEGQLL NGSAQTACQE
760 770 780 790 800
NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA STIGLIMGGT LLALLRKRFR
810 820 830
QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP
Length:830
Mass (Da):90,834
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF53BC476AB6F70AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5R341Q5R341_HUMAN
P-selectin
SELP hCG_38007
768Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5R345Q5R345_HUMAN
P-selectin
SELP
768Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5R342Q5R342_HUMAN
P-selectin
SELP
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5R349Q5R349_HUMAN
P-selectin
SELP
789Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VVT6F6VVT6_HUMAN
P-selectin
SELP
444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019381179G → R1 PublicationCorresponds to variant dbSNP:rs3917718Ensembl.1
Natural variantiVAR_013910209V → M2 PublicationsCorresponds to variant dbSNP:rs6125Ensembl.1
Natural variantiVAR_019382230C → F1 PublicationCorresponds to variant dbSNP:rs3917869Ensembl.1
Natural variantiVAR_019383274T → I2 PublicationsCorresponds to variant dbSNP:rs3917724Ensembl.1
Natural variantiVAR_013911301P → L1 PublicationCorresponds to variant dbSNP:rs6124Ensembl.1
Natural variantiVAR_004192331S → N3 PublicationsCorresponds to variant dbSNP:rs6131Ensembl.1
Natural variantiVAR_013912365M → V1 PublicationCorresponds to variant dbSNP:rs6134Ensembl.1
Natural variantiVAR_019384385S → L1 PublicationCorresponds to variant dbSNP:rs3917742Ensembl.1
Natural variantiVAR_013913500S → F1 PublicationCorresponds to variant dbSNP:rs6130Ensembl.1
Natural variantiVAR_019385542E → K1 PublicationCorresponds to variant dbSNP:rs3917769Ensembl.1
Natural variantiVAR_004193603D → N4 PublicationsCorresponds to variant dbSNP:rs6127Ensembl.1
Natural variantiVAR_019386619S → A1 PublicationCorresponds to variant dbSNP:rs2228672Ensembl.1
Natural variantiVAR_019387631G → V1 PublicationCorresponds to variant dbSNP:rs3917812Ensembl.1
Natural variantiVAR_004194640L → V Associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6133Ensembl.1
Natural variantiVAR_019388661T → N1 PublicationCorresponds to variant dbSNP:rs3917814Ensembl.1
Natural variantiVAR_019389673N → S1 PublicationCorresponds to variant dbSNP:rs3917815Ensembl.1
Natural variantiVAR_004195756T → P Reduced frequency in patients with myocardial infarction. 3 PublicationsCorresponds to variant dbSNP:rs6136EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60234
, M60217, M60218, M60219, M60222, M60223, M60224, M60225, M60226, M60227, M60228, M60229, M60231, M60232, M60233 Genomic DNA Translation: AAA35910.1
M25322 mRNA Translation: AAA35911.1
AF542391 Genomic DNA Translation: AAN06828.1
AL022146 Genomic DNA No translation available.
Z99572 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90851.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1282.1

Protein sequence database of the Protein Information Resource

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PIRi
A30359

NCBI Reference Sequences

More...
RefSeqi
NP_002996.2, NM_003005.3
XP_005245492.1, XM_005245435.1
XP_005245493.1, XM_005245436.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.73800

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263686; ENSP00000263686; ENSG00000174175

Database of genes from NCBI RefSeq genomes

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GeneIDi
6403

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6403

UCSC genome browser

More...
UCSCi
uc001ggi.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

P-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60234
, M60217, M60218, M60219, M60222, M60223, M60224, M60225, M60226, M60227, M60228, M60229, M60231, M60232, M60233 Genomic DNA Translation: AAA35910.1
M25322 mRNA Translation: AAA35911.1
AF542391 Genomic DNA Translation: AAN06828.1
AL022146 Genomic DNA No translation available.
Z99572 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90851.1
CCDSiCCDS1282.1
PIRiA30359
RefSeqiNP_002996.2, NM_003005.3
XP_005245492.1, XM_005245435.1
XP_005245493.1, XM_005245436.3
UniGeneiHs.73800

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSBNMR-A160-199[»]
1G1QX-ray2.40A/B/C/D42-198[»]
1G1RX-ray3.40A/B/C/D42-198[»]
1G1SX-ray1.90A/B42-198[»]
1HESX-ray3.00P813-830[»]
1KJDmodel-A42-161[»]
ProteinModelPortaliP16109
SMRiP16109
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112303, 9 interactors
DIPiDIP-37667N
ELMiP16109
IntActiP16109, 2 interactors
STRINGi9606.ENSP00000263686

Chemistry databases

BindingDBiP16109
ChEMBLiCHEMBL5378
DrugBankiDB06779 Dalteparin
DB01109 Heparin
DB03721 N-acetyl-alpha-neuraminic acid
DB08813 Nadroparin

Protein family/group databases

UniLectiniP16109

PTM databases

iPTMnetiP16109
PhosphoSitePlusiP16109
SwissPalmiP16109

Polymorphism and mutation databases

BioMutaiSELP
DMDMi215274139

Proteomic databases

PaxDbiP16109
PeptideAtlasiP16109
PRIDEiP16109
ProteomicsDBi53287

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263686; ENSP00000263686; ENSG00000174175
GeneIDi6403
KEGGihsa:6403
UCSCiuc001ggi.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6403
DisGeNETi6403
EuPathDBiHostDB:ENSG00000174175.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SELP
HGNCiHGNC:10721 SELP
HPAiCAB002145
HPA002655
HPA005990
MalaCardsiSELP
MIMi173610 gene+phenotype
601367 phenotype
neXtProtiNX_P16109
PharmGKBiPA35643

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IS44 Eukaryota
ENOG410Y5JF LUCA
HOGENOMiHOG000236254
HOVERGENiHBG052375
InParanoidiP16109
KOiK06496
OrthoDBiEOG091G00VV
PhylomeDBiP16109
TreeFamiTF326910

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-202733 Cell surface interactions at the vascular wall
SIGNORiP16109

Miscellaneous databases

EvolutionaryTraceiP16109

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
P-selectin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6403

Protein Ontology

More...
PROi
PR:P16109

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174175 Expressed in 136 organ(s), highest expression level in adrenal gland
CleanExiHS_SELP
ExpressionAtlasiP16109 baseline and differential
GenevisibleiP16109 HS

Family and domain databases

CDDicd00033 CCP, 9 hits
cd03592 CLECT_selectins_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR033991 Selectin_CTLD
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 9 hits
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 9 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 9 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYAM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16109
Secondary accession number(s): Q5R344, Q8IVD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 215 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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