Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor receptor 1

Gene

Fgfr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).By similarity6 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Activity regulationi

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei514ATPPROSITE-ProRule annotation1
Binding sitei568ATPPROSITE-ProRule annotation1
Active sitei623Proton acceptorPROSITE-ProRule annotation1
Binding sitei627ATPPROSITE-ProRule annotation1
Binding sitei641ATPPROSITE-ProRule annotation1
Sitei766Mediates interaction with PLCG1 and SHBBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi484 – 490ATPPROSITE-ProRule annotation7
Nucleotide bindingi562 – 564ATPPROSITE-ProRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190370 FGFR1b ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190374 FGFR1c and Klotho ligand binding and activation
R-MMU-445144 Signal transduction by L1
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor 1 (EC:2.7.10.1By similarity)
Short name:
FGFR-1
Short name:
bFGF-R-1
Alternative name(s):
Basic fibroblast growth factor receptor 1
MFR
Proto-oncogene c-Fgr
CD_antigen: CD331
Gene namesi
Name:Fgfr1
Synonyms:Flg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95522 Fgfr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 376ExtracellularSequence analysisAdd BLAST355
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 822CytoplasmicSequence analysisAdd BLAST425

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality around gastrulation, due to growth defects during early embryonic development and aberrant mesoderm patterning.2 Publications

Chemistry databases

ChEMBLiCHEMBL3960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001678122 – 822Fibroblast growth factor receptor 1Add BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 101PROSITE-ProRule annotation
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 230PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi277 ↔ 341PROSITE-ProRule annotation
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei463Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei583Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei585Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei653Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei654Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei730Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei766Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Initial autophosphorylation at Tyr-653 increases the kinase activity by a factor of 50 to 100. After this, Tyr-583 becomes phosphorylated, followed by phosphorylation of Tyr-463, Tyr-766, Tyr-583 and Tyr-585. In a third stage, Tyr-654 is autophosphorylated, resulting in a further tenfold increase of kinase activity. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity).By similarity
Ubiquitinated. FGFR1 is rapidly ubiquitinated by NEDD4 after autophosphorylation, leading to internalization and lysosomal degradation. CBL is recruited to activated FGFR1 via FRS2 and GRB2, and mediates ubiquitination and subsequent degradation of FGFR1 (By similarity).By similarity
N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP16092
PaxDbiP16092
PeptideAtlasiP16092
PRIDEiP16092

PTM databases

iPTMnetiP16092
PhosphoSitePlusiP16092

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000031565 Expressed in 403 organ(s), highest expression level in decidua
CleanExiMM_FGFR1
MM_FLG
ExpressionAtlasiP16092 baseline and differential
GenevisibleiP16092 MM

Interactioni

Subunit structurei

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro) (PubMed:10821861, PubMed:1309590, PubMed:17086194). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2. Interacts with RPS6KA1. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (PubMed:17086194). Interacts with SHB (via SH2 domain) (PubMed:12181353). Interacts with GRB10 (By similarity). Interacts with ANOS1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2 (By similarity). Interacts with SOX2 and SOX3 (PubMed:17728342). Interacts with FLRT1, FLRT2 and FLRT3 (PubMed:16872596). Found in a ternary complex with FGF1 and ITGAV:ITGB3 (By similarity).By similarity8 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199656, 14 interactors
DIPiDIP-6033N
IntActiP16092, 11 interactors
MINTiP16092
STRINGi10090.ENSMUSP00000081041

Chemistry databases

BindingDBiP16092

Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP16092
SMRiP16092
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16092

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 119Ig-like C2-type 1Add BLAST95
Domaini158 – 246Ig-like C2-type 2Add BLAST89
Domaini255 – 357Ig-like C2-type 3Add BLAST103
Domaini478 – 767Protein kinasePROSITE-ProRule annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 177Heparin-bindingAdd BLAST18

Domaini

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity).By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
InParanoidiP16092
KOiK04362
OMAiYPEKMEK
PhylomeDBiP16092
TreeFamiTF316307

Family and domain databases

CDDicd05098 PTKc_FGFR1, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR028174 FGF_rcpt_1
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16092-1) [UniParc]FASTAAdd to basket
Also known as: FGFR1-IIIc, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGWKCLLFW AVLVTATLCT ARPAPTLPEQ AQPWGVPVEV ESLLVHPGDL
60 70 80 90 100
LQLRCRLRDD VQSINWLRDG VQLVESNRTR ITGEEVEVRD SIPADSGLYA
110 120 130 140 150
CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRRP
160 170 180 190 200
VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPNPTLRW LKNGKEFKPD
210 220 230 240 250
HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER
260 270 280 290 300
SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
310 320 330 340 350
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS
360 370 380 390 400
HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM LGSVIIYKMK
410 420 430 440 450
SGTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS
460 470 480 490 500
SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL
510 520 530 540 550
DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA
560 570 580 590 600
CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
610 620 630 640 650
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH
660 670 680 690 700
IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP
710 720 730 740 750
YPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWHAV PSQRPTFKQL
760 770 780 790 800
VEDLDRIVAL TSNQEYLDLS IPLDQYSPSF PDTRSSTCSS GEDSVFSHEP
810 820
LPEEPCLPRH PTQLANSGLK RR
Length:822
Mass (Da):91,981
Last modified:May 1, 1991 - v2
Checksum:iD5A4695FA680926B
GO
Isoform 2 (identifier: P16092-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     31-119: Missing.

Show »
Length:733
Mass (Da):82,211
Checksum:i50E95FE644692528
GO
Isoform 3 (identifier: P16092-3) [UniParc]FASTAAdd to basket
Also known as: Variant

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: Q → QGSSSWPLWVAAA
     148-149: Missing.

Show »
Length:832
Mass (Da):92,882
Checksum:iCD67254989FA0D33
GO
Isoform 4 (identifier: P16092-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-119: Missing.
     148-149: Missing.

Show »
Length:731
Mass (Da):81,899
Checksum:i2E88793289A97818
GO
Isoform 5 (identifier: P16092-5) [UniParc]FASTAAdd to basket
Also known as: FGFR1-IIIb

The sequence of this isoform differs from the canonical sequence as follows:
     31-119: Missing.
     148-149: Missing.
     313-323: TAGVNTTDKEM → HSGINSSDA
     327-336: HLRNVSFEDA → TLFNVTEAQS
     340-352: TCLAGNSIGLSHH → VCKVSNYIGEANQ
     359-360: LE → TRPVAK

Show »
Length:733
Mass (Da):82,067
Checksum:iC3B28DB146613C31
GO
Isoform 6 (identifier: P16092-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-149: Missing.

Show »
Length:820
Mass (Da):91,669
Checksum:i58319BDB3EEA9D34
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QN85J3QN85_MOUSE
Fibroblast growth factor receptor
Fgfr1
833Annotation score:
D3Z4V6D3Z4V6_MOUSE
Fibroblast growth factor receptor 1
Fgfr1
104Annotation score:
A0A1B0GSQ7A0A1B0GSQ7_MOUSE
Fibroblast growth factor receptor 1
Fgfr1
86Annotation score:
D3YW77D3YW77_MOUSE
Fibroblast growth factor receptor 1
Fgfr1
50Annotation score:
A0A1B0GSZ6A0A1B0GSZ6_MOUSE
Fibroblast growth factor receptor 1
Fgfr1
300Annotation score:
A0A1B0GSD9A0A1B0GSD9_MOUSE
Fibroblast growth factor receptor 1
Fgfr1
47Annotation score:

Sequence cautioni

The sequence AAB32845 differs from that shown. Proposes two coding sequences for the same mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229T → S in AAA37622 (PubMed:2161540).Curated1
Sequence conflicti256 – 258ILQ → HPS in AAA37290 (PubMed:1689490).Curated3
Sequence conflicti256 – 258ILQ → HPS in AAA37620 (PubMed:1708247).Curated3
Sequence conflicti265K → E in AAC52183 (PubMed:7897669).Curated1
Sequence conflicti270G → A in AAA37622 (PubMed:2161540).Curated1
Sequence conflicti387I → M in AAA37620 (PubMed:1708247).Curated1
Sequence conflicti440G → A in CAA36175 (PubMed:2161096).Curated1
Sequence conflicti457L → P in AAC52183 (PubMed:7897669).Curated1
Sequence conflicti508V → L in AAA37620 (PubMed:1708247).Curated1
Sequence conflicti544I → M in AAA37622 (PubMed:2161540).Curated1
Sequence conflicti549G → E in AAF05312 (PubMed:10821861).Curated1
Sequence conflicti753D → V in AAF05312 (PubMed:10821861).Curated1
Sequence conflicti756R → H in AAA37290 (PubMed:1689490).Curated1
Sequence conflicti763N → S in AAC52183 (PubMed:7897669).Curated1
Sequence conflicti765E → D in AAA37622 (PubMed:2161540).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00296130Q → QGSSSWPLWVAAA in isoform 3. 1 Publication1
Alternative sequenceiVSP_00296231 – 119Missing in isoform 2, isoform 4 and isoform 5. 5 PublicationsAdd BLAST89
Alternative sequenceiVSP_002963148 – 149Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 4 Publications2
Alternative sequenceiVSP_041919313 – 323TAGVNTTDKEM → HSGINSSDA in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_041920327 – 336HLRNVSFEDA → TLFNVTEAQS in isoform 5. 1 Publication10
Alternative sequenceiVSP_041921340 – 352TCLAG…GLSHH → VCKVSNYIGEANQ in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_041922359 – 360LE → TRPVAK in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28998 mRNA Translation: AAA37290.1
X51893 mRNA Translation: CAA36175.1
M65053 mRNA Translation: AAA37620.1
M33760 mRNA Translation: AAA37622.1
U23445 mRNA Translation: AAC52183.1
AF176552 mRNA Translation: AAF05312.1
AK028354 mRNA Translation: BAC25899.1
S74765 mRNA Translation: AAB32845.1 Sequence problems.
AC160526 Genomic DNA No translation available.
BC033447 mRNA Translation: AAH33447.1
CCDSiCCDS40304.1 [P16092-2]
CCDS52526.1 [P16092-1]
CCDS57614.1 [P16092-6]
PIRiA34849 TVMSFG
B42057
I49293
JH0393
RefSeqiNP_001073377.1, NM_001079908.2 [P16092-6]
NP_001073378.1, NM_001079909.2 [P16092-2]
NP_034336.2, NM_010206.3 [P16092-1]
XP_006509073.1, XM_006509010.2 [P16092-1]
XP_006509075.1, XM_006509012.1 [P16092-1]
XP_011240423.1, XM_011242121.1 [P16092-4]
UniGeneiMm.265716

Genome annotation databases

EnsembliENSMUST00000084027; ENSMUSP00000081041; ENSMUSG00000031565 [P16092-1]
ENSMUST00000117179; ENSMUSP00000113909; ENSMUSG00000031565 [P16092-6]
ENSMUST00000119398; ENSMUSP00000113855; ENSMUSG00000031565 [P16092-2]
ENSMUST00000167764; ENSMUSP00000131343; ENSMUSG00000031565 [P16092-5]
ENSMUST00000178276; ENSMUSP00000137515; ENSMUSG00000031565 [P16092-5]
GeneIDi14182
KEGGimmu:14182
UCSCiuc009lfy.2 mouse [P16092-1]
uc009lga.2 mouse [P16092-2]
uc033jet.1 mouse [P16092-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28998 mRNA Translation: AAA37290.1
X51893 mRNA Translation: CAA36175.1
M65053 mRNA Translation: AAA37620.1
M33760 mRNA Translation: AAA37622.1
U23445 mRNA Translation: AAC52183.1
AF176552 mRNA Translation: AAF05312.1
AK028354 mRNA Translation: BAC25899.1
S74765 mRNA Translation: AAB32845.1 Sequence problems.
AC160526 Genomic DNA No translation available.
BC033447 mRNA Translation: AAH33447.1
CCDSiCCDS40304.1 [P16092-2]
CCDS52526.1 [P16092-1]
CCDS57614.1 [P16092-6]
PIRiA34849 TVMSFG
B42057
I49293
JH0393
RefSeqiNP_001073377.1, NM_001079908.2 [P16092-6]
NP_001073378.1, NM_001079909.2 [P16092-2]
NP_034336.2, NM_010206.3 [P16092-1]
XP_006509073.1, XM_006509010.2 [P16092-1]
XP_006509075.1, XM_006509012.1 [P16092-1]
XP_011240423.1, XM_011242121.1 [P16092-4]
UniGeneiMm.265716

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CKNNMR-A25-119[»]
ProteinModelPortaliP16092
SMRiP16092
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199656, 14 interactors
DIPiDIP-6033N
IntActiP16092, 11 interactors
MINTiP16092
STRINGi10090.ENSMUSP00000081041

Chemistry databases

BindingDBiP16092
ChEMBLiCHEMBL3960

PTM databases

iPTMnetiP16092
PhosphoSitePlusiP16092

Proteomic databases

MaxQBiP16092
PaxDbiP16092
PeptideAtlasiP16092
PRIDEiP16092

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084027; ENSMUSP00000081041; ENSMUSG00000031565 [P16092-1]
ENSMUST00000117179; ENSMUSP00000113909; ENSMUSG00000031565 [P16092-6]
ENSMUST00000119398; ENSMUSP00000113855; ENSMUSG00000031565 [P16092-2]
ENSMUST00000167764; ENSMUSP00000131343; ENSMUSG00000031565 [P16092-5]
ENSMUST00000178276; ENSMUSP00000137515; ENSMUSG00000031565 [P16092-5]
GeneIDi14182
KEGGimmu:14182
UCSCiuc009lfy.2 mouse [P16092-1]
uc009lga.2 mouse [P16092-2]
uc033jet.1 mouse [P16092-4]

Organism-specific databases

CTDi2260
MGIiMGI:95522 Fgfr1

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
InParanoidiP16092
KOiK04362
OMAiYPEKMEK
PhylomeDBiP16092
TreeFamiTF316307

Enzyme and pathway databases

BRENDAi2.7.10.1 3474
ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190370 FGFR1b ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190374 FGFR1c and Klotho ligand binding and activation
R-MMU-445144 Signal transduction by L1
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

ChiTaRSiFgfr1 mouse
EvolutionaryTraceiP16092
PROiPR:P16092
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031565 Expressed in 403 organ(s), highest expression level in decidua
CleanExiMM_FGFR1
MM_FLG
ExpressionAtlasiP16092 baseline and differential
GenevisibleiP16092 MM

Family and domain databases

CDDicd05098 PTKc_FGFR1, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR028174 FGF_rcpt_1
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGFR1_MOUSE
AccessioniPrimary (citable) accession number: P16092
Secondary accession number(s): E9Q2P4
, Q01736, Q60830, Q61562, Q80T10, Q8CFK8, Q9QZM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again