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UniProtKB - P16083 (NQO2_HUMAN)

Entry version 221 (25 May 2022)
Sequence version 5 (11 Jan 2011)
Previous versions | rss
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Protein

Ribosyldihydronicotinamide dehydrogenase [quinone]

Gene

NQO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

1 Publication

Miscellaneous

Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=28 µM for NRH2 Publications
  2. KM=11.6 µM for menadione2 Publications
  3. KM=252 µM for NADH2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei12FAD2 Publications1
Binding sitei156FAD2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi174Zinc1
Metal bindingi178Zinc1
Binding sitei194FAD2 Publications1
Binding sitei201FAD2 Publications1
Metal bindingi223Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 21FAD2 Publications4
Nucleotide bindingi104 – 107FAD2 Publications4
Nucleotide bindingi148 – 151FAD2 Publications4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.10.5.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16083

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211945, Phase I - Functionalization of compounds

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P16083

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P16083

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosyldihydronicotinamide dehydrogenase [quinone] (EC:1.10.5.11 Publication)
Alternative name(s):
NRH dehydrogenase [quinone] 2
NRH:quinone oxidoreductase 2
Quinone reductase 2
Short name:
QR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NQO2
Synonyms:NMOR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7856, NQO2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		160998, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16083

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124588

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi162N → H: Loss of activity toward CB1954, no effect toward menadione. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4835

MalaCards human disease database

More...MalaCardsi		NQO2

Open Targets

More...OpenTargetsi		ENSG00000124588

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31745

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16083, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3959

Drug and drug target database

More...DrugBanki		DB07339, (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione
DB03541, 10-Propargyl-5,8-Dideazafolic Acid
DB08228, 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
DB08744, Casimiroin
DB06695, Dabigatran etexilate
DB03147, Flavin adenine dinucleotide
DB01065, Melatonin
DB00170, Menadione
DB08190, N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide
DB00157, NADH
DB01087, Primaquine
DB04216, Quercetin
DB02709, Resveratrol
DB04253, Tretazicar

DrugCentral

More...DrugCentrali		P16083

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NQO2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373581

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000716261 – 231Ribosyldihydronicotinamide dehydrogenase [quinone]Add BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei80PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P16083

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16083

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16083

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16083

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16083

PeptideAtlas

More...PeptideAtlasi		P16083

PRoteomics IDEntifications database

More...PRIDEi		P16083

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53285

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16083

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16083

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124588, Expressed in nephron tubule and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16083, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16083, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124588, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110898, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P16083

Database of interacting proteins

More...DIPi		DIP-39704N

Protein interaction database and analysis system

More...IntActi		P16083, 16 interactors

Molecular INTeraction database

More...MINTi		P16083

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369822

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P16083

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16083, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P16083

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16083

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16083

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 129Substrate binding3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NAD(P)H dehydrogenase (quinone) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWY5, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058643_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16083

Identification of Orthologs from Complete Genome Data

More...OMAi		LFPIHHG

Database of Orthologous Groups

More...OrthoDBi		1394543at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16083

TreeFam database of animal gene trees

More...TreeFami		TF300296

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003680, Flavodoxin_fold
IPR029039, Flavoprotein-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02525, Flavodoxin_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52218, SSF52218, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P16083-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGKKVLIVY AHQEPKSFNG SLKNVAVDEL SRQGCTVTVS DLYAMNLEPR 
        60         70         80         90        100
ATDKDITGTL SNPEVFNYGV ETHEAYKQRS LASDITDEQK KVREADLVIF 
       110        120        130        140        150
QFPLYWFSVP AILKGWMDRV LCQGFAFDIP GFYDSGLLQG KLALLSVTTG 
       160        170        180        190        200
GTAEMYTKTG VNGDSRYFLW PLQHGTLHFC GFKVLAPQIS FAPEIASEEE 
       210        220        230 
RKGMVAAWSQ RLQTIWKEEP IPCTAHWHFG Q
Length:231
Mass (Da):25,919
Last modified:January 11, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE1F4D577517B972
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TD07Q5TD07_HUMAN
Ribosyldihydronicotinamide dehydrog...
NQO2
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TD05Q5TD05_HUMAN
Ribosyldihydronicotinamide dehydrog...
NQO2
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A2U4A2A2U4_HUMAN
Ribosyldihydronicotinamide dehydrog...
NQO2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQG7U3KQG7_HUMAN
Ribosyldihydronicotinamide dehydrog...
NQO2
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140G → C in AAB60642 (PubMed:8182056).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02139916K → R1 PublicationCorresponds to variant dbSNP:rs28383623Ensembl.1
Natural variantiVAR_02140029E → G1 PublicationCorresponds to variant dbSNP:rs17136117Ensembl.1
Natural variantiVAR_02140147L → F7 PublicationsCorresponds to variant dbSNP:rs1143684Ensembl.1
Natural variantiVAR_02140258G → D1 PublicationCorresponds to variant dbSNP:rs17300141Ensembl.1
Natural variantiVAR_021403184V → A1 PublicationCorresponds to variant dbSNP:rs28383651Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02888 mRNA Translation: AAA60239.1
AY299456 Genomic DNA Translation: AAB60642.3
AB050248 Genomic DNA Translation: BAB16974.1
AY855291 Genomic DNA Translation: AAW29945.1
AK311746 mRNA Translation: BAG34689.1
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55107.1
BC006096 mRNA Translation: AAH06096.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4481.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32667

NCBI Reference Sequences

More...RefSeqi		NP_000895.2, NM_000904.4
NP_001277150.1, NM_001290221.1
NP_001305869.1, NM_001318940.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338130.7; ENSP00000337773.2; ENSG00000124588.22
ENST00000380430.6; ENSP00000369795.1; ENSG00000124588.22
ENST00000380455.11; ENSP00000369822.4; ENSG00000124588.22

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4835

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4835

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000380455.11; ENSP00000369822.4; NM_000904.6; NP_000895.2

UCSC genome browser

More...UCSCi		uc003mus.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02888 mRNA Translation: AAA60239.1
AY299456 Genomic DNA Translation: AAB60642.3
AB050248 Genomic DNA Translation: BAB16974.1
AY855291 Genomic DNA Translation: AAW29945.1
AK311746 mRNA Translation: BAG34689.1
AL133351 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55107.1
BC006096 mRNA Translation: AAH06096.1
CCDSiCCDS4481.1
PIRiA32667
RefSeqiNP_000895.2, NM_000904.4
NP_001277150.1, NM_001290221.1
NP_001305869.1, NM_001318940.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QR2X-ray2.10A/B2-231[»]
1SG0X-ray1.50A/B2-231[»]
1XI2X-ray1.50A/B2-231[»]
1ZX1X-ray2.16A/B1-231[»]
2BZSX-ray2.00A/B2-231[»]
2QMYX-ray2.50A/B2-231[»]
2QMZX-ray2.10A/B2-231[»]
2QR2X-ray2.45A/B2-231[»]
2QWXX-ray1.50A/B1-231[»]
2QX4X-ray1.65A/B2-231[»]
2QX6X-ray1.75A/B2-231[»]
2QX8X-ray1.60A/B2-231[»]
2QX9X-ray2.31A/B2-231[»]
3FW1X-ray1.75A1-231[»]
3G5MX-ray1.84A/B1-231[»]
3GAMX-ray1.98A/B1-231[»]
3NFRX-ray1.57A/B2-231[»]
3NHFX-ray2.00A/B2-231[»]
3NHJX-ray2.33A/B2-231[»]
3NHKX-ray1.96A/B2-231[»]
3NHLX-ray1.57A/B2-231[»]
3NHPX-ray1.70A/B2-231[»]
3NHRX-ray1.80A/B2-231[»]
3NHSX-ray1.78A/B2-231[»]
3NHUX-ray1.90A/B2-231[»]
3NHWX-ray1.65A/B2-231[»]
3NHYX-ray1.90A/B2-231[»]
3O2NX-ray1.60A/B2-231[»]
3O73X-ray2.00A/B1-231[»]
3OVMX-ray2.09A/B1-231[»]
3OWHX-ray2.28A/B1-231[»]
3OWXX-ray1.85A/B1-231[»]
3OX1X-ray2.00A/B1-231[»]
3OX2X-ray2.41A/B1-231[»]
3OX3X-ray1.80A/B1-231[»]
3TE7X-ray1.70A/B3-230[»]
3TEMX-ray1.45A/B3-230[»]
3TZBX-ray2.19A/B/C/D3-230[»]
3UXEX-ray1.50A/B2-231[»]
3UXHX-ray1.53A/B2-231[»]
4FGJX-ray1.35A/B1-231[»]
4FGKX-ray1.40A/B1-231[»]
4FGLX-ray1.20A/B/C/D1-231[»]
4GQIX-ray1.95A/B2-231[»]
4GR9X-ray2.29A/B2-231[»]
4QODX-ray1.35A/B1-231[»]
4QOEX-ray1.45A/B1-231[»]
4QOFX-ray1.55A/B1-231[»]
4QOGX-ray1.40A/B1-231[»]
4QOHX-ray1.60A/B1-231[»]
4QOIX-ray1.55A/B1-231[»]
4QOJX-ray1.85A/B1-231[»]
4U7FX-ray1.80A/B2-231[»]
4U7GX-ray1.96A/B2-231[»]
4U7HX-ray1.48A/B2-231[»]
4XDGX-ray1.50A/B1-231[»]
4XDHX-ray1.90A/B1-231[»]
4ZVKX-ray1.87A/B2-231[»]
4ZVLX-ray1.90A/B2-231[»]
4ZVMX-ray1.97A/B2-231[»]
4ZVNX-ray1.87A/B2-231[»]
5BUCX-ray1.87A/B2-231[»]
5LBTX-ray1.75A/B1-231[»]
5LBUX-ray1.65A/B1-231[»]
5LBWX-ray1.90A/B1-231[»]
5LBYX-ray1.40A/B1-231[»]
5LBZX-ray1.40A/B1-231[»]
AlphaFoldDBiP16083
SMRiP16083
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110898, 20 interactors
CORUMiP16083
DIPiDIP-39704N
IntActiP16083, 16 interactors
MINTiP16083
STRINGi9606.ENSP00000369822

Chemistry databases

BindingDBiP16083
ChEMBLiCHEMBL3959
DrugBankiDB07339, (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione
DB03541, 10-Propargyl-5,8-Dideazafolic Acid
DB08228, 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
DB08744, Casimiroin
DB06695, Dabigatran etexilate
DB03147, Flavin adenine dinucleotide
DB01065, Melatonin
DB00170, Menadione
DB08190, N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide
DB00157, NADH
DB01087, Primaquine
DB04216, Quercetin
DB02709, Resveratrol
DB04253, Tretazicar
DrugCentraliP16083

PTM databases

iPTMnetiP16083
PhosphoSitePlusiP16083

Genetic variation databases

BioMutaiNQO2
DMDMi317373581

Proteomic databases

EPDiP16083
jPOSTiP16083
MassIVEiP16083
MaxQBiP16083
PaxDbiP16083
PeptideAtlasiP16083
PRIDEiP16083
ProteomicsDBi53285

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9328, 535 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		4835

Genome annotation databases

EnsembliENST00000338130.7; ENSP00000337773.2; ENSG00000124588.22
ENST00000380430.6; ENSP00000369795.1; ENSG00000124588.22
ENST00000380455.11; ENSP00000369822.4; ENSG00000124588.22
GeneIDi4835
KEGGihsa:4835
MANE-SelectiENST00000380455.11; ENSP00000369822.4; NM_000904.6; NP_000895.2
UCSCiuc003mus.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4835
DisGeNETi4835

GeneCards: human genes, protein and diseases

More...GeneCardsi		NQO2
HGNCiHGNC:7856, NQO2
HPAiENSG00000124588, Low tissue specificity
MalaCardsiNQO2
MIMi160998, gene
neXtProtiNX_P16083
OpenTargetsiENSG00000124588
PharmGKBiPA31745
VEuPathDBiHostDB:ENSG00000124588

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWY5, Eukaryota
GeneTreeiENSGT00940000156563
HOGENOMiCLU_058643_2_0_1
InParanoidiP16083
OMAiLFPIHHG
OrthoDBi1394543at2759
PhylomeDBiP16083
TreeFamiTF300296

Enzyme and pathway databases

BRENDAi1.10.5.1, 2681
PathwayCommonsiP16083
ReactomeiR-HSA-211945, Phase I - Functionalization of compounds
SABIO-RKiP16083
SignaLinkiP16083

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4835, 8 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NQO2, human
EvolutionaryTraceiP16083

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NAD(P)H_dehydrogenase,_quinone_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4835
PharosiP16083, Tchem

Protein Ontology

More...PROi		PR:P16083
RNActiP16083, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124588, Expressed in nephron tubule and 235 other tissues
ExpressionAtlasiP16083, baseline and differential
GenevisibleiP16083, HS

Family and domain databases

Gene3Di3.40.50.360, 1 hit
InterProiView protein in InterPro
IPR003680, Flavodoxin_fold
IPR029039, Flavoprotein-like_sf
PfamiView protein in Pfam
PF02525, Flavodoxin_2, 1 hit
SUPFAMiSSF52218, SSF52218, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNQO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16083
Secondary accession number(s): B2R492, Q5TD04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 221 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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