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UniProtKB - P16071 (HN_PI1HW)
Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
Status
Functioni
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
By similarityNeuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
By similarityCatalytic activityi
- Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. EC:3.2.1.18
GO - Molecular functioni
- exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
- host cell surface receptor binding Source: InterPro
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Hemagglutinin, Hydrolase |
Biological process | Host-virus interaction, Viral attachment to host cell, Virus entry into host cell |
Protein family/group databases
CAZyi | GH83, Glycoside Hydrolase Family 83 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HN |
Organismi | Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1) |
Taxonomic identifieri | 11211 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Respirovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Subcellular locationi
- Virion membrane Curated; Single-pass type II membrane protein Curated
- Host cell membrane Curated; Single-pass type II membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 34 | IntravirionSequence analysisAdd BLAST | 34 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 575 | Virion surfaceSequence analysisAdd BLAST | 520 |
Keywords - Cellular componenti
Host cell membrane, Host membrane, Membrane, Viral envelope protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142621 | 1 – 575 | Hemagglutinin-neuraminidaseAdd BLAST | 575 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 77 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 499 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 511 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd15469, HN, 1 hit |
InterProi | View protein in InterPro IPR016285, Hemagglutn-neuramid IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
PIRSFi | PIRSF001072, Hemagglut-neuramid_paramyxoV, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
i Sequence
Sequence statusi: Complete.
P16071-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKGKTNSS YWSTTRNDNS TVNTYIDTPA GKTHIWLLIA TTMHTILSFI
60 70 80 90 100
IMILCIDLII KQDTCMKTNI MTVSSMNESA KTIKETITEL IRQEVISRTI
110 120 130 140 150
NIQSSVQSGI PILLNKQSRD LTQLIEKSCN RQELAQICEN TIAIHHADGI
160 170 180 190 200
SPLDPHDFWR CPVGEPLLSN NPNISLLPGP SLLSGSTTIS GCVRLPSLSI
210 220 230 240 250
GDAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMYPD LKPVISHTYD
260 270 280 290 300
INDNRKSCSV IAAGTRGYQL CSLPTVNETT DYSSEGIEDL VFDILDLKGK
310 320 330 340 350
TKSHRYKNED ITFDHPFSAM YPSVGSGIKI ENTLIFLGYG GLTTPLQGDT
360 370 380 390 400
KCVTNRCANV NQSVCNDALK ITWLKKRQVV NVLIRINNYL SDRPKIVVET
410 420 430 440 450
IPITQNYLGA EGRLLKLGKK IYIYTRSSGW HSHLQIGSLD INNPMTIKWA
460 470 480 490 500
PHEVLSRPGN QDCNWYNRCP RECISGVYTD AYPLSPDAVN VATTTLYANT
510 520 530 540 550
SRVNPTIMYS NTSEIINMLR LKNVQLEAAY TTTSCITHFG KGYCFHIVEI
560 570
NQTSLNTLQP MLFKTSIPKI CKITS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31228 Genomic RNA Translation: AAA46798.1 |
PIRi | A34682, HNNZ39 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31228 Genomic RNA Translation: AAA46798.1 |
PIRi | A34682, HNNZ39 |
3D structure databases
SMRi | P16071 |
ModBasei | Search... |
Protein family/group databases
CAZyi | GH83, Glycoside Hydrolase Family 83 |
Family and domain databases
CDDi | cd15469, HN, 1 hit |
InterProi | View protein in InterPro IPR016285, Hemagglutn-neuramid IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
PIRSFi | PIRSF001072, Hemagglut-neuramid_paramyxoV, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HN_PI1HW | |
Accessioni | P16071Primary (citable) accession number: P16071 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Documents
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families