UniProtKB - P16070 (CD44_HUMAN)
CD44 antigen
CD44
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | HyaluronanBy similarity | 1 | |
Binding sitei | 78 | HyaluronanBy similarity | 1 | |
Binding sitei | 79 | HyaluronanBy similarity | 1 | |
Binding sitei | 105 | HyaluronanBy similarity | 1 |
GO - Molecular functioni
- collagen binding Source: UniProtKB
- hyaluronic acid binding Source: UniProtKB
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- cartilage development Source: UniProtKB
- cell adhesion Source: UniProtKB
- cell-cell adhesion Source: UniProtKB
- cell-matrix adhesion Source: UniProtKB
- cell migration Source: UniProtKB
- cellular response to fibroblast growth factor stimulus Source: UniProtKB
- extracellular matrix disassembly Source: Reactome
- extracellular matrix organization Source: Reactome
- hyaluronan catabolic process Source: UniProtKB
- inflammatory response Source: GO_Central
- interferon-gamma-mediated signaling pathway Source: Reactome
- leukocyte migration Source: Reactome
- monocyte aggregation Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
- neutrophil degranulation Source: Reactome
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
- positive regulation of monocyte aggregation Source: BHF-UCL
- positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- regulation of lamellipodium morphogenesis Source: UniProtKB
- T cell activation Source: UniProtKB
- wound healing, spreading of cells Source: UniProtKB
Keywordsi
Molecular function | Blood group antigen, Receptor |
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P16070 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-2160916, Hyaluronan uptake and degradation R-HSA-6798695, Neutrophil degranulation R-HSA-877300, Interferon gamma signaling |
SIGNORi | P16070 |
Names & Taxonomyi
Protein namesi | Recommended name: CD44 antigenAlternative name(s): CDw44 Epican Extracellular matrix receptor III Short name: ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Heparan sulfate proteoglycan Hermes antigen Hyaluronate receptor Phagocytic glycoprotein 1 Short name: PGP-1 Phagocytic glycoprotein I Short name: PGP-I CD_antigen: CD44 |
Gene namesi | Name:CD44 Synonyms:LHR, MDU2, MDU3, MIC4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1681, CD44 |
MIMi | 107269, gene 172290, gene |
neXtProti | NX_P16070 |
VEuPathDBi | HostDB:ENSG00000026508.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Other locations
- microvillus By similarity
Note: Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains.By similarity1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- lamellipodium membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell projection Source: UniProtKB
- cell surface Source: UniProtKB
- focal adhesion Source: UniProtKB
- macrophage migration inhibitory factor receptor complex Source: BHF-UCL
- microvillus Source: UniProtKB
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 649 | ExtracellularSequence analysisAdd BLAST | 629 | |
Transmembranei | 650 – 670 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 671 – 742 | CytoplasmicSequence analysisAdd BLAST | 72 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 960 |
MIMi | 609027, phenotype |
OpenTargetsi | ENSG00000026508 |
PharmGKBi | PA26221 |
Miscellaneous databases
Pharosi | P16070, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3232692 |
DrugBanki | DB06550, Bivatuzumab DB08818, Hyaluronic acid |
Genetic variation databases
BioMutai | CD44 |
DMDMi | 308153615 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000026687 | 21 – 742 | CD44 antigenAdd BLAST | 722 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 28 ↔ 129 | Combined sources1 Publication | ||
Disulfide bondi | 53 ↔ 118 | Combined sources1 Publication | ||
Glycosylationi | 57 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 77 ↔ 97 | Combined sources1 Publication | ||
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 599 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 636 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 672 | Phosphoserine; by PKC1 Publication | 1 | |
Modified residuei | 686 | PhosphoserineCombined sources | 1 | |
Modified residuei | 697 | PhosphoserineBy similarity | 1 | |
Modified residuei | 706 | PhosphoserineCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, ProteoglycanProteomic databases
CPTACi | CPTAC-668 CPTAC-692 |
EPDi | P16070 |
jPOSTi | P16070 |
MassIVEi | P16070 |
MaxQBi | P16070 |
PaxDbi | P16070 |
PeptideAtlasi | P16070 |
PRIDEi | P16070 |
ProteomicsDBi | 53266 [P16070-1] 53267 [P16070-10] 53268 [P16070-11] 53269 [P16070-12] 53270 [P16070-13] 53271 [P16070-14] 53272 [P16070-15] 53273 [P16070-16] 53274 [P16070-17] 53275 [P16070-18] 53276 [P16070-19] 53277 [P16070-2] 53278 [P16070-3] 53279 [P16070-4] 53280 [P16070-5] 53281 [P16070-6] 53282 [P16070-7] 53283 [P16070-8] 53284 [P16070-9] |
TopDownProteomicsi | P16070-12 [P16070-12] P16070-14 [P16070-14] P16070-18 [P16070-18] P16070-4 [P16070-4] P16070-7 [P16070-7] |
2D gel databases
SWISS-2DPAGEi | P16070 |
PTM databases
GlyConnecti | 736, 42 N-Linked glycans (2 sites) |
GlyGeni | P16070, 25 sites, 2 O-linked glycans (10 sites) |
iPTMneti | P16070 |
MetOSitei | P16070 |
PhosphoSitePlusi | P16070 |
SwissPalmi | P16070 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 241 other tissues |
ExpressionAtlasi | P16070, baseline and differential |
Genevisiblei | P16070, HS |
Organism-specific databases
HPAi | ENSG00000026508, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PKN2 (PubMed:15123640).
Interacts with TIAM1 and TIAM2 (By similarity).
Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435, PubMed:25195884).
Interacts with UNC119 (PubMed:19381274).
Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267).
Interacts with RDX, EZR and MSN (By similarity).
Interacts with EGFR (PubMed:18757307, PubMed:23589287).
Interacts with CD74; this complex is essential for the MIF-induced signaling cascade that results in B cell survival (By similarity).
By similarity8 PublicationsBinary interactionsi
Hide detailsP16070
With | #Exp. | IntAct |
---|---|---|
CD74 [P04233] | 9 | EBI-490245,EBI-2622890 |
MSN [P26038] | 6 | EBI-490245,EBI-528768 |
SLC7A11 [Q9UPY5] | 4 | EBI-490245,EBI-3843348 |
ipaB [P18011] from Shigella flexneri. | 4 | EBI-490245,EBI-490239 |
Protein-protein interaction databases
BioGRIDi | 107398, 180 interactors |
CORUMi | P16070 |
DIPi | DIP-1121N |
ELMi | P16070 |
IntActi | P16070, 118 interactors |
MINTi | P16070 |
STRINGi | 9606.ENSP00000398632 |
Chemistry databases
BindingDBi | P16070 |
Miscellaneous databases
RNActi | P16070, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P16070 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16070 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 120 | LinkPROSITE-ProRule annotationAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 224 – 649 | StemAdd BLAST | 426 | |
Regioni | 673 – 691 | Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST | 19 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 150 – 158 | Arg/Lys-rich (basic) | 9 |
Domaini
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RX7Q, Eukaryota |
GeneTreei | ENSGT00530000063822 |
HOGENOMi | CLU_391256_0_0_1 |
InParanoidi | P16070 |
OMAi | RIPATNM |
OrthoDBi | 1098342at2759 |
PhylomeDBi | P16070 |
TreeFami | TF334173 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
s (19+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 19 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 19 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR
160 170 180 190 200
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST
210 220 230 240 250
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL
260 270 280 290 300
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD
310 320 330 340 350
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN
360 370 380 390 400
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK
410 420 430 440 450
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW
460 470 480 490 500
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP
510 520 530 540 550
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS
560 570 580 590 600
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR
610 620 630 640 650
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW
660 670 680 690 700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN
710 720 730 740
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → N
224-472: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-535: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → R
224-604: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → N
224-472: Missing.
536-536: N → R
537-604: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → N
224-472: Missing.
506-506: Q → R
507-535: Missing.
536-536: N → R
537-604: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → R
224-604: Missing.
675-675: R → S
676-742: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
192-192: G → A
193-223: Missing.
385-385: I → T
386-428: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
266-273: Missing.
385-385: I → T
386-428: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
223-223: T → R
224-604: Missing.
605-625: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
78-139: RYGFIEGHVV...TSVTDLPNAF → SLHCSQQSKK...VRNSRPVYDS
140-742: Missing.
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y5E4 | H0Y5E4_HUMAN | CD44 antigen | CD44 | 294 | Annotation score: | ||
H0YD90 | H0YD90_HUMAN | CD44 antigen | CD44 | 195 | Annotation score: | ||
H0YCV9 | H0YCV9_HUMAN | CD44 antigen | CD44 | 277 | Annotation score: | ||
H0Y2P0 | H0Y2P0_HUMAN | CD44 antigen | CD44 | 287 | Annotation score: | ||
H0YD13 | H0YD13_HUMAN | CD44 antigen | CD44 | 206 | Annotation score: | ||
H0YD17 | H0YD17_HUMAN | CD44 antigen | CD44 | 229 | Annotation score: | ||
H0YDX6 | H0YDX6_HUMAN | CD44 antigen | CD44 | 183 | Annotation score: | ||
H0YDW7 | H0YDW7_HUMAN | CD44 antigen | CD44 | 240 | Annotation score: | ||
E9PKC6 | E9PKC6_HUMAN | CD44 antigen | CD44 | 78 | Annotation score: | ||
Q86UZ1 | Q86UZ1_HUMAN | CD44 antigen | CD44 | 80 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | I → M in AAA82949 (Ref. 10) Curated | 1 | |
Sequence conflicti | 109 | S → Y in AAA35674 (PubMed:2466575).Curated | 1 | |
Sequence conflicti | 109 | S → Y in AAA51950 (PubMed:1840487).Curated | 1 | |
Sequence conflicti | 109 | S → Y in CAA38951 (PubMed:1991450).Curated | 1 | |
Sequence conflicti | 109 | S → Y in CAB61878 (PubMed:7508842).Curated | 1 | |
Sequence conflicti | 221 | A → R in CAA38951 (PubMed:1991450).Curated | 1 | |
Sequence conflicti | 241 | T → A in CAB61878 (PubMed:7508842).Curated | 1 | |
Sequence conflicti | 410 | E → V in CAA47271 (PubMed:1281868).Curated | 1 | |
Sequence conflicti | 494 | D → N in CAB61878 (PubMed:7508842).Curated | 1 | |
Sequence conflicti | 555 | T → H in CAA38951 (PubMed:1991450).Curated | 1 | |
Sequence conflicti | 620 | G → E in AAA35674 (PubMed:2466575).Curated | 1 | |
Sequence conflicti | 697 | S → I in AAM50041 (Ref. 11) Curated | 1 | |
Sequence conflicti | 697 | S → I in AAH67348 (Ref. 16) Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006490 | 46 | R → P in In(A) antigen. 1 PublicationCorresponds to variant dbSNP:rs369473842Ensembl. | 1 | |
Natural variantiVAR_030325 | 393 | T → M. Corresponds to variant dbSNP:rs11607491EnsemblClinVar. | 1 | |
Natural variantiVAR_021147 | 417 | K → R4 PublicationsCorresponds to variant dbSNP:rs9666607Ensembl. | 1 | |
Natural variantiVAR_030326 | 479 | I → T9 PublicationsCorresponds to variant dbSNP:rs1467558Ensembl. | 1 | |
Natural variantiVAR_030327 | 494 | D → H1 PublicationCorresponds to variant dbSNP:rs12273397Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005303 | 23 – 29 | DLNITCR → GVGRRKS in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_005304 | 30 – 742 | Missing in isoform 2. 1 PublicationAdd BLAST | 713 | |
Alternative sequenceiVSP_043870 | 78 – 139 | RYGFI…LPNAF → SLHCSQQSKKVWAEEKASDQ QWQWSCGGQKAKWTQRRGQQ VSGNGAFGEQGVVRNSRPVY DS in isoform 19. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_043871 | 140 – 742 | Missing in isoform 19. 1 PublicationAdd BLAST | 603 | |
Alternative sequenceiVSP_005305 | 192 | G → A in isoform 3 and isoform 16. Curated | 1 | |
Alternative sequenceiVSP_005306 | 193 – 223 | Missing in isoform 3 and isoform 16. CuratedAdd BLAST | 31 | |
Alternative sequenceiVSP_022797 | 223 – 535 | Missing in isoform 11. 2 PublicationsAdd BLAST | 313 | |
Alternative sequenceiVSP_005309 | 223 | T → N in isoform 10, isoform 13 and isoform 14. 5 Publications | 1 | |
Alternative sequenceiVSP_005311 | 223 | T → R in isoform 12, isoform 15 and isoform 18. 8 Publications | 1 | |
Alternative sequenceiVSP_005307 | 223 | T → S in isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_005312 | 224 – 604 | Missing in isoform 12, isoform 15 and isoform 18. 8 PublicationsAdd BLAST | 381 | |
Alternative sequenceiVSP_005310 | 224 – 472 | Missing in isoform 10, isoform 13 and isoform 14. 5 PublicationsAdd BLAST | 249 | |
Alternative sequenceiVSP_005308 | 224 – 266 | Missing in isoform 4. 2 PublicationsAdd BLAST | 43 | |
Alternative sequenceiVSP_005313 | 266 – 273 | Missing in isoform 5 and isoform 17. Curated | 8 | |
Alternative sequenceiVSP_005314 | 385 | I → T in isoform 6, isoform 16 and isoform 17. Curated | 1 | |
Alternative sequenceiVSP_005315 | 386 – 428 | Missing in isoform 6, isoform 16 and isoform 17. CuratedAdd BLAST | 43 | |
Alternative sequenceiVSP_005316 | 506 | Q → R in isoform 7 and isoform 14. 1 Publication | 1 | |
Alternative sequenceiVSP_005317 | 507 – 535 | Missing in isoform 7 and isoform 14. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_005318 | 536 | N → R in isoform 8, isoform 13 and isoform 14. 1 Publication | 1 | |
Alternative sequenceiVSP_005319 | 537 – 604 | Missing in isoform 8, isoform 13 and isoform 14. 1 PublicationAdd BLAST | 68 | |
Alternative sequenceiVSP_043575 | 605 – 625 | Missing in isoform 18. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_005320 | 675 | R → S in isoform 9 and isoform 15. 1 Publication | 1 | |
Alternative sequenceiVSP_005321 | 676 – 742 | Missing in isoform 9 and isoform 15. 1 PublicationAdd BLAST | 67 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000263398; ENSP00000263398; ENSG00000026508 [P16070-12] ENST00000278386; ENSP00000278386; ENSG00000026508 [P16070-19] ENST00000352818; ENSP00000309732; ENSG00000026508 [P16070-18] ENST00000415148; ENSP00000389830; ENSG00000026508 [P16070-4] ENST00000428726; ENSP00000398632; ENSG00000026508 [P16070-1] ENST00000433892; ENSP00000392331; ENSG00000026508 [P16070-10] ENST00000434472; ENSP00000404447; ENSG00000026508 [P16070-11] |
GeneIDi | 960 |
KEGGi | hsa:960 |
UCSCi | uc001mvu.4, human [P16070-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
dbRBC/BGMUT Blood group antigen gene mutation database |
Wikipedia CD44 entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1POZ | NMR | - | A | 20-178 | [»] | |
1UUH | X-ray | 2.20 | A/B | 20-178 | [»] | |
2I83 | NMR | - | A | 21-178 | [»] | |
4PZ3 | X-ray | 1.08 | A/B | 18-170 | [»] | |
4PZ4 | X-ray | 1.60 | A/B | 18-171 | [»] | |
6TXS | X-ray | 2.20 | BBB | 678-685 | [»] | |
SMRi | P16070 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107398, 180 interactors |
CORUMi | P16070 |
DIPi | DIP-1121N |
ELMi | P16070 |
IntActi | P16070, 118 interactors |
MINTi | P16070 |
STRINGi | 9606.ENSP00000398632 |
Chemistry databases
BindingDBi | P16070 |
ChEMBLi | CHEMBL3232692 |
DrugBanki | DB06550, Bivatuzumab DB08818, Hyaluronic acid |
PTM databases
GlyConnecti | 736, 42 N-Linked glycans (2 sites) |
GlyGeni | P16070, 25 sites, 2 O-linked glycans (10 sites) |
iPTMneti | P16070 |
MetOSitei | P16070 |
PhosphoSitePlusi | P16070 |
SwissPalmi | P16070 |
Genetic variation databases
BioMutai | CD44 |
DMDMi | 308153615 |
2D gel databases
SWISS-2DPAGEi | P16070 |
Proteomic databases
CPTACi | CPTAC-668 CPTAC-692 |
EPDi | P16070 |
jPOSTi | P16070 |
MassIVEi | P16070 |
MaxQBi | P16070 |
PaxDbi | P16070 |
PeptideAtlasi | P16070 |
PRIDEi | P16070 |
ProteomicsDBi | 53266 [P16070-1] 53267 [P16070-10] 53268 [P16070-11] 53269 [P16070-12] 53270 [P16070-13] 53271 [P16070-14] 53272 [P16070-15] 53273 [P16070-16] 53274 [P16070-17] 53275 [P16070-18] 53276 [P16070-19] 53277 [P16070-2] 53278 [P16070-3] 53279 [P16070-4] 53280 [P16070-5] 53281 [P16070-6] 53282 [P16070-7] 53283 [P16070-8] 53284 [P16070-9] |
TopDownProteomicsi | P16070-12 [P16070-12] P16070-14 [P16070-14] P16070-18 [P16070-18] P16070-4 [P16070-4] P16070-7 [P16070-7] |
Protocols and materials databases
ABCDi | P16070, 22 sequenced antibodies |
Antibodypediai | 804, 5247 antibodies |
CPTCi | P16070, 2 antibodies |
DNASUi | 960 |
Genome annotation databases
Organism-specific databases
CTDi | 960 |
DisGeNETi | 960 |
GeneCardsi | CD44 |
HGNCi | HGNC:1681, CD44 |
HPAi | ENSG00000026508, Low tissue specificity |
MIMi | 107269, gene 172290, gene 609027, phenotype |
neXtProti | NX_P16070 |
OpenTargetsi | ENSG00000026508 |
PharmGKBi | PA26221 |
VEuPathDBi | HostDB:ENSG00000026508.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RX7Q, Eukaryota |
GeneTreei | ENSGT00530000063822 |
HOGENOMi | CLU_391256_0_0_1 |
InParanoidi | P16070 |
OMAi | RIPATNM |
OrthoDBi | 1098342at2759 |
PhylomeDBi | P16070 |
TreeFami | TF334173 |
Enzyme and pathway databases
PathwayCommonsi | P16070 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-216083, Integrin cell surface interactions R-HSA-2160916, Hyaluronan uptake and degradation R-HSA-6798695, Neutrophil degranulation R-HSA-877300, Interferon gamma signaling |
SIGNORi | P16070 |
Miscellaneous databases
BioGRID-ORCSi | 960, 20 hits in 995 CRISPR screens |
ChiTaRSi | CD44, human |
EvolutionaryTracei | P16070 |
GeneWikii | CD44 |
GenomeRNAii | 960 |
Pharosi | P16070, Tbio |
PROi | PR:P16070 |
RNActi | P16070, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 241 other tissues |
ExpressionAtlasi | P16070, baseline and differential |
Genevisiblei | P16070, HS |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR001231, CD44_antigen IPR043210, CD44_antigen-like IPR016187, CTDL_fold IPR000538, Link_dom |
PANTHERi | PTHR10225, PTHR10225, 2 hits PTHR10225:SF6, PTHR10225:SF6, 2 hits |
Pfami | View protein in Pfam PF00193, Xlink, 1 hit |
PRINTSi | PR00658, CD44 PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00445, LINK, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS01241, LINK_1, 1 hit PS50963, LINK_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD44_HUMAN | |
Accessioni | P16070Primary (citable) accession number: P16070 Secondary accession number(s): A5YRN9 Q9UJ36 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | October 5, 2010 | |
Last modified: | April 7, 2021 | |
This is version 243 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Blood group antigen proteins
Nomenclature of blood group antigens and list of entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references