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UniProtKB - P16070 (CD44_HUMAN)

Entry version 242 (10 Feb 2021)
Sequence version 3 (05 Oct 2010)
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Protein

CD44 antigen

Gene

CD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41HyaluronanBy similarity1
Binding sitei78HyaluronanBy similarity1
Binding sitei79HyaluronanBy similarity1
Binding sitei105HyaluronanBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, Receptor
Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P16070

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-216083, Integrin cell surface interactions
R-HSA-2160916, Hyaluronan uptake and degradation
R-HSA-6798695, Neutrophil degranulation
R-HSA-877300, Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P16070

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
CDw44
Epican
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Heparan sulfate proteoglycan
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD44
Synonyms:LHR, MDU2, MDU3, MIC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1681, CD44

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		107269, gene
172290, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P16070

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000026508.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 649ExtracellularSequence analysisAdd BLAST629
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 742CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		960
MIMi609027, phenotype

Open Targets

More...OpenTargetsi		ENSG00000026508

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26221

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P16070, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3232692

Drug and drug target database

More...DrugBanki		DB06550, Bivatuzumab
DB08818, Hyaluronic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD44

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153615

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002668721 – 742CD44 antigenAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 129Combined sources1 Publication
Disulfide bondi53 ↔ 118Combined sources1 Publication
Glycosylationi57N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi77 ↔ 97Combined sources1 Publication
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei672Phosphoserine; by PKC1 Publication1
Modified residuei686PhosphoserineCombined sources1
Modified residuei697PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.1 Publication
N-glycosylated.4 Publications
O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.2 Publications
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-668
CPTAC-692

Encyclopedia of Proteome Dynamics

More...EPDi		P16070

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P16070

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P16070

MaxQB - The MaxQuant DataBase

More...MaxQBi		P16070

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P16070

PeptideAtlas

More...PeptideAtlasi		P16070

PRoteomics IDEntifications database

More...PRIDEi		P16070

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53266 [P16070-1]
53267 [P16070-10]
53268 [P16070-11]
53269 [P16070-12]
53270 [P16070-13]
53271 [P16070-14]
53272 [P16070-15]
53273 [P16070-16]
53274 [P16070-17]
53275 [P16070-18]
53276 [P16070-19]
53277 [P16070-2]
53278 [P16070-3]
53279 [P16070-4]
53280 [P16070-5]
53281 [P16070-6]
53282 [P16070-7]
53283 [P16070-8]
53284 [P16070-9]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P16070-12 [P16070-12]
P16070-14 [P16070-14]
P16070-18 [P16070-18]
P16070-4 [P16070-4]
P16070-7 [P16070-7]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P16070

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		736, 42 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P16070, 25 sites, 2 O-linked glycans (10 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P16070

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P16070

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P16070

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P16070

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the developing retina between 16 and 19 weeks post-conception, specifically in the outer neuroblastic zone, inner neuroblastic zone, interphotoreceptor zone and the retinal pigment epithelium (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000026508, Expressed in parotid gland and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P16070, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P16070, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000026508, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PKN2 (PubMed:15123640).

Interacts with TIAM1 and TIAM2 (By similarity).

Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435, PubMed:25195884).

Interacts with UNC119 (PubMed:19381274).

Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267).

Interacts with RDX, EZR and MSN (By similarity).

Interacts with EGFR (PubMed:18757307, PubMed:23589287).

Interacts with CD74; this complex is essential for the MIF-induced signaling cascade that results in B cell survival (By similarity).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107398, 167 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P16070

Database of interacting proteins

More...DIPi		DIP-1121N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P16070

Protein interaction database and analysis system

More...IntActi		P16070, 117 interactors

Molecular INTeraction database

More...MINTi		P16070

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000398632

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P16070

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P16070, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P16070

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P16070

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 120LinkPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni224 – 649StemAdd BLAST426
Regioni673 – 691Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi150 – 158Arg/Lys-rich (basic)9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RX7Q, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063822

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_391256_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P16070

Identification of Orthologs from Complete Genome Data

More...OMAi		RIPATNM

Database of Orthologous Groups

More...OrthoDBi		1098342at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P16070

TreeFam database of animal gene trees

More...TreeFami		TF334173

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR001231, CD44_antigen
IPR043210, CD44_antigen-like
IPR016187, CTDL_fold
IPR000538, Link_dom

The PANTHER Classification System

More...PANTHERi		PTHR10225, PTHR10225, 2 hits
PTHR10225:SF6, PTHR10225:SF6, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00193, Xlink, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00658, CD44
PR01265, LINKMODULE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00445, LINK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (19+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 19 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Additional isoforms are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. Additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. A variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. Isoform CD44 is expected to be expressed in normal cells. Splice variants have been found in many tumor cell lines. Exons 5, 6, 7, 8, 9, 10, 11, 13, 14 and 19 are alternatively spliced. Experimental confirmation may be lacking for some isoforms.1 Publication

This entry has 19 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16070-1) [UniParc]FASTAAdd to basket
Also known as: CD44

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA 
        60         70         80         90        100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN 
       110        120        130        140        150
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR 
       160        170        180        190        200
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST 
       210        220        230        240        250
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL 
       260        270        280        290        300
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 
       310        320        330        340        350
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN 
       360        370        380        390        400
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK 
       410        420        430        440        450
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW 
       460        470        480        490        500
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP 
       510        520        530        540        550
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS 
       560        570        580        590        600
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR 
       610        620        630        640        650
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW 
       660        670        680        690        700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN 
       710        720        730        740 
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV
Note: Corresponds to the largest isoform.
Length:742
Mass (Da):81,538
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB9B66B19B970349
GO
Isoform 2 (identifier: P16070-2) [UniParc]FASTAAdd to basket
Also known as: CD44SP

The sequence of this isoform differs from the canonical sequence as follows:
     23-29: DLNITCR → GVGRRKS
     30-742: Missing.

Show »
Length:29
Mass (Da):3,327
Checksum:iFD28FA0E33AB08B9
GO
Isoform 3 (identifier: P16070-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.

Note: Alternative splice donor/acceptor on exon 5.Curated
Show »
Length:711
Mass (Da):77,983
Checksum:iEF48BFB8E4478B97
GO
Isoform 4 (identifier: P16070-4) [UniParc]FASTAAdd to basket
Also known as: Epidermal

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → S
     224-266: Missing.

Note: Lacks exon 6.Curated
Show »
Length:699
Mass (Da):76,612
Checksum:iCEC79496379F44FF
GO
Isoform 5 (identifier: P16070-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.

Note: Alternative splice donor/acceptor on exon 7.Curated
Show »
Length:734
Mass (Da):80,790
Checksum:i48D27AD91375BCDC
GO
Isoform 6 (identifier: P16070-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-385: I → T
     386-428: Missing.

Note: Lacks exon 10.Curated
Show »
Length:699
Mass (Da):76,705
Checksum:iA150D6FA11DAABD6
GO
Isoform 7 (identifier: P16070-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-506: Q → R
     507-535: Missing.

Note: Lacks exon 13.Curated
Show »
Length:713
Mass (Da):78,446
Checksum:i2C2098B56FF4F30E
GO
Isoform 8 (identifier: P16070-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     536-536: N → R
     537-604: Missing.

Note: Lacks exon 14.Curated
Show »
Length:674
Mass (Da):74,388
Checksum:i538CB559E671CF23
GO
Isoform 9 (identifier: P16070-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-675: R → S
     676-742: Missing.

Note: Lacks exon 19.Curated
Show »
Length:675
Mass (Da):74,196
Checksum:i3891F679BC733F89
GO
Isoform 10 (identifier: P16070-10) [UniParc]FASTAAdd to basket
Also known as: CD44E, CD44R1, Epithelial, Keratinocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.

Note: Lacks exons 6-11.Curated
Show »
Length:493
Mass (Da):53,411
Checksum:iA494CCC37F161EF2
GO
Isoform 11 (identifier: P16070-11) [UniParc]FASTAAdd to basket
Also known as: CD44R2

The sequence of this isoform differs from the canonical sequence as follows:
     223-535: Missing.

Note: Lacks exons 6-13.Curated
Show »
Length:429
Mass (Da):46,565
Checksum:i557BD4FED59E0867
GO
Isoform 12 (identifier: P16070-12) [UniParc]FASTAAdd to basket
Also known as: CDw44, Reticulocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.

Note: Lacks exons 6-14.Curated
Show »
Length:361
Mass (Da):39,416
Checksum:iF51A746B442E0D33
GO
Isoform 13 (identifier: P16070-13) [UniParc]FASTAAdd to basket
Also known as: CD44R4

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11 and exon 14.Curated
Show »
Length:425
Mass (Da):46,261
Checksum:i47F544DD9890917B
GO
Isoform 14 (identifier: P16070-14) [UniParc]FASTAAdd to basket
Also known as: CD44R5

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     506-506: Q → R
     507-535: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11, exon 13 and exon 14.Curated
Show »
Length:396
Mass (Da):43,169
Checksum:i5118DABF71C1F7D0
GO
Isoform 15 (identifier: P16070-15) [UniParc]FASTAAdd to basket
Also known as: Hermes

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     675-675: R → S
     676-742: Missing.

Note: Lacks exons 6-14 and exon 19.Curated
Show »
Length:294
Mass (Da):32,075
Checksum:iE11B9B38F4A74817
GO
Isoform 16 (identifier: P16070-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 5 and lacks exon 10.Curated
Show »
Length:668
Mass (Da):73,150
Checksum:iD719820A01C4517F
GO
Isoform 17 (identifier: P16070-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 7 and lacks exon 10.Curated
Show »
Length:691
Mass (Da):75,957
Checksum:i737967321EE8F579
GO
Isoform 18 (identifier: P16070-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     605-625: Missing.

Show »
Length:340
Mass (Da):37,278
Checksum:iC2E036A7DAB5717B
GO
Isoform 19 (identifier: P16070-19) [UniParc]FASTAAdd to basket
Also known as: CD44RC

The sequence of this isoform differs from the canonical sequence as follows:
     78-139: RYGFIEGHVV...TSVTDLPNAF → SLHCSQQSKK...VRNSRPVYDS
     140-742: Missing.

Note: Soluble isoform, has enhanced hyaluronan binding.Curated
Show »
Length:139
Mass (Da):15,635
Checksum:i4A127F5C54BB7B62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5E4H0Y5E4_HUMAN
CD44 antigen
CD44
294Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD90H0YD90_HUMAN
CD44 antigen
CD44
195Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCV9H0YCV9_HUMAN
CD44 antigen
CD44
277Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2P0H0Y2P0_HUMAN
CD44 antigen
CD44
287Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD13H0YD13_HUMAN
CD44 antigen
CD44
206Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD17H0YD17_HUMAN
CD44 antigen
CD44
229Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDX6H0YDX6_HUMAN
CD44 antigen
CD44
183Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDW7H0YDW7_HUMAN
CD44 antigen
CD44
240Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKC6E9PKC6_HUMAN
CD44 antigen
CD44
78Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86UZ1Q86UZ1_HUMAN
CD44 antigen
CD44
80Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26I → M in AAA82949 (Ref. 10) Curated1
Sequence conflicti109S → Y in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti109S → Y in AAA51950 (PubMed:1840487).Curated1
Sequence conflicti109S → Y in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti109S → Y in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti221A → R in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti241T → A in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti410E → V in CAA47271 (PubMed:1281868).Curated1
Sequence conflicti494D → N in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti555T → H in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti620G → E in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti697S → I in AAM50041 (Ref. 11) Curated1
Sequence conflicti697S → I in AAH67348 (Ref. 16) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00649046R → P in In(A) antigen. 1 PublicationCorresponds to variant dbSNP:rs369473842Ensembl.1
Natural variantiVAR_030325393T → M. Corresponds to variant dbSNP:rs11607491EnsemblClinVar.1
Natural variantiVAR_021147417K → R4 PublicationsCorresponds to variant dbSNP:rs9666607Ensembl.1
Natural variantiVAR_030326479I → T9 PublicationsCorresponds to variant dbSNP:rs1467558Ensembl.1
Natural variantiVAR_030327494D → H1 PublicationCorresponds to variant dbSNP:rs12273397Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00530323 – 29DLNITCR → GVGRRKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_00530430 – 742Missing in isoform 2. 1 PublicationAdd BLAST713
Alternative sequenceiVSP_04387078 – 139RYGFI…LPNAF → SLHCSQQSKKVWAEEKASDQ QWQWSCGGQKAKWTQRRGQQ VSGNGAFGEQGVVRNSRPVY DS in isoform 19. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_043871140 – 742Missing in isoform 19. 1 PublicationAdd BLAST603
Alternative sequenceiVSP_005305192G → A in isoform 3 and isoform 16. Curated1
Alternative sequenceiVSP_005306193 – 223Missing in isoform 3 and isoform 16. CuratedAdd BLAST31
Alternative sequenceiVSP_022797223 – 535Missing in isoform 11. 2 PublicationsAdd BLAST313
Alternative sequenceiVSP_005309223T → N in isoform 10, isoform 13 and isoform 14. 5 Publications1
Alternative sequenceiVSP_005311223T → R in isoform 12, isoform 15 and isoform 18. 8 Publications1
Alternative sequenceiVSP_005307223T → S in isoform 4. 2 Publications1
Alternative sequenceiVSP_005312224 – 604Missing in isoform 12, isoform 15 and isoform 18. 8 PublicationsAdd BLAST381
Alternative sequenceiVSP_005310224 – 472Missing in isoform 10, isoform 13 and isoform 14. 5 PublicationsAdd BLAST249
Alternative sequenceiVSP_005308224 – 266Missing in isoform 4. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_005313266 – 273Missing in isoform 5 and isoform 17. Curated8
Alternative sequenceiVSP_005314385I → T in isoform 6, isoform 16 and isoform 17. Curated1
Alternative sequenceiVSP_005315386 – 428Missing in isoform 6, isoform 16 and isoform 17. CuratedAdd BLAST43
Alternative sequenceiVSP_005316506Q → R in isoform 7 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005317507 – 535Missing in isoform 7 and isoform 14. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_005318536N → R in isoform 8, isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005319537 – 604Missing in isoform 8, isoform 13 and isoform 14. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_043575605 – 625Missing in isoform 18. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_005320675R → S in isoform 9 and isoform 15. 1 Publication1
Alternative sequenceiVSP_005321676 – 742Missing in isoform 9 and isoform 15. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M24915 mRNA Translation: AAA35674.1
M59040 mRNA Translation: AAA51950.1
X55150 mRNA Translation: CAA38951.1
X56794 mRNA Translation: CAA40133.1
X66733 mRNA Translation: CAA47271.1
L05423 M69215 Genomic DNA Translation: AAB13622.1
L05423 M69215 Genomic DNA Translation: AAB13623.1
L05424 M69215 Genomic DNA Translation: AAB13624.1
L05424 M69215 Genomic DNA Translation: AAB13625.1
L05424 M69215 Genomic DNA Translation: AAB13626.1
L05424 M69215 Genomic DNA Translation: AAB13627.1
L05424 M69215 Genomic DNA Translation: AAB13628.1
AJ251595 mRNA Translation: CAB61878.1
S66400 mRNA Translation: AAB27917.1
S66400 mRNA Translation: AAB27918.2
S66400 mRNA Translation: AAB27919.1
AF098641 mRNA Translation: AAC70782.1
U40373 mRNA Translation: AAA82949.1
AY101192 mRNA Translation: AAM50040.1
AY101193 mRNA Translation: AAM50041.1
EF581837 mRNA Translation: ABQ59315.1
FJ216964 mRNA Translation: ACI46596.1
AL832642 mRNA Translation: CAD89965.1
AL133330 Genomic DNA No translation available.
AL136989 Genomic DNA No translation available.
AL356215 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68147.1
CH471064 Genomic DNA Translation: EAW68148.1
CH471064 Genomic DNA Translation: EAW68149.1
CH471064 Genomic DNA Translation: EAW68151.1
CH471064 Genomic DNA Translation: EAW68152.1
BC004372 mRNA Translation: AAH04372.1
BC067348 mRNA Translation: AAH67348.1
M25078 mRNA Translation: AAA36138.1
X55938 mRNA Translation: CAA39404.1
S72928 Genomic DNA Translation: AAB30429.1
X62739 mRNA Translation: CAA44602.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31455.1 [P16070-4]
CCDS31456.1 [P16070-10]
CCDS31457.1 [P16070-12]
CCDS31458.1 [P16070-19]
CCDS55754.1 [P16070-11]
CCDS55755.1 [P16070-18]
CCDS7897.1 [P16070-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A47195
I37369
I77371
I77372
JH0417
JH0518
S13530
S24222

NCBI Reference Sequences

More...RefSeqi		NP_000601.3, NM_000610.3 [P16070-1]
NP_001001389.1, NM_001001389.1 [P16070-4]
NP_001001390.1, NM_001001390.1 [P16070-10]
NP_001001391.1, NM_001001391.1 [P16070-12]
NP_001001392.1, NM_001001392.1 [P16070-19]
NP_001189484.1, NM_001202555.1 [P16070-11]
NP_001189485.1, NM_001202556.1 [P16070-18]
NP_001189486.1, NM_001202557.1 [P16070-15]
XP_011518790.1, XM_011520488.1 [P16070-13]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263398; ENSP00000263398; ENSG00000026508 [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508 [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508 [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508 [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508 [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508 [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508 [P16070-11]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		960

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:960

UCSC genome browser

More...UCSCi		uc001mvu.4, human [P16070-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

CD44 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24915 mRNA Translation: AAA35674.1
M59040 mRNA Translation: AAA51950.1
X55150 mRNA Translation: CAA38951.1
X56794 mRNA Translation: CAA40133.1
X66733 mRNA Translation: CAA47271.1
L05423 M69215 Genomic DNA Translation: AAB13622.1
L05423 M69215 Genomic DNA Translation: AAB13623.1
L05424 M69215 Genomic DNA Translation: AAB13624.1
L05424 M69215 Genomic DNA Translation: AAB13625.1
L05424 M69215 Genomic DNA Translation: AAB13626.1
L05424 M69215 Genomic DNA Translation: AAB13627.1
L05424 M69215 Genomic DNA Translation: AAB13628.1
AJ251595 mRNA Translation: CAB61878.1
S66400 mRNA Translation: AAB27917.1
S66400 mRNA Translation: AAB27918.2
S66400 mRNA Translation: AAB27919.1
AF098641 mRNA Translation: AAC70782.1
U40373 mRNA Translation: AAA82949.1
AY101192 mRNA Translation: AAM50040.1
AY101193 mRNA Translation: AAM50041.1
EF581837 mRNA Translation: ABQ59315.1
FJ216964 mRNA Translation: ACI46596.1
AL832642 mRNA Translation: CAD89965.1
AL133330 Genomic DNA No translation available.
AL136989 Genomic DNA No translation available.
AL356215 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68147.1
CH471064 Genomic DNA Translation: EAW68148.1
CH471064 Genomic DNA Translation: EAW68149.1
CH471064 Genomic DNA Translation: EAW68151.1
CH471064 Genomic DNA Translation: EAW68152.1
BC004372 mRNA Translation: AAH04372.1
BC067348 mRNA Translation: AAH67348.1
M25078 mRNA Translation: AAA36138.1
X55938 mRNA Translation: CAA39404.1
S72928 Genomic DNA Translation: AAB30429.1
X62739 mRNA Translation: CAA44602.1
CCDSiCCDS31455.1 [P16070-4]
CCDS31456.1 [P16070-10]
CCDS31457.1 [P16070-12]
CCDS31458.1 [P16070-19]
CCDS55754.1 [P16070-11]
CCDS55755.1 [P16070-18]
CCDS7897.1 [P16070-1]
PIRiA47195
I37369
I77371
I77372
JH0417
JH0518
S13530
S24222
RefSeqiNP_000601.3, NM_000610.3 [P16070-1]
NP_001001389.1, NM_001001389.1 [P16070-4]
NP_001001390.1, NM_001001390.1 [P16070-10]
NP_001001391.1, NM_001001391.1 [P16070-12]
NP_001001392.1, NM_001001392.1 [P16070-19]
NP_001189484.1, NM_001202555.1 [P16070-11]
NP_001189485.1, NM_001202556.1 [P16070-18]
NP_001189486.1, NM_001202557.1 [P16070-15]
XP_011518790.1, XM_011520488.1 [P16070-13]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POZNMR-A20-178[»]
1UUHX-ray2.20A/B20-178[»]
2I83NMR-A21-178[»]
4PZ3X-ray1.08A/B18-170[»]
4PZ4X-ray1.60A/B18-171[»]
6TXSX-ray2.20BBB678-685[»]
SMRiP16070
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107398, 167 interactors
CORUMiP16070
DIPiDIP-1121N
ELMiP16070
IntActiP16070, 117 interactors
MINTiP16070
STRINGi9606.ENSP00000398632

Chemistry databases

BindingDBiP16070
ChEMBLiCHEMBL3232692
DrugBankiDB06550, Bivatuzumab
DB08818, Hyaluronic acid

PTM databases

GlyConnecti736, 42 N-Linked glycans (2 sites)
GlyGeniP16070, 25 sites, 2 O-linked glycans (10 sites)
iPTMnetiP16070
MetOSiteiP16070
PhosphoSitePlusiP16070
SwissPalmiP16070

Genetic variation databases

BioMutaiCD44
DMDMi308153615

2D gel databases

SWISS-2DPAGEiP16070

Proteomic databases

CPTACiCPTAC-668
CPTAC-692
EPDiP16070
jPOSTiP16070
MassIVEiP16070
MaxQBiP16070
PaxDbiP16070
PeptideAtlasiP16070
PRIDEiP16070
ProteomicsDBi53266 [P16070-1]
53267 [P16070-10]
53268 [P16070-11]
53269 [P16070-12]
53270 [P16070-13]
53271 [P16070-14]
53272 [P16070-15]
53273 [P16070-16]
53274 [P16070-17]
53275 [P16070-18]
53276 [P16070-19]
53277 [P16070-2]
53278 [P16070-3]
53279 [P16070-4]
53280 [P16070-5]
53281 [P16070-6]
53282 [P16070-7]
53283 [P16070-8]
53284 [P16070-9]
TopDownProteomicsiP16070-12 [P16070-12]
P16070-14 [P16070-14]
P16070-18 [P16070-18]
P16070-4 [P16070-4]
P16070-7 [P16070-7]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P16070, 22 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		804, 5195 antibodies

The CPTC Antibody Portal

More...CPTCi		P16070, 2 antibodies

The DNASU plasmid repository

More...DNASUi		960

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508 [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508 [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508 [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508 [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508 [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508 [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508 [P16070-11]
GeneIDi960
KEGGihsa:960
UCSCiuc001mvu.4, human [P16070-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		960
DisGeNETi960

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD44
HGNCiHGNC:1681, CD44
HPAiENSG00000026508, Low tissue specificity
MIMi107269, gene
172290, gene
609027, phenotype
neXtProtiNX_P16070
OpenTargetsiENSG00000026508
PharmGKBiPA26221
VEuPathDBiHostDB:ENSG00000026508.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RX7Q, Eukaryota
GeneTreeiENSGT00530000063822
HOGENOMiCLU_391256_0_0_1
InParanoidiP16070
OMAiRIPATNM
OrthoDBi1098342at2759
PhylomeDBiP16070
TreeFamiTF334173

Enzyme and pathway databases

PathwayCommonsiP16070
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-216083, Integrin cell surface interactions
R-HSA-2160916, Hyaluronan uptake and degradation
R-HSA-6798695, Neutrophil degranulation
R-HSA-877300, Interferon gamma signaling
SIGNORiP16070

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		960, 15 hits in 881 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD44, human
EvolutionaryTraceiP16070

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD44

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		960
PharosiP16070, Tbio

Protein Ontology

More...PROi		PR:P16070
RNActiP16070, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000026508, Expressed in parotid gland and 241 other tissues
ExpressionAtlasiP16070, baseline and differential
GenevisibleiP16070, HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186, C-type_lectin-like/link_sf
IPR001231, CD44_antigen
IPR043210, CD44_antigen-like
IPR016187, CTDL_fold
IPR000538, Link_dom
PANTHERiPTHR10225, PTHR10225, 2 hits
PTHR10225:SF6, PTHR10225:SF6, 2 hits
PfamiView protein in Pfam
PF00193, Xlink, 1 hit
PRINTSiPR00658, CD44
PR01265, LINKMODULE
SMARTiView protein in SMART
SM00445, LINK, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241, LINK_1, 1 hit
PS50963, LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD44_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16070
Secondary accession number(s): A5YRN9
, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: February 10, 2021
This is version 242 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
  5. Human variants curated from literature reports
    Index of human variants curated from literature reports
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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