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UniProtKB - P16070 (CD44_HUMAN)

Protein

CD44 antigen

Gene

CD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41HyaluronanBy similarity1
Binding sitei78HyaluronanBy similarity1
Binding sitei79HyaluronanBy similarity1
Binding sitei105HyaluronanBy similarity1

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • hyaluronic acid binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionBlood group antigen, Receptor
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
SIGNORiP16070

Names & Taxonomyi

Protein namesi
Recommended name:
CD44 antigen
Alternative name(s):
CDw44
Epican
Extracellular matrix receptor III
Short name:
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
Heparan sulfate proteoglycan
Hermes antigen
Hyaluronate receptor
Phagocytic glycoprotein 1
Short name:
PGP-1
Phagocytic glycoprotein I
Short name:
PGP-I
CD_antigen: CD44
Gene namesi
Name:CD44
Synonyms:LHR, MDU2, MDU3, MIC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000026508.16
HGNCiHGNC:1681 CD44
MIMi107269 gene
172290 gene
neXtProtiNX_P16070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 649ExtracellularSequence analysisAdd BLAST629
Transmembranei650 – 670HelicalSequence analysisAdd BLAST21
Topological domaini671 – 742CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi960
MIMi609027 phenotype
OpenTargetsiENSG00000026508
PharmGKBiPA26221

Chemistry databases

ChEMBLiCHEMBL3232692
DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiCD44
DMDMi308153615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002668721 – 742CD44 antigenAdd BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi28 ↔ 129PROSITE-ProRule annotation
Disulfide bondi53 ↔ 118PROSITE-ProRule annotation
Glycosylationi57N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi77 ↔ 97PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi636N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672Phosphoserine; by PKC1 Publication1
Modified residuei686PhosphoserineCombined sources1
Modified residuei697PhosphoserineBy similarity1
Modified residuei706PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.1 Publication
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.4 Publications
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiP16070
MaxQBiP16070
PaxDbiP16070
PeptideAtlasiP16070
PRIDEiP16070
ProteomicsDBi53266
53267 [P16070-10]
53268 [P16070-11]
53269 [P16070-12]
53270 [P16070-13]
53271 [P16070-14]
53272 [P16070-15]
53273 [P16070-16]
53274 [P16070-17]
53275 [P16070-18]
53276 [P16070-19]
53277 [P16070-2]
53278 [P16070-3]
53279 [P16070-4]
53280 [P16070-5]
53281 [P16070-6]
53282 [P16070-7]
53283 [P16070-8]
53284 [P16070-9]
TopDownProteomicsiP16070-12 [P16070-12]
P16070-14 [P16070-14]
P16070-18 [P16070-18]
P16070-4 [P16070-4]
P16070-7 [P16070-7]

2D gel databases

SWISS-2DPAGEiP16070

PTM databases

GlyConnecti736
iPTMnetiP16070
PhosphoSitePlusiP16070
SwissPalmiP16070
UniCarbKBiP16070

Expressioni

Tissue specificityi

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Gene expression databases

BgeeiENSG00000026508 Expressed in 228 organ(s), highest expression level in parotid gland
ExpressionAtlasiP16070 baseline and differential
GenevisibleiP16070 HS

Organism-specific databases

HPAiCAB000112
CAB000316
HPA005785

Interactioni

Subunit structurei

Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with UNC119 (PubMed:19381274). Interacts with PDPN (via extracellular domain); this interaction is required for PDPN-mediated directional migration and regulation of lamellipodia extension/stabilization during cell spreading and migration (PubMed:20962267). Interacts with RDX, EZR and MSN (By similarity).By similarity4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi107398, 109 interactors
DIPiDIP-1121N
ELMiP16070
IntActiP16070, 57 interactors
MINTiP16070
STRINGi9606.ENSP00000398632

Chemistry databases

BindingDBiP16070

Structurei

Secondary structure

1742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP16070
SMRiP16070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP16070

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 120LinkPROSITE-ProRule annotationAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni224 – 649StemAdd BLAST426
Regioni673 – 691Required for interaction with EZR, MSN and RDX and for co-localization to microvilliBy similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 158Arg/Lys-rich (basic)9

Domaini

The lectin-like LINK domain is responsible for hyaluronan binding.By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZCP Eukaryota
ENOG4111S6T LUCA
GeneTreeiENSGT00530000063822
HOGENOMiHOG000115236
HOVERGENiHBG003850
InParanoidiP16070
KOiK06256
OMAiSHPMGRG
OrthoDBiEOG091G0F98
PhylomeDBiP16070
TreeFamiTF334173

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom
PANTHERiPTHR10225:SF6 PTHR10225:SF6, 1 hit
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
PRINTSiPR00658 CD44
PR01265 LINKMODULE
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

Sequences (19+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 19 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Additional isoforms are produced by alternative splicing of 10 out of 19 exons within the extracellular domain. Additional diversity is generated through the utilization of internal splice donor and acceptor sites within 2 of the exons. A variation in the cytoplasmic domain was shown to result from the alternative splicing of 2 exons. Isoform CD44 is expected to be expressed in normal cells. Splice variants have been found in many tumor cell lines. Exons 5, 6, 7, 8, 9, 10, 11, 13, 14 and 19 are alternatively spliced. Experimental confirmation may be lacking for some isoforms.1 Publication

This entry has 19 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16070-1) [UniParc]FASTAAdd to basket
Also known as: CD44

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA 
        60         70         80         90        100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN 
       110        120        130        140        150
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR 
       160        170        180        190        200
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST 
       210        220        230        240        250
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL 
       260        270        280        290        300
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD 
       310        320        330        340        350
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN 
       360        370        380        390        400
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK 
       410        420        430        440        450
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW 
       460        470        480        490        500
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP 
       510        520        530        540        550
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS 
       560        570        580        590        600
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR 
       610        620        630        640        650
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW 
       660        670        680        690        700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN 
       710        720        730        740 
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV
Note: Corresponds to the largest isoform.
Length:742
Mass (Da):81,538
Last modified:October 5, 2010 - v3
Checksum:iBB9B66B19B970349
GO
Isoform 2 (identifier: P16070-2) [UniParc]FASTAAdd to basket
Also known as: CD44SP

The sequence of this isoform differs from the canonical sequence as follows:
     23-29: DLNITCR → GVGRRKS
     30-742: Missing.

Show »
Length:29
Mass (Da):3,327
Checksum:iFD28FA0E33AB08B9
GO
Isoform 3 (identifier: P16070-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.

Note: Alternative splice donor/acceptor on exon 5.
Show »
Length:711
Mass (Da):77,983
Checksum:iEF48BFB8E4478B97
GO
Isoform 4 (identifier: P16070-4) [UniParc]FASTAAdd to basket
Also known as: Epidermal

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → S
     224-266: Missing.

Note: Lacks exon 6.
Show »
Length:699
Mass (Da):76,612
Checksum:iCEC79496379F44FF
GO
Isoform 5 (identifier: P16070-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.

Note: Alternative splice donor/acceptor on exon 7.
Show »
Length:734
Mass (Da):80,790
Checksum:i48D27AD91375BCDC
GO
Isoform 6 (identifier: P16070-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     385-385: I → T
     386-428: Missing.

Note: Lacks exon 10.
Show »
Length:699
Mass (Da):76,705
Checksum:iA150D6FA11DAABD6
GO
Isoform 7 (identifier: P16070-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-506: Q → R
     507-535: Missing.

Note: Lacks exon 13.
Show »
Length:713
Mass (Da):78,446
Checksum:i2C2098B56FF4F30E
GO
Isoform 8 (identifier: P16070-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     536-536: N → R
     537-604: Missing.

Note: Lacks exon 14.
Show »
Length:674
Mass (Da):74,388
Checksum:i538CB559E671CF23
GO
Isoform 9 (identifier: P16070-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     675-675: R → S
     676-742: Missing.

Note: Lacks exon 19.
Show »
Length:675
Mass (Da):74,196
Checksum:i3891F679BC733F89
GO
Isoform 10 (identifier: P16070-10) [UniParc]FASTAAdd to basket
Also known as: CD44E, CD44R1, Epithelial, Keratinocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.

Note: Lacks exons 6-11.
Show »
Length:493
Mass (Da):53,411
Checksum:iA494CCC37F161EF2
GO
Isoform 11 (identifier: P16070-11) [UniParc]FASTAAdd to basket
Also known as: CD44R2

The sequence of this isoform differs from the canonical sequence as follows:
     223-535: Missing.

Note: Lacks exons 6-13.
Show »
Length:429
Mass (Da):46,565
Checksum:i557BD4FED59E0867
GO
Isoform 12 (identifier: P16070-12) [UniParc]FASTAAdd to basket
Also known as: CDw44, Reticulocyte

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.

Note: Lacks exons 6-14.
Show »
Length:361
Mass (Da):39,416
Checksum:iF51A746B442E0D33
GO
Isoform 13 (identifier: P16070-13) [UniParc]FASTAAdd to basket
Also known as: CD44R4

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11 and exon 14.
Show »
Length:425
Mass (Da):46,261
Checksum:i47F544DD9890917B
GO
Isoform 14 (identifier: P16070-14) [UniParc]FASTAAdd to basket
Also known as: CD44R5

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → N
     224-472: Missing.
     506-506: Q → R
     507-535: Missing.
     536-536: N → R
     537-604: Missing.

Note: Lacks exons 6-11, exon 13 and exon 14.
Show »
Length:396
Mass (Da):43,169
Checksum:i5118DABF71C1F7D0
GO
Isoform 15 (identifier: P16070-15) [UniParc]FASTAAdd to basket
Also known as: Hermes

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     675-675: R → S
     676-742: Missing.

Note: Lacks exons 6-14 and exon 19.
Show »
Length:294
Mass (Da):32,075
Checksum:iE11B9B38F4A74817
GO
Isoform 16 (identifier: P16070-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-192: G → A
     193-223: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 5 and lacks exon 10.
Show »
Length:668
Mass (Da):73,150
Checksum:iD719820A01C4517F
GO
Isoform 17 (identifier: P16070-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-273: Missing.
     385-385: I → T
     386-428: Missing.

Note: Alternative splice donor/acceptor on exon 7 and lacks exon 10.
Show »
Length:691
Mass (Da):75,957
Checksum:i737967321EE8F579
GO
Isoform 18 (identifier: P16070-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-223: T → R
     224-604: Missing.
     605-625: Missing.

Note: No experimental confirmation available.
Show »
Length:340
Mass (Da):37,278
Checksum:iC2E036A7DAB5717B
GO
Isoform 19 (identifier: P16070-19) [UniParc]FASTAAdd to basket
Also known as: CD44RC

The sequence of this isoform differs from the canonical sequence as follows:
     78-139: RYGFIEGHVV...TSVTDLPNAF → SLHCSQQSKK...VRNSRPVYDS
     140-742: Missing.

Note: Soluble isoform, has enhanced hyaluronan binding.
Show »
Length:139
Mass (Da):15,635
Checksum:i4A127F5C54BB7B62
GO

Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEV3H0YEV3_HUMAN
CD44 antigen
CD44
243Annotation score:
H0YD13H0YD13_HUMAN
CD44 antigen
CD44
206Annotation score:
H0Y5E4H0Y5E4_HUMAN
CD44 antigen
CD44
294Annotation score:
H0YD90H0YD90_HUMAN
CD44 antigen
CD44
195Annotation score:
E9PKC6E9PKC6_HUMAN
CD44 antigen
CD44
78Annotation score:
H0YCV9H0YCV9_HUMAN
CD44 antigen
CD44
277Annotation score:
Q86UZ1Q86UZ1_HUMAN
CD44 antigen
CD44
80Annotation score:
H0Y2P0H0Y2P0_HUMAN
CD44 antigen
CD44
287Annotation score:
H0YDX6H0YDX6_HUMAN
CD44 antigen
CD44
183Annotation score:
H0YD17H0YD17_HUMAN
CD44 antigen
CD44
229Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26I → M in AAA82949 (Ref. 10) Curated1
Sequence conflicti109S → Y in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti109S → Y in AAA51950 (PubMed:1840487).Curated1
Sequence conflicti109S → Y in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti109S → Y in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti221A → R in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti241T → A in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti410E → V in CAA47271 (PubMed:1281868).Curated1
Sequence conflicti494D → N in CAB61878 (PubMed:7508842).Curated1
Sequence conflicti555T → H in CAA38951 (PubMed:1991450).Curated1
Sequence conflicti620G → E in AAA35674 (PubMed:2466575).Curated1
Sequence conflicti697S → I in AAM50041 (Ref. 11) Curated1
Sequence conflicti697S → I in AAH67348 (Ref. 16) Curated1

Polymorphismi

CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00649046R → P in In(A) antigen. 1 PublicationCorresponds to variant dbSNP:rs369473842Ensembl.1
Natural variantiVAR_030325393T → M. Corresponds to variant dbSNP:rs11607491Ensembl.1
Natural variantiVAR_021147417K → R4 PublicationsCorresponds to variant dbSNP:rs9666607Ensembl.1
Natural variantiVAR_030326479I → T9 PublicationsCorresponds to variant dbSNP:rs1467558Ensembl.1
Natural variantiVAR_030327494D → H1 PublicationCorresponds to variant dbSNP:rs12273397Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00530323 – 29DLNITCR → GVGRRKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_00530430 – 742Missing in isoform 2. 1 PublicationAdd BLAST713
Alternative sequenceiVSP_04387078 – 139RYGFI…LPNAF → SLHCSQQSKKVWAEEKASDQ QWQWSCGGQKAKWTQRRGQQ VSGNGAFGEQGVVRNSRPVY DS in isoform 19. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_043871140 – 742Missing in isoform 19. 1 PublicationAdd BLAST603
Alternative sequenceiVSP_005305192G → A in isoform 3 and isoform 16. Curated1
Alternative sequenceiVSP_005306193 – 223Missing in isoform 3 and isoform 16. CuratedAdd BLAST31
Alternative sequenceiVSP_022797223 – 535Missing in isoform 11. 2 PublicationsAdd BLAST313
Alternative sequenceiVSP_005309223T → N in isoform 10, isoform 13 and isoform 14. 5 Publications1
Alternative sequenceiVSP_005311223T → R in isoform 12, isoform 15 and isoform 18. 8 Publications1
Alternative sequenceiVSP_005307223T → S in isoform 4. 2 Publications1
Alternative sequenceiVSP_005312224 – 604Missing in isoform 12, isoform 15 and isoform 18. 8 PublicationsAdd BLAST381
Alternative sequenceiVSP_005310224 – 472Missing in isoform 10, isoform 13 and isoform 14. 5 PublicationsAdd BLAST249
Alternative sequenceiVSP_005308224 – 266Missing in isoform 4. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_005313266 – 273Missing in isoform 5 and isoform 17. Curated8
Alternative sequenceiVSP_005314385I → T in isoform 6, isoform 16 and isoform 17. Curated1
Alternative sequenceiVSP_005315386 – 428Missing in isoform 6, isoform 16 and isoform 17. CuratedAdd BLAST43
Alternative sequenceiVSP_005316506Q → R in isoform 7 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005317507 – 535Missing in isoform 7 and isoform 14. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_005318536N → R in isoform 8, isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_005319537 – 604Missing in isoform 8, isoform 13 and isoform 14. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_043575605 – 625Missing in isoform 18. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_005320675R → S in isoform 9 and isoform 15. 1 Publication1
Alternative sequenceiVSP_005321676 – 742Missing in isoform 9 and isoform 15. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24915 mRNA Translation: AAA35674.1
M59040 mRNA Translation: AAA51950.1
X55150 mRNA Translation: CAA38951.1
X56794 mRNA Translation: CAA40133.1
X66733 mRNA Translation: CAA47271.1
L05423
, L05407, L05408, L05409, L05410, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13622.1
L05423
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13623.1
L05424
, L05407, L05408, L05410, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13624.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13625.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13626.1
L05424
, L05407, L05408, L05410, L05417, L05418, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13627.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13628.1
AJ251595 mRNA Translation: CAB61878.1
S66400 mRNA Translation: AAB27917.1
S66400 mRNA Translation: AAB27918.2
S66400 mRNA Translation: AAB27919.1
AF098641 mRNA Translation: AAC70782.1
U40373 mRNA Translation: AAA82949.1
AY101192 mRNA Translation: AAM50040.1
AY101193 mRNA Translation: AAM50041.1
EF581837 mRNA Translation: ABQ59315.1
FJ216964 mRNA Translation: ACI46596.1
AL832642 mRNA Translation: CAD89965.1
AL133330 Genomic DNA No translation available.
AL136989 Genomic DNA No translation available.
AL356215 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68147.1
CH471064 Genomic DNA Translation: EAW68148.1
CH471064 Genomic DNA Translation: EAW68149.1
CH471064 Genomic DNA Translation: EAW68151.1
CH471064 Genomic DNA Translation: EAW68152.1
BC004372 mRNA Translation: AAH04372.1
BC067348 mRNA Translation: AAH67348.1
M25078 mRNA Translation: AAA36138.1
X55938 mRNA Translation: CAA39404.1
S72928 Genomic DNA Translation: AAB30429.1
X62739 mRNA Translation: CAA44602.1
CCDSiCCDS31455.1 [P16070-4]
CCDS31456.1 [P16070-10]
CCDS31457.1 [P16070-12]
CCDS31458.1 [P16070-19]
CCDS55754.1 [P16070-11]
CCDS55755.1 [P16070-18]
CCDS7897.1 [P16070-1]
PIRiA47195
I37369
I77371
I77372
JH0417
JH0518
S13530
S24222
RefSeqiNP_000601.3, NM_000610.3 [P16070-1]
NP_001001389.1, NM_001001389.1 [P16070-4]
NP_001001390.1, NM_001001390.1 [P16070-10]
NP_001001391.1, NM_001001391.1 [P16070-12]
NP_001001392.1, NM_001001392.1 [P16070-19]
NP_001189484.1, NM_001202555.1 [P16070-11]
NP_001189485.1, NM_001202556.1 [P16070-18]
NP_001189486.1, NM_001202557.1 [P16070-15]
XP_011518790.1, XM_011520488.1 [P16070-13]
UniGeneiHs.502328

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508 [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508 [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508 [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508 [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508 [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508 [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508 [P16070-11]
GeneIDi960
KEGGihsa:960
UCSCiuc001mvu.4 human [P16070-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

CD44 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24915 mRNA Translation: AAA35674.1
M59040 mRNA Translation: AAA51950.1
X55150 mRNA Translation: CAA38951.1
X56794 mRNA Translation: CAA40133.1
X66733 mRNA Translation: CAA47271.1
L05423
, L05407, L05408, L05409, L05410, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13622.1
L05423
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13623.1
L05424
, L05407, L05408, L05410, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13624.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13625.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13626.1
L05424
, L05407, L05408, L05410, L05417, L05418, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13627.1
L05424
, L05407, L05408, L05410, L05411, L05412, L05414, L05415, L05416, L05417, L05418, L05419, L05420, L05421, L05422, M69215 Genomic DNA Translation: AAB13628.1
AJ251595 mRNA Translation: CAB61878.1
S66400 mRNA Translation: AAB27917.1
S66400 mRNA Translation: AAB27918.2
S66400 mRNA Translation: AAB27919.1
AF098641 mRNA Translation: AAC70782.1
U40373 mRNA Translation: AAA82949.1
AY101192 mRNA Translation: AAM50040.1
AY101193 mRNA Translation: AAM50041.1
EF581837 mRNA Translation: ABQ59315.1
FJ216964 mRNA Translation: ACI46596.1
AL832642 mRNA Translation: CAD89965.1
AL133330 Genomic DNA No translation available.
AL136989 Genomic DNA No translation available.
AL356215 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68147.1
CH471064 Genomic DNA Translation: EAW68148.1
CH471064 Genomic DNA Translation: EAW68149.1
CH471064 Genomic DNA Translation: EAW68151.1
CH471064 Genomic DNA Translation: EAW68152.1
BC004372 mRNA Translation: AAH04372.1
BC067348 mRNA Translation: AAH67348.1
M25078 mRNA Translation: AAA36138.1
X55938 mRNA Translation: CAA39404.1
S72928 Genomic DNA Translation: AAB30429.1
X62739 mRNA Translation: CAA44602.1
CCDSiCCDS31455.1 [P16070-4]
CCDS31456.1 [P16070-10]
CCDS31457.1 [P16070-12]
CCDS31458.1 [P16070-19]
CCDS55754.1 [P16070-11]
CCDS55755.1 [P16070-18]
CCDS7897.1 [P16070-1]
PIRiA47195
I37369
I77371
I77372
JH0417
JH0518
S13530
S24222
RefSeqiNP_000601.3, NM_000610.3 [P16070-1]
NP_001001389.1, NM_001001389.1 [P16070-4]
NP_001001390.1, NM_001001390.1 [P16070-10]
NP_001001391.1, NM_001001391.1 [P16070-12]
NP_001001392.1, NM_001001392.1 [P16070-19]
NP_001189484.1, NM_001202555.1 [P16070-11]
NP_001189485.1, NM_001202556.1 [P16070-18]
NP_001189486.1, NM_001202557.1 [P16070-15]
XP_011518790.1, XM_011520488.1 [P16070-13]
UniGeneiHs.502328

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1POZNMR-A20-178[»]
1UUHX-ray2.20A/B20-178[»]
2I83NMR-A21-178[»]
4PZ3X-ray1.08A/B18-170[»]
4PZ4X-ray1.60A/B18-171[»]
ProteinModelPortaliP16070
SMRiP16070
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107398, 109 interactors
DIPiDIP-1121N
ELMiP16070
IntActiP16070, 57 interactors
MINTiP16070
STRINGi9606.ENSP00000398632

Chemistry databases

BindingDBiP16070
ChEMBLiCHEMBL3232692
DrugBankiDB08818 Hyaluronic acid

PTM databases

GlyConnecti736
iPTMnetiP16070
PhosphoSitePlusiP16070
SwissPalmiP16070
UniCarbKBiP16070

Polymorphism and mutation databases

BioMutaiCD44
DMDMi308153615

2D gel databases

SWISS-2DPAGEiP16070

Proteomic databases

EPDiP16070
MaxQBiP16070
PaxDbiP16070
PeptideAtlasiP16070
PRIDEiP16070
ProteomicsDBi53266
53267 [P16070-10]
53268 [P16070-11]
53269 [P16070-12]
53270 [P16070-13]
53271 [P16070-14]
53272 [P16070-15]
53273 [P16070-16]
53274 [P16070-17]
53275 [P16070-18]
53276 [P16070-19]
53277 [P16070-2]
53278 [P16070-3]
53279 [P16070-4]
53280 [P16070-5]
53281 [P16070-6]
53282 [P16070-7]
53283 [P16070-8]
53284 [P16070-9]
TopDownProteomicsiP16070-12 [P16070-12]
P16070-14 [P16070-14]
P16070-18 [P16070-18]
P16070-4 [P16070-4]
P16070-7 [P16070-7]

Protocols and materials databases

DNASUi960
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263398; ENSP00000263398; ENSG00000026508 [P16070-12]
ENST00000278386; ENSP00000278386; ENSG00000026508 [P16070-19]
ENST00000352818; ENSP00000309732; ENSG00000026508 [P16070-18]
ENST00000415148; ENSP00000389830; ENSG00000026508 [P16070-4]
ENST00000428726; ENSP00000398632; ENSG00000026508 [P16070-1]
ENST00000433892; ENSP00000392331; ENSG00000026508 [P16070-10]
ENST00000434472; ENSP00000404447; ENSG00000026508 [P16070-11]
GeneIDi960
KEGGihsa:960
UCSCiuc001mvu.4 human [P16070-1]

Organism-specific databases

CTDi960
DisGeNETi960
EuPathDBiHostDB:ENSG00000026508.16
GeneCardsiCD44
HGNCiHGNC:1681 CD44
HPAiCAB000112
CAB000316
HPA005785
MIMi107269 gene
172290 gene
609027 phenotype
neXtProtiNX_P16070
OpenTargetsiENSG00000026508
PharmGKBiPA26221
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZCP Eukaryota
ENOG4111S6T LUCA
GeneTreeiENSGT00530000063822
HOGENOMiHOG000115236
HOVERGENiHBG003850
InParanoidiP16070
KOiK06256
OMAiSHPMGRG
OrthoDBiEOG091G0F98
PhylomeDBiP16070
TreeFamiTF334173

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-216083 Integrin cell surface interactions
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-6798695 Neutrophil degranulation
R-HSA-877300 Interferon gamma signaling
SIGNORiP16070

Miscellaneous databases

ChiTaRSiCD44 human
EvolutionaryTraceiP16070
GeneWikiiCD44
GenomeRNAii960
PROiPR:P16070
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000026508 Expressed in 228 organ(s), highest expression level in parotid gland
ExpressionAtlasiP16070 baseline and differential
GenevisibleiP16070 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR001231 CD44_antigen
IPR016187 CTDL_fold
IPR000538 Link_dom
PANTHERiPTHR10225:SF6 PTHR10225:SF6, 1 hit
PfamiView protein in Pfam
PF00193 Xlink, 1 hit
PRINTSiPR00658 CD44
PR01265 LINKMODULE
SMARTiView protein in SMART
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD44_HUMAN
AccessioniPrimary (citable) accession number: P16070
Secondary accession number(s): A5YRN9
, B6EAT9, D3DR12, D3DR13, O95370, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q86T72, Q86Z27, Q8N694, Q92493, Q96J24, Q9H5A5, Q9UC28, Q9UC29, Q9UC30, Q9UCB0, Q9UJ36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 223 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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