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Protein

Atrial natriuretic peptide receptor 1

Gene

NPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei85ChlorideBy similarity1
Binding sitei117Chloride; via amide nitrogenBy similarity1
Binding sitei118Chloride; via amide nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: InterPro
  • G protein-coupled peptide receptor activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: UniProtKB
  • hormone binding Source: UniProtKB
  • natriuretic peptide receptor activity Source: UniProtKB
  • peptide hormone binding Source: UniProtKB
  • peptide receptor activity Source: GO_Central
  • protein kinase activity Source: InterPro
  • protein kinase binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Receptor, Vasoactive
Biological processcGMP biosynthesis
LigandChloride, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.6.1.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578768 Physiological factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P16066

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P16066

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Atrial natriuretic peptide receptor 1 (EC:4.6.1.2)
Alternative name(s):
Atrial natriuretic peptide receptor type A
Short name:
ANP-A
Short name:
ANPR-A
Short name:
NPR-A
Guanylate cyclase A
Short name:
GC-A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NPR1
Synonyms:ANPRA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169418.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7943 NPR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
108960 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 473ExtracellularSequence analysisAdd BLAST441
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 1061CytoplasmicSequence analysisAdd BLAST567

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4881

Open Targets

More...
OpenTargetsi
ENSG00000169418

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31736

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1988

Drug and drug target database

More...
DrugBanki
DB01612 Amyl Nitrite
DB01613 Erythrityl Tetranitrate
DB00883 Isosorbide Dinitrate
DB04899 Nesiritide
DB00727 Nitroglycerin
DB00325 Nitroprusside
DB05034 Ularitide

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1747

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NPR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113912

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Add BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001236033 – 1061Atrial natriuretic peptide receptor 1Add BLAST1029

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi92 ↔ 118By similarity
Disulfide bondi196 ↔ 245By similarity
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi455 ↔ 464By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei519Phosphoserine1 Publication1
Modified residuei529Phosphoserine1 Publication1
Modified residuei532Phosphothreonine1 Publication1
Modified residuei534Phosphoserine1 Publication1
Modified residuei538Phosphoserine1 Publication1
Modified residuei542PhosphoserineBy similarity1
Modified residuei545PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of the protein kinase-like domain is required for full activation by ANP.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P16066

MaxQB - The MaxQuant DataBase

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MaxQBi
P16066

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16066

PeptideAtlas

More...
PeptideAtlasi
P16066

PRoteomics IDEntifications database

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PRIDEi
P16066

ProteomicsDB human proteome resource

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ProteomicsDBi
53265

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P16066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P16066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169418 Expressed in 215 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

More...
CleanExi
HS_NPR1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16066 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16066 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA031087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110941, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-35 ANPR-A receptor complex

Database of interacting proteins

More...
DIPi
DIP-46246N

Protein interaction database and analysis system

More...
IntActi
P16066, 5 interactors

Molecular INTeraction database

More...
MINTi
P16066

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357669

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P16066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P16066

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P16066

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini528 – 805Protein kinasePROSITE-ProRule annotationAdd BLAST278
Domaini876 – 1006Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1023 Eukaryota
COG2114 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156223

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293307

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051862

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16066

KEGG Orthology (KO)

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KOi
K12323

Identification of Orthologs from Complete Genome Data

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OMAi
REDPSML

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02QS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P16066

TreeFam database of animal gene trees

More...
TreeFami
TF106338

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR001170 ANPR/GUC
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00255 NATPEPTIDER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00458 ANF_RECEPTORS, 1 hit
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P16066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPRRPAGS RLRLLLLLLL PPLLLLLRGS HAGNLTVAVV LPLANTSYPW
60 70 80 90 100
SWARVGPAVE LALAQVKARP DLLPGWTVRT VLGSSENALG VCSDTAAPLA
110 120 130 140 150
AVDLKWEHNP AVFLGPGCVY AAAPVGRFTA HWRVPLLTAG APALGFGVKD
160 170 180 190 200
EYALTTRAGP SYAKLGDFVA ALHRRLGWER QALMLYAYRP GDEEHCFFLV
210 220 230 240 250
EGLFMRVRDR LNITVDHLEF AEDDLSHYTR LLRTMPRKGR VIYICSSPDA
260 270 280 290 300
FRTLMLLALE AGLCGEDYVF FHLDIFGQSL QGGQGPAPRR PWERGDGQDV
310 320 330 340 350
SARQAFQAAK IITYKDPDNP EYLEFLKQLK HLAYEQFNFT MEDGLVNTIP
360 370 380 390 400
ASFHDGLLLY IQAVTETLAH GGTVTDGENI TQRMWNRSFQ GVTGYLKIDS
410 420 430 440 450
SGDRETDFSL WDMDPENGAF RVVLNYNGTS QELVAVSGRK LNWPLGYPPP
460 470 480 490 500
DIPKCGFDNE DPACNQDHLS TLEVLALVGS LSLLGILIVS FFIYRKMQLE
510 520 530 540 550
KELASELWRV RWEDVEPSSL ERHLRSAGSR LTLSGRGSNY GSLLTTEGQF
560 570 580 590 600
QVFAKTAYYK GNLVAVKRVN RKRIELTRKV LFELKHMRDV QNEHLTRFVG
610 620 630 640 650
ACTDPPNICI LTEYCPRGSL QDILENESIT LDWMFRYSLT NDIVKGMLFL
660 670 680 690 700
HNGAICSHGN LKSSNCVVDG RFVLKITDYG LESFRDLDPE QGHTVYAKKL
710 720 730 740 750
WTAPELLRMA SPPVRGSQAG DVYSFGIILQ EIALRSGVFH VEGLDLSPKE
760 770 780 790 800
IIERVTRGEQ PPFRPSLALQ SHLEELGLLM QRCWAEDPQE RPPFQQIRLT
810 820 830 840 850
LRKFNRENSS NILDNLLSRM EQYANNLEEL VEERTQAYLE EKRKAEALLY
860 870 880 890 900
QILPHSVAEQ LKRGETVQAE AFDSVTIYFS DIVGFTALSA ESTPMQVVTL
910 920 930 940 950
LNDLYTCFDA VIDNFDVYKV ETIGDAYMVV SGLPVRNGRL HACEVARMAL
960 970 980 990 1000
ALLDAVRSFR IRHRPQEQLR LRIGIHTGPV CAGVVGLKMP RYCLFGDTVN
1010 1020 1030 1040 1050
TASRMESNGE ALKIHLSSET KAVLEEFGGF ELELRGDVEM KGKGKVRTYW
1060
LLGERGSSTR G
Length:1,061
Mass (Da):118,919
Last modified:April 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6B5BD0FCA32F70D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344G → V in AAH63304 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042214182A → V1 PublicationCorresponds to variant dbSNP:rs56019647Ensembl.1
Natural variantiVAR_042215270F → C in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042216755V → M1 PublicationCorresponds to variant dbSNP:rs55837780Ensembl.1
Natural variantiVAR_042217939R → Q1 PublicationCorresponds to variant dbSNP:rs35240348Ensembl.1
Natural variantiVAR_042218967E → K1 PublicationCorresponds to variant dbSNP:rs35479618Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15357 mRNA Translation: CAA33417.1
AB010491 Genomic DNA Translation: BAA31199.1
AF190631 Genomic DNA Translation: AAF01340.1
EU326310 Genomic DNA Translation: ACA05918.1
AL713889 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53284.1
BC063304 mRNA Translation: AAH63304.1
S72628 mRNA Translation: AAD14112.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1051.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04459 OYHUAR

NCBI Reference Sequences

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RefSeqi
NP_000897.3, NM_000906.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.490330

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368680; ENSP00000357669; ENSG00000169418

Database of genes from NCBI RefSeq genomes

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GeneIDi
4881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4881

UCSC genome browser

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UCSCi
uc001fcs.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15357 mRNA Translation: CAA33417.1
AB010491 Genomic DNA Translation: BAA31199.1
AF190631 Genomic DNA Translation: AAF01340.1
EU326310 Genomic DNA Translation: ACA05918.1
AL713889 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53284.1
BC063304 mRNA Translation: AAH63304.1
S72628 mRNA Translation: AAD14112.1
CCDSiCCDS1051.1
PIRiS04459 OYHUAR
RefSeqiNP_000897.3, NM_000906.3
UniGeneiHs.490330

3D structure databases

ProteinModelPortaliP16066
SMRiP16066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110941, 6 interactors
ComplexPortaliCPX-35 ANPR-A receptor complex
DIPiDIP-46246N
IntActiP16066, 5 interactors
MINTiP16066
STRINGi9606.ENSP00000357669

Chemistry databases

BindingDBiP16066
ChEMBLiCHEMBL1988
DrugBankiDB01612 Amyl Nitrite
DB01613 Erythrityl Tetranitrate
DB00883 Isosorbide Dinitrate
DB04899 Nesiritide
DB00727 Nitroglycerin
DB00325 Nitroprusside
DB05034 Ularitide
GuidetoPHARMACOLOGYi1747

PTM databases

iPTMnetiP16066
PhosphoSitePlusiP16066

Polymorphism and mutation databases

BioMutaiNPR1
DMDMi113912

Proteomic databases

EPDiP16066
MaxQBiP16066
PaxDbiP16066
PeptideAtlasiP16066
PRIDEiP16066
ProteomicsDBi53265

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4881
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368680; ENSP00000357669; ENSG00000169418
GeneIDi4881
KEGGihsa:4881
UCSCiuc001fcs.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4881
DisGeNETi4881
EuPathDBiHostDB:ENSG00000169418.9

GeneCards: human genes, protein and diseases

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GeneCardsi
NPR1
HGNCiHGNC:7943 NPR1
HPAiHPA031087
MIMi108960 gene
neXtProtiNX_P16066
OpenTargetsiENSG00000169418
PharmGKBiPA31736

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000156223
HOGENOMiHOG000293307
HOVERGENiHBG051862
InParanoidiP16066
KOiK12323
OMAiREDPSML
OrthoDBiEOG091G02QS
PhylomeDBiP16066
TreeFamiTF106338

Enzyme and pathway databases

BRENDAi4.6.1.2 2681
ReactomeiR-HSA-5578768 Physiological factors
SignaLinkiP16066
SIGNORiP16066

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NPR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NPR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4881

Protein Ontology

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PROi
PR:P16066

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169418 Expressed in 215 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_NPR1
ExpressionAtlasiP16066 baseline and differential
GenevisibleiP16066 HS

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR001170 ANPR/GUC
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00255 NATPEPTIDER
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00458 ANF_RECEPTORS, 1 hit
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANPRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16066
Secondary accession number(s): B0ZBF0, Q5SR08, Q6P4Q3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: December 5, 2018
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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