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Protein

Galectin-1

Gene

Lgals1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.By similarity1 Publication

Caution

Was originally thought to originate from human.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Beta-galactosideBy similarity1
Binding sitei62Beta-galactosideBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • galactose binding Source: UniProtKB
  • lactose binding Source: MGI
  • laminin binding Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

UniLectiniP16045

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-1
Short name:
Gal-1
Alternative name(s):
14 kDa lectin
Beta-galactoside-binding lectin L-14-I
Galaptin
Lactose-binding lectin 1
Lectin galactoside-binding soluble 1
S-Lac lectin 1
Gene namesi
Name:Lgals1
Synonyms:Gbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96777 Lgals1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000769182 – 135Galectin-1Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei19N6-acetyllysineCombined sources1
Modified residuei29N6-acetyllysineCombined sources1
Modified residuei30PhosphoserineBy similarity1
Modified residuei108N6-acetyllysine; alternateCombined sources1
Modified residuei108N6-succinyllysine; alternateCombined sources1
Modified residuei128N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP16045
MaxQBiP16045
PaxDbiP16045
PeptideAtlasiP16045
PRIDEiP16045
TopDownProteomicsiP16045

2D gel databases

REPRODUCTION-2DPAGEiIPI00229517
P16045
SWISS-2DPAGEiP16045
UCD-2DPAGEiP16045

PTM databases

iPTMnetiP16045
PhosphoSitePlusiP16045
SwissPalmiP16045

Expressioni

Gene expression databases

BgeeiENSMUSG00000068220
CleanExiMM_LGALS1
GenevisibleiP16045 MM

Interactioni

Subunit structurei

Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD6, CD7, CD43, ALCAM and CD45. Interacts with laminin (via poly-N-acetyllactosamine). Interacts with SUSD2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201142, 4 interactors
ComplexPortaliCPX-94 Galectin-1 complex
IntActiP16045, 6 interactors
MINTiP16045
STRINGi10090.ENSMUSP00000086795

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Beta strandi17 – 24Combined sources8
Beta strandi33 – 38Combined sources6
Beta strandi41 – 49Combined sources9
Beta strandi58 – 65Combined sources8
Beta strandi73 – 75Combined sources3
Beta strandi84 – 92Combined sources9
Beta strandi94 – 100Combined sources7
Beta strandi106 – 110Combined sources5
Beta strandi120 – 123Combined sources4
Beta strandi127 – 135Combined sources9

3D structure databases

ProteinModelPortaliP16045
SMRiP16045
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 135GalectinPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 49Beta-galactoside bindingBy similarity5
Regioni69 – 72Beta-galactoside bindingBy similarity4

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00440000034263
HOVERGENiHBG006255
InParanoidiP16045
KOiK06830
OMAiCNSKEDG
OrthoDBiEOG091G0S7H
PhylomeDBiP16045
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGLVASNL NLKPGECLKV RGEVASDAKS FVLNLGKDSN NLCLHFNPRF
60 70 80 90 100
NAHGDANTIV CNTKEDGTWG TEHREPAFPF QPGSITEVCI TFDQADLTIK
110 120 130
LPDGHEFKFP NRLNMEAINY MAADGDFKIK CVAFE
Length:135
Mass (Da):14,866
Last modified:January 23, 2007 - v3
Checksum:iFD6967C1F4117122
GO

Sequence cautioni

The sequence AAA37313 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AK004298 differs from that shown. Reason: Frameshift at position 117.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78F → S in AAA37667 (PubMed:1986871).Curated1
Sequence conflicti86T → I in AAH02063 (PubMed:15489334).Curated1
Sequence conflicti131 – 134CVAF → VRGL in AAA36172 (PubMed:3020551).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15986 mRNA Translation: CAA34117.1
X53067 mRNA Translation: CAA37242.1
X51577, X51578, X51579 Genomic DNA Translation: CAA35930.1
M57470 mRNA Translation: AAA37667.1
X66532 mRNA Translation: CAA47143.1
AK004298 mRNA No translation available.
BC002063 mRNA Translation: AAH02063.1
BC099479 mRNA Translation: AAH99479.1
X51903 mRNA Translation: CAA36183.1
M33214 mRNA Translation: AAA37313.1 Frameshift.
M14087 mRNA Translation: AAA36172.1
CCDSiCCDS27628.1
PIRiB26495
S07162
S11718 LNMSGB
RefSeqiNP_032521.1, NM_008495.2
UniGeneiMm.43831

Genome annotation databases

EnsembliENSMUST00000089377; ENSMUSP00000086795; ENSMUSG00000068220
GeneIDi16852
KEGGimmu:16852
UCSCiuc007wrv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLEG1_MOUSE
AccessioniPrimary (citable) accession number: P16045
Secondary accession number(s): P05163
, P11946, P17601, Q4FZH4, Q99M27, Q9D0X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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