UniProtKB - P16038 (CSH_SHEEP)
Protein
Chorionic somatomammotropin hormone
Gene
CSH
Organism
Ovis aries (Sheep)
Status
Functioni
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- prolactin receptor binding Source: AgBase
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Chorionic somatomammotropin hormoneAlternative name(s): Placental lactogen Short name: PL |
Gene namesi | Name:CSH |
Organismi | Ovis aries (Sheep) |
Taxonomic identifieri | 9940 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | Sequence analysisAdd BLAST | 36 | |
ChainiPRO_0000032966 | 37 – 236 | Chorionic somatomammotropin hormoneAdd BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 51 | |||
Disulfide bondi | 97 ↔ 212 | |||
Disulfide bondi | 229 ↔ 234 |
Keywords - PTMi
Disulfide bondInteractioni
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- prolactin receptor binding Source: AgBase
Protein-protein interaction databases
MINTi | P16038 |
STRINGi | 9940.ENSOARP00000009523 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P16038 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P16038 |
Family & Domainsi
Sequence similaritiesi
Belongs to the somatotropin/prolactin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QYU3, Eukaryota |
OrthoDBi | 1290070at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00266, SOMATOTROPIN_1, 1 hit PS00338, SOMATOTROPIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P16038-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPASSHREH QWTCNLVRGS RLLLLLVVSN LILCQGQAQH PPYCRNQPGK
60 70 80 90 100
CQIPLQSLFD RATTVANYNS KLAGEMVNRF DEQYGQGINS ESKVINCHTS
110 120 130 140 150
SITTPNSKAE AINTEDKILF KLVISLLHSW DEPLHHAVTE LANSKGTSPA
160 170 180 190 200
LLTKAQEIKE KAKVLVDGVE VIQKRIHPGE KNEPYPVWSE QSSLTSQDEN
210 220 230
VRRVAFYRLF HCLHRDSSKI YTYLRILKCR LTSCET
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31660 mRNA Translation: AAA31577.1 |
PIRi | A40143 S70031 |
RefSeqi | NP_001009309.2, NM_001009309.3 |
Genome annotation databases
Ensembli | ENSOART00020024258; ENSOARP00020020112; ENSOARG00020015814 |
GeneIDi | 443319 |
KEGGi | oas:443319 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31660 mRNA Translation: AAA31577.1 |
PIRi | A40143 S70031 |
RefSeqi | NP_001009309.2, NM_001009309.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F6F | X-ray | 2.30 | A | 38-236 | [»] | |
SMRi | P16038 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P16038 |
STRINGi | 9940.ENSOARP00000009523 |
Genome annotation databases
Ensembli | ENSOART00020024258; ENSOARP00020020112; ENSOARG00020015814 |
GeneIDi | 443319 |
KEGGi | oas:443319 |
Phylogenomic databases
eggNOGi | ENOG502QYU3, Eukaryota |
OrthoDBi | 1290070at2759 |
Miscellaneous databases
EvolutionaryTracei | P16038 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR001400, Somatotropin/Prolactin IPR018116, Somatotropin_CS |
PANTHERi | PTHR11417, PTHR11417, 1 hit |
Pfami | View protein in Pfam PF00103, Hormone_1, 1 hit |
PRINTSi | PR00836, SOMATOTROPIN |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00266, SOMATOTROPIN_1, 1 hit PS00338, SOMATOTROPIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSH_SHEEP | |
Accessioni | P16038Primary (citable) accession number: P16038 Secondary accession number(s): Q7M2L2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families