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Protein

Phosphate carrier protein, mitochondrial

Gene

Slc25a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H+. May play a role regulation of the mitochondrial permeability transition pore (mPTP).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate carrier protein, mitochondrial
Alternative name(s):
Phosphate transport protein
Short name:
PTP
Solute carrier family 25 member 3
Gene namesi
Name:Slc25a3
Synonyms:Phc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70986 Slc25a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini45 – 57Mitochondrial intermembraneSequence analysisAdd BLAST13
Transmembranei58 – 80Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini81 – 115Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei116 – 135Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini136 – 155Mitochondrial intermembraneSequence analysisAdd BLAST20
Transmembranei156 – 177Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini178 – 212Mitochondrial matrixSequence analysisAdd BLAST35
Transmembranei213 – 232Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini233 – 255Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei256 – 278Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini279 – 308Mitochondrial matrixSequence analysisAdd BLAST30
Transmembranei309 – 327Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini328 – 356Mitochondrial intermembraneSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44Mitochondrion2 PublicationsAdd BLAST44
ChainiPRO_000001925845 – 356Phosphate carrier protein, mitochondrialAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93N6-acetyllysineBy similarity1
Modified residuei106N6-methyllysineBy similarity1
Modified residuei190PhosphotyrosineBy similarity1
Modified residuei203N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP16036
PRIDEiP16036

PTM databases

iPTMnetiP16036
PhosphoSitePlusiP16036
SwissPalmiP16036

Interactioni

Subunit structurei

Interacts with PPIF; the interaction is impaired by CsA.1 Publication

Protein-protein interaction databases

CORUMiP16036
IntActiP16036, 2 interactors
STRINGi10116.ENSRNOP00000011494

Structurei

3D structure databases

ProteinModelPortaliP16036
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 141Solcar 1Add BLAST85
Repeati154 – 238Solcar 2Add BLAST85
Repeati255 – 333Solcar 3Add BLAST79

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0767 Eukaryota
ENOG410XPST LUCA
HOGENOMiHOG000164438
HOVERGENiHBG024440
InParanoidiP16036

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSVAHLAR ANPFNAPHLQ LVHDVSGPRS PPGPPRRSRH LAAAAVEGYS
60 70 80 90 100
CEFGSMKYYA LCGFGGVLSC GLTHTAVVPL DLVKCRMQVD PQKYKGIFNG
110 120 130 140 150
FSITLKEDGV RGLAKGWAPT LIGYSMQGLC KFGFYEVFKA LYSNILGEEN
160 170 180 190 200
TYLWRTSLYL AASASAEFFA DIALAPMEAA KVRIQTQPGY ANTLREAVPK
210 220 230 240 250
MYKEEGLNAF YKGVAPVWMR QIPYTMMKFA CFERTVEALY KFVVPKPRSE
260 270 280 290 300
CTKAEQLVVT FVAGYIAGVF CAIVSHPADS VVSVLNKEKG STASQVLQRL
310 320 330 340 350
GFRGVWKGLF ARIIMIGTLT ALQWFIYDSV KVYFRLPRPP PPEMPESLKK

KLGLTE
Length:356
Mass (Da):39,445
Last modified:April 1, 1990 - v1
Checksum:i64AF5FD9DD671DBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23984 mRNA Translation: AAA41634.1
PIRiA34350
UniGeneiRn.3606

Genome annotation databases

UCSCiRGD:70986 rat

Similar proteinsi

Entry informationi

Entry nameiMPCP_RAT
AccessioniPrimary (citable) accession number: P16036
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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