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Protein

Secretogranin-1

Gene

Chgb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-1
Alternative name(s):
Chromogranin-B
Short name:
CgB
Secretogranin I
Short name:
SgI
Cleaved into the following 2 chains:
Gene namesi
Name:Chgb
Synonyms:Scg-1, Scg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88395 Chgb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000544121 – 677Secretogranin-1Add BLAST657
PeptideiPRO_0000432731575 – 585PE-111 PublicationAdd BLAST11
PeptideiPRO_0000411988617 – 677CCB peptideBy similarityAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 57By similarity
Modified residuei93PhosphoserineBy similarity1
Modified residuei99PhosphoserineSequence analysis1
Modified residuei100PhosphoserineSequence analysis1
Glycosylationi115O-linked (GalNAc...) threonineCurated1
Modified residuei129PhosphoserineBy similarity1
Modified residuei147PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei220PhosphoserineCombined sources1
Modified residuei256PhosphoserineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei300PhosphoserineSequence analysis1
Modified residuei301PhosphoserineSequence analysis1
Modified residuei318PhosphoserineBy similarity1
Modified residuei342PhosphoserineCombined sources1
Modified residuei348SulfotyrosineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei472SulfotyrosineBy similarity1
Modified residuei493PhosphoserineCombined sources1
Modified residuei532PhosphoserineSequence analysis1
Modified residuei543PhosphoserineSequence analysis1
Modified residuei566SulfotyrosineBy similarity1
Modified residuei624SulfotyrosineBy similarity1
Modified residuei626PhosphoserineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP16014
PeptideAtlasiP16014
PRIDEiP16014

PTM databases

iPTMnetiP16014
PhosphoSitePlusiP16014

Miscellaneous databases

PMAP-CutDBiP16014

Expressioni

Gene expression databases

BgeeiENSMUSG00000027350 Expressed in 195 organ(s), highest expression level in pineal body
CleanExiMM_CHGB
ExpressionAtlasiP16014 baseline and differential
GenevisibleiP16014 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SOD1P004416EBI-990820,EBI-990792From Homo sapiens.

Protein-protein interaction databases

IntActiP16014, 2 interactors
STRINGi10090.ENSMUSP00000028826

Structurei

3D structure databases

ProteinModelPortaliP16014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVJ3 Eukaryota
ENOG410ZHMS LUCA
GeneTreeiENSGT00730000111312
HOGENOMiHOG000132984
HOVERGENiHBG057317
InParanoidiP16014
KOiK19991
OMAiNWGYEKR
OrthoDBiEOG091G07VF
PhylomeDBiP16014
TreeFamiTF336596

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16014-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPAMLLGLL GAAALAAVSS APVDNRDHNE EMVTRCIIEV LSNALSKSSV
60 70 80 90 100
PTITPECRQV LKKSGKEVKG EEKGENQNSK FEVRLLRDPA DASGTRWASS
110 120 130 140 150
REDAGAPVED SQGQTKVGNE KWTEGGGHSR EGVDDQESLR PSNQQASKEA
160 170 180 190 200
KIYHSEERVG KEREKEEGKI YPMGEHREDA GEEKKHIEDS GEKPNTFSNK
210 220 230 240 250
RSEASAKKKD ESVARADAHS MELEEKTHSR EQSSQESGEE TRRQEKPQEL
260 270 280 290 300
TDQDQSQEES QEGEEGEEGE EGEEGEEDSA SEVTKRRPRH HHGRSGSNKS
310 320 330 340 350
SYEGHPLSEE RRPSPKESKE ADVATVRLGE KRSHHLAHYR ASEEEPEYGE
360 370 380 390 400
ESRSYRGLQY RGRGSEEDRA PRPRSEESQE REYKRNHPDS ELESTANRHG
410 420 430 440 450
EETEEERSYE GANGRQHRGR GREPGAHSAL DTREEKRLLD EGHYPVRESP
460 470 480 490 500
IDTAKRYPQS KWQEQEKNYL NYGEEGDQGR WWQQEEQLGP EESREEVRFP
510 520 530 540 550
DRQYEPYPIT EKRKRLGALF NPYFDPLQWK NSDFEKRGNP DDSFLEDEGE
560 570 580 590 600
DRNGVTLTEK NSFPEYNYDW WERRPFSEDV NWGYEKRSFA RAPQLDLKRQ
610 620 630 640 650
YDGVAELDQL LHYRKKADEF PDFYDSEEQM GPHQEANDEK ARADQRVLTA
660 670
EEKKELENLA AMDLELQKIA EKFSQRG
Length:677
Mass (Da):77,969
Last modified:February 1, 1991 - v2
Checksum:iC73291E781E4F9B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti422 – 424REP → LGA in CAA35792 (PubMed:2320426).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53028 mRNA Translation: CAA37199.1
X51429 mRNA Translation: CAA35792.1
BC014736 mRNA Translation: AAH14736.1
CCDSiCCDS16777.1
PIRiS09078
RefSeqiNP_031720.1, NM_007694.4
UniGeneiMm.255241

Genome annotation databases

EnsembliENSMUST00000028826; ENSMUSP00000028826; ENSMUSG00000027350
GeneIDi12653
KEGGimmu:12653
UCSCiuc008mnf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53028 mRNA Translation: CAA37199.1
X51429 mRNA Translation: CAA35792.1
BC014736 mRNA Translation: AAH14736.1
CCDSiCCDS16777.1
PIRiS09078
RefSeqiNP_031720.1, NM_007694.4
UniGeneiMm.255241

3D structure databases

ProteinModelPortaliP16014
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP16014, 2 interactors
STRINGi10090.ENSMUSP00000028826

PTM databases

iPTMnetiP16014
PhosphoSitePlusiP16014

Proteomic databases

PaxDbiP16014
PeptideAtlasiP16014
PRIDEiP16014

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028826; ENSMUSP00000028826; ENSMUSG00000027350
GeneIDi12653
KEGGimmu:12653
UCSCiuc008mnf.1 mouse

Organism-specific databases

CTDi1114
MGIiMGI:88395 Chgb

Phylogenomic databases

eggNOGiENOG410IVJ3 Eukaryota
ENOG410ZHMS LUCA
GeneTreeiENSGT00730000111312
HOGENOMiHOG000132984
HOVERGENiHBG057317
InParanoidiP16014
KOiK19991
OMAiNWGYEKR
OrthoDBiEOG091G07VF
PhylomeDBiP16014
TreeFamiTF336596

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiChgb mouse
PMAP-CutDBiP16014
PROiPR:P16014
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027350 Expressed in 195 organ(s), highest expression level in pineal body
CleanExiMM_CHGB
ExpressionAtlasiP16014 baseline and differential
GenevisibleiP16014 MM

Family and domain databases

InterProiView protein in InterPro
IPR001819 Chromogranin_AB
IPR018054 Chromogranin_CS
IPR001990 Granin
PANTHERiPTHR10583 PTHR10583, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PRINTSiPR00659 CHROMOGRANIN
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
PS00423 GRANINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG1_MOUSE
AccessioniPrimary (citable) accession number: P16014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1991
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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