UniProtKB - P15993 (AROP_ECOLI)
Protein
Aromatic amino acid transport protein AroP
Gene
aroP
Organism
Escherichia coli (strain K12)
Status
Functioni
Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
GO - Molecular functioni
- L-phenylalanine transmembrane transporter activity Source: EcoCyc
- L-tryptophan transmembrane transporter activity Source: EcoCyc
- L-tyrosine transmembrane transporter activity Source: EcoCyc
- proton motive force dependent protein transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- phenylalanine transport Source: EcoCyc
- tryptophan transport Source: EcoCyc
- tyrosine transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:AROP-MONOMER ECOL316407:JW0108-MONOMER MetaCyc:AROP-MONOMER |
Protein family/group databases
TCDBi | 2.A.3.1.3 the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Aromatic amino acid transport protein AroPAlternative name(s): General aromatic amino acid permease |
Gene namesi | Name:aroP Ordered Locus Names:b0112, JW0108 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 42 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 86 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 117 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 155 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 201 | PeriplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 202 – 222 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 240 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 241 – 261 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 271 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 272 – 292 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 293 – 333 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 – 358 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 359 – 379 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 380 – 400 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 425 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 426 – 446 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 447 – 457 | CytoplasmicSequence analysisAdd BLAST | 11 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054193 | 1 – 457 | Aromatic amino acid transport protein AroPAdd BLAST | 457 |
Proteomic databases
PaxDbi | P15993 |
PRIDEi | P15993 |
Expressioni
Inductioni
Its activity is regulated by protein TyrR.
Interactioni
Protein-protein interaction databases
BioGridi | 4259731, 11 interactors |
STRINGi | 511145.b0112 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105C85 Bacteria COG1113 LUCA |
HOGENOMi | HOG000261849 |
InParanoidi | P15993 |
KOi | K11734 |
PhylomeDBi | P15993 |
Family and domain databases
InterProi | View protein in InterPro IPR004841 AA-permease/SLC12A_dom IPR002293 AA/rel_permease1 IPR004840 Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324 AA_permease, 1 hit |
PIRSFi | PIRSF006060 AA_transporter, 1 hit |
PROSITEi | View protein in PROSITE PS00218 AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P15993-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL
60 70 80 90 100
GYAIAGFIAF LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW
110 120 130 140 150
VLYVLVAMAE LTAVGKYIQF WYPEIPTWVS AAVFFVVINA INLTNVKVFG
160 170 180 190 200
EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG GPQATVSNLW DQGGFLPHGF
210 220 230 240 250
TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ VIYRILIFYI
260 270 280 290 300
GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY
310 320 330 340 350
NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI
360 370 380 390 400
NYLAPESAFG LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL
410 420 430 440 450
LYPLGNWICL LFMAAVLVIM LMTPGMAISV YLIPVWLIVL GIGYLFKEKT
AKAVKAH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | A → S in CAA35211 (PubMed:2408019).Curated | 1 | |
Sequence conflicti | 199 | G → A in CAA35211 (PubMed:2408019).Curated | 1 | |
Sequence conflicti | 199 | G → A in AAC45299 (PubMed:9150230).Curated | 1 | |
Sequence conflicti | 398 – 399 | PA → L in CAA35211 (PubMed:2408019).Curated | 2 | |
Sequence conflicti | 424 | P → R in CAA35211 (PubMed:2408019).Curated | 1 | |
Sequence conflicti | 424 | P → R in AAC45299 (PubMed:9150230).Curated | 1 | |
Sequence conflicti | 427 | A → G in CAA35211 (PubMed:2408019).Curated | 1 | |
Sequence conflicti | 429 | S → W in CAA35211 (PubMed:2408019).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17333 Genomic DNA Translation: CAA35211.1 U87285 Genomic DNA Translation: AAC45299.1 U00096 Genomic DNA Translation: AAC73223.1 AP009048 Genomic DNA Translation: BAB96681.2 |
PIRi | H64733 QRECAA |
RefSeqi | NP_414654.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC73223; AAC73223; b0112 BAB96681; BAB96681; BAB96681 |
GeneIDi | 946018 |
KEGGi | ecj:JW0108 eco:b0112 |
PATRICi | fig|511145.12.peg.114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17333 Genomic DNA Translation: CAA35211.1 U87285 Genomic DNA Translation: AAC45299.1 U00096 Genomic DNA Translation: AAC73223.1 AP009048 Genomic DNA Translation: BAB96681.2 |
PIRi | H64733 QRECAA |
RefSeqi | NP_414654.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 4259731, 11 interactors |
STRINGi | 511145.b0112 |
Protein family/group databases
TCDBi | 2.A.3.1.3 the amino acid-polyamine-organocation (apc) family |
Proteomic databases
PaxDbi | P15993 |
PRIDEi | P15993 |
Genome annotation databases
EnsemblBacteriai | AAC73223; AAC73223; b0112 BAB96681; BAB96681; BAB96681 |
GeneIDi | 946018 |
KEGGi | ecj:JW0108 eco:b0112 |
PATRICi | fig|511145.12.peg.114 |
Organism-specific databases
EchoBASEi | EB0082 |
Phylogenomic databases
eggNOGi | ENOG4105C85 Bacteria COG1113 LUCA |
HOGENOMi | HOG000261849 |
InParanoidi | P15993 |
KOi | K11734 |
PhylomeDBi | P15993 |
Enzyme and pathway databases
BioCyci | EcoCyc:AROP-MONOMER ECOL316407:JW0108-MONOMER MetaCyc:AROP-MONOMER |
Miscellaneous databases
PROi | PR:P15993 |
Family and domain databases
InterProi | View protein in InterPro IPR004841 AA-permease/SLC12A_dom IPR002293 AA/rel_permease1 IPR004840 Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324 AA_permease, 1 hit |
PIRSFi | PIRSF006060 AA_transporter, 1 hit |
PROSITEi | View protein in PROSITE PS00218 AMINO_ACID_PERMEASE_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AROP_ECOLI | |
Accessioni | P15993Primary (citable) accession number: P15993 Secondary accession number(s): P75650 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | June 20, 2003 | |
Last modified: | November 13, 2019 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene