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UniProtKB - P15993 (AROP_ECOLI)

Entry version 167 (02 Jun 2021)
Sequence version 3 (20 Jun 2003)
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Protein

Aromatic amino acid transport protein AroP

Gene

aroP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:AROP-MONOMER
MetaCyc:AROP-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.1.3, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aromatic amino acid transport protein AroP
Alternative name(s):
General aromatic amino acid permease
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aroP
Ordered Locus Names:b0112, JW0108
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42PeriplasmicSequence analysis1
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 86CytoplasmicSequence analysisAdd BLAST23
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 117PeriplasmicSequence analysis10
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 155CytoplasmicSequence analysisAdd BLAST17
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 201PeriplasmicSequence analysisAdd BLAST25
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 240CytoplasmicSequence analysisAdd BLAST18
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 271PeriplasmicSequence analysis10
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 333CytoplasmicSequence analysisAdd BLAST41
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 358PeriplasmicSequence analysis4
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 400CytoplasmicSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 425PeriplasmicSequence analysis4
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 457CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541931 – 457Aromatic amino acid transport protein AroPAdd BLAST457

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15993

PRoteomics IDEntifications database

More...PRIDEi		P15993

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Its activity is regulated by protein TyrR.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4259731, 11 interactors

STRING: functional protein association networks

More...STRINGi		511145.b0112

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1113, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_9_3_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15993

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15993

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00324, AA_permease, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15993-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL 
        60         70         80         90        100
GYAIAGFIAF LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW 
       110        120        130        140        150
VLYVLVAMAE LTAVGKYIQF WYPEIPTWVS AAVFFVVINA INLTNVKVFG 
       160        170        180        190        200
EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG GPQATVSNLW DQGGFLPHGF 
       210        220        230        240        250
TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ VIYRILIFYI 
       260        270        280        290        300
GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY 
       310        320        330        340        350
NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI 
       360        370        380        390        400
NYLAPESAFG LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL 
       410        420        430        440        450
LYPLGNWICL LFMAAVLVIM LMTPGMAISV YLIPVWLIVL GIGYLFKEKT 

AKAVKAH
Length:457
Mass (Da):49,690
Last modified:June 20, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2F66D3F73CD78BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28A → S in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti199G → A in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti199G → A in AAC45299 (PubMed:9150230).Curated1
Sequence conflicti398 – 399PA → L in CAA35211 (PubMed:2408019).Curated2
Sequence conflicti424P → R in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti424P → R in AAC45299 (PubMed:9150230).Curated1
Sequence conflicti427A → G in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti429S → W in CAA35211 (PubMed:2408019).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X17333 Genomic DNA Translation: CAA35211.1
U87285 Genomic DNA Translation: AAC45299.1
U00096 Genomic DNA Translation: AAC73223.1
AP009048 Genomic DNA Translation: BAB96681.2

Protein sequence database of the Protein Information Resource

More...PIRi		H64733, QRECAA

NCBI Reference Sequences

More...RefSeqi		NP_414654.1, NC_000913.3
WP_000969915.1, NZ_SSZK01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC73223; AAC73223; b0112
BAB96681; BAB96681; BAB96681

Database of genes from NCBI RefSeq genomes

More...GeneIDi		60903337
946018

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW0108
eco:b0112

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|511145.12.peg.114

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17333 Genomic DNA Translation: CAA35211.1
U87285 Genomic DNA Translation: AAC45299.1
U00096 Genomic DNA Translation: AAC73223.1
AP009048 Genomic DNA Translation: BAB96681.2
PIRiH64733, QRECAA
RefSeqiNP_414654.1, NC_000913.3
WP_000969915.1, NZ_SSZK01000004.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4259731, 11 interactors
STRINGi511145.b0112

Protein family/group databases

TCDBi2.A.3.1.3, the amino acid-polyamine-organocation (apc) family

Proteomic databases

PaxDbiP15993
PRIDEiP15993

Genome annotation databases

EnsemblBacteriaiAAC73223; AAC73223; b0112
BAB96681; BAB96681; BAB96681
GeneIDi60903337
946018
KEGGiecj:JW0108
eco:b0112
PATRICifig|511145.12.peg.114

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0082

Phylogenomic databases

eggNOGiCOG1113, Bacteria
HOGENOMiCLU_007946_9_3_6
InParanoidiP15993
PhylomeDBiP15993

Enzyme and pathway databases

BioCyciEcoCyc:AROP-MONOMER
MetaCyc:AROP-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P15993

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PROSITEiView protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAROP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15993
Secondary accession number(s): P75650
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 20, 2003
Last modified: June 2, 2021
This is version 167 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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