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Entry version 150 (11 Dec 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Collagen alpha-3(VI) chain

Gene

COL6A3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Collagen VI acts as a cell-binding protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3082 – 3083Reactive bondBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-3(VI) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL6A3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000584626 – 3137Collagen alpha-3(VI) chainAdd BLAST3112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2084N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2683N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2867N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3072 ↔ 3122PROSITE-ProRule annotation
Disulfide bondi3081 ↔ 3105PROSITE-ProRule annotation
Disulfide bondi3097 ↔ 3118PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15989

PRoteomics IDEntifications database

More...
PRIDEi
P15989

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000006240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15989

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 212VWFA 1PROSITE-ProRule annotationAdd BLAST175
Domaini241 – 418VWFA 2PROSITE-ProRule annotationAdd BLAST178
Domaini444 – 623VWFA 3PROSITE-ProRule annotationAdd BLAST180
Domaini644 – 817VWFA 4PROSITE-ProRule annotationAdd BLAST174
Domaini842 – 1014VWFA 5PROSITE-ProRule annotationAdd BLAST173
Domaini1035 – 1207VWFA 6PROSITE-ProRule annotationAdd BLAST173
Domaini1239 – 1410VWFA 7PROSITE-ProRule annotationAdd BLAST172
Domaini1441 – 1621VWFA 8PROSITE-ProRule annotationAdd BLAST181
Domaini1641 – 1814VWFA 9PROSITE-ProRule annotationAdd BLAST174
Domaini1840 – 2029VWFA 10PROSITE-ProRule annotationAdd BLAST190
Domaini2407 – 2587VWFA 11PROSITE-ProRule annotationAdd BLAST181
Domaini2625 – 2821VWFA 12PROSITE-ProRule annotationAdd BLAST197
Domaini2957 – 3051Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini3068 – 3137BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 2042Nonhelical regionAdd BLAST2017
Regioni2043 – 2379Triple-helical regionAdd BLAST337
Regioni2166 – 2172Interruption in collagenous region7
Regioni2254 – 2259Interruption in collagenous region6
Regioni2308 – 2309Interruption in collagenous region2
Regioni2380 – 3137Nonhelical regionAdd BLAST758

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2045 – 2047Cell attachment site3
Motifi2153 – 2155Cell attachment site3
Motifi2159 – 2161Cell attachment site3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type VI collagen family.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG41103QR LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168250

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15989

Database of Orthologous Groups

More...
OrthoDBi
1049829at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15989

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.40.50.410, 12 hits
4.10.410.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 2 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 11 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 12 hits
SSF57362 SSF57362, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: At least 2 isoforms are produced.
Isoform 1 (identifier: P15989-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKHRHLPLA AILGLLLSGF CSVGAQQQAA VRNVAVADII FLVDSSWSIG
60 70 80 90 100
KEHFQLVREF LYDVVKALDV GGNDFRFALV QFSGNPHTEF QLNTYPSNQD
110 120 130 140 150
VLSHIANMPY MGGGSKTGKG LEYLIENHLT KAAGSRASEG VPQVIIVLTD
160 170 180 190 200
GQSQDDVALP SSVLKSAHVN MIAVGVQDAV EGELKEIASR PFDTHLFNLE
210 220 230 240 250
NFTALHGIVG DLVASVRTSM TPEQAGAKGL VKDITAQESA DLIFLIDGSD
260 270 280 290 300
NIGSVNFQAI RDFLVNLIES LRVGAQQIHI GVVQYSDQPR TEFALNSYST
310 320 330 340 350
KADVLDAVKA LSFRGGKEAN TGAALEYVVE NLFTQAGGSR IEEAVPQILV
360 370 380 390 400
LISGGESSDD IREGLLAVKQ ASIFSFSIGV LNADSAELQQ IATDGSFAFT
410 420 430 440 450
ALDIRNLAAL RELLLPNIVG VAQRLILLEA PTIVTEVIEV NKKDIVFLID
460 470 480 490 500
GSTALGTGPF NSIRDFVAKI VQRLEVGPDL IQVAVAQYAD TVRPEFYFNT
510 520 530 540 550
HQNRKDVMAN VKKMKLMGGT ALNTGSALDF VRNNFFTSAA GCRMEEGVLP
560 570 580 590 600
MLVLITGGKS MDAVEQAAAE MKRNRIVILA VGSRNADVAE LQEIAHERDF
610 620 630 640 650
VFQPNDFRLQ FMQAILPEVL SPIRTLSGGM VIHETPSVQV TKRDIIFLLD
660 670 680 690 700
GSLNVGNANF PFVRDFVVTL VNYLDVGTDK IRVGLVQFSD TPKTEFSLYS
710 720 730 740 750
YQTKSDIIQR LGQLRPKGGS VLNTGSALNF VLSNHFTEAG GSRINEQVPQ
760 770 780 790 800
VLVLVTAGRS AVPFLQVSND LARAGVLTFA VGVRNADKAE LEQIAFNPKM
810 820 830 840 850
VYFMDDFSDL TTLPQELKKP ITTIVSGGVE EVPLAPTESK KDILFLIDGS
860 870 880 890 900
ANLLGSFPAV RDFIHKVISD LNVGPDATRV AVAQFSDNIQ IEFDFAELPS
910 920 930 940 950
KQDMLLKVKR MRLKTGKQLN IGVALDEVMR RLFVKEAGSR IEEGIPQFLV
960 970 980 990 1000
LLAAGRSTDE VERPSGALKE AGVVTFAIKA KNADLSELER IAYAPQFILN
1010 1020 1030 1040 1050
VESLPRISEL QANIVNLLKT IQFQPTVVER GEKKDVVFLI DGSDGVRRGF
1060 1070 1080 1090 1100
PLLKTFVERV VESLDIGRDK VRVAIVQYSN AIQPEFLLDA YEDKADLVSA
1110 1120 1130 1140 1150
IQALTIMGGS PLNTGAALDY LIKNVFTVSS GSRIAEGVPQ FLILLTADRS
1160 1170 1180 1190 1200
QDDVRRPSVV LKTSGTVPFG IGIGNADLTE LQTISFLPDF AISVPDFSQL
1210 1220 1230 1240 1250
DSVQQAVSNR VIRLTKKEIE SLAPDLVFTS PSPVGVKRDV VFLVDGSRYA
1260 1270 1280 1290 1300
AQEFYLIRDL IERIVNNLDV GFDTTRISVV QFSEHPHVEF LLNAHSTKDE
1310 1320 1330 1340 1350
VQGAVRRLRP RGGQQVNVGE ALEFVAKTIF TRPSGSRIEE GVPQFLVILS
1360 1370 1380 1390 1400
SRKSDDDLEF PSVQVKQVGV APMVIAKNMD PEEMVQISLS PDYVFQVSSF
1410 1420 1430 1440 1450
QELPSLEQKL LAPIETLTAD QIRQLLGDVT TIPDVSGEEK DVVFLIDSSD
1460 1470 1480 1490 1500
SVRSDGLAHI RDFISRIVQQ LDVGPNKVRI GVVQFSNNVF PEFYLRTHKS
1510 1520 1530 1540 1550
KNAVLQAIRR LRLRGGYPVN AGKALDYVVK NYFIKSAGSR IEDGVPQHLV
1560 1570 1580 1590 1600
VILGDQSQDD VNRPANVISS TSIQPLGVGA RNVDRNQLQV ITNDPGRVLV
1610 1620 1630 1640 1650
VQDFTGLPTL ERKVQNILEE LTVPTTEGPV YPGPEGKKQA DIVFLLDGSI
1660 1670 1680 1690 1700
NLGRDNFQEV LQFVYSIVDA IYEDGDSIQV GLAQYNSDVT DEFFLKDYSS
1710 1720 1730 1740 1750
KPEILDAINK VIYKGGRVAN TGAAIKHLQA KHFVKEAGSR IDQRVPQIAF
1760 1770 1780 1790 1800
IITGGKSSDD GQGASMEVAQ KGVKVFAVGV RNIDLEEVSK LASESATSFR
1810 1820 1830 1840 1850
VSTAQELSEL NEQVLVTLAA AMKEKLCPGT TDVTRDCDLD VILGFDVSDV
1860 1870 1880 1890 1900
GAGQNIFNSQ RGLESRVEAV LNRITQMQKI SCTGSRAPSV RVAIMAQSRG
1910 1920 1930 1940 1950
GPVEGLDFSE YQPELFERFQ GMRTRGPYFL TAETLKSYQN KFRSAPSGST
1960 1970 1980 1990 2000
KVVIHFTDGT DDYLDQMKTA SADLRRQGVH ALLFVGLDRV KNFEEVMQLE
2010 2020 2030 2040 2050
FGRGFTYNRP LRVNLLDLDF ELAEQLDNIA ERTCCGVPCK CSGQRGDRGL
2060 2070 2080 2090 2100
PGPIGPKGAT GEIGYGGYPG DEGGPGERGP PGVNGTQGFQ GCPGHRGTKG
2110 2120 2130 2140 2150
SRGFPGEKGE LGEMGLDGID GEEGDKGLPG FSGEKGFSGR RGSKGAKGER
2160 2170 2180 2190 2200
GERGDRGLRG DPGESGADNT QRGTRGQKGE IGQMGEPGPA GQRGQDGGVG
2210 2220 2230 2240 2250
RKGMAGRRGP IGVKGTKGAL GQPGPAGEQG MRGPQGPPGQ IGTPGIRGEQ
2260 2270 2280 2290 2300
GIPGPRAGGG QPGAPGERGR IGPLGRKGEP GNPGPRGPNG QQGPRGEMGD
2310 2320 2330 2340 2350
DGRDGIGGPG PKGRKGERGF VGYPGPKGGP GDRGGAGGPG PKGNRGRRGN
2360 2370 2380 2390 2400
AGNPGTPGQK GEIGYPGPSG LKGDKGPSIS QCALVQNIKD KCPCCYGPKE
2410 2420 2430 2440 2450
CPVFPTELAF AIDTSSGVGR DVFNRMKQTV LRVVSNLTIA ESNCPRGARV
2460 2470 2480 2490 2500
ALVTYNNEVT TEIRFADARK KSSLLQQIQN FQATLTTKPR SLETAMSFVA
2510 2520 2530 2540 2550
RNTFKRARSG FLMRKVAVFF SNGETRASPQ LNDAVLKLYD AGVTPVFLTS
2560 2570 2580 2590 2600
RQDAVLERAL EINNTAVGHA IVLPTSGSQL NDTIRRLLTC HVCLDVCEPD
2610 2620 2630 2640 2650
PICGYGSQRP VFRDRRAAPT DVDTDIAFIM DSSASTTPLQ FNEMKKYISH
2660 2670 2680 2690 2700
LVSNMEISSE PKISQHHARV AVLQQAPYDH ETNSSFPPVK TEFSLTDYGS
2710 2720 2730 2740 2750
KEKIINYLHN QMTQLYGTMA MGSAVEHTVA HVFESAPNPR DLKVIVLMIT
2760 2770 2780 2790 2800
GKMEKQELEY LREAVIDAKC KGYLFVILGI GKNVDVKNIY SLASEPNDVF
2810 2820 2830 2840 2850
FKLVSKPGEL HEEPLLRFGR LLPSFIRSDF AFYLSPEIRK QCKWLQADQT
2860 2870 2880 2890 2900
PKSPGHTGQK AVYIAPNGTV TQTISTTTTL STTFKPAAST SAHAKTTTAS
2910 2920 2930 2940 2950
TTAQTRATER PTESTTVQVN ATVQSQGSTA ANTKATSRTT TSTTAAAASG
2960 2970 2980 2990 3000
RRRQGAKMND IQITDVTENS ARLRWASPEP HNAYVFDLAI TLAHDHSLVL
3010 3020 3030 3040 3050
KQNVTGTERV IGGLRSGQKY LVFITGYLKS QPKVTYTGTF STKTPAQPKV
3060 3070 3080 3090 3100
ALANMMLNAE PLEGPENVMD ICLLQKEEGT CRDFVLKWHY DLKTKSCARF
3110 3120 3130
WYGGCGGNEN RFNTQKECEK ACSPGNISPG VVTTIGT
Length:3,137
Mass (Da):339,599
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECB428578B536357
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M24282 mRNA Translation: AAA03201.1

Protein sequence database of the Protein Information Resource

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PIRi
A37797

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24282 mRNA Translation: AAA03201.1
PIRiA37797

3D structure databases

SMRiP15989
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006240

Proteomic databases

PaxDbiP15989
PRIDEiP15989

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG41103QR LUCA
HOGENOMiHOG000168250
InParanoidiP15989
OrthoDBi1049829at2759
PhylomeDBiP15989

Family and domain databases

CDDicd00063 FN3, 1 hit
cd00109 KU, 1 hit
cd01481 vWA_collagen_alpha3-VI-like, 6 hits
Gene3Di2.60.40.10, 1 hit
3.40.50.410, 12 hits
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR041900 vWA_collagen_alpha3-VI-like
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00014 Kunitz_BPTI, 1 hit
PF00092 VWA, 11 hits
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SM00327 VWA, 12 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 12 hits
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS50853 FN3, 1 hit
PS50234 VWFA, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO6A3_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15989
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 1, 1996
Last modified: December 11, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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