UniProtKB - P15982 (HB2C_PIG)
Protein
SLA class II histocompatibility antigen, DQ haplotype C beta chain
Gene
N/A
Organism
Sus scrofa (Pig)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: SLA class II histocompatibility antigen, DQ haplotype C beta chain |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 230 | ExtracellularSequence analysisAdd BLAST | 199 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 261 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Membrane, MHC IIPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Add BLAST | 31 | |
ChainiPRO_0000019008 | 32 – 261 | SLA class II histocompatibility antigen, DQ haplotype C beta chainAdd BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 47 ↔ 111 | PROSITE-ProRule annotation | ||
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 205 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P15982 |
PeptideAtlasi | P15982 |
PRIDEi | P15982 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 233 | Ig-like C1-typeAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 32 – 126 | Beta-1Add BLAST | 95 | |
Regioni | 127 – 220 | Beta-2Add BLAST | 94 | |
Regioni | 221 – 230 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class II family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
OrthoDBi | 1186163at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P15982-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGMVALRLP RGLWTAALTV MLVVLGAPVA EGRDSPQDFV FQFKGECYFY
60 70 80 90 100
NGTQRVRGVA RYIYNQEEHL RFDSDVGEFR AVTPLGRPEA DSWNSQKDVL
110 120 130 140 150
EQMRAEVDRV CKHNYQIEEG TTLQRRVQPT VTISPSKAEA LNHHNLLVCA
160 170 180 190 200
VTDFYPSQVK VQWFRNGQEE TAGVVSTPLI RNGDWTYQVL VMLEMNLQRG
210 220 230 240 250
DVYTCRVEHS SLQNPILVEW RAQSESAQSK MLSGVGGFVL GLIFLGLGLF
260
IRHRSQKGLV R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31497 mRNA Translation: AAA31084.1 M32117 mRNA Translation: AAA53110.1 |
PIRi | A60404 |
RefSeqi | NP_001107166.1, NM_001113694.1 |
Genome annotation databases
GeneIDi | 100037921 |
KEGGi | ssc:100037921 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31497 mRNA Translation: AAA31084.1 M32117 mRNA Translation: AAA53110.1 |
PIRi | A60404 |
RefSeqi | NP_001107166.1, NM_001113694.1 |
3D structure databases
SMRi | P15982 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000001575 |
Proteomic databases
PaxDbi | P15982 |
PeptideAtlasi | P15982 |
PRIDEi | P15982 |
Genome annotation databases
GeneIDi | 100037921 |
KEGGi | ssc:100037921 |
Organism-specific databases
CTDi | 100037921 |
Phylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
OrthoDBi | 1186163at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HB2C_PIG | |
Accessioni | P15982Primary (citable) accession number: P15982 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families