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Entry version 118 (13 Feb 2019)
Sequence version 2 (07 Feb 2006)
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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 53

Gene

Usp53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (PubMed:26609154). Has no peptidase activity (PubMed:26609154).1 Publication

Caution

Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 53
Alternative name(s):
Inactive ubiquitin-specific peptidase 53
Per-hexamer repeat protein 3
Protein mambo1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp53Imported
Synonyms:Phxr3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139607 Usp53

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi228C → S: Associated with a progressive hearing loss; outer hair cells degenerate rapidly after the first postnatal week. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806821 – 1069Inactive ubiquitin carboxyl-terminal hydrolase 53Add BLAST1069

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15975

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15975

PRoteomics IDEntifications database

More...
PRIDEi
P15975

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15975

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15975

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cochlea. Isoform 1 expression levels are 10-fold higher than isoform 2 expression levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039701 Expressed in 244 organ(s), highest expression level in decidua

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15975 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15975 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the C-terminal region) with the heterodimer TJP1:TJP2.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000087857

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15975

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 351USPAdd BLAST322

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1887 Eukaryota
ENOG410XSNE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156337

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236318

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG068627

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15975

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIRCHFQ

Database of Orthologous Groups

More...
OrthoDBi
101145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15975

TreeFam database of animal gene trees

More...
TreeFami
TF323194

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040143 USP53
IPR028889 USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22975:SF6 PTHR22975:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15975-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWVKFLRKP SGNLGKAYQA GSLLSLAPTV GLLNEPGQNS CFLNSAVQVL
60 70 80 90 100
WQLDIFRRSL RALTGHICQG DACIFCALKT IFAQFQHSRE KALPSDNIRH
110 120 130 140 150
ALAESFKDEQ RFQLGLMDDA AECFENILAR IHFHLVPNRD ADMCTSKSCV
160 170 180 190 200
THQKFAMTLY EQCVCRSCGA SSDPLPFTEL VRYISTTALC NEVERMMERH
210 220 230 240 250
ERVKPEMFAE LLQAANTADD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV
260 270 280 290 300
WDSEHSDLTE DVVRSLATHL YLPGLFYRVT DENATDSELH LVGMICYTSR
310 320 330 340 350
HYCAFAFHTK SSKWVFFDDA HVKEMGTRWK DVVSKCIRCH LQPLLLFYAN
360 370 380 390 400
PDGTAVSTED ALRQVVHWSH YRSGEENMGC GKPIIYKPDN SKENGFGGQT
410 420 430 440 450
KQKENHKFQT DISSLNRSQM QTSGRRAPVK LSHDQREKIK DISRECALKA
460 470 480 490 500
IEQKNALSSQ RKDLEKGQRK DTGRHRDLVD EVLASFKSGS PPASDGFRQQ
510 520 530 540 550
GNPHLYHSQG KGPCKHDRAT HESYTSGKVI SSSKSQNLLV PGEKTTGKAK
560 570 580 590 600
SDSGTGYETD SSQDSRDKGG SYSSKTKSRH RGWKPMRETL NVDSVFSESE
610 620 630 640 650
KRQHSPRRKS DIGSRPRCSK DQSFNNWPKA NPKQKGLMTI YEDEMKQEAG
660 670 680 690 700
SRSSLETNGK GAEKNLSAAE SRGPGTSWQM QRTESGYESS DHVSNGSASL
710 720 730 740 750
DSPGVEGSGA VMDVGGGKAF SEHIKMNSHN MDSMEYISHH CKDHPEGFRK
760 770 780 790 800
ELQDLEADDK IHELHPESHV QIKSHLIKRS QIGETNDKLF PSASPQTLAR
810 820 830 840 850
EHVYQTNEHK VERPDRSKCS ERHNTENSEG TGLPFHVDES SVAGKRVDSN
860 870 880 890 900
ETVSPSSLPS SVRTAGLKPE TGPLMFWSQQ NITEQGYSDN SLSRELTLLS
910 920 930 940 950
ACNADSCQMP KLHCHRSPPP LPPKKYSTAS APRLERVGLS PDVGVTEAFN
960 970 980 990 1000
TNPSSLPKHS LSPASGPSLE GSPCMTQERD KETIQVKQLA ANSYPSSCST
1010 1020 1030 1040 1050
NSFQPDQDST SVCPNETISL TTYFSVDSCM TDTYRLKYHQ RPKLYFPESS
1060
GHHSNNSLSQ TEQVEGSIT
Length:1,069
Mass (Da):119,255
Last modified:February 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D35E3FE657D57C8
GO
Isoform 2 (identifier: P15975-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-283: LFYRVTDEN → VSQLLSFKR
     284-1069: Missing.

Show »
Length:283
Mass (Da):31,950
Checksum:i28535D27F9FE7D7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3USD9Q3USD9_MOUSE
Inactive ubiquitin carboxyl-termina...
Usp53
427Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BSX5Q8BSX5_MOUSE
Inactive ubiquitin carboxyl-termina...
Usp53
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFC5A0A0G2JFC5_MOUSE
Inactive ubiquitin carboxyl-termina...
Usp53
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG80A0A0G2JG80_MOUSE
Inactive ubiquitin carboxyl-termina...
Usp53
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA31296 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192E → G in BAC32545 (PubMed:3267239).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058590275 – 283LFYRVTDEN → VSQLLSFKR in isoform 2. 9
Alternative sequenceiVSP_058591284 – 1069Missing in isoform 2. Add BLAST786

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK036876 mRNA Translation: BAC29614.1
AK045953 mRNA Translation: BAC32545.1
BC022221 mRNA Translation: AAH22221.1
BC132339 mRNA Translation: AAI32340.1
BC145707 mRNA Translation: AAI45708.1
X12807 mRNA Translation: CAA31296.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17815.1 [P15975-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S02187

NCBI Reference Sequences

More...
RefSeqi
NP_598618.1, NM_133857.3 [P15975-1]
XP_011238619.1, XM_011240317.1 [P15975-1]
XP_017175309.1, XM_017319820.1 [P15975-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.491248

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000090379; ENSMUSP00000087857; ENSMUSG00000039701 [P15975-1]
ENSMUST00000197314; ENSMUSP00000142600; ENSMUSG00000039701 [P15975-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
99526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:99526

UCSC genome browser

More...
UCSCi
uc008rez.1 mouse [P15975-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036876 mRNA Translation: BAC29614.1
AK045953 mRNA Translation: BAC32545.1
BC022221 mRNA Translation: AAH22221.1
BC132339 mRNA Translation: AAI32340.1
BC145707 mRNA Translation: AAI45708.1
X12807 mRNA Translation: CAA31296.1 Sequence problems.
CCDSiCCDS17815.1 [P15975-1]
PIRiS02187
RefSeqiNP_598618.1, NM_133857.3 [P15975-1]
XP_011238619.1, XM_011240317.1 [P15975-1]
XP_017175309.1, XM_017319820.1 [P15975-1]
UniGeneiMm.491248

3D structure databases

ProteinModelPortaliP15975
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087857

Protein family/group databases

MEROPSiC19.081

PTM databases

iPTMnetiP15975
PhosphoSitePlusiP15975

Proteomic databases

MaxQBiP15975
PaxDbiP15975
PRIDEiP15975

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090379; ENSMUSP00000087857; ENSMUSG00000039701 [P15975-1]
ENSMUST00000197314; ENSMUSP00000142600; ENSMUSG00000039701 [P15975-2]
GeneIDi99526
KEGGimmu:99526
UCSCiuc008rez.1 mouse [P15975-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54532
MGIiMGI:2139607 Usp53

Phylogenomic databases

eggNOGiKOG1887 Eukaryota
ENOG410XSNE LUCA
GeneTreeiENSGT00940000156337
HOGENOMiHOG000236318
HOVERGENiHBG068627
InParanoidiP15975
OMAiCIRCHFQ
OrthoDBi101145at2759
PhylomeDBiP15975
TreeFamiTF323194

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P15975

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039701 Expressed in 244 organ(s), highest expression level in decidua
ExpressionAtlasiP15975 baseline and differential
GenevisibleiP15975 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR040143 USP53
IPR028889 USP_dom
PANTHERiPTHR22975:SF6 PTHR22975:SF6, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP53_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15975
Secondary accession number(s): A2RT25
, Q8BR11, Q8CB37, Q8R251
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: February 7, 2006
Last modified: February 13, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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