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UniProtKB - P15966 (MATA_BPFR)
Protein
Maturation protein A
Gene
A
Organism
Enterobacteria phage fr (Bacteriophage fr)
Status
Functioni
The maturation protein is required for the typical attachment of the phage to the side of the bacterial pili. Binds to sequences located toward each end of the genome, hence circularizing it. The RNA genome-maturation protein A complex is released from the capsid upon host receptor binding. Maturation protein A enters the cell along with the viral RNA.
By similarityGO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- viral genome circularization Source: UniProtKB-KW
- virion attachment to host cell pilus Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Maturation protein AShort name: MP Alternative name(s): Assembly protein Short name: A protein |
Gene namesi | Name:A |
Organismi | Enterobacteria phage fr (Bacteriophage fr) |
Taxonomic identifieri | 12017 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Lenarviricota › Allassoviricetes › Levivirales › Leviviridae › Levivirus › |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
Subcellular locationi
- Virion By similarity Note: A single copy of the maturation protein is present in the virion.By similarity
Keywords - Cellular componenti
VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164857 | 1 – 393 | Maturation protein AAdd BLAST | 393 |
Post-translational modificationi
During internalization, MP is proteolytically cleaved into two fragments allowing translation and replication to start.By similarity
Interactioni
Subunit structurei
Interacts with the host pilus.
By similarityFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 233 | Viral RNA-bindingBy similarityAdd BLAST | 208 |
Sequence similaritiesi
Belongs to the Levivirus maturation protein family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005563, A_protein |
Pfami | View protein in Pfam PF03863, Phage_mat-A, 1 hit |
i Sequence
Sequence statusi: Complete.
P15966-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRKFIPTERM SKSHVVSVRE YADGELEDNS LPLIYRSNWS PGQYTSTGPR
60 70 80 90 100
TKEWHYPSSY SRGAIGIKAL DQGKYARLGT SWGREFEERA GYGMSIDARS
110 120 130 140 150
CYSLFPVSQN LTWIDVPTNV ANRATTEVLG KVTQGNFNLG VALAEARSTA
160 170 180 190 200
SQLSTQTIAL IKAYTAARRG NWRQALRYLA LNENRKFNSK SVASRWLELQ
210 220 230 240 250
FGWMPLLSDI QGAYEMLTKV HLKAFMPMRA VRQVGQNVSL SGRLTSPAAS
260 270 280 290 300
YKSTCNISRR IVIWFYINDA RLAWLSSLGI LNPLGIVWEK VPFSFLVDWL
310 320 330 340 350
LPVGNMLEGL TAPIGCSYQS GTVTDVISGE STITADDIYG WDTVRPATAK
360 370 380 390
VQISAVHRGV QSVWPTTGVY VKSPFSMVHT LDALALFRQR LWK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 232 | R → S in AAA32188 (PubMed:3628010).Curated | 1 | |
Sequence conflicti | 334 | T → I in AAA32188 (PubMed:3628010).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15031 mRNA Translation: CAA33135.1 M31635 Genomic RNA Translation: AAA32188.1 |
PIRi | S08017 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15031 mRNA Translation: CAA33135.1 M31635 Genomic RNA Translation: AAA32188.1 |
PIRi | S08017 |
3D structure databases
SMRi | P15966 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR005563, A_protein |
Pfami | View protein in Pfam PF03863, Phage_mat-A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MATA_BPFR | |
Accessioni | P15966Primary (citable) accession number: P15966 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |