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UniProtKB - P15965 (RDRP_BPFR)
Protein
RNA-directed RNA polymerase beta chain
Gene
N/A
Organism
Enterobacteria phage fr (Bacteriophage fr)
Status
Functioni
This is the catalytic subunit of the viral RNA-dependent RNA polymerase complex. This complex is involved in viral RNA replication that produces (+)-stranded genomes via a complementary, (-)-stranded intermediate.
By similarityCatalytic activityi
- a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)PROSITE-ProRule annotationBy similarityEC:2.7.7.48PROSITE-ProRule annotationBy similarity
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-directed RNA polymerase beta chain (EC:2.7.7.48By similarity)Alternative name(s): RNA replicase beta chain |
Organismi | Enterobacteria phage fr (Bacteriophage fr) |
Taxonomic identifieri | 12017 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Lenarviricota › Allassoviricetes › Levivirales › Leviviridae › Levivirus › |
Virus hosti | Escherichia coli [TaxID: 562] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000164851 | 1 – 545 | RNA-directed RNA polymerase beta chainAdd BLAST | 545 |
Interactioni
Subunit structurei
Part of the viral RNA-dependent RNA polymerase complex, the other subunits are probably the host ribosomal protein S1, EF-Tu and EF-Ts.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 243 – 373 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 131 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR007096, RNA-dir_Rpol_phage_catalytic IPR005093, RNArep_beta |
Pfami | View protein in Pfam PF03431, RNA_replicase_B, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50522, RDRP_PHAGE, 1 hit |
i Sequence
Sequence statusi: Complete.
P15965-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKSTKKFNS LCIDLSRDLS LEVYQSIASV ATGSSDPHSD DFTAIAYLRD
60 70 80 90 100
ELLTKHPNLG DGNDEATRRS LAIAKLLEAN DRCGQINRDG FLHDATASWD
110 120 130 140 150
PDVLQTSIRS LIGNLLSGYS SQLFRHCTFS NGASMGHKLQ DAAPYKKFAE
160 170 180 190 200
QATVTPRALK AAVLVKDQCS PWIRHSHVFP ESYTFRLVGG NGVFTVPKNN
210 220 230 240 250
KIDRAACKEP DMNMYLQKGV GGFIRRRLKT VGIDLNDQTI NQRLAQQGSR
260 270 280 290 300
DGSLATIDLS SASDSISDRL VWSFLPPELY SYLDMIRSHY GYVNGKMIRW
310 320 330 340 350
ELFSTMGNGF TFELESMIFW AIVRATQIHF RNTGTIGIYG DDIICPTEIA
360 370 380 390 400
PRVLEALSFY GFKPNLRKTF TSGSFRESCG AHYFRGVDVK PFYIKKPITD
410 420 430 440 450
LFSLMLILNR IRGWGVVNGI ADPRLYEVWE KLSRLVPRYL FGGTDLQADY
460 470 480 490 500
YVVSPPILKG IYSKMNGRRE YAEARTTGFK LARIARWRKH FSDKHDSGRY
510 520 530 540
IAWFHTGGEI TDSMKSAGVR VMRTSEWLQP VPVFPQECGP ASSPQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15031 mRNA Translation: CAA33138.1 M31635 Genomic RNA Translation: AAA32190.1 M35063 Genomic RNA Translation: AAA32191.1 M38325 Genomic RNA Translation: AAA32192.1 |
PIRi | S08020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15031 mRNA Translation: CAA33138.1 M31635 Genomic RNA Translation: AAA32190.1 M35063 Genomic RNA Translation: AAA32191.1 M38325 Genomic RNA Translation: AAA32192.1 |
PIRi | S08020 |
3D structure databases
SMRi | P15965 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR007096, RNA-dir_Rpol_phage_catalytic IPR005093, RNArep_beta |
Pfami | View protein in Pfam PF03431, RNA_replicase_B, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50522, RDRP_PHAGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_BPFR | |
Accessioni | P15965Primary (citable) accession number: P15965 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | February 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 81 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |