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Protein

Kallikrein 1-related peptidase b9

Gene

Klk1b9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B40 3474
ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiS01.071

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b9 (EC:3.4.21.35)
Alternative name(s):
Epidermal growth factor-binding protein type C
Short name:
EGF-BP C
Glandular kallikrein K9
Short name:
mGK-9
Tissue kallikrein-9
Gene namesi
Name:Klk1b9
Synonyms:Egfbp3, Klk-9, Klk9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95293 Klk1b9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002797919 – 24Activation peptide6
ChainiPRO_000002798025 – 261Kallikrein 1-related peptidase b9Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15949
PaxDbiP15949
PRIDEiP15949

Expressioni

Gene expression databases

BgeeiENSMUSG00000059042 Expressed in 9 organ(s), highest expression level in pancreas
CleanExiMM_KLK1B9
GenevisibleiP15949 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080133

Structurei

3D structure databases

ProteinModelPortaliP15949
SMRiP15949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149111
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15949
KOiK01325
OMAiRYNEYIC
OrthoDBiEOG091G0DF7
PhylomeDBiP15949
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15949-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFLILFLAL SLGGIDAAPP VHSRIVGGFK CEKNSQPWHV AVYRYNEYIC
60 70 80 90 100
GGVLLDANWV LTAAHCYYEE NKVSLGKNNL YEEEPSAQHR LVSKSFLHPG
110 120 130 140 150
YNRSLHRNHI RHPEYDYSND LMLLRLSKPA DITDVVKPIA LPTEEPKLGS
160 170 180 190 200
TCLASGWGST TPFKFQNAKD LQCVNLKLLP NEDCGKAHIE KVTDVMLCAG
210 220 230 240 250
ETDGGKDTCK GDSGGPLICD GVLQGITSWG FTPCGEPKKP GVYTKLIKFT
260
SWIKDTMAKN L
Length:261
Mass (Da):28,900
Last modified:April 1, 1990 - v1
Checksum:i796FD4DAE56020D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17962 mRNA Translation: AAA37541.1
M17985, M17983, M17984 Genomic DNA Translation: AAA37681.1
BC024624 mRNA Translation: AAH24624.1
BC048869 mRNA Translation: AAH48869.1
M18588 Genomic DNA Translation: AAA39350.1 Sequence problems.
M18608 Genomic DNA Translation: AAA39351.1
CCDSiCCDS21191.1
PIRiC29746 A29745
I70014
RefSeqiNP_034246.1, NM_010116.1
UniGeneiMm.440884

Genome annotation databases

EnsembliENSMUST00000081399; ENSMUSP00000080133; ENSMUSG00000059042
GeneIDi13648
KEGGimmu:13648
UCSCiuc009god.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1KB9_MOUSE
AccessioniPrimary (citable) accession number: P15949
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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