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Protein

Kallikrein 1-related peptidase b11

Gene

Klk1b11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B42 3474
ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiS01.041

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b11 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K11
Short name:
mGK-11
Tissue kallikrein-11
Gene namesi
Name:Klk1b11
Synonyms:Klk-11, Klk11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:892023 Klk1b11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002798119 – 24Activation peptideCurated6
ChainiPRO_000002798225 – 261Kallikrein 1-related peptidase b11Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15946
PaxDbiP15946
PeptideAtlasiP15946
PRIDEiP15946

Expressioni

Gene expression databases

BgeeiENSMUSG00000044485 Expressed in 34 organ(s), highest expression level in submandibular gland
CleanExiMM_KLK11
MM_KLK1B11
ExpressionAtlasiP15946 baseline and differential
GenevisibleiP15946 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007156

Structurei

3D structure databases

ProteinModelPortaliP15946
SMRiP15946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149111
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15946
KOiK01325
OMAiESNDLML
OrthoDBiEOG091G0DF7
PhylomeDBiP15946
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRIVGGFN CEKNSQPWHV AVYRYNKYIC
60 70 80 90 100
GGVLLDRNWV LTAAHCHVSQ YNVWLGKTKL FQREPSAQHR MVSKSFPHPD
110 120 130 140 150
YNMSLLIIHN PEPEDDESND LMLLRLSEPA DITDAVKPIA LPTEEPKLGS
160 170 180 190 200
TCLVSGWGSI TPTKFQTPDD LQCVSIKLLP NEVCVKNHNQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCK GDSGGPLICD GVLHGITAWG PIPCGKPNTP GVYTKLIKFT
260
NWIKDTMAKN P
Length:261
Mass (Da):28,727
Last modified:April 1, 1990 - v1
Checksum:i8D32EFE8D835EA7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13215
, X13216, X13217, X13218 Genomic DNA Translation: CAA31604.3
BC013660 mRNA Translation: AAH13660.1
M18590 Genomic DNA Translation: AAA39352.1 Sequence problems.
M18610 Genomic DNA Translation: AAA39353.1
CCDSiCCDS21192.1
PIRiI70022
S01971
RefSeqiNP_034770.1, NM_010640.2
UniGeneiMm.443378

Genome annotation databases

EnsembliENSMUST00000007156; ENSMUSP00000007156; ENSMUSG00000044485
GeneIDi16613
KEGGimmu:16613
UCSCiuc009goe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13215
, X13216, X13217, X13218 Genomic DNA Translation: CAA31604.3
BC013660 mRNA Translation: AAH13660.1
M18590 Genomic DNA Translation: AAA39352.1 Sequence problems.
M18610 Genomic DNA Translation: AAA39353.1
CCDSiCCDS21192.1
PIRiI70022
S01971
RefSeqiNP_034770.1, NM_010640.2
UniGeneiMm.443378

3D structure databases

ProteinModelPortaliP15946
SMRiP15946
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007156

Protein family/group databases

MEROPSiS01.041

Proteomic databases

MaxQBiP15946
PaxDbiP15946
PeptideAtlasiP15946
PRIDEiP15946

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007156; ENSMUSP00000007156; ENSMUSG00000044485
GeneIDi16613
KEGGimmu:16613
UCSCiuc009goe.1 mouse

Organism-specific databases

CTDi16613
MGIiMGI:892023 Klk1b11

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149111
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15946
KOiK01325
OMAiESNDLML
OrthoDBiEOG091G0DF7
PhylomeDBiP15946
TreeFamiTF331065

Enzyme and pathway databases

BRENDAi3.4.21.B42 3474
ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

PROiPR:P15946
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044485 Expressed in 34 organ(s), highest expression level in submandibular gland
CleanExiMM_KLK11
MM_KLK1B11
ExpressionAtlasiP15946 baseline and differential
GenevisibleiP15946 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1B11_MOUSE
AccessioniPrimary (citable) accession number: P15946
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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