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UniProtKB - P15924 (DESP_HUMAN)

Entry version 249 (23 Feb 2022)
Sequence version 3 (03 Oct 2006)
Previous versions | rss
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Protein

Desmoplakin

Gene

DSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P15924

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
R-HSA-9696264, RND3 GTPase cycle
R-HSA-9696273, RND1 GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P15924

SIGNOR Signaling Network Open Resource

More...SIGNORi		P15924

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Desmoplakin
Short name:
DP
Alternative name(s):
250/210 kDa paraneoplastic pemphigus antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3052, DSP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		125647, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P15924

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000096696

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keratoderma, palmoplantar, striate 2 (SPPK2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by thickening of the skin on the palms (linear pattern) and the soles (island-like pattern) and flexor aspect of the fingers. Abnormalities of the nails, the teeth and the hair are rarely present.
Related information in OMIM
Cardiomyopathy, dilated, with woolly hair and keratoderma (DCWHK)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive cardiocutaneous syndrome characterized by a generalized striate keratoderma particularly affecting the palmoplantar epidermis, woolly hair, and dilated left ventricular cardiomyopathy.
Related information in OMIM
Arrhythmogenic right ventricular dysplasia, familial, 8 (ARVD8)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015402299S → R in ARVD8; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121912992EnsemblClinVar.1
Natural variantiVAR_065693445I → V in ARVD8. Corresponds to variant dbSNP:rs934142779Ensembl.1
Natural variantiVAR_0238141255R → K in ARVD8. 2 PublicationsCorresponds to variant dbSNP:rs777407386EnsemblClinVar.1
Natural variantiVAR_0238161775R → I in ARVD8; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs34738426EnsemblClinVar.1
Skin fragility-woolly hair syndrome (SFWHS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive genodermatosis characterized by skin fragility with blistering, focal and diffuse palmoplantar keratoderma, hyperkeratotic plaques on the trunk and limbs, and woolly hair with varying degrees of alopecia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015569287N → K in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs121912993EnsemblClinVar.1
Natural variantiVAR_0155702366R → C in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs28931610EnsemblClinVar.1
Epidermolysis bullosa, lethal acantholytic (EBLA)
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epidermolysis bullosa characterized by severe fragility of skin and mucous membranes. The phenotype is lethal in the neonatal period because of immense transcutaneous fluid loss. Typical features include universal alopecia, neonatal teeth, and nail loss. Histopathology of the skin shows suprabasal clefting and acantholysis throughout the spinous layer, mimicking pemphigus.
Related information in OMIM
Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis (DCWHKTA)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA cardiocutaneous syndrome characterized by biventricular dilated cardiomyopathy, hyperkeratosis, woolly hair, palmoplantar keratoderma, and hypo/oligodontia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072432564T → I in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231295EnsemblClinVar.1
Natural variantiVAR_072433597S → L in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231294EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2849S → G: Increases association with KRT5-KRT14, KRT8-KRT18 or VIM intermediate filaments. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease variant, Epidermolysis bullosa, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		1832

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DSP

MalaCards human disease database

More...MalaCardsi		DSP
MIMi605676, phenotype
607450, phenotype
607655, phenotype
609638, phenotype
612908, phenotype
615821, phenotype

Open Targets

More...OpenTargetsi		ENSG00000096696

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		65282, Carvajal syndrome
476096, Erythrokeratodermia-cardiomyopathy syndrome
293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154, Familial isolated dilated cardiomyopathy
2032, Idiopathic pulmonary fibrosis
158687, Lethal acantholytic erosive disorder
369992, Severe dermatitis-multiple allergies-metabolic wasting syndrome
293165, Skin fragility-woolly hair-palmoplantar keratoderma syndrome
50942, Striate palmoplantar keratoderma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27505

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P15924, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638, Artenimol
DB01593, Zinc
DB14487, Zinc acetate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DSP

Domain mapping of disease mutations (DMDM)

More...DMDMi		115502381

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781441 – 2871DesmoplakinAdd BLAST2871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphotyrosineBy similarity1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei1658PhosphoserineCombined sources1
Modified residuei1708PhosphoserineCombined sources1
Modified residuei2024PhosphoserineCombined sources1
Modified residuei2207PhosphoserineCombined sources1
Modified residuei2209PhosphoserineCombined sources1
Modified residuei2225PhosphoserineCombined sources1
Modified residuei2810PhosphoserineCombined sources1
Modified residuei2815PhosphoserineCombined sources1
Modified residuei2817PhosphotyrosineCombined sources1
Modified residuei2820PhosphoserineCombined sources1
Modified residuei2821PhosphoserineCombined sources1
Modified residuei2825PhosphoserineCombined sources1
Modified residuei2826Omega-N-methylarginineBy similarity1
Modified residuei2847Omega-N-methylarginineBy similarity1
Modified residuei2849PhosphoserineCombined sources1
Modified residuei2853PhosphothreonineCombined sources1
Modified residuei2868PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ser-2849 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2849 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-498
CPTAC-499

Encyclopedia of Proteome Dynamics

More...EPDi		P15924

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P15924

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P15924

MaxQB - The MaxQuant DataBase

More...MaxQBi		P15924

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P15924

PeptideAtlas

More...PeptideAtlasi		P15924

PRoteomics IDEntifications database

More...PRIDEi		P15924

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53244 [P15924-1]
53245 [P15924-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P15924

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P15924, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P15924

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P15924

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P15924

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P15924

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000096696, Expressed in zone of skin and 203 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P15924, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000096696, Group enriched (esophagus, skin, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments.

Interacts with DSC2.

Interacts with PKP2.

Interacts weakly with TMEM65 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108166, 231 interactors

Database of interacting proteins

More...DIPi		DIP-109N

Protein interaction database and analysis system

More...IntActi		P15924, 109 interactors

Molecular INTeraction database

More...MINTi		P15924

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369129

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P15924, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		P15924

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P15924

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P15924

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati178 – 271Spectrin 1Add BLAST94
Repeati272 – 375Spectrin 2Add BLAST104
Repeati376 – 446Spectrin 3aAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini458 – 515SH3PROSITE-ProRule annotationAdd BLAST58
Repeati516 – 545Spectrin 3bAdd BLAST30
Repeati546 – 627Spectrin 4Add BLAST82
Repeati654 – 769Spectrin 5Add BLAST116
Repeati770 – 883Spectrin 6Add BLAST114
Repeati2009 – 2045Plectin 1Add BLAST37
Repeati2046 – 2083Plectin 2Add BLAST38
Repeati2084 – 2121Plectin 3Add BLAST38
Repeati2122 – 2159Plectin 4Add BLAST38
Repeati2163 – 2197Plectin 5Add BLAST35
Repeati2198 – 2233Plectin 6Add BLAST36
Repeati2251 – 2288Plectin 7Add BLAST38
Repeati2289 – 2326Plectin 8Add BLAST38
Repeati2327 – 2364Plectin 9Add BLAST38
Repeati2365 – 2402Plectin 10Add BLAST38
Repeati2406 – 2440Plectin 11Add BLAST35
Repeati2456 – 2493Plectin 12Add BLAST38
Repeati2507 – 2544Plectin 13Add BLAST38
Repeati2610 – 2647Plectin 14Add BLAST38
Repeati2648 – 2685Plectin 15Add BLAST38
Repeati2724 – 2761Plectin 16Add BLAST38
Repeati2762 – 2799Plectin 17Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1056Globular 1Add BLAST1056
Regioni1 – 584Interaction with plakophilin 1 and junction plakoglobinAdd BLAST584
Regioni1057 – 1945Central fibrous rod domainAdd BLAST889
Regioni1946 – 2871Globular 2Add BLAST926
Regioni1960 – 22084.5 X 38 AA tandem repeats (Domain A)Add BLAST249
Regioni2244 – 24464.5 X 38 AA tandem repeats (Domain B)Add BLAST203
Regioni2609 – 28224.5 X 38 AA tandem repeats (Domain C)Add BLAST214
Regioni2810 – 2871DisorderedSequence analysisAdd BLAST62
Regioni2824 – 28476 X 4 AA tandem repeats of G-S-R-[SR]Add BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1018 – 1945Sequence analysisAdd BLAST928

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2811 – 2871Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermediate filaments proteins and most likely involves recognition sites located in the rod domain of these keratins.
The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1.
The three tandem plakin repeat regions in the C-terminus mediate binding to intermediate filaments.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000679_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P15924

Identification of Orthologs from Complete Genome Data

More...OMAi		SLGWQKM

Database for complete collections of gene phylogenies

More...PhylomeDBi		P15924

TreeFam database of animal gene trees

More...TreeFami		TF106435

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.1290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028462, Desmoplakin
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 1 hit
PTHR23169:SF26, PTHR23169:SF26, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00250, PLEC, 18 hits
SM00150, SPEC, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform DPI (identifier: P15924-1) [UniParc]FASTAAdd to basket
Also known as: DP1

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD 
        60         70         80         90        100
QNSDGYCQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ 
       110        120        130        140        150
LTRSRELDEC FAQANDQMEI LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR 
       160        170        180        190        200
ALYKAISVPR VRRASSKGGG GYTCQSGSGW DEFTKHVTSE CLGWMRQQRA 
       210        220        230        240        250
EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA DLREKSAIYQ 
       260        270        280        290        300
LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD 
       310        320        330        340        350
KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY 
       360        370        380        390        400
MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR 
       410        420        430        440        450
KKYPCDKNMP LQHLLEQIKE LEKEREKILE YKRQVQNLVN KSKKIVQLKP 
       460        470        480        490        500
RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER SKWYVTGPGG 
       510        520        530        540        550
VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL YINMKSLVSW 
       560        570        580        590        600
HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF 
       610        620        630        640        650
GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN 
       660        670        680        690        700
HNKVIETNRE NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH 
       710        720        730        740        750
HITVKINELK SVQNDSQAIA EVLNQLKDML ANFRGSEKYC YLQNEVFGLF 
       760        770        780        790        800
QKLENINGVT DGYLNSLCTV RALLQAILQT EDMLKVYEAR LTEEETVCLD 
       810        820        830        840        850
LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS QTSQQYPLYD 
       860        870        880        890        900
LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK 
       910        920        930        940        950
WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI 
       960        970        980        990       1000
AELCANSIKD YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH 
      1010       1020       1030       1040       1050
ARYIELLTRS GDYYRFLSEM LKSLEDLKLK NTKIEVLEEE LRLARDANSE 
      1060       1070       1080       1090       1100
NCNKNKFLDQ NLQKYQAECS QFKAKLASLE ELKRQAELDG KSAKQNLDKC 
      1110       1120       1130       1140       1150
YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD QLQKARQCEK 
      1160       1170       1180       1190       1200
ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN 
      1210       1220       1230       1240       1250
EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK 
      1260       1270       1280       1290       1300
DEIVRLNDSI LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ 
      1310       1320       1330       1340       1350
QRSEDNARHK QSLEEAAKTI QDKNKEIERL KAEFQEEAKR RWEYENELSK 
      1360       1370       1380       1390       1400
VRNNYDEEII SLKNQFETEI NITKTTIHQL TMQKEEDTSG YRAQIDNLTR 
      1410       1420       1430       1440       1450
ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV SQRKQQLEVE 
      1460       1470       1480       1490       1500
LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL 
      1510       1520       1530       1540       1550
EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT 
      1560       1570       1580       1590       1600
VKDQDITRFQ NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG 
      1610       1620       1630       1640       1650
MRRSLKEQAI KITNLTQQLE QASIVKKRSE DDLRQQRDVL DGHLREKQRT 
      1660       1670       1680       1690       1700
QEELRRLSSE VEALRRQLLQ EQESVKQAHL RNEHFQKAIE DKSRSLNESK 
      1710       1720       1730       1740       1750
IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE ADSDKNATIL 
      1760       1770       1780       1790       1800
ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE 
      1810       1820       1830       1840       1850
SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK 
      1860       1870       1880       1890       1900
QRLECEKQQI QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE 
      1910       1920       1930       1940       1950
RLQAEIKRIE ERCRRKLEDS TRETQSQLET ERSRYQREID KLRQRPYGSH 
      1960       1970       1980       1990       2000
RETQTECEWT VDTSKLVFDG LRKKVTAMQL YECQLIDKTT LDKLLKGKKS 
      2010       2020       2030       2040       2050
VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI SPESTVMLLE 
      2060       2070       2080       2090       2100
AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF 
      2110       2120       2130       2140       2150
SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA 
      2160       2170       2180       2190       2200
RGLIDRDLYR SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL 
      2210       2220       2230       2240       2250
LSVQKRSMSF QGIRQPVTVT ELVDSGILRP STVNELESGQ ISYDEVGERI 
      2260       2270       2280       2290       2300
KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI GLVRPGTALE LLEAQAATGF 
      2310       2320       2330       2340       2350
IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN DPETGNIISL 
      2360       2370       2380       2390       2400
FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE 
      2410       2420       2430       2440       2450
LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK 
      2460       2470       2480       2490       2500
KQVQTSQKNT LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE 
      2510       2520       2530       2540       2550
CEWEEITITG SDGSTRVVLV DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG 
      2560       2570       2580       2590       2600
SLSLTQFADM ISLKNGVGTS SSMGSGVSDD VFSSSRHESV SKISTISSVR 
      2610       2620       2630       2640       2650
NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG IVDSITGQRL 
      2660       2670       2680       2690       2700
LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG 
      2710       2720       2730       2740       2750
VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA 
      2760       2770       2780       2790       2800
IRKGFIDGRA AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL 
      2810       2820       2830       2840       2850
RLLEAASVSS KGLPSPYNMS SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF 
      2860       2870 
DATGNSSYSY SYSFSSSSIG H
Length:2,871
Mass (Da):331,774
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5770CC6B4F9F9F7B
GO
Isoform DPII (identifier: P15924-2) [UniParc]FASTAAdd to basket
Also known as: DP2

The sequence of this isoform differs from the canonical sequence as follows:
     1195-1793: Missing.

Show »
Length:2,272
Mass (Da):260,119
Checksum:i84F0CD39B48E1339
GO
Isoform DSPIa (identifier: P15924-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1351-1793: Missing.

Note: Minor isoform.Curated
Show »
Length:2,428
Mass (Da):278,916
Checksum:iB26951DA08A0620C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A804HL18A0A804HL18_HUMAN
Desmoplakin
DSP
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti905A → R in AAA85135 (PubMed:1731325).Curated1
Sequence conflicti1120D → R in AAA35766 (PubMed:1689290).Curated1
Sequence conflicti2687 – 2688RL → SV in AAA85135 (PubMed:1731325).Curated2
Sequence conflicti2687 – 2688RL → SV in AAA35766 (PubMed:1689290).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015569287N → K in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs121912993EnsemblClinVar.1
Natural variantiVAR_015402299S → R in ARVD8; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121912992EnsemblClinVar.1
Natural variantiVAR_033862305I → F2 PublicationsCorresponds to variant dbSNP:rs17604693EnsemblClinVar.1
Natural variantiVAR_065693445I → V in ARVD8. Corresponds to variant dbSNP:rs934142779Ensembl.1
Natural variantiVAR_072432564T → I in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231295EnsemblClinVar.1
Natural variantiVAR_072433597S → L in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231294EnsemblClinVar.1
Natural variantiVAR_0238141255R → K in ARVD8. 2 PublicationsCorresponds to variant dbSNP:rs777407386EnsemblClinVar.1
Natural variantiVAR_0656941505A → V1 PublicationCorresponds to variant dbSNP:rs375919492EnsemblClinVar.1
Natural variantiVAR_0204681512Y → C2 PublicationsCorresponds to variant dbSNP:rs2076299EnsemblClinVar.1
Natural variantiVAR_0656951526N → K2 PublicationsCorresponds to variant dbSNP:rs28763966EnsemblClinVar.1
Natural variantiVAR_0656961537R → C2 PublicationsCorresponds to variant dbSNP:rs28763967EnsemblClinVar.1
Natural variantiVAR_0238151738R → Q2 PublicationsCorresponds to variant dbSNP:rs6929069EnsemblClinVar.1
Natural variantiVAR_0238161775R → I in ARVD8; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs34738426EnsemblClinVar.1
Natural variantiVAR_0656971833E → V2 PublicationsCorresponds to variant dbSNP:rs78652302EnsemblClinVar.1
Natural variantiVAR_0155702366R → C in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs28931610EnsemblClinVar.1
Natural variantiVAR_0181582375G → R in a case of recessive arrhythmogenic right ventricular cardiomyopathy with skin abnormalities and woolly hair. 1 PublicationCorresponds to variant dbSNP:rs376923069EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050701195 – 1793Missing in isoform DPII. 1 PublicationAdd BLAST599
Alternative sequenceiVSP_0537691351 – 1793Missing in isoform DSPIa. 1 PublicationAdd BLAST443

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M77830 mRNA Translation: AAA85135.1
HM151899 mRNA Translation: ADI58529.1
AL031058 Genomic DNA No translation available.
BC140802 mRNA Translation: AAI40803.1
J05211 mRNA Translation: AAA35766.1
AF139065 mRNA Translation: AAF19785.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4501.1 [P15924-1]
CCDS47368.1 [P15924-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A38194

NCBI Reference Sequences

More...RefSeqi		NP_001008844.1, NM_001008844.2 [P15924-2]
NP_001305963.1, NM_001319034.1 [P15924-3]
NP_004406.2, NM_004415.3 [P15924-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379802; ENSP00000369129; ENSG00000096696
ENST00000418664; ENSP00000396591; ENSG00000096696 [P15924-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1832

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000379802.8; ENSP00000369129.3; NM_004415.4; NP_004406.2

UCSC genome browser

More...UCSCi		uc003mxp.2, human [P15924-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Desmoplakin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77830 mRNA Translation: AAA85135.1
HM151899 mRNA Translation: ADI58529.1
AL031058 Genomic DNA No translation available.
BC140802 mRNA Translation: AAI40803.1
J05211 mRNA Translation: AAA35766.1
AF139065 mRNA Translation: AAF19785.1
CCDSiCCDS4501.1 [P15924-1]
CCDS47368.1 [P15924-2]
PIRiA38194
RefSeqiNP_001008844.1, NM_001008844.2 [P15924-2]
NP_001305963.1, NM_001319034.1 [P15924-3]
NP_004406.2, NM_004415.3 [P15924-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LM5X-ray1.80A/B2609-2822[»]
1LM7X-ray3.00A/B2209-2456[»]
3R6NX-ray2.95A/B178-627[»]
5DZZX-ray2.60A1960-2448[»]
SASBDBiP15924
SMRiP15924
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108166, 231 interactors
DIPiDIP-109N
IntActiP15924, 109 interactors
MINTiP15924
STRINGi9606.ENSP00000369129

Chemistry databases

DrugBankiDB11638, Artenimol
DB01593, Zinc
DB14487, Zinc acetate

PTM databases

CarbonylDBiP15924
GlyGeniP15924, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP15924
MetOSiteiP15924
PhosphoSitePlusiP15924
SwissPalmiP15924

Genetic variation databases

BioMutaiDSP
DMDMi115502381

Proteomic databases

CPTACiCPTAC-498
CPTAC-499
EPDiP15924
jPOSTiP15924
MassIVEiP15924
MaxQBiP15924
PaxDbiP15924
PeptideAtlasiP15924
PRIDEiP15924
ProteomicsDBi53244 [P15924-1]
53245 [P15924-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24671, 323 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		1832

Genome annotation databases

EnsembliENST00000379802; ENSP00000369129; ENSG00000096696
ENST00000418664; ENSP00000396591; ENSG00000096696 [P15924-2]
GeneIDi1832
KEGGihsa:1832
MANE-SelectiENST00000379802.8; ENSP00000369129.3; NM_004415.4; NP_004406.2
UCSCiuc003mxp.2, human [P15924-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1832
DisGeNETi1832

GeneCards: human genes, protein and diseases

More...GeneCardsi		DSP
GeneReviewsiDSP
HGNCiHGNC:3052, DSP
HPAiENSG00000096696, Group enriched (esophagus, skin, vagina)
MalaCardsiDSP
MIMi125647, gene
605676, phenotype
607450, phenotype
607655, phenotype
609638, phenotype
612908, phenotype
615821, phenotype
neXtProtiNX_P15924
OpenTargetsiENSG00000096696
Orphaneti65282, Carvajal syndrome
476096, Erythrokeratodermia-cardiomyopathy syndrome
293899, Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888, Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910, Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
154, Familial isolated dilated cardiomyopathy
2032, Idiopathic pulmonary fibrosis
158687, Lethal acantholytic erosive disorder
369992, Severe dermatitis-multiple allergies-metabolic wasting syndrome
293165, Skin fragility-woolly hair-palmoplantar keratoderma syndrome
50942, Striate palmoplantar keratoderma
PharmGKBiPA27505
VEuPathDBiHostDB:ENSG00000096696

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000154843
HOGENOMiCLU_000679_1_0_1
InParanoidiP15924
OMAiSLGWQKM
PhylomeDBiP15924
TreeFamiTF106435

Enzyme and pathway databases

PathwayCommonsiP15924
ReactomeiR-HSA-351906, Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope
R-HSA-9696264, RND3 GTPase cycle
R-HSA-9696273, RND1 GTPase cycle
SignaLinkiP15924
SIGNORiP15924

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1832, 7 hits in 1043 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DSP, human
EvolutionaryTraceiP15924

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Desmoplakin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1832
PharosiP15924, Tbio

Protein Ontology

More...PROi		PR:P15924
RNActiP15924, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000096696, Expressed in zone of skin and 203 other tissues
GenevisibleiP15924, HS

Family and domain databases

Gene3Di3.90.1290.10, 3 hits
InterProiView protein in InterPro
IPR028462, Desmoplakin
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 1 hit
PTHR23169:SF26, PTHR23169:SF26, 1 hit
PfamiView protein in Pfam
PF00681, Plectin, 8 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00250, PLEC, 18 hits
SM00150, SPEC, 3 hits
SUPFAMiSSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDESP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15924
Secondary accession number(s): B2RTT2
, D7RX09, O75993, Q14189, Q9UHN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2006
Last modified: February 23, 2022
This is version 249 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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