Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Desmoplakin

Gene

DSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell adhesion molecule binding Source: InterPro
  • cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication Source: BHF-UCL
  • protein binding, bridging Source: UniProtKB
  • protein kinase C binding Source: BHF-UCL
  • RNA binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc
  • structural molecule activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P15924

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Desmoplakin
Short name:
DP
Alternative name(s):
250/210 kDa paraneoplastic pemphigus antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000096696.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3052 DSP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
125647 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15924

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keratoderma, palmoplantar, striate 2 (SPPK2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by thickening of the skin on the palms (linear pattern) and the soles (island-like pattern) and flexor aspect of the fingers. Abnormalities of the nails, the teeth and the hair are rarely present.
See also OMIM:612908
Cardiomyopathy, dilated, with woolly hair and keratoderma (DCWHK)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive cardiocutaneous syndrome characterized by a generalized striate keratoderma particularly affecting the palmoplantar epidermis, woolly hair, and dilated left ventricular cardiomyopathy.
See also OMIM:605676
Arrhythmogenic right ventricular dysplasia, familial, 8 (ARVD8)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
See also OMIM:607450
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015402299S → R in ARVD8; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121912992EnsemblClinVar.1
Natural variantiVAR_065693445I → V in ARVD8. Corresponds to variant dbSNP:rs934142779Ensembl.1
Natural variantiVAR_0238141255R → K in ARVD8. 2 PublicationsCorresponds to variant dbSNP:rs777407386Ensembl.1
Natural variantiVAR_0238161775R → I in ARVD8; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs34738426EnsemblClinVar.1
Skin fragility-woolly hair syndrome (SFWHS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive genodermatosis characterized by skin fragility with blistering, focal and diffuse palmoplantar keratoderma, hyperkeratotic plaques on the trunk and limbs, and woolly hair with varying degrees of alopecia.
See also OMIM:607655
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015569287N → K in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs121912993EnsemblClinVar.1
Natural variantiVAR_0155702366R → C in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs28931610EnsemblClinVar.1
Epidermolysis bullosa, lethal acantholytic (EBLA)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epidermolysis bullosa characterized by severe fragility of skin and mucous membranes. The phenotype is lethal in the neonatal period because of immense transcutaneous fluid loss. Typical features include universal alopecia, neonatal teeth, and nail loss. Histopathology of the skin shows suprabasal clefting and acantholysis throughout the spinous layer, mimicking pemphigus.
See also OMIM:609638
Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis (DCWHKTA)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA cardiocutaneous syndrome characterized by biventricular dilated cardiomyopathy, hyperkeratosis, woolly hair, palmoplantar keratoderma, and hypo/oligodontia.
See also OMIM:615821
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072432564T → I in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231295EnsemblClinVar.1
Natural variantiVAR_072433597S → L in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231294EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2849S → G: Increases association with KRT5-KRT14, KRT8-KRT18 or VIM intermediate filaments. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Epidermolysis bullosa, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
1832

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DSP

MalaCards human disease database

More...
MalaCardsi
DSP
MIMi605676 phenotype
607450 phenotype
607655 phenotype
609638 phenotype
612908 phenotype
615821 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000096696

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
65282 Carvajal syndrome
476096 Erythrokeratodermia-cardiomyopathy syndrome
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
2032 Idiopathic pulmonary fibrosis
158687 Lethal acantholytic epidermolysis bullosa
369992 Severe dermatitis-multiple allergies-metabolic wasting syndrome
293165 Skin fragility-woolly hair-palmoplantar keratoderma syndrome
50942 Striate palmoplantar keratoderma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27505

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DSP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115502381

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000781441 – 2871DesmoplakinAdd BLAST2871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphotyrosineBy similarity1
Modified residuei61PhosphothreonineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei1658PhosphoserineCombined sources1
Modified residuei1708PhosphoserineCombined sources1
Modified residuei2024PhosphoserineCombined sources1
Modified residuei2207PhosphoserineCombined sources1
Modified residuei2209PhosphoserineCombined sources1
Modified residuei2225PhosphoserineCombined sources1
Modified residuei2810PhosphoserineCombined sources1
Modified residuei2815PhosphoserineCombined sources1
Modified residuei2817PhosphotyrosineCombined sources1
Modified residuei2820PhosphoserineCombined sources1
Modified residuei2821PhosphoserineCombined sources1
Modified residuei2825PhosphoserineCombined sources1
Modified residuei2826Omega-N-methylarginineBy similarity1
Modified residuei2847Omega-N-methylarginineBy similarity1
Modified residuei2849PhosphoserineCombined sources1
Modified residuei2853PhosphothreonineCombined sources1
Modified residuei2868PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ser-2849 is probably phosphorylated by a cAMP-dependent protein kinase. Phosphorylation on Ser-2849 probably affects its association with epidermal, simple cytokeratins and VIM intermediate filaments.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P15924

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15924

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15924

PeptideAtlas

More...
PeptideAtlasi
P15924

PRoteomics IDEntifications database

More...
PRIDEi
P15924

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53244
53245 [P15924-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P15924

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15924

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15924

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15924

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000096696 Expressed in 190 organ(s), highest expression level in zone of skin

CleanEx database of gene expression profiles

More...
CleanExi
HS_DSP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15924 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037324
HPA045840
HPA054950

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Interacts with PKP2. Interacts weakly with TMEM65 (By similarity).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108166, 113 interactors

Database of interacting proteins

More...
DIPi
DIP-109N

Protein interaction database and analysis system

More...
IntActi
P15924, 63 interactors

Molecular INTeraction database

More...
MINTi
P15924

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15924

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15924

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15924

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati178 – 271Spectrin 1Add BLAST94
Repeati272 – 375Spectrin 2Add BLAST104
Repeati376 – 446Spectrin 3aAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini458 – 515SH3PROSITE-ProRule annotationAdd BLAST58
Repeati516 – 545Spectrin 3bAdd BLAST30
Repeati546 – 627Spectrin 4Add BLAST82
Repeati654 – 769Spectrin 5Add BLAST116
Repeati770 – 883Spectrin 6Add BLAST114
Repeati2009 – 2045Plectin 1Add BLAST37
Repeati2046 – 2083Plectin 2Add BLAST38
Repeati2084 – 2121Plectin 3Add BLAST38
Repeati2122 – 2159Plectin 4Add BLAST38
Repeati2163 – 2197Plectin 5Add BLAST35
Repeati2198 – 2233Plectin 6Add BLAST36
Repeati2251 – 2288Plectin 7Add BLAST38
Repeati2289 – 2326Plectin 8Add BLAST38
Repeati2327 – 2364Plectin 9Add BLAST38
Repeati2365 – 2402Plectin 10Add BLAST38
Repeati2406 – 2440Plectin 11Add BLAST35
Repeati2456 – 2493Plectin 12Add BLAST38
Repeati2507 – 2544Plectin 13Add BLAST38
Repeati2610 – 2647Plectin 14Add BLAST38
Repeati2648 – 2685Plectin 15Add BLAST38
Repeati2724 – 2761Plectin 16Add BLAST38
Repeati2762 – 2799Plectin 17Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1056Globular 1Add BLAST1056
Regioni1 – 584Interaction with plakophilin 1 and junction plakoglobinAdd BLAST584
Regioni1057 – 1945Central fibrous rod domainAdd BLAST889
Regioni1946 – 2871Globular 2Add BLAST926
Regioni1960 – 22084.5 X 38 AA tandem repeats (Domain A)Add BLAST249
Regioni2244 – 24464.5 X 38 AA tandem repeats (Domain B)Add BLAST203
Regioni2609 – 28224.5 X 38 AA tandem repeats (Domain C)Add BLAST214
Regioni2824 – 28476 X 4 AA tandem repeats of G-S-R-[SR]Add BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1018 – 1945Sequence analysisAdd BLAST928

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Its association with epidermal and simple keratins is dependent on the tertiary structure induced by heterodimerization of these intermediate filaments proteins and most likely involves recognition sites located in the rod domain of these keratins.
The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1.
The three tandem plakin repeat regions in the C-terminus mediate binding to intermediate filaments.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQBR Eukaryota
ENOG4111ACS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112198

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081434

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15924

KEGG Orthology (KO)

More...
KOi
K10381

Identification of Orthologs from Complete Genome Data

More...
OMAi
KNQFETE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G003R

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15924

TreeFam database of animal gene trees

More...
TreeFami
TF106435

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028462 Desmoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR44773 PTHR44773, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681 Plectin, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform DPI (identifier: P15924-1) [UniParc]FASTAAdd to basket
Also known as: DP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCNGGSHPR INTLGRMIRA ESGPDLRYEV TSGGGGTSRM YYSRRGVITD
60 70 80 90 100
QNSDGYCQTG TMSRHQNQNT IQELLQNCSD CLMRAELIVQ PELKYGDGIQ
110 120 130 140 150
LTRSRELDEC FAQANDQMEI LDSLIREMRQ MGQPCDAYQK RLLQLQEQMR
160 170 180 190 200
ALYKAISVPR VRRASSKGGG GYTCQSGSGW DEFTKHVTSE CLGWMRQQRA
210 220 230 240 250
EMDMVAWGVD LASVEQHINS HRGIHNSIGD YRWQLDKIKA DLREKSAIYQ
260 270 280 290 300
LEEEYENLLK ASFERMDHLR QLQNIIQATS REIMWINDCE EEELLYDWSD
310 320 330 340 350
KNTNIAQKQE AFSIRMSQLE VKEKELNKLK QESDQLVLNQ HPASDKIEAY
360 370 380 390 400
MDTLQTQWSW ILQITKCIDV HLKENAAYFQ FFEEAQSTEA YLKGLQDSIR
410 420 430 440 450
KKYPCDKNMP LQHLLEQIKE LEKEREKILE YKRQVQNLVN KSKKIVQLKP
460 470 480 490 500
RNPDYRSNKP IILRALCDYK QDQKIVHKGD ECILKDNNER SKWYVTGPGG
510 520 530 540 550
VDMLVPSVGL IIPPPNPLAV DLSCKIEQYY EAILALWNQL YINMKSLVSW
560 570 580 590 600
HYCMIDIEKI RAMTIAKLKT MRQEDYMKTI ADLELHYQEF IRNSQGSEMF
610 620 630 640 650
GDDDKRKIQS QFTDAQKHYQ TLVIQLPGYP QHQTVTTTEI THHGTCQDVN
660 670 680 690 700
HNKVIETNRE NDKQETWMLM ELQKIRRQIE HCEGRMTLKN LPLADQGSSH
710 720 730 740 750
HITVKINELK SVQNDSQAIA EVLNQLKDML ANFRGSEKYC YLQNEVFGLF
760 770 780 790 800
QKLENINGVT DGYLNSLCTV RALLQAILQT EDMLKVYEAR LTEEETVCLD
810 820 830 840 850
LDKVEAYRCG LKKIKNDLNL KKSLLATMKT ELQKAQQIHS QTSQQYPLYD
860 870 880 890 900
LDLGKFGEKV TQLTDRWQRI DKQIDFRLWD LEKQIKQLRN YRDNYQAFCK
910 920 930 940 950
WLYDAKRRQD SLESMKFGDS NTVMRFLNEQ KNLHSEISGK RDKSEEVQKI
960 970 980 990 1000
AELCANSIKD YELQLASYTS GLETLLNIPI KRTMIQSPSG VILQEAADVH
1010 1020 1030 1040 1050
ARYIELLTRS GDYYRFLSEM LKSLEDLKLK NTKIEVLEEE LRLARDANSE
1060 1070 1080 1090 1100
NCNKNKFLDQ NLQKYQAECS QFKAKLASLE ELKRQAELDG KSAKQNLDKC
1110 1120 1130 1140 1150
YGQIKELNEK ITRLTYEIED EKRRRKSVED RFDQQKNDYD QLQKARQCEK
1160 1170 1180 1190 1200
ENLGWQKLES EKAIKEKEYE IERLRVLLQE EGTRKREYEN ELAKVRNHYN
1210 1220 1230 1240 1250
EEMSNLRNKY ETEINITKTT IKEISMQKED DSKNLRNQLD RLSRENRDLK
1260 1270 1280 1290 1300
DEIVRLNDSI LQATEQRRRA EENALQQKAC GSEIMQKKQH LEIELKQVMQ
1310 1320 1330 1340 1350
QRSEDNARHK QSLEEAAKTI QDKNKEIERL KAEFQEEAKR RWEYENELSK
1360 1370 1380 1390 1400
VRNNYDEEII SLKNQFETEI NITKTTIHQL TMQKEEDTSG YRAQIDNLTR
1410 1420 1430 1440 1450
ENRSLSEEIK RLKNTLTQTT ENLRRVEEDI QQQKATGSEV SQRKQQLEVE
1460 1470 1480 1490 1500
LRQVTQMRTE ESVRYKQSLD DAAKTIQDKN KEIERLKQLI DKETNDRKCL
1510 1520 1530 1540 1550
EDENARLQRV QYDLQKANSS ATETINKLKV QEQELTRLRI DYERVSQERT
1560 1570 1580 1590 1600
VKDQDITRFQ NSLKELQLQK QKVEEELNRL KRTASEDSCK RKKLEEELEG
1610 1620 1630 1640 1650
MRRSLKEQAI KITNLTQQLE QASIVKKRSE DDLRQQRDVL DGHLREKQRT
1660 1670 1680 1690 1700
QEELRRLSSE VEALRRQLLQ EQESVKQAHL RNEHFQKAIE DKSRSLNESK
1710 1720 1730 1740 1750
IEIERLQSLT ENLTKEHLML EEELRNLRLE YDDLRRGRSE ADSDKNATIL
1760 1770 1780 1790 1800
ELRSQLQISN NRTLELQGLI NDLQRERENL RQEIEKFQKQ ALEASNRIQE
1810 1820 1830 1840 1850
SKNQCTQVVQ ERESLLVKIK VLEQDKARLQ RLEDELNRAK STLEAETRVK
1860 1870 1880 1890 1900
QRLECEKQQI QNDLNQWKTQ YSRKEEAIRK IESEREKSER EKNSLRSEIE
1910 1920 1930 1940 1950
RLQAEIKRIE ERCRRKLEDS TRETQSQLET ERSRYQREID KLRQRPYGSH
1960 1970 1980 1990 2000
RETQTECEWT VDTSKLVFDG LRKKVTAMQL YECQLIDKTT LDKLLKGKKS
2010 2020 2030 2040 2050
VEEVASEIQP FLRGAGSIAG ASASPKEKYS LVEAKRKKLI SPESTVMLLE
2060 2070 2080 2090 2100
AQAATGGIID PHRNEKLTVD SAIARDLIDF DDRQQIYAAE KAITGFDDPF
2110 2120 2130 2140 2150
SGKTVSVSEA IKKNLIDRET GMRLLEAQIA SGGVVDPVNS VFLPKDVALA
2160 2170 2180 2190 2200
RGLIDRDLYR SLNDPRDSQK NFVDPVTKKK VSYVQLKERC RIEPHTGLLL
2210 2220 2230 2240 2250
LSVQKRSMSF QGIRQPVTVT ELVDSGILRP STVNELESGQ ISYDEVGERI
2260 2270 2280 2290 2300
KDFLQGSSCI AGIYNETTKQ KLGIYEAMKI GLVRPGTALE LLEAQAATGF
2310 2320 2330 2340 2350
IVDPVSNLRL PVEEAYKRGL VGIEFKEKLL SAERAVTGYN DPETGNIISL
2360 2370 2380 2390 2400
FQAMNKELIE KGHGIRLLEA QIATGGIIDP KESHRLPVDI AYKRGYFNEE
2410 2420 2430 2440 2450
LSEILSDPSD DTKGFFDPNT EENLTYLQLK ERCIKDEETG LCLLPLKEKK
2460 2470 2480 2490 2500
KQVQTSQKNT LRKRRVVIVD PETNKEMSVQ EAYKKGLIDY ETFKELCEQE
2510 2520 2530 2540 2550
CEWEEITITG SDGSTRVVLV DRKTGSQYDI QDAIDKGLVD RKFFDQYRSG
2560 2570 2580 2590 2600
SLSLTQFADM ISLKNGVGTS SSMGSGVSDD VFSSSRHESV SKISTISSVR
2610 2620 2630 2640 2650
NLTIRSSSFS DTLEESSPIA AIFDTENLEK ISITEGIERG IVDSITGQRL
2660 2670 2680 2690 2700
LEAQACTGGI IHPTTGQKLS LQDAVSQGVI DQDMATRLKP AQKAFIGFEG
2710 2720 2730 2740 2750
VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE VHGRISTEEA
2760 2770 2780 2790 2800
IRKGFIDGRA AQRLQDTSSY AKILTCPKTK LKISYKDAIN RSMVEDITGL
2810 2820 2830 2840 2850
RLLEAASVSS KGLPSPYNMS SAPGSRSGSR SGSRSGSRSG SRSGSRRGSF
2860 2870
DATGNSSYSY SYSFSSSSIG H
Length:2,871
Mass (Da):331,774
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5770CC6B4F9F9F7B
GO
Isoform DPII (identifier: P15924-2) [UniParc]FASTAAdd to basket
Also known as: DP2

The sequence of this isoform differs from the canonical sequence as follows:
     1195-1793: Missing.

Show »
Length:2,272
Mass (Da):260,119
Checksum:i84F0CD39B48E1339
GO
Isoform DSPIa (identifier: P15924-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1351-1793: Missing.

Note: Minor isoform.
Show »
Length:2,428
Mass (Da):278,916
Checksum:iB26951DA08A0620C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti905A → R in AAA85135 (PubMed:1731325).Curated1
Sequence conflicti1120D → R in AAA35766 (PubMed:1689290).Curated1
Sequence conflicti2687 – 2688RL → SV in AAA85135 (PubMed:1731325).Curated2
Sequence conflicti2687 – 2688RL → SV in AAA35766 (PubMed:1689290).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015569287N → K in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs121912993EnsemblClinVar.1
Natural variantiVAR_015402299S → R in ARVD8; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs121912992EnsemblClinVar.1
Natural variantiVAR_033862305I → F2 PublicationsCorresponds to variant dbSNP:rs17604693EnsemblClinVar.1
Natural variantiVAR_065693445I → V in ARVD8. Corresponds to variant dbSNP:rs934142779Ensembl.1
Natural variantiVAR_072432564T → I in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231295EnsemblClinVar.1
Natural variantiVAR_072433597S → L in DCWHKTA. 1 PublicationCorresponds to variant dbSNP:rs606231294EnsemblClinVar.1
Natural variantiVAR_0238141255R → K in ARVD8. 2 PublicationsCorresponds to variant dbSNP:rs777407386Ensembl.1
Natural variantiVAR_0656941505A → V1 PublicationCorresponds to variant dbSNP:rs375919492EnsemblClinVar.1
Natural variantiVAR_0204681512Y → C2 PublicationsCorresponds to variant dbSNP:rs2076299EnsemblClinVar.1
Natural variantiVAR_0656951526N → K2 PublicationsCorresponds to variant dbSNP:rs28763966EnsemblClinVar.1
Natural variantiVAR_0656961537R → C2 PublicationsCorresponds to variant dbSNP:rs28763967EnsemblClinVar.1
Natural variantiVAR_0238151738R → Q2 PublicationsCorresponds to variant dbSNP:rs6929069EnsemblClinVar.1
Natural variantiVAR_0238161775R → I in ARVD8; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs34738426EnsemblClinVar.1
Natural variantiVAR_0656971833E → V2 PublicationsCorresponds to variant dbSNP:rs78652302EnsemblClinVar.1
Natural variantiVAR_0155702366R → C in SFWHS. 1 PublicationCorresponds to variant dbSNP:rs28931610EnsemblClinVar.1
Natural variantiVAR_0181582375G → R in a case of recessive arrhythmogenic right ventricular cardiomyopathy with skin abnormalities and woolly hair. 1 PublicationCorresponds to variant dbSNP:rs376923069Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050701195 – 1793Missing in isoform DPII. 1 PublicationAdd BLAST599
Alternative sequenceiVSP_0537691351 – 1793Missing in isoform DSPIa. 1 PublicationAdd BLAST443

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M77830 mRNA Translation: AAA85135.1
HM151899 mRNA Translation: ADI58529.1
AL031058 Genomic DNA No translation available.
BC140802 mRNA Translation: AAI40803.1
J05211 mRNA Translation: AAA35766.1
AF139065 mRNA Translation: AAF19785.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4501.1 [P15924-1]
CCDS47368.1 [P15924-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A38194

NCBI Reference Sequences

More...
RefSeqi
NP_001008844.1, NM_001008844.2 [P15924-2]
NP_001305963.1, NM_001319034.1 [P15924-3]
NP_004406.2, NM_004415.3 [P15924-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.519873

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379802; ENSP00000369129; ENSG00000096696 [P15924-1]
ENST00000418664; ENSP00000396591; ENSG00000096696 [P15924-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1832

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1832

UCSC genome browser

More...
UCSCi
uc003mxp.2 human [P15924-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Desmoplakin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77830 mRNA Translation: AAA85135.1
HM151899 mRNA Translation: ADI58529.1
AL031058 Genomic DNA No translation available.
BC140802 mRNA Translation: AAI40803.1
J05211 mRNA Translation: AAA35766.1
AF139065 mRNA Translation: AAF19785.1
CCDSiCCDS4501.1 [P15924-1]
CCDS47368.1 [P15924-2]
PIRiA38194
RefSeqiNP_001008844.1, NM_001008844.2 [P15924-2]
NP_001305963.1, NM_001319034.1 [P15924-3]
NP_004406.2, NM_004415.3 [P15924-1]
UniGeneiHs.519873

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LM5X-ray1.80A/B2609-2822[»]
1LM7X-ray3.00A/B2209-2456[»]
3R6NX-ray2.95A/B178-627[»]
5DZZX-ray2.60A1960-2448[»]
ProteinModelPortaliP15924
SMRiP15924
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108166, 113 interactors
DIPiDIP-109N
IntActiP15924, 63 interactors
MINTiP15924
STRINGi9606.ENSP00000369129

PTM databases

CarbonylDBiP15924
iPTMnetiP15924
PhosphoSitePlusiP15924
SwissPalmiP15924

Polymorphism and mutation databases

BioMutaiDSP
DMDMi115502381

Proteomic databases

EPDiP15924
MaxQBiP15924
PaxDbiP15924
PeptideAtlasiP15924
PRIDEiP15924
ProteomicsDBi53244
53245 [P15924-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379802; ENSP00000369129; ENSG00000096696 [P15924-1]
ENST00000418664; ENSP00000396591; ENSG00000096696 [P15924-2]
GeneIDi1832
KEGGihsa:1832
UCSCiuc003mxp.2 human [P15924-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1832
DisGeNETi1832
EuPathDBiHostDB:ENSG00000096696.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DSP
GeneReviewsiDSP
HGNCiHGNC:3052 DSP
HPAiCAB037324
HPA045840
HPA054950
MalaCardsiDSP
MIMi125647 gene
605676 phenotype
607450 phenotype
607655 phenotype
609638 phenotype
612908 phenotype
615821 phenotype
neXtProtiNX_P15924
OpenTargetsiENSG00000096696
Orphaneti65282 Carvajal syndrome
476096 Erythrokeratodermia-cardiomyopathy syndrome
293899 Familial isolated arrhythmogenic ventricular dysplasia, biventricular form
293888 Familial isolated arrhythmogenic ventricular dysplasia, left dominant form
293910 Familial isolated arrhythmogenic ventricular dysplasia, right dominant form
2032 Idiopathic pulmonary fibrosis
158687 Lethal acantholytic epidermolysis bullosa
369992 Severe dermatitis-multiple allergies-metabolic wasting syndrome
293165 Skin fragility-woolly hair-palmoplantar keratoderma syndrome
50942 Striate palmoplantar keratoderma
PharmGKBiPA27505

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQBR Eukaryota
ENOG4111ACS LUCA
GeneTreeiENSGT00940000154843
HOGENOMiHOG000112198
HOVERGENiHBG081434
InParanoidiP15924
KOiK10381
OMAiKNQFETE
OrthoDBiEOG091G003R
PhylomeDBiP15924
TreeFamiTF106435

Enzyme and pathway databases

ReactomeiR-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP15924

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DSP human
EvolutionaryTraceiP15924

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Desmoplakin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1832

Protein Ontology

More...
PROi
PR:P15924

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000096696 Expressed in 190 organ(s), highest expression level in zone of skin
CleanExiHS_DSP
GenevisibleiP15924 HS

Family and domain databases

Gene3Di3.90.1290.10, 3 hits
InterProiView protein in InterPro
IPR028462 Desmoplakin
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR44773 PTHR44773, 1 hit
PfamiView protein in Pfam
PF00681 Plectin, 8 hits
SMARTiView protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 3 hits
SUPFAMiSSF75399 SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDESP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15924
Secondary accession number(s): B2RTT2
, D7RX09, O75993, Q14189, Q9UHN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2006
Last modified: December 5, 2018
This is version 229 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again