UniProtKB - P15923 (TFE2_HUMAN)
Transcription factor E2-alpha
TCF3
Functioni
Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity).
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity).
Together with TCF15, required for the mesenchymal to epithelial transition (By similarity).
Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity).
Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990).
Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).
By similarity1 PublicationFacilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
1 PublicationGO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor binding Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- E-box binding Source: UniProtKB
- mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
- vitamin D response element binding Source: BHF-UCL
GO - Biological processi
- B cell differentiation Source: UniProtKB
- B cell lineage commitment Source: UniProtKB
- immunoglobulin V(D)J recombination Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- nervous system development Source: UniProtKB-KW
- positive regulation of B cell proliferation Source: UniProtKB
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P15923 |
Reactomei | R-HSA-525793, Myogenesis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P15923 |
SIGNORi | P15923 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor E2-alphaAlternative name(s): Class B basic helix-loop-helix protein 21 Short name: bHLHb21 Immunoglobulin enhancer-binding factor E12/E47 Immunoglobulin transcription factor 1 Kappa-E2-binding factor Transcription factor 3 Short name: TCF-3 Transcription factor ITF-1 |
Gene namesi | Name:TCF3 Synonyms:BHLHB21, E2A, ITF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11633, TCF3 |
MIMi | 147141, gene |
neXtProti | NX_P15923 |
VEuPathDBi | HostDB:ENSG00000071564 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
- RNA polymerase II transcription regulator complex Source: BHF-UCL
Other locations
- chromatin Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- euchromatin Source: ARUK-UCL
- protein-containing complex Source: UniProtKB
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Agammaglobulinemia 8, autosomal dominant (AGM8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform E47 (identifier: P15923-2) | |||||
Natural variantiVAR_082832 | 555 | E → K in AGM8, localizes normally to the nucleus, does not perform proper DNA binding, acts in a dominant-negative manner when coexpressed with wild-type) (Ref.29. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 483 – 484 | Breakpoint for translocation to form TCF3-PBX1 oncogene | 2 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 6929 |
MalaCardsi | TCF3 |
MIMi | 616941, phenotype |
OpenTargetsi | ENSG00000071564 |
Orphaneti | 33110, Autosomal agammaglobulinemia 99860, Precursor B-cell acute lymphoblastic leukemia |
PharmGKBi | PA164742580 |
Miscellaneous databases
Pharosi | P15923, Tbio |
Genetic variation databases
BioMutai | TCF3 |
DMDMi | 135655 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127466 | 1 – 654 | Transcription factor E2-alphaAdd BLAST | 654 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 134 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 139 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 355 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 359 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 371 | Omega-N-methylarginineBy similarity | 1 | ||
Modified residuei | 379 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 498 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 529 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 625 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform E47 (identifier: P15923-2) | |||||
Modified residuei | 531 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P15923 |
jPOSTi | P15923 |
MassIVEi | P15923 |
MaxQBi | P15923 |
PaxDbi | P15923 |
PeptideAtlasi | P15923 |
PRIDEi | P15923 |
ProteomicsDBi | 53242 [P15923-1] 53243 [P15923-2] 61481 |
PTM databases
iPTMneti | P15923 |
PhosphoSitePlusi | P15923 |
Expressioni
Gene expression databases
Bgeei | ENSG00000071564, Expressed in testis and 246 other tissues |
ExpressionAtlasi | P15923, baseline and differential |
Genevisiblei | P15923, HS |
Organism-specific databases
HPAi | ENSG00000071564, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:2112746, PubMed:14752053). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (By similarity).
Forms a heterodimer with ASH1, TWIST1 and TWIST2 (By similarity).
Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities (By similarity).
Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element (PubMed:14752053).
Forms a heterodimer with TCF15; the heterodimer binds E-box element (By similarity).
Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3/NEUROG3 dimer-induced transactivation of E box-dependent promoters (By similarity).
Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity).
Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity).
Interacts with EP300 and UBE2I (PubMed:9409784, PubMed:14752053).
Interacts with BHLHA9 (PubMed:25466284).
Interacts with ASB2; the interaction is mediated by SKP2 and targets TCF3 for Notch-induced proteasomal degradation (PubMed:21119685).
By similarity5 PublicationsBinary interactionsi
P15923
With | #Exp. | IntAct |
---|---|---|
ASCL1 [P50553] | 3 | EBI-769630,EBI-957042 |
FOXH1 [O75593] | 2 | EBI-769630,EBI-1759806 |
ID3 [Q02535] | 3 | EBI-769630,EBI-1387094 |
TAL1 [P17542] | 7 | EBI-769630,EBI-1753878 |
TCAF1 [Q9Y4C2] | 3 | EBI-769630,EBI-750484 |
Isoform E12 [P15923-1]
With | #Exp. | IntAct |
---|---|---|
CCNDBP1 [O95273] | 3 | EBI-769645,EBI-748961 |
ID2 [Q02363] | 3 | EBI-769645,EBI-713450 |
MYOD1 [P15172] | 2 | EBI-769645,EBI-488878 |
PSMD9 [O00233] | 2 | EBI-769645,EBI-750973 |
TWIST1 [Q15672] | 6 | EBI-769645,EBI-1797287 |
Isoform 3 [P15923-3]
GO - Molecular functioni
- bHLH transcription factor binding Source: BHF-UCL
- DNA-binding transcription factor binding Source: UniProtKB
- mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 112791, 214 interactors |
CORUMi | P15923 |
DIPi | DIP-74N |
IntActi | P15923, 48 interactors |
MINTi | P15923 |
STRINGi | 9606.ENSP00000262965 |
Miscellaneous databases
RNActi | P15923, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P15923 |
SMRi | P15923 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 549 – 602 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 103 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 135 – 205 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 239 – 268 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 292 – 329 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 343 – 385 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 389 – 425 | Leucine-zipperAdd BLAST | 37 | |
Regioni | 461 – 552 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 633 – 654 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 19 – 27 | 9aaTAD | 9 | |
Motifi | 170 – 176 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 96 | Polar residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 139 – 163 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 292 – 327 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 343 – 366 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 494 – 552 | Basic and acidic residuesSequence analysisAdd BLAST | 59 |
Domaini
Phylogenomic databases
eggNOGi | KOG3910, Eukaryota |
GeneTreei | ENSGT00940000157036 |
HOGENOMi | CLU_021099_2_1_1 |
InParanoidi | P15923 |
OMAi | AHVHRPH |
OrthoDBi | 571132at2759 |
PhylomeDBi | P15923 |
TreeFami | TF321672 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
IDEALi | IID00541 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNQPQRMAPV GTDKELSDLL DFSMMFPLPV TNGKGRPASL AGAQFGGSGL
60 70 80 90 100
EDRPSSGSWG SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG
110 120 130 140 150
KSGERGAYAS FGRDAGVGGL TQAGFLSGEL ALNSPGPLSP SGMKGTSQYY
160 170 180 190 200
PSYSGSSRRR AADGSLDTQP KKVRKVPPGL PSSVYPPSSG EDYGRDATAY
210 220 230 240 250
PSAKTPSSTY PAPFYVADGS LHPSAELWSP PGQAGFGPML GGGSSPLPLP
260 270 280 290 300
PGSGPVGSSG SSSTFGGLHQ HERMGYQLHG AEVNGGLPSA SSFSSAPGAT
310 320 330 340 350
YGGVSSHTPP VSGADSLLGS RGTTAGSSGD ALGKALASIY SPDHSSNNFS
360 370 380 390 400
SSPSTPVGSP QGLAGTSQWP RAGAPGALSP SYDGGLHGLQ SKIEDHLDEA
410 420 430 440 450
IHVLRSHAVG TAGDMHTLLP GHGALASGFT GPMSLGGRHA GLVGGSHPED
460 470 480 490 500
GLAGSTSLMH NHAALPSQPG TLPDLSRPPD SYSGLGRAGA TAAASEIKRE
510 520 530 540 550
EKEDEENTSA ADHSEEEKKE LKAPRARTSP DEDEDDLLPP EQKAEREKER
560 570 580 590 600
RVANNARERL RVRDINEAFK ELGRMCQLHL NSEKPQTKLL ILHQAVSVIL
610 620 630 640 650
NLEQQVRERN LNPKAACLKR REEEKVSGVV GDPQMVLSAP HPGLSEAHNP
AGHM
The sequence of this isoform differs from the canonical sequence as follows:
530-601: PDEDEDDLLP...LHQAVSVILN → STDEVLSLEE...LQQAVQVILG
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRB7 | A0A0A0MRB7_HUMAN | Transcription factor E2-alpha | TCF3 | 600 | Annotation score: | ||
X6REB3 | X6REB3_HUMAN | Transcription factor E2-alpha | TCF3 | 679 | Annotation score: | ||
K7EMM4 | K7EMM4_HUMAN | Transcription factor E2-alpha | TCF3 | 220 | Annotation score: | ||
K7ENH8 | K7ENH8_HUMAN | Transcription factor E2-alpha | TCF3 | 314 | Annotation score: | ||
K7ERZ7 | K7ERZ7_HUMAN | Transcription factor E2-alpha | TCF3 | 204 | Annotation score: | ||
K7EPH6 | K7EPH6_HUMAN | Transcription factor E2-alpha | TCF3 | 96 | Annotation score: | ||
K7EKB9 | K7EKB9_HUMAN | Transcription factor E2-alpha | TCF3 | 179 | Annotation score: | ||
A0A494C1R3 | A0A494C1R3_HUMAN | Transcription factor E2-alpha | TCF3 | 139 | Annotation score: | ||
K7ELF3 | K7ELF3_HUMAN | Transcription factor E2-alpha | TCF3 | 151 | Annotation score: | ||
K7ENI0 | K7ENI0_HUMAN | Transcription factor E2-alpha | TCF3 | 95 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 – 99 | FDPSR…GPGLG → GGGECLAWCGPSAVHRCADV GLGMVSARTAP in CAA36297 (PubMed:2308859).CuratedAdd BLAST | 31 | |
Sequence conflicti | 214 – 216 | FYV → EFR in AAA56830 (PubMed:2493990).Curated | 3 | |
Sequence conflicti | 302 | Missing in AAA36764 (PubMed:1967983).Curated | 1 | |
Sequence conflicti | 390 | Missing in AAA56830 (PubMed:2493990).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_036396 | 8 | A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs376780559EnsemblClinVar. | 1 | ||
Natural variantiVAR_049552 | 120 | L → P. Corresponds to variant dbSNP:rs35354874EnsemblClinVar. | 1 | ||
Natural variantiVAR_049553 | 198 | T → A. Corresponds to variant dbSNP:rs11879402EnsemblClinVar. | 1 | ||
Natural variantiVAR_049554 | 431 | G → S. Corresponds to variant dbSNP:rs1052692Ensembl. | 1 | ||
Isoform E47 (identifier: P15923-2) | |||||
Natural variantiVAR_082832 | 555 | E → K in AGM8, localizes normally to the nucleus, does not perform proper DNA binding, acts in a dominant-negative manner when coexpressed with wild-type) (Ref.29. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057277 | 49 – 99 | Missing in isoform 3. 1 PublicationAdd BLAST | 51 | |
Alternative sequenceiVSP_057278 | 528 | T → TRCQPTPRHSPPSPHQDAHV HRPHAHRTHTGRPSAGPTLF PQPHCLPLAPSRRPPH in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_002155 | 530 – 601 | PDEDE…SVILN → STDEVLSLEEKDLRDRERRM ANNARERVRVRDINEAFREL GRMCQMHLKSDKAQTKLLIL QQAVQVILG in isoform E47. 4 PublicationsAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31523 mRNA Translation: AAA61146.1 M31522 mRNA Translation: AAA36764.1 Different termination. M31222 mRNA Translation: AAA52331.1 Different initiation. AC006274 Genomic DNA Translation: AAC99797.1 AC005321 Genomic DNA Translation: AAC27373.1 KC877695 Genomic DNA No translation available. BC110579 mRNA Translation: AAI10580.1 BC110580 mRNA Translation: AAI10581.1 M24404 mRNA Translation: AAA56829.1 M24405 mRNA Translation: AAA56830.1 X52078 mRNA Translation: CAA36297.1 M65214 mRNA Translation: AAC41693.1 |
CCDSi | CCDS12074.1 [P15923-1] CCDS45899.1 [P15923-2] |
PIRi | A34734 S10099 |
RefSeqi | NP_001129611.1, NM_001136139.2 [P15923-2] NP_003191.1, NM_003200.3 [P15923-1] XP_016882669.1, XM_017027180.1 [P15923-3] XP_016882670.1, XM_017027181.1 [P15923-1] XP_016882671.1, XM_017027182.1 |
Genome annotation databases
Ensembli | ENST00000262965; ENSP00000262965; ENSG00000071564 ENST00000395423; ENSP00000378813; ENSG00000071564 [P15923-3] ENST00000588136; ENSP00000468487; ENSG00000071564 [P15923-2] ENST00000611869; ENSP00000480564; ENSG00000071564 [P15923-2] |
GeneIDi | 6929 |
KEGGi | hsa:6929 |
MANE-Selecti | ENST00000262965.12; ENSP00000262965.5; NM_003200.5; NP_003191.1 |
UCSCi | uc002ltr.3, human [P15923-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31523 mRNA Translation: AAA61146.1 M31522 mRNA Translation: AAA36764.1 Different termination. M31222 mRNA Translation: AAA52331.1 Different initiation. AC006274 Genomic DNA Translation: AAC99797.1 AC005321 Genomic DNA Translation: AAC27373.1 KC877695 Genomic DNA No translation available. BC110579 mRNA Translation: AAI10580.1 BC110580 mRNA Translation: AAI10581.1 M24404 mRNA Translation: AAA56829.1 M24405 mRNA Translation: AAA56830.1 X52078 mRNA Translation: CAA36297.1 M65214 mRNA Translation: AAC41693.1 |
CCDSi | CCDS12074.1 [P15923-1] CCDS45899.1 [P15923-2] |
PIRi | A34734 S10099 |
RefSeqi | NP_001129611.1, NM_001136139.2 [P15923-2] NP_003191.1, NM_003200.3 [P15923-1] XP_016882669.1, XM_017027180.1 [P15923-3] XP_016882670.1, XM_017027181.1 [P15923-1] XP_016882671.1, XM_017027182.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MH0 | NMR | - | A | 1-37 | [»] | |
2YPA | X-ray | 2.80 | B | 546-616 | [»] | |
2YPB | X-ray | 2.87 | B | 546-616 | [»] | |
3U5V | X-ray | 1.70 | A | 563-613 | [»] | |
6MGN | X-ray | 1.90 | A | 561-612 | [»] | |
BMRBi | P15923 | |||||
SMRi | P15923 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112791, 214 interactors |
CORUMi | P15923 |
DIPi | DIP-74N |
IntActi | P15923, 48 interactors |
MINTi | P15923 |
STRINGi | 9606.ENSP00000262965 |
PTM databases
iPTMneti | P15923 |
PhosphoSitePlusi | P15923 |
Genetic variation databases
BioMutai | TCF3 |
DMDMi | 135655 |
Proteomic databases
EPDi | P15923 |
jPOSTi | P15923 |
MassIVEi | P15923 |
MaxQBi | P15923 |
PaxDbi | P15923 |
PeptideAtlasi | P15923 |
PRIDEi | P15923 |
ProteomicsDBi | 53242 [P15923-1] 53243 [P15923-2] 61481 |
Protocols and materials databases
Antibodypediai | 4332, 591 antibodies from 46 providers |
DNASUi | 6929 |
Genome annotation databases
Ensembli | ENST00000262965; ENSP00000262965; ENSG00000071564 ENST00000395423; ENSP00000378813; ENSG00000071564 [P15923-3] ENST00000588136; ENSP00000468487; ENSG00000071564 [P15923-2] ENST00000611869; ENSP00000480564; ENSG00000071564 [P15923-2] |
GeneIDi | 6929 |
KEGGi | hsa:6929 |
MANE-Selecti | ENST00000262965.12; ENSP00000262965.5; NM_003200.5; NP_003191.1 |
UCSCi | uc002ltr.3, human [P15923-1] |
Organism-specific databases
CTDi | 6929 |
DisGeNETi | 6929 |
GeneCardsi | TCF3 |
HGNCi | HGNC:11633, TCF3 |
HPAi | ENSG00000071564, Low tissue specificity |
MalaCardsi | TCF3 |
MIMi | 147141, gene 616941, phenotype |
neXtProti | NX_P15923 |
OpenTargetsi | ENSG00000071564 |
Orphaneti | 33110, Autosomal agammaglobulinemia 99860, Precursor B-cell acute lymphoblastic leukemia |
PharmGKBi | PA164742580 |
VEuPathDBi | HostDB:ENSG00000071564 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3910, Eukaryota |
GeneTreei | ENSGT00940000157036 |
HOGENOMi | CLU_021099_2_1_1 |
InParanoidi | P15923 |
OMAi | AHVHRPH |
OrthoDBi | 571132at2759 |
PhylomeDBi | P15923 |
TreeFami | TF321672 |
Enzyme and pathway databases
PathwayCommonsi | P15923 |
Reactomei | R-HSA-525793, Myogenesis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs |
SignaLinki | P15923 |
SIGNORi | P15923 |
Miscellaneous databases
BioGRID-ORCSi | 6929, 44 hits in 1071 CRISPR screens |
ChiTaRSi | TCF3, human |
GeneWikii | TCF3 |
GenomeRNAii | 6929 |
Pharosi | P15923, Tbio |
PROi | PR:P15923 |
RNActi | P15923, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000071564, Expressed in testis and 246 other tissues |
ExpressionAtlasi | P15923, baseline and differential |
Genevisiblei | P15923, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
IDEALi | IID00541 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TFE2_HUMAN | |
Accessioni | P15923Primary (citable) accession number: P15923 Secondary accession number(s): P15883 Q9UPI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 238 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references