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Entry version 212 (11 Dec 2019)
Sequence version 3 (15 Dec 1998)
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Protein

Transcription factor 4

Gene

TCF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-525793 Myogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P15884

SIGNOR Signaling Network Open Resource

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SIGNORi
P15884

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 4
Short name:
TCF-4
Alternative name(s):
Class B basic helix-loop-helix protein 19
Short name:
bHLHb19
Immunoglobulin transcription factor 2
Short name:
ITF-2
SL3-3 enhancer factor 2
Short name:
SEF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCF4
Synonyms:BHLHB19, ITF2, SEF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196628.13

Human Gene Nomenclature Database

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HGNCi
HGNC:11634 TCF4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602272 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P15884

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pitt-Hopkins syndrome (PTHS)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by mental retardation, wide mouth and distinctive facial features, and intermittent hyperventilation followed by apnea. Features include intellectual disability with severe speech impairment, normal growth parameters at birth, postnatal microcephaly, breathing anomalies, severe motor developmental delay, motor incoordination, ocular anomalies, constipation, seizures, typical behavior and subtle brain abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066839358G → V in PTHS; also expressed in the nucleus with a pattern indistinguishable from the wild-type; does not have a major impact on homodimer formation; affects transcriptional activity in a context-dependent manner. 2 Publications1
Natural variantiVAR_078644385 – 667Missing in PTHS. 1 PublicationAdd BLAST283
Natural variantiVAR_058632535D → G in PTHS; loss of function; also expressed in the nucleus with a pattern indistinguishable from the wild-type; does not have a major impact on homodimer formation; affects transcriptional activity in a context-dependent manner. 2 Publications1
Natural variantiVAR_066970565R → W in PTHS. 1 Publication1
Natural variantiVAR_058633572R → G in PTHS; loss of function. 2 Publications1
Natural variantiVAR_066971572R → Q in PTHS. 1 PublicationCorresponds to variant dbSNP:rs1057521070Ensembl.1
Natural variantiVAR_066972574R → H in PTHS. 1 PublicationCorresponds to variant dbSNP:rs121909123Ensembl.1
Natural variantiVAR_066840574R → P in PTHS; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 3 PublicationsCorresponds to variant dbSNP:rs121909123Ensembl.1
Natural variantiVAR_034704576R → Q in PTHS; loss of function. 3 PublicationsCorresponds to variant dbSNP:rs121909121Ensembl.1
Natural variantiVAR_034705576R → W in PTHS; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 4 PublicationsCorresponds to variant dbSNP:rs121909120Ensembl.1
Natural variantiVAR_066841578R → H in PTHS. 1 Publication1
Natural variantiVAR_066973578R → P in PTHS. 2 Publications1
Natural variantiVAR_066974583A → P in PTHS. 1 Publication1
Natural variantiVAR_058634610A → V in PTHS; loss of function; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 3 Publications1
Corneal dystrophy, Fuchs endothelial, 3 (FECD3)3 Publications
The disease is caused by mutations affecting the gene represented in this entry. Causative mutations are heterozygous TCF4 intronic trinucleotide repeat expansions (CTG)n.3 Publications
Disease descriptionA late-onset form of Fuchs endothelial corneal dystrophy, a disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
Related information in OMIM
Defects in TCF4 may cause autosomal dominant symmetrical acral keratoderma (SAK)syndrome. Symmetrical acral keratodermadefines is characterized by brown/black hyperkeratotic patches symmetrically distributed on the acral regions, especially the wrists, ankles, dorsa of hands, fingers and feet affects young and middle aged men. Patients have epidermis thickened by acanthosis and compact stratum corneum(PubMed:28921696).1 Publication

Keywords - Diseasei

Corneal dystrophy, Disease mutation, Epilepsy, Mental retardation, Primary microcephaly

Organism-specific databases

DisGeNET

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DisGeNETi
6925

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TCF4

MalaCards human disease database

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MalaCardsi
TCF4
MIMi610954 phenotype
613267 phenotype

Open Targets

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OpenTargetsi
ENSG00000196628

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178469 Autosomal dominant non-syndromic intellectual disability
98974 Fuchs endothelial corneal dystrophy
2896 Pitt-Hopkins syndrome
171 Primary sclerosing cholangitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA164742621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P15884 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3885541

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TCF4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001272561 – 667Transcription factor 4Add BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei372PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P15884

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15884

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P15884

MaxQB - The MaxQuant DataBase

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MaxQBi
P15884

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P15884

PeptideAtlas

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PeptideAtlasi
P15884

PRoteomics IDEntifications database

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PRIDEi
P15884

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
32164
32165
32166
32167
32168
3668
3707
41559
5186
53237 [P15884-1]
53238 [P15884-2]
53239 [P15884-3]
6700
6818

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
2086

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P15884

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15884

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196628 Expressed in 250 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15884 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15884 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB020722
HPA025958

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin.

Interacts with HIVEP2.

Interacts with NEUROD2 (By similarity).

Interacts with AGBL1.

Interacts with BHLHA9.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-533224,EBI-533224
Q53FW83EBI-533224,EBI-10242473
P299723EBI-533224,EBI-745213
Q928883EBI-533224,EBI-465400
Q9H6L43EBI-533224,EBI-742909
P505537EBI-533224,EBI-957042
Q6XD763EBI-533224,EBI-10254793
Q9BZE93EBI-533224,EBI-1993677
P212813EBI-533224,EBI-4290814
O759343EBI-533224,EBI-1050106
Q928433EBI-533224,EBI-707714
Q9NX043EBI-533224,EBI-8643161
Q9NP863EBI-533224,EBI-10311131
P389363EBI-533224,EBI-375077
P427733EBI-13636688,EBI-711290
Q6ZQR23EBI-533224,EBI-10255140
Q131113EBI-533224,EBI-1020839
Q9Y6H13EBI-533224,EBI-2321769
Q9UKJ53EBI-533224,EBI-741528
P610243EBI-533224,EBI-456371
P3522222EBI-533224,EBI-491549
P262332EBI-533224,EBI-7373758From Xenopus laevis.
P261963EBI-533224,EBI-351257
Q9H4E73EBI-533224,EBI-745369
Q9NQL93EBI-533224,EBI-9679045
Q5JVL46EBI-533224,EBI-743105
O605733EBI-533224,EBI-398610
Q135413EBI-533224,EBI-74090
Q9Y2J2-33EBI-533224,EBI-10326138
O15197-23EBI-533224,EBI-10182490
Q9Y3B23EBI-533224,EBI-371892
P169303EBI-533224,EBI-4397076
Q9H5Z63EBI-533224,EBI-741626
Q5TZK33EBI-533224,EBI-10247271
Q96RJ64EBI-533224,EBI-10183007
Q96AC16EBI-533224,EBI-4399465
Q8NFF53EBI-533224,EBI-742815
P21333-23EBI-533224,EBI-9641086
O435593EBI-533224,EBI-725515
P550403EBI-533224,EBI-744104
O760033EBI-533224,EBI-374781
P501513EBI-533224,EBI-10211741
Q0D2H93EBI-533224,EBI-10181276
Q08AF83EBI-533224,EBI-10181260
Q9H8Y83EBI-533224,EBI-739467
Q96NT33EBI-533224,EBI-8293751
P612963EBI-533224,EBI-10218584
O149293EBI-533224,EBI-2339359
V9HWF53EBI-533224,EBI-10330249
Q9UBY93EBI-533224,EBI-739361
P411343EBI-533224,EBI-1215527
Q023633EBI-533224,EBI-713450
Q025355EBI-533224,EBI-1387094
I3WAC93EBI-533224,EBI-10178524
Q9BQ133EBI-533224,EBI-10189448
Q6P5973EBI-533224,EBI-1643885
Q5THT13EBI-533224,EBI-10247181
Q148473EBI-533224,EBI-742828
Q96BZ83EBI-533224,EBI-726510
Q8TCE93EBI-533224,EBI-10274069
A0A0S2Z5S93EBI-13636688,EBI-16429099
P258003EBI-533224,EBI-8639312
P619683EBI-533224,EBI-2798728
Q9UIQ63EBI-533224,EBI-2805360
Q9UI953EBI-533224,EBI-77889
Q96A723EBI-533224,EBI-746778
O603363EBI-533224,EBI-947402
O152323EBI-533224,EBI-6262458
Q9Y3163EBI-533224,EBI-1104564
Q6P2C63EBI-533224,EBI-5773143
Q8NDC43EBI-533224,EBI-10269566
Q96HT83EBI-533224,EBI-748896
Q7Z7H83EBI-533224,EBI-723524
Q8IXL73EBI-533224,EBI-8634060
Q9ULV03EBI-533224,EBI-311356
O436393EBI-533224,EBI-713635
Q9UHB43EBI-533224,EBI-10249760
Q9HC983EBI-533224,EBI-740364
Q86SG63EBI-533224,EBI-1752987
Q8WWR8-23EBI-533224,EBI-10277551
Q928863EBI-533224,EBI-10279647
Q9Y5B83EBI-533224,EBI-744782
Q9GZQ43EBI-533224,EBI-10303844
Q5SY163EBI-533224,EBI-1055462
Q86WQ03EBI-533224,EBI-10260040
Q8NFP73EBI-533224,EBI-726826
O439293EBI-533224,EBI-374889
Q9UJX03EBI-533224,EBI-9057006
Q018043EBI-533224,EBI-1054396
Q8WXA23EBI-533224,EBI-10277790
P300393EBI-533224,EBI-750589
Q135263EBI-533224,EBI-714158
Q494U13EBI-533224,EBI-10241513
O956023EBI-533224,EBI-359472
O151603EBI-533224,EBI-1055079
Q9Y3C63EBI-533224,EBI-2557649
Q6NYC83EBI-533224,EBI-2557469
P546463EBI-533224,EBI-1383852
P257863EBI-533224,EBI-359352
Q969U73EBI-533224,EBI-723276
P43115-123EBI-533224,EBI-10234038
Q5JT253EBI-533224,EBI-10244509
P472243EBI-533224,EBI-713992
Q6P9E23EBI-533224,EBI-10253121
Q04206-33EBI-533224,EBI-10223388
Q8IX063EBI-533224,EBI-10262361
A0A0S2Z4G93EBI-13636688,EBI-16428950
Q9UHP63EBI-533224,EBI-748350
Q9UIL13EBI-533224,EBI-2686537
Q9UDX33EBI-533224,EBI-10320311
Q6NXQ03EBI-533224,EBI-10251550
Q96ES75EBI-533224,EBI-743117
Q9NUL53EBI-533224,EBI-10313866
O436993EBI-533224,EBI-2814604
Q96H723EBI-533224,EBI-10287091
Q9BWU03EBI-533224,EBI-1999704
P499013EBI-533224,EBI-750494
Q9H4F83EBI-533224,EBI-2801103
Q614735EBI-533224,EBI-9106822From Mus musculus.
Q068312EBI-533224,EBI-6262177From Mus musculus.
Q9H0A93EBI-533224,EBI-372911
Q9NZD83EBI-533224,EBI-742688
Q96FJ03EBI-533224,EBI-745021
O757163EBI-533224,EBI-749295
O755583EBI-533224,EBI-714135
Q5T011-53EBI-533224,EBI-10245139
Q165593EBI-533224,EBI-10237959
Q155603EBI-533224,EBI-710310
P562793EBI-533224,EBI-749995
Q081173EBI-533224,EBI-717810
P046372EBI-533224,EBI-366083
Q9UL333EBI-533224,EBI-747601
Q96PN83EBI-533224,EBI-3918381
Q156724EBI-533224,EBI-1797287
Q8WVJ94EBI-533224,EBI-1797313
Q9NX013EBI-533224,EBI-10309345
Q9BRU93EBI-533224,EBI-5457544
Q548N13EBI-533224,EBI-10243107
Q6UX983EBI-533224,EBI-10254561
Q159733EBI-533224,EBI-2555767
Q8TAU33EBI-533224,EBI-740727
Q96SQ53EBI-533224,EBI-6427977
A0A0S2Z5X43EBI-13636688,EBI-16429014
A0A0S2Z6P03EBI-13636688,EBI-16429989

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112787, 223 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P15884

Database of interacting proteins

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DIPi
DIP-163N

Protein interaction database and analysis system

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IntActi
P15884, 269 interactors

Molecular INTeraction database

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MINTi
P15884

STRING: functional protein association networks

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STRINGi
9606.ENSP00000381382

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P15884 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1667
Legend: HelixTurnBeta strandPDB Structure known for this area
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3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15884

Database of comparative protein structure models

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ModBasei
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Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P15884

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini564 – 617bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 83Essential for MYOD1 inhibitionBy similarityAdd BLAST83
Regioni379 – 400Leucine-zipperAdd BLAST22
Regioni619 – 642Class A specific domainAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi18 – 269aaTAD9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 231Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3910 Eukaryota
ENOG410XYUA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159129

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234180

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15884

KEGG Orthology (KO)

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KOi
K15603

Database of Orthologous Groups

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OrthoDBi
162721at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15884

TreeFam database of animal gene trees

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TreeFami
TF321672

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 16 described isoforms and 48 potential isoforms that are computationally mapped.Show allAlign All

Isoform SEF2-1B (identifier: P15884-1) [UniParc]FASTAAdd to basket
Also known as: B-

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHHQQRMAAL GTDKELSDLL DFSAMFSPPV SSGKNGPTSL ASGHFTGSNV
60 70 80 90 100
EDRSSSGSWG NGGHPSPSRN YGDGTPYDHM TSRDLGSHDN LSPPFVNSRI
110 120 130 140 150
QSKTERGSYS SYGRESNLQG CHQQSLLGGD MDMGNPGTLS PTKPGSQYYQ
160 170 180 190 200
YSSNNPRRRP LHSSAMEVQT KKVRKVPPGL PSSVYAPSAS TADYNRDSPG
210 220 230 240 250
YPSSKPATST FPSSFFMQDG HHSSDPWSSS SGMNQPGYAG MLGNSSHIPQ
260 270 280 290 300
SSSYCSLHPH ERLSYPSHSS ADINSSLPPM STFHRSGTNH YSTSSCTPPA
310 320 330 340 350
NGTDSIMANR GSGAAGSSQT GDALGKALAS IYSPDHTNNS FSSNPSTPVG
360 370 380 390 400
SPPSLSAGTA VWSRNGGQAS SSPNYEGPLH SLQSRIEDRL ERLDDAIHVL
410 420 430 440 450
RNHAVGPSTA MPGGHGDMHG IIGPSHNGAM GGLGSGYGTG LLSANRHSLM
460 470 480 490 500
VGTHREDGVA LRGSHSLLPN QVPVPQLPVQ SATSPDLNPP QDPYRGMPPG
510 520 530 540 550
LQGQSVSSGS SEIKSDDEGD ENLQDTKSSE DKKLDDDKKD IKSITSNNDD
560 570 580 590 600
EDLTPEQKAE REKERRMANN ARERLRVRDI NEAFKELGRM VQLHLKSDKP
610 620 630 640 650
QTKLLILHQA VAVILSLEQQ VRERNLNPKA ACLKRREEEK VSSEPPPLSL
660
AGPHPGMGDA SNHMGQM
Length:667
Mass (Da):71,308
Last modified:December 15, 1998 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53459FC7989D9487
GO
Isoform SEF2-1A (identifier: P15884-2) [UniParc]FASTAAdd to basket
Also known as: A+

The sequence of this isoform differs from the canonical sequence as follows:
     1-160: Missing.
     161-183: LHSSAMEVQTKKVRKVPPGLPSS → MYCAYTIPGMGGNSLMYYYNGKA
     545-545: T → TRSRS

Show »
Length:511
Mass (Da):54,621
Checksum:i53BE8B2756C9C26B
GO
Isoform SEF2-1D (identifier: P15884-3) [UniParc]FASTAAdd to basket
Also known as: B+

The sequence of this isoform differs from the canonical sequence as follows:
     545-545: T → TRSRS

Show »
Length:671
Mass (Da):71,795
Checksum:i2A3AE4C1E87B81E4
GO
Isoform B+delta (identifier: P15884-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-183: Missing.
     545-545: T → TRSRS

Show »
Length:611
Mass (Da):65,282
Checksum:iC9C6986AA5563828
GO
Isoform B-delta (identifier: P15884-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-183: Missing.

Show »
Length:607
Mass (Da):64,796
Checksum:iAE68260B30C1B9E6
GO
Isoform A- (identifier: P15884-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MHHQQRMAALGTDKELSDLLDFS → MYCAYTIPGMGGNSLMYYYNGKA
     24-123: Missing.
     124-183: Missing.

Show »
Length:507
Mass (Da):54,135
Checksum:i2DF7DC48C2D3EE83
GO
Isoform G- (identifier: P15884-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MHHQQRMAALGTDKELSDLLDFSAMFSPPVSS → MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLR
     33-102: Missing.
     123-123: Missing.

Show »
Length:596
Mass (Da):64,116
Checksum:i5912C40D16E30908
GO
Isoform H- (identifier: P15884-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MHHQQRMAALGTDKELSDLLDFS → MKFKQCRCSDTGLCCLDHEGKAE
     24-183: Missing.

Show »
Length:507
Mass (Da):54,169
Checksum:iF88FFDCB9733FB31
GO
Isoform D- (identifier: P15884-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Show »
Length:537
Mass (Da):57,425
Checksum:i7F77B2E736AC27E4
GO
Isoform F- (identifier: P15884-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSN → MEEDSRD

Show »
Length:625
Mass (Da):67,027
Checksum:i36CF6C747000814D
GO
Isoform 11 (identifier: P15884-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: MHHQQRMAAL...PPFVNSRIQS → MKDIFFQFIIARVRKCYSLSCLHTLPVVPTLR
     123-123: Missing.
     545-545: T → TRSRS

Show »
Length:600
Mass (Da):64,602
Checksum:iFA530DE0722CDA2E
GO
Isoform E- (identifier: P15884-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MHHQQRMAALGTDKELSDLLDFSA → MQRAKTELFRLQIVTDDLRKNE
     357-357: Missing.

Show »
Length:664
Mass (Da):71,227
Checksum:i064EA9F64B55C741
GO
Isoform 13 (identifier: P15884-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     545-545: T → TRSRS

Show »
Length:647
Mass (Da):69,098
Checksum:i1ED8C14A73F678C1
GO
Isoform C- (identifier: P15884-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:643
Mass (Da):68,611
Checksum:i68C866E2BBBAB621
GO
Isoform C-delta (identifier: P15884-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     124-183: Missing.

Show »
Length:583
Mass (Da):62,099
Checksum:i6B694DB9DDCB93B6
GO
Isoform I- (identifier: P15884-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Show »
Length:451
Mass (Da):48,098
Checksum:iFD0EE9CD3312CFB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 48 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PH57E9PH57_HUMAN
Transcription factor 4
TCF4 hCG_1811800
773Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPJ7H3BPJ7_HUMAN
Transcription factor 4
TCF4
642Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTP3H3BTP3_HUMAN
Transcription factor 4
TCF4
677Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW91A0A1B0GW91_HUMAN
Transcription factor 4
TCF4
455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVR6A0A1B0GVR6_HUMAN
Transcription factor 4
TCF4
680Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWD5A0A1B0GWD5_HUMAN
Transcription factor 4
TCF4
541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVB8A0A1B0GVB8_HUMAN
Transcription factor 4
TCF4
631Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMC8H3BMC8_HUMAN
Transcription factor 4
TCF4
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNI2H3BNI2_HUMAN
Transcription factor 4
TCF4
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTZ0H3BTZ0_HUMAN
Transcription factor 4
TCF4
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60310 differs from that shown. Incomplete and probable erroneous sequence.Curated
The sequence AAA60312 differs from that shown. Incomplete and probable erroneous sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46 – 49TGSN → EFGG in CAA36298 (PubMed:2308860).Curated4
Sequence conflicti205Missing in AV761952 (Ref. 7) Curated1
Sequence conflicti334P → S in CAA36298 (PubMed:2308860).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07972629P → T Probable disease-associated mutation found in a family with symmetrical acral keratoderma. 1 Publication1
Natural variantiVAR_066839358G → V in PTHS; also expressed in the nucleus with a pattern indistinguishable from the wild-type; does not have a major impact on homodimer formation; affects transcriptional activity in a context-dependent manner. 2 Publications1
Natural variantiVAR_078644385 – 667Missing in PTHS. 1 PublicationAdd BLAST283
Natural variantiVAR_049545450M → I. Corresponds to variant dbSNP:rs11660217EnsemblClinVar.1
Natural variantiVAR_058632535D → G in PTHS; loss of function; also expressed in the nucleus with a pattern indistinguishable from the wild-type; does not have a major impact on homodimer formation; affects transcriptional activity in a context-dependent manner. 2 Publications1
Natural variantiVAR_066970565R → W in PTHS. 1 Publication1
Natural variantiVAR_058633572R → G in PTHS; loss of function. 2 Publications1
Natural variantiVAR_066971572R → Q in PTHS. 1 PublicationCorresponds to variant dbSNP:rs1057521070Ensembl.1
Natural variantiVAR_066972574R → H in PTHS. 1 PublicationCorresponds to variant dbSNP:rs121909123Ensembl.1
Natural variantiVAR_066840574R → P in PTHS; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 3 PublicationsCorresponds to variant dbSNP:rs121909123Ensembl.1
Natural variantiVAR_034704576R → Q in PTHS; loss of function. 3 PublicationsCorresponds to variant dbSNP:rs121909121Ensembl.1
Natural variantiVAR_034705576R → W in PTHS; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 4 PublicationsCorresponds to variant dbSNP:rs121909120Ensembl.1
Natural variantiVAR_066841578R → H in PTHS. 1 Publication1
Natural variantiVAR_066973578R → P in PTHS. 2 Publications1
Natural variantiVAR_066974583A → P in PTHS. 1 Publication1
Natural variantiVAR_058634610A → V in PTHS; loss of function; mislocalized to small spherical punctae that are dispersed throughout the nucleus; can attenuate homo- and heterodimer formation; affects transcriptional activity in a context-dependent manner. 3 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0542791 – 216Missing in isoform I-. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_0308191 – 160Missing in isoform SEF2-1A. 4 PublicationsAdd BLAST160
Alternative sequenceiVSP_0451491 – 130Missing in isoform D-. 2 PublicationsAdd BLAST130
Alternative sequenceiVSP_0451501 – 102MHHQQ…SRIQS → MKDIFFQFIIARVRKCYSLS CLHTLPVVPTLR in isoform 11. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_0451511 – 49MHHQQ…FTGSN → MEEDSRD in isoform F-. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0443341 – 32MHHQQ…PPVSS → MKDIFFQFIIARVRKCYSLS CLHTLPVVPTLR in isoform G-. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_0470811 – 24Missing in isoform 13, isoform C- and isoform C-delta. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_0470821 – 24MHHQQ…LDFSA → MQRAKTELFRLQIVTDDLRK NE in isoform E-. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0443361 – 23MHHQQ…LLDFS → MYCAYTIPGMGGNSLMYYYN GKA in isoform A-. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0443351 – 23MHHQQ…LLDFS → MKFKQCRCSDTGLCCLDHEG KAE in isoform H-. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_05736424 – 183Missing in isoform H-. 1 PublicationAdd BLAST160
Alternative sequenceiVSP_04433724 – 123Missing in isoform A-. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_04433833 – 102Missing in isoform G-. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_044339123Missing in isoform G- and isoform 11. 2 Publications1
Alternative sequenceiVSP_044340124 – 183Missing in isoform A-, isoform B-delta, isoform B+delta and isoform C-delta. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_002111161 – 183LHSSA…GLPSS → MYCAYTIPGMGGNSLMYYYN GKA in isoform SEF2-1A. 4 PublicationsAdd BLAST23
Alternative sequenceiVSP_047083357Missing in isoform E-. 1 Publication1
Alternative sequenceiVSP_002112545T → TRSRS in isoform B+delta, isoform SEF2-1A, isoform SEF2-1D, isoform 11 and isoform 13. 5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74718 mRNA Translation: AAA60310.1 Sequence problems.
M74719 mRNA Translation: AAA60311.1
M74720 mRNA Translation: AAA60312.1 Sequence problems.
FR748210 mRNA Translation: CBY80189.1
FR748211 mRNA Translation: CBY80190.1
FR748212 mRNA Translation: CBY80191.1
FR748213 mRNA Translation: CBY80192.1
FR748214 mRNA Translation: CBY80193.1
FR748215 mRNA Translation: CBY80194.1
FR748216 mRNA Translation: CBY80195.1
FR748217 mRNA Translation: CBY80196.1
FR748218 mRNA Translation: CBY80197.1
FR748219 mRNA Translation: CBY80198.1
FR748220 mRNA Translation: CBY80199.1
FR748221 mRNA Translation: CBY80200.1
FR748222 mRNA Translation: CBY80201.1
FR748223 mRNA Translation: CBY80202.1
AK095041 mRNA Translation: BAG52974.1
AK096862 mRNA Translation: BAG53382.1
AK299169 mRNA Translation: BAH12962.1
AK300636 mRNA Translation: BAG62325.1
AK300038 mRNA Translation: BAG61849.1
AK301144 mRNA Translation: BAH13417.1
AK300612 mRNA Translation: BAH13314.1
AK316165 mRNA Translation: BAH14536.1
AC013587 Genomic DNA No translation available.
AC018994 Genomic DNA No translation available.
AC090383 Genomic DNA No translation available.
AC090684 Genomic DNA No translation available.
AC091103 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63017.1
CH471096 Genomic DNA Translation: EAW63018.1
BC125084 mRNA Translation: AAI25085.1
BC125085 mRNA Translation: AAI25086.1
AV761952 mRNA No translation available.
U75701 Genomic DNA Translation: AAC51824.1
X52079 mRNA Translation: CAA36298.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11960.1 [P15884-1]
CCDS42438.1 [P15884-3]
CCDS58623.1 [P15884-8]
CCDS58624.1 [P15884-2]
CCDS58625.1 [P15884-6]
CCDS58626.1 [P15884-9]
CCDS58627.1 [P15884-11]
CCDS58628.1 [P15884-10]
CCDS58629.1 [P15884-13]
CCDS59321.1 [P15884-12]
CCDS77191.1 [P15884-7]
CCDS77192.1 [P15884-14]

Protein sequence database of the Protein Information Resource

More...
PIRi
A41311

NCBI Reference Sequences

More...
RefSeqi
NP_001077431.1, NM_001083962.1 [P15884-3]
NP_001230155.2, NM_001243226.2
NP_001230156.1, NM_001243227.1 [P15884-13]
NP_001230157.1, NM_001243228.1
NP_001230159.1, NM_001243230.1 [P15884-12]
NP_001230160.1, NM_001243231.1 [P15884-10]
NP_001230161.1, NM_001243232.1 [P15884-11]
NP_001230162.1, NM_001243233.1 [P15884-9]
NP_001230163.1, NM_001243234.1 [P15884-2]
NP_001230164.1, NM_001243235.1 [P15884-6]
NP_001230165.1, NM_001243236.1 [P15884-8]
NP_001293136.1, NM_001306207.1 [P15884-14]
NP_001293137.1, NM_001306208.1 [P15884-7]
NP_001335140.1, NM_001348211.1
NP_001335141.1, NM_001348212.1 [P15884-9]
NP_001335142.1, NM_001348213.1
NP_001335143.1, NM_001348214.1
NP_001335144.1, NM_001348215.1
NP_001335145.1, NM_001348216.1
NP_001335146.1, NM_001348217.1 [P15884-13]
NP_001335147.1, NM_001348218.1 [P15884-13]
NP_001335148.1, NM_001348219.1 [P15884-14]
NP_001335149.1, NM_001348220.1
NP_003190.1, NM_003199.2 [P15884-1]
XP_005266796.2, XM_005266739.3
XP_006722599.1, XM_006722536.2
XP_006722600.1, XM_006722537.2
XP_016881425.1, XM_017025936.1
XP_016881429.1, XM_017025940.1
XP_016881430.1, XM_017025941.1
XP_016881435.1, XM_017025946.1
XP_016881445.1, XM_017025956.1 [P15884-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354452; ENSP00000346440; ENSG00000196628 [P15884-3]
ENST00000356073; ENSP00000348374; ENSG00000196628 [P15884-1]
ENST00000457482; ENSP00000409447; ENSG00000196628 [P15884-2]
ENST00000537578; ENSP00000440731; ENSG00000196628 [P15884-13]
ENST00000537856; ENSP00000439827; ENSG00000196628 [P15884-9]
ENST00000540999; ENSP00000445202; ENSG00000196628 [P15884-14]
ENST00000543082; ENSP00000439656; ENSG00000196628 [P15884-10]
ENST00000544241; ENSP00000441562; ENSG00000196628 [P15884-11]
ENST00000561831; ENSP00000457765; ENSG00000196628 [P15884-8]
ENST00000561992; ENSP00000455179; ENSG00000196628 [P15884-9]
ENST00000564228; ENSP00000455261; ENSG00000196628 [P15884-7]
ENST00000564999; ENSP00000457649; ENSG00000196628 [P15884-1]
ENST00000565018; ENSP00000455984; ENSG00000196628 [P15884-15]
ENST00000566279; ENSP00000456125; ENSG00000196628 [P15884-4]
ENST00000566286; ENSP00000455418; ENSG00000196628 [P15884-12]
ENST00000567880; ENSP00000454366; ENSG00000196628 [P15884-5]
ENST00000568673; ENSP00000455135; ENSG00000196628 [P15884-13]
ENST00000570177; ENSP00000454647; ENSG00000196628 [P15884-9]
ENST00000570287; ENSP00000455763; ENSG00000196628 [P15884-6]
ENST00000616053; ENSP00000478549; ENSG00000196628 [P15884-15]
ENST00000626584; ENSP00000486072; ENSG00000196628 [P15884-16]
ENST00000629387; ENSP00000486670; ENSG00000196628 [P15884-3]
ENST00000636400; ENSP00000490006; ENSG00000196628 [P15884-13]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6925

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6925

UCSC genome browser

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UCSCi
uc002lfw.5 human [P15884-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74718 mRNA Translation: AAA60310.1 Sequence problems.
M74719 mRNA Translation: AAA60311.1
M74720 mRNA Translation: AAA60312.1 Sequence problems.
FR748210 mRNA Translation: CBY80189.1
FR748211 mRNA Translation: CBY80190.1
FR748212 mRNA Translation: CBY80191.1
FR748213 mRNA Translation: CBY80192.1
FR748214 mRNA Translation: CBY80193.1
FR748215 mRNA Translation: CBY80194.1
FR748216 mRNA Translation: CBY80195.1
FR748217 mRNA Translation: CBY80196.1
FR748218 mRNA Translation: CBY80197.1
FR748219 mRNA Translation: CBY80198.1
FR748220 mRNA Translation: CBY80199.1
FR748221 mRNA Translation: CBY80200.1
FR748222 mRNA Translation: CBY80201.1
FR748223 mRNA Translation: CBY80202.1
AK095041 mRNA Translation: BAG52974.1
AK096862 mRNA Translation: BAG53382.1
AK299169 mRNA Translation: BAH12962.1
AK300636 mRNA Translation: BAG62325.1
AK300038 mRNA Translation: BAG61849.1
AK301144 mRNA Translation: BAH13417.1
AK300612 mRNA Translation: BAH13314.1
AK316165 mRNA Translation: BAH14536.1
AC013587 Genomic DNA No translation available.
AC018994 Genomic DNA No translation available.
AC090383 Genomic DNA No translation available.
AC090684 Genomic DNA No translation available.
AC091103 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63017.1
CH471096 Genomic DNA Translation: EAW63018.1
BC125084 mRNA Translation: AAI25085.1
BC125085 mRNA Translation: AAI25086.1
AV761952 mRNA No translation available.
U75701 Genomic DNA Translation: AAC51824.1
X52079 mRNA Translation: CAA36298.1
CCDSiCCDS11960.1 [P15884-1]
CCDS42438.1 [P15884-3]
CCDS58623.1 [P15884-8]
CCDS58624.1 [P15884-2]
CCDS58625.1 [P15884-6]
CCDS58626.1 [P15884-9]
CCDS58627.1 [P15884-11]
CCDS58628.1 [P15884-10]
CCDS58629.1 [P15884-13]
CCDS59321.1 [P15884-12]
CCDS77191.1 [P15884-7]
CCDS77192.1 [P15884-14]
PIRiA41311
RefSeqiNP_001077431.1, NM_001083962.1 [P15884-3]
NP_001230155.2, NM_001243226.2
NP_001230156.1, NM_001243227.1 [P15884-13]
NP_001230157.1, NM_001243228.1
NP_001230159.1, NM_001243230.1 [P15884-12]
NP_001230160.1, NM_001243231.1 [P15884-10]
NP_001230161.1, NM_001243232.1 [P15884-11]
NP_001230162.1, NM_001243233.1 [P15884-9]
NP_001230163.1, NM_001243234.1 [P15884-2]
NP_001230164.1, NM_001243235.1 [P15884-6]
NP_001230165.1, NM_001243236.1 [P15884-8]
NP_001293136.1, NM_001306207.1 [P15884-14]
NP_001293137.1, NM_001306208.1 [P15884-7]
NP_001335140.1, NM_001348211.1
NP_001335141.1, NM_001348212.1 [P15884-9]
NP_001335142.1, NM_001348213.1
NP_001335143.1, NM_001348214.1
NP_001335144.1, NM_001348215.1
NP_001335145.1, NM_001348216.1
NP_001335146.1, NM_001348217.1 [P15884-13]
NP_001335147.1, NM_001348218.1 [P15884-13]
NP_001335148.1, NM_001348219.1 [P15884-14]
NP_001335149.1, NM_001348220.1
NP_003190.1, NM_003199.2 [P15884-1]
XP_005266796.2, XM_005266739.3
XP_006722599.1, XM_006722536.2
XP_006722600.1, XM_006722537.2
XP_016881425.1, XM_017025936.1
XP_016881429.1, XM_017025940.1
XP_016881430.1, XM_017025941.1
XP_016881435.1, XM_017025946.1
XP_016881445.1, XM_017025956.1 [P15884-9]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KWFNMR-B11-27[»]
6OD3X-ray1.49A/B/E/F/G/H/I/J565-624[»]
6OD4X-ray1.70A/B/G/H565-624[»]
6OD5X-ray2.05A/B/C/D565-624[»]
SMRiP15884
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112787, 223 interactors
CORUMiP15884
DIPiDIP-163N
IntActiP15884, 269 interactors
MINTiP15884
STRINGi9606.ENSP00000381382

Chemistry databases

ChEMBLiCHEMBL3885541

PTM databases

GlyConnecti2086
iPTMnetiP15884
PhosphoSitePlusiP15884

Polymorphism and mutation databases

BioMutaiTCF4

Proteomic databases

EPDiP15884
jPOSTiP15884
MassIVEiP15884
MaxQBiP15884
PaxDbiP15884
PeptideAtlasiP15884
PRIDEiP15884
ProteomicsDBi32164
32165
32166
32167
32168
3668
3707
41559
5186
53237 [P15884-1]
53238 [P15884-2]
53239 [P15884-3]
6700
6818

Genome annotation databases

EnsembliENST00000354452; ENSP00000346440; ENSG00000196628 [P15884-3]
ENST00000356073; ENSP00000348374; ENSG00000196628 [P15884-1]
ENST00000457482; ENSP00000409447; ENSG00000196628 [P15884-2]
ENST00000537578; ENSP00000440731; ENSG00000196628 [P15884-13]
ENST00000537856; ENSP00000439827; ENSG00000196628 [P15884-9]
ENST00000540999; ENSP00000445202; ENSG00000196628 [P15884-14]
ENST00000543082; ENSP00000439656; ENSG00000196628 [P15884-10]
ENST00000544241; ENSP00000441562; ENSG00000196628 [P15884-11]
ENST00000561831; ENSP00000457765; ENSG00000196628 [P15884-8]
ENST00000561992; ENSP00000455179; ENSG00000196628 [P15884-9]
ENST00000564228; ENSP00000455261; ENSG00000196628 [P15884-7]
ENST00000564999; ENSP00000457649; ENSG00000196628 [P15884-1]
ENST00000565018; ENSP00000455984; ENSG00000196628 [P15884-15]
ENST00000566279; ENSP00000456125; ENSG00000196628 [P15884-4]
ENST00000566286; ENSP00000455418; ENSG00000196628 [P15884-12]
ENST00000567880; ENSP00000454366; ENSG00000196628 [P15884-5]
ENST00000568673; ENSP00000455135; ENSG00000196628 [P15884-13]
ENST00000570177; ENSP00000454647; ENSG00000196628 [P15884-9]
ENST00000570287; ENSP00000455763; ENSG00000196628 [P15884-6]
ENST00000616053; ENSP00000478549; ENSG00000196628 [P15884-15]
ENST00000626584; ENSP00000486072; ENSG00000196628 [P15884-16]
ENST00000629387; ENSP00000486670; ENSG00000196628 [P15884-3]
ENST00000636400; ENSP00000490006; ENSG00000196628 [P15884-13]
GeneIDi6925
KEGGihsa:6925
UCSCiuc002lfw.5 human [P15884-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6925
DisGeNETi6925
EuPathDBiHostDB:ENSG00000196628.13

GeneCards: human genes, protein and diseases

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GeneCardsi
TCF4
GeneReviewsiTCF4
HGNCiHGNC:11634 TCF4
HPAiCAB020722
HPA025958
MalaCardsiTCF4
MIMi602272 gene
610954 phenotype
613267 phenotype
neXtProtiNX_P15884
OpenTargetsiENSG00000196628
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
98974 Fuchs endothelial corneal dystrophy
2896 Pitt-Hopkins syndrome
171 Primary sclerosing cholangitis
PharmGKBiPA164742621

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3910 Eukaryota
ENOG410XYUA LUCA
GeneTreeiENSGT00940000159129
HOGENOMiHOG000234180
InParanoidiP15884
KOiK15603
OrthoDBi162721at2759
PhylomeDBiP15884
TreeFamiTF321672

Enzyme and pathway databases

ReactomeiR-HSA-525793 Myogenesis
SignaLinkiP15884
SIGNORiP15884

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TCF4 human
EvolutionaryTraceiP15884

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TCF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6925
PharosiP15884 Tbio

Protein Ontology

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PROi
PR:P15884
RNActiP15884 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196628 Expressed in 250 organ(s), highest expression level in cerebellum
ExpressionAtlasiP15884 baseline and differential
GenevisibleiP15884 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15884
Secondary accession number(s): B3KT62
, B3KUC0, B4DT37, B4DUG3, B7Z5M6, B7Z6Y1, G0LNT9, G0LNU0, G0LNU1, G0LNU2, G0LNU4, G0LNU5, G0LNU8, G0LNU9, G0LNV0, G0LNV1, G0LNV2, H3BPQ1, Q08AP2, Q08AP3, Q15439, Q15440, Q15441
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 15, 1998
Last modified: December 11, 2019
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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