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Entry version 205 (08 May 2019)
Sequence version 2 (01 Oct 1996)
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Protein

40S ribosomal protein S2

Gene

RPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-8876725 Protein methylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
40S ribosomal protein S4
Protein LLRep3
Small ribosomal subunit protein uS51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS2
Synonyms:RPS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:10404 RPS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603624 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15880

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58K → R: Does not affect readthrough on the poly(A)-stall sequences; when associated with R-275. 1 Publication1
Mutagenesisi275K → R: Does not affect readthrough on the poly(A)-stall sequences; when associated with R-58. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6187

Open Targets

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OpenTargetsi
ENSG00000140988

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34806

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1710756

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001316732 – 29340S ribosomal protein S2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei252PhosphothreonineCombined sources1
Modified residuei263N6-acetyllysineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei270PhosphothreonineCombined sources1
Modified residuei275N6-acetyllysine; alternateCombined sources1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei281PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.1 Publication
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P15880

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15880

MaxQB - The MaxQuant DataBase

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MaxQBi
P15880

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P15880

PeptideAtlas

More...
PeptideAtlasi
P15880

PRoteomics IDEntifications database

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PRIDEi
P15880

ProteomicsDB human proteome resource

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ProteomicsDBi
53233

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15880

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15880

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P15880

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000140988 Expressed in 88 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P15880 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15880 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA055133

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-443446,EBI-5323863

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112101, 326 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P15880

Protein interaction database and analysis system

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IntActi
P15880, 64 interactors

Molecular INTeraction database

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MINTi
P15880

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SC1-293[»]
4V6Xelectron microscopy5.00AC1-293[»]
5A2Qelectron microscopy3.90C1-293[»]
5AJ0electron microscopy3.50BC1-293[»]
5FLXelectron microscopy3.90C1-293[»]
5LKSelectron microscopy3.60SC1-293[»]
5OA3electron microscopy4.30C1-293[»]
5T2Celectron microscopy3.60AJ1-293[»]
5VYCX-ray6.00C1/C2/C3/C4/C5/C61-293[»]
6EK0electron microscopy2.90SC1-293[»]
6G18electron microscopy3.60C1-293[»]
6G4Selectron microscopy4.00C1-293[»]
6G51electron microscopy4.10C1-293[»]
6G53electron microscopy4.50C1-293[»]
6G5Helectron microscopy3.60C1-293[»]
6G5Ielectron microscopy3.50C1-293[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15880

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 165S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 53Arg/Gly-richAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0877 Eukaryota
COG0098 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153095

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000072596

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P15880

KEGG Orthology (KO)

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KOi
K02981

Identification of Orthologs from Complete Genome Data

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OMAi
EYQIIDY

Database of Orthologous Groups

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OrthoDBi
1197354at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P15880

TreeFam database of animal gene trees

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TreeFami
TF300806

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.230.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005711 Ribosomal_S5_euk/arc
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS

The PANTHER Classification System

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PANTHERi
PTHR13718 PTHR13718, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54211 SSF54211, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01020 uS5_euk_arch, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P15880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,324
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66C0DB7ED393B036
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM36E9PM36_HUMAN
40S ribosomal protein S2
RPS2
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMM9E9PMM9_HUMAN
40S ribosomal protein S2
RPS2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEN5H0YEN5_HUMAN
40S ribosomal protein S2
RPS2
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L404I3L404_HUMAN
40S ribosomal protein S2
RPS2
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPT0E9PPT0_HUMAN
40S ribosomal protein S2
RPS2
197Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQD7E9PQD7_HUMAN
40S ribosomal protein S2
RPS2
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNG3H3BNG3_HUMAN
40S ribosomal protein S2
RPS2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YE27H0YE27_HUMAN
40S ribosomal protein S2
RPS2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35078 differs from that shown. Reason: Frameshift at positions 14, 27, 40, 46, 48 and 52.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X17206 mRNA Translation: CAA35078.1 Frameshift.
AK312173 mRNA Translation: BAG35107.1
CH471112 Genomic DNA Translation: EAW85592.1
CH471112 Genomic DNA Translation: EAW85595.1
BC001795 mRNA Translation: AAH01795.1
BC006559 mRNA Translation: AAH06559.1
BC008862 mRNA Translation: AAH08862.1
BC010165 mRNA Translation: AAH10165.1
BC012354 mRNA Translation: AAH12354.1
BC016178 mRNA Translation: AAH16178.1
BC016951 mRNA Translation: AAH16951.1
BC018993 mRNA Translation: AAH18993.1
BC021545 mRNA Translation: AAH21545.1
BC023541 mRNA Translation: AAH23541.1
BC025677 mRNA Translation: AAH25677.1
BC066321 mRNA Translation: AAH66321.1
BC068051 mRNA Translation: AAH68051.1
BC071922 mRNA Translation: AAH71922.1
BC071923 mRNA Translation: AAH71923.1
BC071924 mRNA Translation: AAH71924.1
BC073966 mRNA Translation: AAH73966.1
BC075830 mRNA Translation: AAH75830.1
BC103756 mRNA Translation: AAI03757.1
BC105985 mRNA Translation: AAI05986.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10452.1

Protein sequence database of the Protein Information Resource

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PIRi
S08228

NCBI Reference Sequences

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RefSeqi
NP_002943.2, NM_002952.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343262; ENSP00000341885; ENSG00000140988

Database of genes from NCBI RefSeq genomes

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GeneIDi
6187

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6187

UCSC genome browser

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UCSCi
uc002cno.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17206 mRNA Translation: CAA35078.1 Frameshift.
AK312173 mRNA Translation: BAG35107.1
CH471112 Genomic DNA Translation: EAW85592.1
CH471112 Genomic DNA Translation: EAW85595.1
BC001795 mRNA Translation: AAH01795.1
BC006559 mRNA Translation: AAH06559.1
BC008862 mRNA Translation: AAH08862.1
BC010165 mRNA Translation: AAH10165.1
BC012354 mRNA Translation: AAH12354.1
BC016178 mRNA Translation: AAH16178.1
BC016951 mRNA Translation: AAH16951.1
BC018993 mRNA Translation: AAH18993.1
BC021545 mRNA Translation: AAH21545.1
BC023541 mRNA Translation: AAH23541.1
BC025677 mRNA Translation: AAH25677.1
BC066321 mRNA Translation: AAH66321.1
BC068051 mRNA Translation: AAH68051.1
BC071922 mRNA Translation: AAH71922.1
BC071923 mRNA Translation: AAH71923.1
BC071924 mRNA Translation: AAH71924.1
BC073966 mRNA Translation: AAH73966.1
BC075830 mRNA Translation: AAH75830.1
BC103756 mRNA Translation: AAI03757.1
BC105985 mRNA Translation: AAI05986.1
CCDSiCCDS10452.1
PIRiS08228
RefSeqiNP_002943.2, NM_002952.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SC1-293[»]
4V6Xelectron microscopy5.00AC1-293[»]
5A2Qelectron microscopy3.90C1-293[»]
5AJ0electron microscopy3.50BC1-293[»]
5FLXelectron microscopy3.90C1-293[»]
5LKSelectron microscopy3.60SC1-293[»]
5OA3electron microscopy4.30C1-293[»]
5T2Celectron microscopy3.60AJ1-293[»]
5VYCX-ray6.00C1/C2/C3/C4/C5/C61-293[»]
6EK0electron microscopy2.90SC1-293[»]
6G18electron microscopy3.60C1-293[»]
6G4Selectron microscopy4.00C1-293[»]
6G51electron microscopy4.10C1-293[»]
6G53electron microscopy4.50C1-293[»]
6G5Helectron microscopy3.60C1-293[»]
6G5Ielectron microscopy3.50C1-293[»]
SMRiP15880
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112101, 326 interactors
CORUMiP15880
IntActiP15880, 64 interactors
MINTiP15880
STRINGi9606.ENSP00000341885

PTM databases

iPTMnetiP15880
PhosphoSitePlusiP15880
SwissPalmiP15880

Polymorphism and mutation databases

BioMutaiRPS2
DMDMi1710756

Proteomic databases

EPDiP15880
jPOSTiP15880
MaxQBiP15880
PaxDbiP15880
PeptideAtlasiP15880
PRIDEiP15880
ProteomicsDBi53233

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6187
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343262; ENSP00000341885; ENSG00000140988
GeneIDi6187
KEGGihsa:6187
UCSCiuc002cno.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6187
DisGeNETi6187

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0029256
HIX0039223
HIX0202579
HGNCiHGNC:10404 RPS2
HPAiHPA055133
MIMi603624 gene
neXtProtiNX_P15880
OpenTargetsiENSG00000140988
PharmGKBiPA34806

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0877 Eukaryota
COG0098 LUCA
GeneTreeiENSGT00940000153095
HOGENOMiHOG000072596
InParanoidiP15880
KOiK02981
OMAiEYQIIDY
OrthoDBi1197354at2759
PhylomeDBiP15880
TreeFamiTF300806

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-8876725 Protein methylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6187

Protein Ontology

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PROi
PR:P15880

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140988 Expressed in 88 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP15880 baseline and differential
GenevisibleiP15880 HS

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005711 Ribosomal_S5_euk/arc
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
TIGRFAMsiTIGR01020 uS5_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15880
Secondary accession number(s): B2R5G0, D3DU82, Q3MIB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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