Alpha-1B adrenergic receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• adrenergic receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• alpha1-adrenergic receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1."
    Kang S.K., Kim D.K., Damron D.S., Baek K.J., Im M.J.
    Biochem. Biophys. Res. Commun. 293:383-390(2002) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: UniProtKB

GO - Biological processⁱ

• adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adult heart development Source: RGDInferred from sequence orthologyⁱ
  • "The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse."
    O'Connell T.D., Ishizaka S., Nakamura A., Swigart P.M., Rodrigo M.C., Simpson G.L., Cotecchia S., Rokosh D.G., Grossman W., Foster E., Simpson P.C.
    J. Clin. Invest. 111:1783-1791(2003) [PubMed] [Europe PMC] [Abstract]
• behavioral response to cocaine Source: RGDInferred from sequence orthologyⁱ
  • "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates."
    Drouin C., Darracq L., Trovero F., Blanc G., Glowinski J., Cotecchia S., Tassin J.P.
    J. Neurosci. 22:2873-2884(2002) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: RGDInferred from sequence orthologyⁱ
  • "Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling."
    Zhang H., Cotecchia S., Thomas S.A., Tanoue A., Tsujimoto G., Faber J.E.
    Am. J. Physiol. Heart Circ. Physiol. 287:H2106-14(2004) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell growth involved in cardiac muscle cell development Source: RGDInferred from sequence orthologyⁱ
  • "The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse."
    O'Connell T.D., Ishizaka S., Nakamura A., Swigart P.M., Rodrigo M.C., Simpson G.L., Cotecchia S., Rokosh D.G., Grossman W., Foster E., Simpson P.C.
    J. Clin. Invest. 111:1783-1791(2003) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype."
    Burcelin R., Uldry M., Foretz M., Perrin C., Dacosta A., Nenniger-Tosato M., Seydoux J., Cotecchia S., Thorens B.
    J. Biol. Chem. 279:1108-1115(2004) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities."
    Spreng M., Cotecchia S., Schenk F.
    Neurobiol Learn Mem 75:214-229(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glycogen catabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype."
    Burcelin R., Uldry M., Foretz M., Perrin C., Dacosta A., Nenniger-Tosato M., Seydoux J., Cotecchia S., Thorens B.
    J. Biol. Chem. 279:1108-1115(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of Rho protein signal transduction Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance."
    Ogata T., Ueyama T., Isodono K., Tagawa M., Takehara N., Kawashima T., Harada K., Takahashi T., Shioi T., Matsubara H., Oh H.
    Mol. Cell. Biol. 28:3424-3436(2008) [PubMed] [Europe PMC] [Abstract]
• neuron-glial cell signaling Source: RGDInferred from sequence orthologyⁱ
  • "Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+) release in Bergmann glial cells in situ."
    Kulik A., Haentzsch A., Luckermann M., Reichelt W., Ballanyi K.
    J. Neurosci. 19:8401-8408(1999) [PubMed] [Europe PMC] [Abstract]
• norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• organ growth Source: RGDInferred from sequence orthologyⁱ
  • "The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse."
    O'Connell T.D., Ishizaka S., Nakamura A., Swigart P.M., Rodrigo M.C., Simpson G.L., Cotecchia S., Rokosh D.G., Grossman W., Foster E., Simpson P.C.
    J. Clin. Invest. 111:1783-1791(2003) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from direct assayⁱ
  • "Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1."
    Kang S.K., Kim D.K., Damron D.S., Baek K.J., Im M.J.
    Biochem. Biophys. Res. Commun. 293:383-390(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glycogen catabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype."
    Burcelin R., Uldry M., Foretz M., Perrin C., Dacosta A., Nenniger-Tosato M., Seydoux J., Cotecchia S., Thorens B.
    J. Biol. Chem. 279:1108-1115(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of heart rate by epinephrine-norepinephrine Source: RGDInferred from sequence orthologyⁱ
  • "The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse."
    O'Connell T.D., Ishizaka S., Nakamura A., Swigart P.M., Rodrigo M.C., Simpson G.L., Cotecchia S., Rokosh D.G., Grossman W., Foster E., Simpson P.C.
    J. Clin. Invest. 111:1783-1791(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: UniProtKB
• positive regulation of smooth muscle contraction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: RGDInferred from sequence orthologyⁱ
  • "Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR."
    Turnbull L., McCloskey D.T., O'Connell T.D., Simpson P.C., Baker A.J.
    Am. J. Physiol. Heart Circ. Physiol. 284:H1104-9(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vasoconstriction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cardiac muscle contraction Source: InterPro
• response to amphetamine Source: RGDInferred from sequence orthologyⁱ
  • "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates."
    Drouin C., Darracq L., Trovero F., Blanc G., Glowinski J., Cotecchia S., Tassin J.P.
    J. Neurosci. 22:2873-2884(2002) [PubMed] [Europe PMC] [Abstract]
  • "Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity."
    Battaglia G., Fornai F., Busceti C.L., Lembo G., Nicoletti F., De Blasi A.
    J. Neurochem. 86:413-421(2003) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells."
    Lindblom J., Petrovska R., Hallberg M., Magnusson K., Nyberg F., Uhlen S.
    Eur. J. Pharmacol. 527:157-162(2005) [PubMed] [Europe PMC] [Abstract]
• response to estrogen Source: RGDInferred from expression patternⁱ
  • "Functional interactions between estrogen and insulin-like growth factor-I in the regulation of alpha 1B-adrenoceptors and female reproductive function."
    Quesada A., Etgen A.M.
    J. Neurosci. 22:2401-2408(2002) [PubMed] [Europe PMC] [Abstract]
• response to hormone Source: RGDInferred from mutant phenotypeⁱ
  • "Adrenaline (via alpha(1B)-adrenoceptors) and ethanol stimulate OH* radical production in isolated rat hepatocytes."
    Castrejon-Sosa M., Villalobos-Molina R., Guinzberg R., Pina E.
    Life Sci. 71:2469-2474(2002) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from sequence orthologyⁱ
  • "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates."
    Drouin C., Darracq L., Trovero F., Blanc G., Glowinski J., Cotecchia S., Tassin J.P.
    J. Neurosci. 22:2873-2884(2002) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from mutant phenotypeⁱ
  • "Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens."
    Campos M., Morais P.d.e. L., Pupo A.S.
    Eur. J. Pharmacol. 471:149-155(2003) [PubMed] [Europe PMC] [Abstract]
• vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: RGDInferred from sequence orthologyⁱ
  • "Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor."
    Cavalli A., Lattion A.L., Hummler E., Nenniger M., Pedrazzini T., Aubert J.F., Michel M.C., Yang M., Lembo G., Vecchione C., Mostardini M., Schmidt A., Beermann F., Cotecchia S.
    Proc. Natl. Acad. Sci. U.S.A. 94:11589-11594(1997) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: RGDInferred from sequence orthologyⁱ
  • "A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities."
    Spreng M., Cotecchia S., Schenk F.
    Neurobiol Learn Mem 75:214-229(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDDNFTGPNQ TSSNSTLPQL DVTRAISVGL 
        60         70         80         90        100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP 
       110        120        130        140        150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 
       160        170        180        190        200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 
       210        220        230        240        250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 
       260        270        280        290        300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
       310        320        330        340        350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 
       360        370        380        390        400
SSKEFKRAFM RILGCQCRGG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS 
       410        420        430        440        450
RKDSLDDSGS CMSGTQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL 
       460        470        480        490        500
LSLPEPPGRR GRLDSGPLFT FKLLGDPESP GTEGDTSNGG CDTTTDLANG 
       510 
QPGFKSNMPL APGHF                                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries