Adra1b

Functionⁱ

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functionⁱ

adrenergic receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
alpha1-adrenergic receptor activity
Source: RGD
Inferred from direct assayⁱ
- 12054611
protein heterodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating adrenergic receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
glucose homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of Rho protein signal transduction
Source: MGI
Inferred from mutant phenotypeⁱ
- 18332105
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: RGD
Inferred from direct assayⁱ
- 12054611
positive regulation of MAPK cascade Source: UniProtKB
positive regulation of smooth muscle contraction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of vasoconstriction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cardiac muscle contraction Source: InterPro
response to drug
Source: RGD
Inferred from expression patternⁱ
- 16309668
response to estrogen
Source: RGD
Inferred from expression patternⁱ
- 11896179
response to hormone
Source: RGD
Inferred from mutant phenotypeⁱ
- 12270752
response to steroid hormone
Source: RGD
Inferred from mutant phenotypeⁱ
- 12818703

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-1B adrenergic receptor Alternative name(s): Alpha-1B adrenoreceptor Short name: Alpha-1B adrenoceptor
Gene namesⁱ	Name:Adra1b
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2054 Adra1b

RGDⁱ

2054 Adra1b

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 45	ExtracellularBy similarityAdd BLAST	45
Transmembraneⁱ	46 – 70	Helical; Name=1By similarityAdd BLAST	25
Topological domainⁱ	71 – 83	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	84 – 105	Helical; Name=2By similarityAdd BLAST	22
Topological domainⁱ	106 – 115	ExtracellularBy similarity	10
Transmembraneⁱ	116 – 141	Helical; Name=3By similarityAdd BLAST	26
Topological domainⁱ	142 – 161	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	162 – 182	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	183 – 201	ExtracellularBy similarityAdd BLAST	19
Transmembraneⁱ	202 – 224	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	225 – 295	CytoplasmicBy similarityAdd BLAST	71
Transmembraneⁱ	296 – 319	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	320 – 326	ExtracellularBy similarity	7
Transmembraneⁱ	327 – 351	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	352 – 515	CytoplasmicBy similarityAdd BLAST	164

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL315
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	23

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069072	1 – 515	Alpha-1B adrenergic receptorAdd BLAST		515

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	118 ↔ 195	PROSITE-ProRule annotation
Modified residueⁱ	264	PhosphothreonineBy similarity	1
Lipidationⁱ	365	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEⁱ	P15823

PRIDEⁱ

P15823

PTM databases

iPTMnetⁱ	P15823
PhosphoSitePlusⁱ	P15823

Interactionⁱ

Subunit structureⁱ

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Drd4	P30729	2	EBI-15185013,EBI-15989078

With

Entry

#Exp.

IntAct

Notes

Drd4

P30729

2

EBI-15185013,EBI-15989078

GO - Molecular functionⁱ

protein heterodimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-59867N
IntActⁱ	P15823, 1 interactor

Chemistry databases

BindingDBⁱ

P15823

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P15823
SMRⁱ	P15823
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	368 – 378	Nuclear localization signalBy similarityAdd BLAST		11

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	371 – 378	Poly-Arg		8

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG106962
InParanoidⁱ	P15823
PhylomeDBⁱ	P15823

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR001115 ADRA1B_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF17 PTHR24248:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00556 ADRENRGCA1BR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P15823-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDDNFTGPNQ TSSNSTLPQL DVTRAISVGL 
        60         70         80         90        100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP 
       110        120        130        140        150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 
       160        170        180        190        200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 
       210        220        230        240        250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 
       260        270        280        290        300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
       310        320        330        340        350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 
       360        370        380        390        400
SSKEFKRAFM RILGCQCRGG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS 
       410        420        430        440        450
RKDSLDDSGS CMSGTQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL 
       460        470        480        490        500
LSLPEPPGRR GRLDSGPLFT FKLLGDPESP GTEGDTSNGG CDTTTDLANG 
       510 
QPGFKSNMPL APGHF

Length:515

Mass (Da):56,586

Last modified:June 1, 1994 - v2

Checksum:ⁱAF0C3759F80C3135

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0G2K564	A0A0G2K564_RAT		Alpha-1B adrenergic receptor Alpha-1B adrenergic receptor	Adra1b	518	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	114 – 116	GRI → LSF in AAA63478 (PubMed:1706716).Curated	3
Sequence conflictⁱ	203	Y → C (PubMed:2156222).Curated	1
Sequence conflictⁱ	203	Y → C (PubMed:7989580).Curated	1
Sequence conflictⁱ	207	S → C (PubMed:2156222).Curated	1
Sequence conflictⁱ	207	S → C (PubMed:7989580).Curated	1
Sequence conflictⁱ	306	C → S in AAA40647 (PubMed:8406017).Curated	1
Sequence conflictⁱ	415 – 416	TQ → QK in CAA35934 (PubMed:2156222).Curated	2
Sequence conflictⁱ	440	C → Y in AAA40647 (PubMed:8406017).Curated	1
Sequence conflictⁱ	484 – 486	GDT → ATA in CAA35934 (PubMed:2156222).Curated	3
Sequence conflictⁱ	493	T → S in AAA40647 (PubMed:8406017).Curated	1
Sequence conflictⁱ	511	A → G in CAA35934 (PubMed:2156222).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51585 mRNA Translation: CAA35934.1 M60655 mRNA Translation: AAA63478.1 L08610, L08609 Genomic DNA Translation: AAA40647.1 D32045 Genomic DNA Translation: BAA06806.1
PIRⁱ	JC1525
UniGeneⁱ	Rn.10032

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2054 rat

UCSCⁱ

RGD:2054 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15823	Alpha-1B adrenergic receptor		MOUSE		514	UniRef90_P97717
Alpha-1B adrenergic receptor		HUMAN		520
Alpha-1B adrenergic receptor		MESAU		515
Alpha-1B adrenergic receptor (Fragment)		CANLF		417
Uncharacterized protein (Fragment)		MACMU		367
+86

Protein	Similar proteins		Species	Score	Length	Source
P15823	Alpha-1B adrenergic receptor		MOUSE		514	UniRef50_P97717
Alpha-1B adrenergic receptor		HUMAN		520
Alpha-1B adrenergic receptor		MESAU		515
Alpha-1B adrenergic receptor (Fragment)		CANLF		417
Uncharacterized protein (Fragment)		MACMU		367
+199

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51585 mRNA Translation: CAA35934.1 M60655 mRNA Translation: AAA63478.1 L08610, L08609 Genomic DNA Translation: AAA40647.1 D32045 Genomic DNA Translation: BAA06806.1
PIRⁱ	JC1525
UniGeneⁱ	Rn.10032

3D structure databases

ProteinModelPortalⁱ	P15823
SMRⁱ	P15823
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-59867N
IntActⁱ	P15823, 1 interactor

Chemistry databases

BindingDBⁱ	P15823
ChEMBLⁱ	CHEMBL315
GuidetoPHARMACOLOGYⁱ	23

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P15823
PhosphoSitePlusⁱ	P15823

Proteomic databases

PRIDEⁱ	P15823

PRIDEⁱ

P15823

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSCⁱ	RGD:2054 rat

UCSCⁱ

RGD:2054 rat

Organism-specific databases

RGDⁱ	2054 Adra1b

Phylogenomic databases

HOVERGENⁱ	HBG106962
InParanoidⁱ	P15823
PhylomeDBⁱ	P15823

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P15823

PROⁱ

PR:P15823

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR001115 ADRA1B_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF17 PTHR24248:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00556 ADRENRGCA1BR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADA1B_RAT
Accessionⁱ	P15823Primary (citable) accession number: P15823 Secondary accession number(s): Q63215
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P15823 (ADA1B_RAT)

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Alpha-1B adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma membrane

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ