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Protein

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha1-adrenergic receptor activity Source: RGD
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:Adra1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2054 Adra1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
Transmembranei46 – 70Helical; Name=1By similarityAdd BLAST25
Topological domaini71 – 83CytoplasmicBy similarityAdd BLAST13
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 115ExtracellularBy similarity10
Transmembranei116 – 141Helical; Name=3By similarityAdd BLAST26
Topological domaini142 – 161CytoplasmicBy similarityAdd BLAST20
Transmembranei162 – 182Helical; Name=4By similarityAdd BLAST21
Topological domaini183 – 201ExtracellularBy similarityAdd BLAST19
Transmembranei202 – 224Helical; Name=5By similarityAdd BLAST23
Topological domaini225 – 295CytoplasmicBy similarityAdd BLAST71
Transmembranei296 – 319Helical; Name=6By similarityAdd BLAST24
Topological domaini320 – 326ExtracellularBy similarity7
Transmembranei327 – 351Helical; Name=7By similarityAdd BLAST25
Topological domaini352 – 515CytoplasmicBy similarityAdd BLAST164

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL315
GuidetoPHARMACOLOGYi23

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690721 – 515Alpha-1B adrenergic receptorAdd BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Modified residuei264PhosphothreonineBy similarity1
Lipidationi365S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiP15823

PTM databases

iPTMnetiP15823
PhosphoSitePlusiP15823

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Drd4P307292EBI-15185013,EBI-15989078

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59867N
IntActiP15823, 1 interactor

Chemistry databases

BindingDBiP15823

Structurei

3D structure databases

ProteinModelPortaliP15823
SMRiP15823
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi368 – 378Nuclear localization signalBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi371 – 378Poly-Arg8

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962
InParanoidiP15823
PhylomeDBiP15823

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001115 ADRA1B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17 PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00556 ADRENRGCA1BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P15823-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDDNFTGPNQ TSSNSTLPQL DVTRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP
110 120 130 140 150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFM RILGCQCRGG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS
410 420 430 440 450
RKDSLDDSGS CMSGTQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL
460 470 480 490 500
LSLPEPPGRR GRLDSGPLFT FKLLGDPESP GTEGDTSNGG CDTTTDLANG
510
QPGFKSNMPL APGHF
Length:515
Mass (Da):56,586
Last modified:June 1, 1994 - v2
Checksum:iAF0C3759F80C3135
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K564A0A0G2K564_RAT
Alpha-1B adrenergic receptor
Adra1b
518Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 116GRI → LSF in AAA63478 (PubMed:1706716).Curated3
Sequence conflicti203Y → C (PubMed:2156222).Curated1
Sequence conflicti203Y → C (PubMed:7989580).Curated1
Sequence conflicti207S → C (PubMed:2156222).Curated1
Sequence conflicti207S → C (PubMed:7989580).Curated1
Sequence conflicti306C → S in AAA40647 (PubMed:8406017).Curated1
Sequence conflicti415 – 416TQ → QK in CAA35934 (PubMed:2156222).Curated2
Sequence conflicti440C → Y in AAA40647 (PubMed:8406017).Curated1
Sequence conflicti484 – 486GDT → ATA in CAA35934 (PubMed:2156222).Curated3
Sequence conflicti493T → S in AAA40647 (PubMed:8406017).Curated1
Sequence conflicti511A → G in CAA35934 (PubMed:2156222).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51585 mRNA Translation: CAA35934.1
M60655 mRNA Translation: AAA63478.1
L08610, L08609 Genomic DNA Translation: AAA40647.1
D32045 Genomic DNA Translation: BAA06806.1
PIRiJC1525
UniGeneiRn.10032

Genome annotation databases

UCSCiRGD:2054 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51585 mRNA Translation: CAA35934.1
M60655 mRNA Translation: AAA63478.1
L08610, L08609 Genomic DNA Translation: AAA40647.1
D32045 Genomic DNA Translation: BAA06806.1
PIRiJC1525
UniGeneiRn.10032

3D structure databases

ProteinModelPortaliP15823
SMRiP15823
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59867N
IntActiP15823, 1 interactor

Chemistry databases

BindingDBiP15823
ChEMBLiCHEMBL315
GuidetoPHARMACOLOGYi23

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP15823
PhosphoSitePlusiP15823

Proteomic databases

PRIDEiP15823

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2054 rat

Organism-specific databases

RGDi2054 Adra1b

Phylogenomic databases

HOVERGENiHBG106962
InParanoidiP15823
PhylomeDBiP15823

Miscellaneous databases

PROiPR:P15823

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001115 ADRA1B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17 PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00556 ADRENRGCA1BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA1B_RAT
AccessioniPrimary (citable) accession number: P15823
Secondary accession number(s): Q63215
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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