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UniProtKB - P15822 (ZEP1_HUMAN)

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Protein

Zinc finger protein 40

Gene

HIVEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Protein family/group databases

MoonDBiP15822 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 40
Alternative name(s):
Cirhin interaction protein
Short name:
CIRIP
Gate keeper of apoptosis-activating protein
Short name:
GAAP
Human immunodeficiency virus type I enhancer-binding protein 1
Short name:
HIV-EP1
Major histocompatibility complex-binding protein 1
Short name:
MBP-1
Positive regulatory domain II-binding factor 1
Short name:
PRDII-BF1
Gene namesi
Name:HIVEP1
Synonyms:ZNF40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000095951.16
HGNCiHGNC:4920 HIVEP1
MIMi194540 gene
neXtProtiNX_P15822

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3096
MalaCardsiHIVEP1
PharmGKBiPA29297

Chemistry databases

ChEMBLiCHEMBL2909

Polymorphism and mutation databases

BioMutaiHIVEP1
DMDMi254763385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473691 – 2718Zinc finger protein 40Add BLAST2718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1268PhosphothreonineCombined sources1
Modified residuei1735PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1884PhosphoserineCombined sources1
Modified residuei2033PhosphoserineCombined sources1
Modified residuei2327PhosphoserineCombined sources1
Modified residuei2599PhosphoserineCombined sources1
Modified residuei2669PhosphoserineCombined sources1
Modified residuei2682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP15822
MaxQBiP15822
PaxDbiP15822
PeptideAtlasiP15822
PRIDEiP15822
ProteomicsDBi53225
53226 [P15822-2]
53227 [P15822-3]

PTM databases

iPTMnetiP15822
PhosphoSitePlusiP15822

Expressioni

Inductioni

By mitogens and phorbol ester.

Gene expression databases

BgeeiENSG00000095951
CleanExiHS_HIVEP1
ExpressionAtlasiP15822 baseline and differential
GenevisibleiP15822 HS

Organism-specific databases

HPAiHPA050724

Interactioni

Subunit structurei

Interacts with UTP4.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109343, 50 interactors
ELMiP15822
IntActiP15822, 79 interactors
MINTiP15822
STRINGi9606.ENSP00000368698

Structurei

Secondary structure

12718
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2091 – 2093Combined sources3
Helixi2100 – 2109Combined sources10
Beta strandi2119 – 2122Combined sources4
Beta strandi2124 – 2127Combined sources4
Helixi2128 – 2136Combined sources9
Beta strandi2137 – 2140Combined sources4

3D structure databases

ProteinModelPortaliP15822
SMRiP15822
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15822

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi803 – 806Poly-Ser4

Domaini

Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000169307
HOVERGENiHBG018160
InParanoidiP15822
KOiK09239
OrthoDBiEOG091G003C
PhylomeDBiP15822
TreeFamiTF331837

Family and domain databases

InterProiView protein in InterPro
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15822-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR 
        60         70         80         90        100
KKIVAENHLK KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI 
       110        120        130        140        150
PVKNGKQFTK QNGETPGIIA EASKSEESVS PKKPLFLQQP SELRRWRSEG 
       160        170        180        190        200
ADPAKFSDLD EQCDSSSLSS KTRTDNSECI SSHCGTTSPS YTNTAFDVLL 
       210        220        230        240        250
KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS MDAPNQTSQE 
       260        270        280        290        300
LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ 
       310        320        330        340        350
LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ 
       360        370        380        390        400
QMDSASPLSI SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP 
       410        420        430        440        450
KKQGKYICEY CNRACAKPSV LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY 
       460        470        480        490        500
KHKKSHAHTI KLGLVLQPDA GGLFLSHESP KALSIHSDVE DSGESEEEGA 
       510        520        530        540        550
TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN VIGDFLLQDR 
       560        570        580        590        600
SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN 
       610        620        630        640        650
VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ 
       660        670        680        690        700
ATDYSQEQQG KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE 
       710        720        730        740        750
QDSGRSNGPS AALVTTSTPS ALPTGEKALL LPGQMRPPLA TKTLEERISK 
       760        770        780        790        800
LISDNEALVD DKQLDSVKPR RTSLSRRGSI DSPKSYIFKD SFQFDLKPVG 
       810        820        830        840        850
RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN SMPTTGYSAV 
       860        870        880        890        900
PANIIPPPHP LRGSQSFDDK IGTFYDDVFV SGPNAPVPQS GHPRTLVRQA 
       910        920        930        940        950
AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK 
       960        970        980        990       1000
SHQGRGTMFE CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS 
      1010       1020       1030       1040       1050
PVPGGLQPQI LHYRVAGSSG IWEQTPQIRK RRKMKSVGDD EELQQNESGT 
      1060       1070       1080       1090       1100
SPKSSEGLQF QNALGCNPSL PKHNVTIRSD QQHKNIQLQN SHIHLVARGP 
      1110       1120       1130       1140       1150
EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN SLSRPNSFDK 
      1160       1170       1180       1190       1200
PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD 
      1210       1220       1230       1240       1250
ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ 
      1260       1270       1280       1290       1300
CHDQEKSEKF SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS 
      1310       1320       1330       1340       1350
TLSRSLSRES SLSHTSSFSA SLDIEDVSKT EASPKIDFLN KAEFLMIPAG 
      1360       1370       1380       1390       1400
LNTLNVPGCH REMRRTASEQ INCTQTSMEV SDLRSKSFDC GSITPPQTTP 
      1410       1420       1430       1440       1450
LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD SHLSPVHPTS 
      1460       1470       1480       1490       1500
FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS 
      1510       1520       1530       1540       1550
TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS 
      1560       1570       1580       1590       1600
KSEDCFAPKY QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT 
      1610       1620       1630       1640       1650
LPTKLIDSMS NSHPLLPPEL RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA 
      1660       1670       1680       1690       1700
TLTSLPQILV TQDLPNQPIC QTNHSVVPIS EEQNSVPTLQ KGHQNALPNP 
      1710       1720       1730       1740       1750
EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES SASSKRMLSP 
      1760       1770       1780       1790       1800
ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR 
      1810       1820       1830       1840       1850
QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE 
      1860       1870       1880       1890       1900
PISELQEFEN IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV 
      1910       1920       1930       1940       1950
KNQGDKVNIQ EQSQQPVTSL SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ 
      1960       1970       1980       1990       2000
KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL PTKVALALLN SKQNTGKSLY 
      2010       2020       2030       2040       2050
CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN KDASEINSEQ 
      2060       2070       2080       2090       2100
DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP 
      2110       2120       2130       2140       2150
SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS 
      2160       2170       2180       2190       2200
VGLIDEQDTE ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE 
      2210       2220       2230       2240       2250
SVLSATPSVT ASPQHLPSRS SLQDPVSTDE DVRITDCFSG VHTDPMDVLP 
      2260       2270       2280       2290       2300
RALLTRMTVL STAQSDYNRK TLSPGKARQR AARDENDTIP SVDTSRSPCH 
      2310       2320       2330       2340       2350
QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH SPQTAAGMPS 
      2360       2370       2380       2390       2400
VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP 
      2410       2420       2430       2440       2450
VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG 
      2460       2470       2480       2490       2500
TTNPAGVAEL SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG 
      2510       2520       2530       2540       2550
LANTNMAPQV HPPGLALNAV GLQVLTANPS SQSSPAPQAH IPGLQILNIA 
      2560       2570       2580       2590       2600
LPTLIPSVSQ VAVDAQGAPE MPASQSKACE TQPKQTSVAS ANQVSRTESP 
      2610       2620       2630       2640       2650
QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS ANHVKPKPEL 
      2660       2670       2680       2690       2700
TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV 
      2710 
HFSDVSSDDD EDRLVIAT
Length:2,718
Mass (Da):296,865
Last modified:July 28, 2009 - v3
Checksum:i64C1C1CF06AC25ED
GO
Isoform 2 (identifier: P15822-2) [UniParc]FASTAAdd to basket
Also known as: Delta 2, GAAP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-2017: Missing.
     2018-2024: KWKSSLS → MGQKFQK

Show »
Length:701
Mass (Da):75,714
Checksum:i001EB17FE50AC810
GO
Isoform 3 (identifier: P15822-3) [UniParc]FASTAAdd to basket
Also known as: GAAP-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-2002: Missing.
     2003-2024: AITTHSKSDLLVYSSKWKSSLS → MGQKFQKKSYRLVLKELRNPLL

Show »
Length:716
Mass (Da):77,538
Checksum:i1F340537E16FCFF1
GO

Sequence cautioni

The sequence CAA35798 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAH73909 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH73982 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14768 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21070 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti515P → N in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1227V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1436N → G in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1660V → E in AAA17534 (PubMed:2108316).Curated1
Sequence conflicti1883I → L in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2067F → C in AAV85766 (Ref. 6) Curated1
Sequence conflicti2080V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2149V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2388S → P in AAV85766 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057383187T → M. Corresponds to variant dbSNP:rs2228209Ensembl.1
Natural variantiVAR_057384362P → L. Corresponds to variant dbSNP:rs34221818Ensembl.1
Natural variantiVAR_057385716T → A. Corresponds to variant dbSNP:rs2228210Ensembl.1
Natural variantiVAR_057386828V → I. Corresponds to variant dbSNP:rs2228218Ensembl.1
Natural variantiVAR_057387873T → A2 PublicationsCorresponds to variant dbSNP:rs6900196Ensembl.1
Natural variantiVAR_0573881074N → S1 PublicationCorresponds to variant dbSNP:rs2228220EnsemblClinVar.1
Natural variantiVAR_0573891170K → N1 PublicationCorresponds to variant dbSNP:rs34258344Ensembl.1
Natural variantiVAR_0573901520A → G1 PublicationCorresponds to variant dbSNP:rs2228212EnsemblClinVar.1
Natural variantiVAR_0573911609M → I1 PublicationCorresponds to variant dbSNP:rs2228213Ensembl.1
Natural variantiVAR_0573921915Q → R1 PublicationCorresponds to variant dbSNP:rs1126472EnsemblClinVar.1
Natural variantiVAR_0598922444T → M. Corresponds to variant dbSNP:rs2228214Ensembl.1
Natural variantiVAR_0598932692A → G2 PublicationsCorresponds to variant dbSNP:rs1042054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377141 – 2017Missing in isoform 2. 1 PublicationAdd BLAST2017
Alternative sequenceiVSP_0377151 – 2002Missing in isoform 3. 1 PublicationAdd BLAST2002
Alternative sequenceiVSP_0377162003 – 2024AITTH…KSSLS → MGQKFQKKSYRLVLKELRNP LL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0377172018 – 2024KWKSSLS → MGQKFQK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51435 mRNA Translation: CAA35798.1 Frameshift.
AL391828
, AL137221, AL157373, Z98050 Genomic DNA Translation: CAH73909.1 Sequence problems.
AL157373
, AL137221, AL391828, Z98050 Genomic DNA Translation: CAH73982.1 Sequence problems.
AL137221
, AL157373, AL391828, Z98050 Genomic DNA Translation: CAI14768.1 Sequence problems.
Z98050
, AL137221, AL157373, AL391828 Genomic DNA Translation: CAI21070.1 Sequence problems.
BC140816 mRNA Translation: AAI40817.1
M32019 mRNA Translation: AAA17534.1
AY673640 mRNA Translation: AAV85766.1
CCDSiCCDS43426.1 [P15822-1]
PIRiA34203
RefSeqiNP_002105.3, NM_002114.3
UniGeneiHs.567284

Genome annotation databases

EnsembliENST00000379388; ENSP00000368698; ENSG00000095951
GeneIDi3096
KEGGihsa:3096
UCSCiuc003nac.4 human [P15822-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZEP1_HUMAN
AccessioniPrimary (citable) accession number: P15822
Secondary accession number(s): B2RTU3
, Q14122, Q5MPB1, Q5VW60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: July 18, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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