UniProtKB - P15822 (ZEP1_HUMAN)
Protein
Zinc finger protein 40
Gene
HIVEP1
Organism
Homo sapiens (Human)
Status
Functioni
This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 406 – 428 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 956 – 986 | CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 2088 – 2110 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 2116 – 2140 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- BMP signaling pathway Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P15822 |
Protein family/group databases
MoonDBi | P15822, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 40Alternative name(s): Cirhin interaction protein Short name: CIRIP Gate keeper of apoptosis-activating protein Short name: GAAP Human immunodeficiency virus type I enhancer-binding protein 1 Short name: HIV-EP1 Major histocompatibility complex-binding protein 1 Short name: MBP-1 Positive regulatory domain II-binding factor 1 Short name: PRDII-BF1 |
Gene namesi | Name:HIVEP1 Synonyms:ZNF40 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000095951.16 |
HGNCi | HGNC:4920, HIVEP1 |
MIMi | 194540, gene |
neXtProti | NX_P15822 |
Subcellular locationi
Nucleus
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3096 |
MalaCardsi | HIVEP1 |
PharmGKBi | PA29297 |
Miscellaneous databases
Pharosi | P15822, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2909 |
Polymorphism and mutation databases
BioMutai | HIVEP1 |
DMDMi | 254763385 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047369 | 1 – 2718 | Zinc finger protein 40Add BLAST | 2718 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources | 1 | |
Modified residuei | 429 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 476 | PhosphoserineCombined sources | 1 | |
Modified residuei | 479 | PhosphoserineCombined sources | 1 | |
Modified residuei | 492 | PhosphoserineCombined sources | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 | |
Modified residuei | 571 | PhosphoserineCombined sources | 1 | |
Modified residuei | 577 | PhosphoserineCombined sources | 1 | |
Modified residuei | 670 | PhosphoserineCombined sources | 1 | |
Modified residuei | 681 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1036 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1051 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1091 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1158 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1180 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1268 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1735 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1740 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1749 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1753 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1884 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2033 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2327 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2599 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2669 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2682 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P15822 |
jPOSTi | P15822 |
MassIVEi | P15822 |
MaxQBi | P15822 |
PaxDbi | P15822 |
PeptideAtlasi | P15822 |
PRIDEi | P15822 |
ProteomicsDBi | 53225 [P15822-1] 53226 [P15822-2] 53227 [P15822-3] |
PTM databases
GlyConnecti | 2896, 1 O-Linked glycan (1 site) |
iPTMneti | P15822 |
PhosphoSitePlusi | P15822 |
Expressioni
Inductioni
By mitogens and phorbol ester.
Gene expression databases
Bgeei | ENSG00000095951, Expressed in calcaneal tendon and 228 other tissues |
ExpressionAtlasi | P15822, baseline and differential |
Genevisiblei | P15822, HS |
Organism-specific databases
HPAi | ENSG00000095951, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with UTP4.
1 PublicationBinary interactionsi
Hide detailsP15822
With | #Exp. | IntAct |
---|---|---|
ATXN1 [P54253] | 6 | EBI-722264,EBI-930964 |
CACNA1A [O00555] | 2 | EBI-722264,EBI-766279 |
UTP4 [Q969X6] | 3 | EBI-722264,EBI-2602591 |
Protein-protein interaction databases
BioGRIDi | 109343, 90 interactors |
ELMi | P15822 |
IntActi | P15822, 87 interactors |
MINTi | P15822 |
STRINGi | 9606.ENSP00000368698 |
Miscellaneous databases
RNActi | P15822, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P15822 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P15822 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 803 – 806 | Poly-Ser | 4 |
Domaini
Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 406 – 428 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 956 – 986 | CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST | 31 | |
Zinc fingeri | 2088 – 2110 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 2116 – 2140 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_000719_2_1_1 |
InParanoidi | P15822 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P15822 |
TreeFami | TF331837 |
Family and domain databases
InterProi | View protein in InterPro IPR034729, ZF_CCHC_HIVEP IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS51811, ZF_CCHC_HIVEP, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P15822-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR
60 70 80 90 100
KKIVAENHLK KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI
110 120 130 140 150
PVKNGKQFTK QNGETPGIIA EASKSEESVS PKKPLFLQQP SELRRWRSEG
160 170 180 190 200
ADPAKFSDLD EQCDSSSLSS KTRTDNSECI SSHCGTTSPS YTNTAFDVLL
210 220 230 240 250
KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS MDAPNQTSQE
260 270 280 290 300
LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ
310 320 330 340 350
LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ
360 370 380 390 400
QMDSASPLSI SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP
410 420 430 440 450
KKQGKYICEY CNRACAKPSV LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY
460 470 480 490 500
KHKKSHAHTI KLGLVLQPDA GGLFLSHESP KALSIHSDVE DSGESEEEGA
510 520 530 540 550
TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN VIGDFLLQDR
560 570 580 590 600
SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN
610 620 630 640 650
VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ
660 670 680 690 700
ATDYSQEQQG KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE
710 720 730 740 750
QDSGRSNGPS AALVTTSTPS ALPTGEKALL LPGQMRPPLA TKTLEERISK
760 770 780 790 800
LISDNEALVD DKQLDSVKPR RTSLSRRGSI DSPKSYIFKD SFQFDLKPVG
810 820 830 840 850
RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN SMPTTGYSAV
860 870 880 890 900
PANIIPPPHP LRGSQSFDDK IGTFYDDVFV SGPNAPVPQS GHPRTLVRQA
910 920 930 940 950
AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK
960 970 980 990 1000
SHQGRGTMFE CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS
1010 1020 1030 1040 1050
PVPGGLQPQI LHYRVAGSSG IWEQTPQIRK RRKMKSVGDD EELQQNESGT
1060 1070 1080 1090 1100
SPKSSEGLQF QNALGCNPSL PKHNVTIRSD QQHKNIQLQN SHIHLVARGP
1110 1120 1130 1140 1150
EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN SLSRPNSFDK
1160 1170 1180 1190 1200
PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD
1210 1220 1230 1240 1250
ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ
1260 1270 1280 1290 1300
CHDQEKSEKF SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS
1310 1320 1330 1340 1350
TLSRSLSRES SLSHTSSFSA SLDIEDVSKT EASPKIDFLN KAEFLMIPAG
1360 1370 1380 1390 1400
LNTLNVPGCH REMRRTASEQ INCTQTSMEV SDLRSKSFDC GSITPPQTTP
1410 1420 1430 1440 1450
LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD SHLSPVHPTS
1460 1470 1480 1490 1500
FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS
1510 1520 1530 1540 1550
TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS
1560 1570 1580 1590 1600
KSEDCFAPKY QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT
1610 1620 1630 1640 1650
LPTKLIDSMS NSHPLLPPEL RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA
1660 1670 1680 1690 1700
TLTSLPQILV TQDLPNQPIC QTNHSVVPIS EEQNSVPTLQ KGHQNALPNP
1710 1720 1730 1740 1750
EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES SASSKRMLSP
1760 1770 1780 1790 1800
ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR
1810 1820 1830 1840 1850
QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE
1860 1870 1880 1890 1900
PISELQEFEN IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV
1910 1920 1930 1940 1950
KNQGDKVNIQ EQSQQPVTSL SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ
1960 1970 1980 1990 2000
KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL PTKVALALLN SKQNTGKSLY
2010 2020 2030 2040 2050
CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN KDASEINSEQ
2060 2070 2080 2090 2100
DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP
2110 2120 2130 2140 2150
SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS
2160 2170 2180 2190 2200
VGLIDEQDTE ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE
2210 2220 2230 2240 2250
SVLSATPSVT ASPQHLPSRS SLQDPVSTDE DVRITDCFSG VHTDPMDVLP
2260 2270 2280 2290 2300
RALLTRMTVL STAQSDYNRK TLSPGKARQR AARDENDTIP SVDTSRSPCH
2310 2320 2330 2340 2350
QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH SPQTAAGMPS
2360 2370 2380 2390 2400
VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP
2410 2420 2430 2440 2450
VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG
2460 2470 2480 2490 2500
TTNPAGVAEL SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG
2510 2520 2530 2540 2550
LANTNMAPQV HPPGLALNAV GLQVLTANPS SQSSPAPQAH IPGLQILNIA
2560 2570 2580 2590 2600
LPTLIPSVSQ VAVDAQGAPE MPASQSKACE TQPKQTSVAS ANQVSRTESP
2610 2620 2630 2640 2650
QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS ANHVKPKPEL
2660 2670 2680 2690 2700
TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV
2710
HFSDVSSDDD EDRLVIAT
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H212 | F5H212_HUMAN | Zinc finger protein 40 | HIVEP1 | 2,717 | Annotation score: | ||
C9JLG1 | C9JLG1_HUMAN | Zinc finger protein 40 | HIVEP1 | 240 | Annotation score: | ||
C9J2N3 | C9J2N3_HUMAN | Zinc finger protein 40 | HIVEP1 | 142 | Annotation score: | ||
C9JAW2 | C9JAW2_HUMAN | Zinc finger protein 40 | HIVEP1 | 128 | Annotation score: | ||
C9JZF8 | C9JZF8_HUMAN | Zinc finger protein 40 | HIVEP1 | 120 | Annotation score: | ||
A0A0D9SFF3 | A0A0D9SFF3_HUMAN | Zinc finger protein 40 | HIVEP1 | 583 | Annotation score: | ||
C9JZV1 | C9JZV1_HUMAN | Zinc finger protein 40 | HIVEP1 | 47 | Annotation score: | ||
H7BYU7 | H7BYU7_HUMAN | Zinc finger protein 40 | HIVEP1 | 43 | Annotation score: |
Sequence cautioni
The sequence CAA35798 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 515 | P → N in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 1227 | V → I in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 1436 | N → G in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 1660 | V → E in AAA17534 (PubMed:2108316).Curated | 1 | |
Sequence conflicti | 1883 | I → L in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 2067 | F → C in AAV85766 (Ref. 6) Curated | 1 | |
Sequence conflicti | 2080 | V → I in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 2149 | V → I in CAA35798 (PubMed:2106471).Curated | 1 | |
Sequence conflicti | 2388 | S → P in AAV85766 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057383 | 187 | T → M. Corresponds to variant dbSNP:rs2228209Ensembl. | 1 | |
Natural variantiVAR_057384 | 362 | P → L. Corresponds to variant dbSNP:rs34221818EnsemblClinVar. | 1 | |
Natural variantiVAR_057385 | 716 | T → A. Corresponds to variant dbSNP:rs2228210Ensembl. | 1 | |
Natural variantiVAR_057386 | 828 | V → I. Corresponds to variant dbSNP:rs2228218EnsemblClinVar. | 1 | |
Natural variantiVAR_057387 | 873 | T → A2 PublicationsCorresponds to variant dbSNP:rs6900196Ensembl. | 1 | |
Natural variantiVAR_057388 | 1074 | N → S1 PublicationCorresponds to variant dbSNP:rs2228220EnsemblClinVar. | 1 | |
Natural variantiVAR_057389 | 1170 | K → N1 PublicationCorresponds to variant dbSNP:rs34258344Ensembl. | 1 | |
Natural variantiVAR_057390 | 1520 | A → G1 PublicationCorresponds to variant dbSNP:rs2228212EnsemblClinVar. | 1 | |
Natural variantiVAR_057391 | 1609 | M → I1 PublicationCorresponds to variant dbSNP:rs2228213Ensembl. | 1 | |
Natural variantiVAR_057392 | 1915 | Q → R1 PublicationCorresponds to variant dbSNP:rs1126472EnsemblClinVar. | 1 | |
Natural variantiVAR_059892 | 2444 | T → M. Corresponds to variant dbSNP:rs2228214EnsemblClinVar. | 1 | |
Natural variantiVAR_059893 | 2692 | A → G2 PublicationsCorresponds to variant dbSNP:rs1042054Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037714 | 1 – 2017 | Missing in isoform 2. 1 PublicationAdd BLAST | 2017 | |
Alternative sequenceiVSP_037715 | 1 – 2002 | Missing in isoform 3. 1 PublicationAdd BLAST | 2002 | |
Alternative sequenceiVSP_037716 | 2003 – 2024 | AITTH…KSSLS → MGQKFQKKSYRLVLKELRNP LL in isoform 3. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_037717 | 2018 – 2024 | KWKSSLS → MGQKFQK in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51435 mRNA Translation: CAA35798.1 Frameshift. AL137221 Genomic DNA No translation available. AL157373 Genomic DNA No translation available. AL391828 Genomic DNA No translation available. Z98050 Genomic DNA No translation available. BC140816 mRNA Translation: AAI40817.1 M32019 mRNA Translation: AAA17534.1 AY673640 mRNA Translation: AAV85766.1 |
CCDSi | CCDS43426.1 [P15822-1] |
PIRi | A34203 |
RefSeqi | NP_002105.3, NM_002114.3 |
Genome annotation databases
Ensembli | ENST00000379388; ENSP00000368698; ENSG00000095951 |
GeneIDi | 3096 |
KEGGi | hsa:3096 |
UCSCi | uc003nac.4, human [P15822-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51435 mRNA Translation: CAA35798.1 Frameshift. AL137221 Genomic DNA No translation available. AL157373 Genomic DNA No translation available. AL391828 Genomic DNA No translation available. Z98050 Genomic DNA No translation available. BC140816 mRNA Translation: AAI40817.1 M32019 mRNA Translation: AAA17534.1 AY673640 mRNA Translation: AAV85766.1 |
CCDSi | CCDS43426.1 [P15822-1] |
PIRi | A34203 |
RefSeqi | NP_002105.3, NM_002114.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BBO | NMR | - | A | 2087-2143 | [»] | |
3ZNF | NMR | - | A | 2114-2143 | [»] | |
4ZNF | NMR | - | A | 2114-2143 | [»] | |
SMRi | P15822 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109343, 90 interactors |
ELMi | P15822 |
IntActi | P15822, 87 interactors |
MINTi | P15822 |
STRINGi | 9606.ENSP00000368698 |
Chemistry databases
ChEMBLi | CHEMBL2909 |
Protein family/group databases
MoonDBi | P15822, Predicted |
PTM databases
GlyConnecti | 2896, 1 O-Linked glycan (1 site) |
iPTMneti | P15822 |
PhosphoSitePlusi | P15822 |
Polymorphism and mutation databases
BioMutai | HIVEP1 |
DMDMi | 254763385 |
Proteomic databases
EPDi | P15822 |
jPOSTi | P15822 |
MassIVEi | P15822 |
MaxQBi | P15822 |
PaxDbi | P15822 |
PeptideAtlasi | P15822 |
PRIDEi | P15822 |
ProteomicsDBi | 53225 [P15822-1] 53226 [P15822-2] 53227 [P15822-3] |
Protocols and materials databases
Antibodypediai | 24904, 33 antibodies |
Genome annotation databases
Ensembli | ENST00000379388; ENSP00000368698; ENSG00000095951 |
GeneIDi | 3096 |
KEGGi | hsa:3096 |
UCSCi | uc003nac.4, human [P15822-1] |
Organism-specific databases
CTDi | 3096 |
DisGeNETi | 3096 |
EuPathDBi | HostDB:ENSG00000095951.16 |
GeneCardsi | HIVEP1 |
HGNCi | HGNC:4920, HIVEP1 |
HPAi | ENSG00000095951, Low tissue specificity |
MalaCardsi | HIVEP1 |
MIMi | 194540, gene |
neXtProti | NX_P15822 |
PharmGKBi | PA29297 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
HOGENOMi | CLU_000719_2_1_1 |
InParanoidi | P15822 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P15822 |
TreeFami | TF331837 |
Enzyme and pathway databases
PathwayCommonsi | P15822 |
Miscellaneous databases
BioGRID-ORCSi | 3096, 4 hits in 866 CRISPR screens |
ChiTaRSi | HIVEP1, human |
EvolutionaryTracei | P15822 |
GeneWikii | HIVEP1 |
GenomeRNAii | 3096 |
Pharosi | P15822, Tbio |
PROi | PR:P15822 |
RNActi | P15822, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000095951, Expressed in calcaneal tendon and 228 other tissues |
ExpressionAtlasi | P15822, baseline and differential |
Genevisiblei | P15822, HS |
Family and domain databases
InterProi | View protein in InterPro IPR034729, ZF_CCHC_HIVEP IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS51811, ZF_CCHC_HIVEP, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZEP1_HUMAN | |
Accessioni | P15822Primary (citable) accession number: P15822 Secondary accession number(s): B2RTU3 Q5VW60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 207 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations