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Protein

Zinc finger protein 40

Gene

HIVEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P15822 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 40
Alternative name(s):
Cirhin interaction protein
Short name:
CIRIP
Gate keeper of apoptosis-activating protein
Short name:
GAAP
Human immunodeficiency virus type I enhancer-binding protein 1
Short name:
HIV-EP1
Major histocompatibility complex-binding protein 1
Short name:
MBP-1
Positive regulatory domain II-binding factor 1
Short name:
PRDII-BF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIVEP1
Synonyms:ZNF40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000095951.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4920 HIVEP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194540 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15822

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3096

MalaCards human disease database

More...
MalaCardsi
HIVEP1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29297

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2909

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HIVEP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763385

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473691 – 2718Zinc finger protein 40Add BLAST2718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1268PhosphothreonineCombined sources1
Modified residuei1735PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1884PhosphoserineCombined sources1
Modified residuei2033PhosphoserineCombined sources1
Modified residuei2327PhosphoserineCombined sources1
Modified residuei2599PhosphoserineCombined sources1
Modified residuei2669PhosphoserineCombined sources1
Modified residuei2682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P15822

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P15822

MaxQB - The MaxQuant DataBase

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MaxQBi
P15822

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15822

PeptideAtlas

More...
PeptideAtlasi
P15822

PRoteomics IDEntifications database

More...
PRIDEi
P15822

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53225
53226 [P15822-2]
53227 [P15822-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P15822

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P15822

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mitogens and phorbol ester.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095951 Expressed in 218 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...
CleanExi
HS_HIVEP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15822 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P15822 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050724

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UTP4.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109343, 51 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P15822

Protein interaction database and analysis system

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IntActi
P15822, 79 interactors

Molecular INTeraction database

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MINTi
P15822

STRING: functional protein association networks

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STRINGi
9606.ENSP00000368698

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12718
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBONMR-A2087-2143[»]
3ZNFNMR-A2114-2143[»]
4ZNFNMR-A2114-2143[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P15822

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P15822

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P15822

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi803 – 806Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169307

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018160

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15822

KEGG Orthology (KO)

More...
KOi
K09239

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15822

TreeFam database of animal gene trees

More...
TreeFami
TF331837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P15822-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR
60 70 80 90 100
KKIVAENHLK KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI
110 120 130 140 150
PVKNGKQFTK QNGETPGIIA EASKSEESVS PKKPLFLQQP SELRRWRSEG
160 170 180 190 200
ADPAKFSDLD EQCDSSSLSS KTRTDNSECI SSHCGTTSPS YTNTAFDVLL
210 220 230 240 250
KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS MDAPNQTSQE
260 270 280 290 300
LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ
310 320 330 340 350
LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ
360 370 380 390 400
QMDSASPLSI SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP
410 420 430 440 450
KKQGKYICEY CNRACAKPSV LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY
460 470 480 490 500
KHKKSHAHTI KLGLVLQPDA GGLFLSHESP KALSIHSDVE DSGESEEEGA
510 520 530 540 550
TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN VIGDFLLQDR
560 570 580 590 600
SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN
610 620 630 640 650
VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ
660 670 680 690 700
ATDYSQEQQG KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE
710 720 730 740 750
QDSGRSNGPS AALVTTSTPS ALPTGEKALL LPGQMRPPLA TKTLEERISK
760 770 780 790 800
LISDNEALVD DKQLDSVKPR RTSLSRRGSI DSPKSYIFKD SFQFDLKPVG
810 820 830 840 850
RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN SMPTTGYSAV
860 870 880 890 900
PANIIPPPHP LRGSQSFDDK IGTFYDDVFV SGPNAPVPQS GHPRTLVRQA
910 920 930 940 950
AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK
960 970 980 990 1000
SHQGRGTMFE CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS
1010 1020 1030 1040 1050
PVPGGLQPQI LHYRVAGSSG IWEQTPQIRK RRKMKSVGDD EELQQNESGT
1060 1070 1080 1090 1100
SPKSSEGLQF QNALGCNPSL PKHNVTIRSD QQHKNIQLQN SHIHLVARGP
1110 1120 1130 1140 1150
EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN SLSRPNSFDK
1160 1170 1180 1190 1200
PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD
1210 1220 1230 1240 1250
ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ
1260 1270 1280 1290 1300
CHDQEKSEKF SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS
1310 1320 1330 1340 1350
TLSRSLSRES SLSHTSSFSA SLDIEDVSKT EASPKIDFLN KAEFLMIPAG
1360 1370 1380 1390 1400
LNTLNVPGCH REMRRTASEQ INCTQTSMEV SDLRSKSFDC GSITPPQTTP
1410 1420 1430 1440 1450
LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD SHLSPVHPTS
1460 1470 1480 1490 1500
FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS
1510 1520 1530 1540 1550
TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS
1560 1570 1580 1590 1600
KSEDCFAPKY QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT
1610 1620 1630 1640 1650
LPTKLIDSMS NSHPLLPPEL RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA
1660 1670 1680 1690 1700
TLTSLPQILV TQDLPNQPIC QTNHSVVPIS EEQNSVPTLQ KGHQNALPNP
1710 1720 1730 1740 1750
EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES SASSKRMLSP
1760 1770 1780 1790 1800
ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR
1810 1820 1830 1840 1850
QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE
1860 1870 1880 1890 1900
PISELQEFEN IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV
1910 1920 1930 1940 1950
KNQGDKVNIQ EQSQQPVTSL SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ
1960 1970 1980 1990 2000
KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL PTKVALALLN SKQNTGKSLY
2010 2020 2030 2040 2050
CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN KDASEINSEQ
2060 2070 2080 2090 2100
DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP
2110 2120 2130 2140 2150
SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS
2160 2170 2180 2190 2200
VGLIDEQDTE ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE
2210 2220 2230 2240 2250
SVLSATPSVT ASPQHLPSRS SLQDPVSTDE DVRITDCFSG VHTDPMDVLP
2260 2270 2280 2290 2300
RALLTRMTVL STAQSDYNRK TLSPGKARQR AARDENDTIP SVDTSRSPCH
2310 2320 2330 2340 2350
QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH SPQTAAGMPS
2360 2370 2380 2390 2400
VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP
2410 2420 2430 2440 2450
VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG
2460 2470 2480 2490 2500
TTNPAGVAEL SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG
2510 2520 2530 2540 2550
LANTNMAPQV HPPGLALNAV GLQVLTANPS SQSSPAPQAH IPGLQILNIA
2560 2570 2580 2590 2600
LPTLIPSVSQ VAVDAQGAPE MPASQSKACE TQPKQTSVAS ANQVSRTESP
2610 2620 2630 2640 2650
QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS ANHVKPKPEL
2660 2670 2680 2690 2700
TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV
2710
HFSDVSSDDD EDRLVIAT
Length:2,718
Mass (Da):296,865
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64C1C1CF06AC25ED
GO
Isoform 2 (identifier: P15822-2) [UniParc]FASTAAdd to basket
Also known as: Delta 2, GAAP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-2017: Missing.
     2018-2024: KWKSSLS → MGQKFQK

Show »
Length:701
Mass (Da):75,714
Checksum:i001EB17FE50AC810
GO
Isoform 3 (identifier: P15822-3) [UniParc]FASTAAdd to basket
Also known as: GAAP-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-2002: Missing.
     2003-2024: AITTHSKSDLLVYSSKWKSSLS → MGQKFQKKSYRLVLKELRNPLL

Show »
Length:716
Mass (Da):77,538
Checksum:i1F340537E16FCFF1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H212F5H212_HUMAN
Zinc finger protein 40
HIVEP1
2,717Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAW2C9JAW2_HUMAN
Zinc finger protein 40
HIVEP1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2N3C9J2N3_HUMAN
Zinc finger protein 40
HIVEP1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZF8C9JZF8_HUMAN
Zinc finger protein 40
HIVEP1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLG1C9JLG1_HUMAN
Zinc finger protein 40
HIVEP1
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFF3A0A0D9SFF3_HUMAN
Zinc finger protein 40
HIVEP1
583Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYU7H7BYU7_HUMAN
Zinc finger protein 40
HIVEP1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZV1C9JZV1_HUMAN
Zinc finger protein 40
HIVEP1
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA35798 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti515P → N in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1227V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1436N → G in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1660V → E in AAA17534 (PubMed:2108316).Curated1
Sequence conflicti1883I → L in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2067F → C in AAV85766 (Ref. 6) Curated1
Sequence conflicti2080V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2149V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2388S → P in AAV85766 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057383187T → M. Corresponds to variant dbSNP:rs2228209Ensembl.1
Natural variantiVAR_057384362P → L. Corresponds to variant dbSNP:rs34221818Ensembl.1
Natural variantiVAR_057385716T → A. Corresponds to variant dbSNP:rs2228210Ensembl.1
Natural variantiVAR_057386828V → I. Corresponds to variant dbSNP:rs2228218Ensembl.1
Natural variantiVAR_057387873T → A2 PublicationsCorresponds to variant dbSNP:rs6900196Ensembl.1
Natural variantiVAR_0573881074N → S1 PublicationCorresponds to variant dbSNP:rs2228220EnsemblClinVar.1
Natural variantiVAR_0573891170K → N1 PublicationCorresponds to variant dbSNP:rs34258344Ensembl.1
Natural variantiVAR_0573901520A → G1 PublicationCorresponds to variant dbSNP:rs2228212EnsemblClinVar.1
Natural variantiVAR_0573911609M → I1 PublicationCorresponds to variant dbSNP:rs2228213Ensembl.1
Natural variantiVAR_0573921915Q → R1 PublicationCorresponds to variant dbSNP:rs1126472EnsemblClinVar.1
Natural variantiVAR_0598922444T → M. Corresponds to variant dbSNP:rs2228214Ensembl.1
Natural variantiVAR_0598932692A → G2 PublicationsCorresponds to variant dbSNP:rs1042054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377141 – 2017Missing in isoform 2. 1 PublicationAdd BLAST2017
Alternative sequenceiVSP_0377151 – 2002Missing in isoform 3. 1 PublicationAdd BLAST2002
Alternative sequenceiVSP_0377162003 – 2024AITTH…KSSLS → MGQKFQKKSYRLVLKELRNP LL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0377172018 – 2024KWKSSLS → MGQKFQK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51435 mRNA Translation: CAA35798.1 Frameshift.
AL137221 Genomic DNA No translation available.
AL157373 Genomic DNA No translation available.
AL391828 Genomic DNA No translation available.
Z98050 Genomic DNA No translation available.
BC140816 mRNA Translation: AAI40817.1
M32019 mRNA Translation: AAA17534.1
AY673640 mRNA Translation: AAV85766.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43426.1 [P15822-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A34203

NCBI Reference Sequences

More...
RefSeqi
NP_002105.3, NM_002114.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.567284

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379388; ENSP00000368698; ENSG00000095951

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3096

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3096

UCSC genome browser

More...
UCSCi
uc003nac.4 human [P15822-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51435 mRNA Translation: CAA35798.1 Frameshift.
AL137221 Genomic DNA No translation available.
AL157373 Genomic DNA No translation available.
AL391828 Genomic DNA No translation available.
Z98050 Genomic DNA No translation available.
BC140816 mRNA Translation: AAI40817.1
M32019 mRNA Translation: AAA17534.1
AY673640 mRNA Translation: AAV85766.1
CCDSiCCDS43426.1 [P15822-1]
PIRiA34203
RefSeqiNP_002105.3, NM_002114.3
UniGeneiHs.567284

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBONMR-A2087-2143[»]
3ZNFNMR-A2114-2143[»]
4ZNFNMR-A2114-2143[»]
ProteinModelPortaliP15822
SMRiP15822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109343, 51 interactors
ELMiP15822
IntActiP15822, 79 interactors
MINTiP15822
STRINGi9606.ENSP00000368698

Chemistry databases

ChEMBLiCHEMBL2909

Protein family/group databases

MoonDBiP15822 Predicted

PTM databases

iPTMnetiP15822
PhosphoSitePlusiP15822

Polymorphism and mutation databases

BioMutaiHIVEP1
DMDMi254763385

Proteomic databases

EPDiP15822
jPOSTiP15822
MaxQBiP15822
PaxDbiP15822
PeptideAtlasiP15822
PRIDEiP15822
ProteomicsDBi53225
53226 [P15822-2]
53227 [P15822-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379388; ENSP00000368698; ENSG00000095951
GeneIDi3096
KEGGihsa:3096
UCSCiuc003nac.4 human [P15822-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3096
DisGeNETi3096
EuPathDBiHostDB:ENSG00000095951.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HIVEP1
HGNCiHGNC:4920 HIVEP1
HPAiHPA050724
MalaCardsiHIVEP1
MIMi194540 gene
neXtProtiNX_P15822
PharmGKBiPA29297

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000169307
HOVERGENiHBG018160
InParanoidiP15822
KOiK09239
OrthoDBi1318335at2759
PhylomeDBiP15822
TreeFamiTF331837

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HIVEP1 human
EvolutionaryTraceiP15822

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HIVEP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3096

Protein Ontology

More...
PROi
PR:P15822

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095951 Expressed in 218 organ(s), highest expression level in amniotic fluid
CleanExiHS_HIVEP1
ExpressionAtlasiP15822 baseline and differential
GenevisibleiP15822 HS

Family and domain databases

InterProiView protein in InterPro
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZEP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15822
Secondary accession number(s): B2RTU3
, Q14122, Q5MPB1, Q5VW60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: January 16, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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