UniProtKB - P15815 (3LKF_BUNFL)
Protein
Kappa-flavitoxin
Gene
N/A
Organism
Bungarus flaviceps flaviceps (Red-headed krait)
Status
Functioni
Postsynaptic neurotoxin that binds and inhibits neuronal nicotinic acetylcholine receptors (nAChR) with high affinity (IC50<100 nM). Is a selective, and slowly reversible antagonist of alpha-3/CHRNA3-containing and some alpha-4/CHRNA4-containing AChRs.2 Publications
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Kappa-flavitoxin1 PublicationShort name: Kappa-ftx1 Publication Short name: Kappa-fvt Alternative name(s): Long neurotoxin 2 |
Organismi | Bungarus flaviceps flaviceps (Red-headed krait) |
Taxonomic identifieri | 8615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Elapidae › Bungarinae › Bungarus › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093533 | 1 – 66 | Kappa-flavitoxinAdd BLAST | 66 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 21 | By similarity | ||
Disulfide bondi | 14 ↔ 42 | By similarity | ||
Disulfide bondi | 27 ↔ 31 | By similarity | ||
Disulfide bondi | 46 ↔ 58 | By similarity | ||
Disulfide bondi | 59 ↔ 64 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Interactioni
Subunit structurei
Homo- and heterodimer; non-covalently linked.By similarity
Structurei
3D structure databases
ProteinModelPortali | P15815 |
SMRi | P15815 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the snake three-finger toxin family. Long-chain subfamily. Kappa-neurotoxin sub-subfamily.Curated
Phylogenomic databases
HOVERGENi | HBG006553 |
Family and domain databases
CDDi | cd00206 snake_toxin, 1 hit |
InterProi | View protein in InterPro IPR003571 Snake_3FTx IPR018354 Snake_toxin_con_site IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
PROSITEi | View protein in PROSITE PS00272 SNAKE_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P15815-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RTCLISPSST SQTCPKGQDI CFTKAFCDRW CSSRGPVIEQ GCAATCPEFT
60
SRYKSLLCCT TDNCNH
Sequence databases
PIRi | A28644 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A28644 |
3D structure databases
ProteinModelPortali | P15815 |
SMRi | P15815 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Phylogenomic databases
HOVERGENi | HBG006553 |
Family and domain databases
CDDi | cd00206 snake_toxin, 1 hit |
InterProi | View protein in InterPro IPR003571 Snake_3FTx IPR018354 Snake_toxin_con_site IPR035076 Toxin/TOLIP |
Pfami | View protein in Pfam PF00087 Toxin_TOLIP, 1 hit |
PROSITEi | View protein in PROSITE PS00272 SNAKE_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | 3LKF_BUNFL | |
Accessioni | P15815Primary (citable) accession number: P15815 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | November 22, 2017 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families