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Protein

T-cell surface glycoprotein CD1e, membrane-associated

Gene

CD1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1e, membrane-associated
Short name:
hCD1e
Alternative name(s):
R2G1
CD_antigen: CD1e
Cleaved into the following chain:
Gene namesi
Name:CD1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158488.15
HGNCiHGNC:1638 CD1E
MIMi188411 gene
neXtProtiNX_P15812

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi913
OpenTargetsiENSG00000158488
PharmGKBiPA26197

Polymorphism and mutation databases

BioMutaiCD1E
DMDMi254763260

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001458220 – 388T-cell surface glycoprotein CD1e, membrane-associatedAdd BLAST369
PropeptideiPRO_000037978020 – 31Removed in sCD1eAdd BLAST12
ChainiPRO_000037978132 – 388T-cell surface glycoprotein CD1e, solubleAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 285PROSITE-ProRule annotation

Post-translational modificationi

Mono-ubiquitinated.1 Publication
Proteolytically cleaved in late endosomes to yield a soluble form.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP15812
PaxDbiP15812
PeptideAtlasiP15812
PRIDEiP15812
ProteomicsDBi53210
53211 [P15812-10]
53212 [P15812-11]
53213 [P15812-12]
53214 [P15812-2]
53215 [P15812-3]
53216 [P15812-4]
53217 [P15812-5]
53218 [P15812-6]
53219 [P15812-7]
53220 [P15812-8]
53221 [P15812-9]

PTM databases

iPTMnetiP15812
PhosphoSitePlusiP15812

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.1 Publication

Gene expression databases

BgeeiENSG00000158488 Expressed in 96 organ(s), highest expression level in thymus
CleanExiHS_CD1E
ExpressionAtlasiP15812 baseline and differential
GenevisibleiP15812 HS

Organism-specific databases

HPAiHPA057769

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107351, 36 interactors
STRINGi9606.ENSP00000357149

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP15812
SMRiP15812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 301Ig-likeAdd BLAST111

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITU1 Eukaryota
ENOG4111EG6 LUCA
GeneTreeiENSGT00480000042665
HOVERGENiHBG004453
InParanoidiP15812
KOiK06448
OMAiMGANTQD
OrthoDBiEOG091G0H36
PhylomeDBiP15812
TreeFamiTF336723

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (13+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P15812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW
60 70 80 90 100
AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY
110 120 130 140 150
FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF
160 170 180 190 200
QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA
210 220 230 240 250
GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE
260 270 280 290 300
QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH
310 320 330 340 350
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM
360 370 380
GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW
Length:388
Mass (Da):43,626
Last modified:July 28, 2009 - v2
Checksum:iF6503AE9608C6568
GO
Isoform 2 (identifier: P15812-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Show »
Length:376
Mass (Da):42,350
Checksum:i52F553915C2B64C6
GO
Isoform 3 (identifier: P15812-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:290
Mass (Da):32,724
Checksum:i424FE9E60BE8A14C
GO
Isoform 4 (identifier: P15812-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Show »
Length:321
Mass (Da):36,381
Checksum:i89D16362E367AF3F
GO
Isoform 5 (identifier: P15812-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Show »
Length:298
Mass (Da):33,553
Checksum:i1F49C172E6EDCDE0
GO
Isoform 6 (identifier: P15812-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Show »
Length:286
Mass (Da):32,276
Checksum:i87E830F20FD041B0
GO
Isoform 7 (identifier: P15812-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Show »
Length:231
Mass (Da):26,308
Checksum:i453FEB8FE4A34853
GO
Isoform 8 (identifier: P15812-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Show »
Length:199
Mass (Da):22,263
Checksum:i51D51CBAF23FA31E
GO
Isoform 9 (identifier: P15812-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Show »
Length:187
Mass (Da):20,987
Checksum:iDB1402070352AEF8
GO
Isoform 10 (identifier: P15812-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:101
Mass (Da):11,361
Checksum:i41978EA9D317C67E
GO
Isoform 11 (identifier: P15812-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Show »
Length:144
Mass (Da):16,294
Checksum:iD433B9593AE045AB
GO
Isoform 12 (identifier: P15812-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Show »
Length:132
Mass (Da):15,018
Checksum:i146E065421A1E709
GO
Isoform 13 (identifier: P15812-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-119: APQALQSYHL...ASAGQFQLEY → D

Show »
Length:289
Mass (Da):32,303
Checksum:i4377F02F388916F9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y345H0Y345_HUMAN
T-cell surface glycoprotein CD1e, m...
CD1E
60Annotation score:

Sequence cautioni

The sequence CAA33100 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209V → A in BAG64215 (PubMed:14702039).Curated1
Sequence conflicti248E → G in BAG64215 (PubMed:14702039).Curated1

Polymorphismi

Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194 (PubMed:12144626, PubMed:11019917, PubMed:18325888). The sequence shown is that of allele CD1E*01.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05603515G → E. Corresponds to variant dbSNP:rs3180089Ensembl.1
Natural variantiVAR_058324102H → R in allele CD1E*05. 1 PublicationCorresponds to variant dbSNP:rs2873587Ensembl.1
Natural variantiVAR_010191106Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. 3 PublicationsCorresponds to variant dbSNP:rs1065457Ensembl.1
Natural variantiVAR_058325149S → N in allele CD1E*05. 1 PublicationCorresponds to variant dbSNP:rs35116276Ensembl.1
Natural variantiVAR_010192164R → W in allele CD1E*03. 2 PublicationsCorresponds to variant dbSNP:rs199655202Ensembl.1
Natural variantiVAR_010193194L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. 2 PublicationsCorresponds to variant dbSNP:rs200741122Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03770820 – 208Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_04696120 – 119APQAL…FQLEY → D in isoform 13. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_037709119 – 209YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_037710248 – 302Missing in isoform 4, isoform 7, isoform 11 and isoform 12. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_037711268 – 290YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_037712291 – 388Missing in isoform 3 and isoform 10. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_037713334 – 345Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14975 Genomic DNA Translation: CAA33100.1 Sequence problems.
AJ289111 mRNA Translation: CAB93150.1
AJ289112 mRNA Translation: CAB93151.1
AJ289113 mRNA Translation: CAB93152.1
AJ289114 mRNA Translation: CAB93153.1
AJ289115 mRNA Translation: CAB93154.1
AJ289116 mRNA Translation: CAB93155.1
AJ289117 mRNA Translation: CAB93156.1
AJ289118 mRNA Translation: CAB93157.1
AJ289119 mRNA Translation: CAB93158.1
AJ289120 mRNA Translation: CAB93159.1
AJ289121 mRNA Translation: CAB93160.1
AJ289122 mRNA Translation: CAB93161.1
AK303108 mRNA Translation: BAG64215.1
AK311643 mRNA No translation available.
AL121986 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52828.1
CH471121 Genomic DNA Translation: EAW52830.1
CH471121 Genomic DNA Translation: EAW52831.1
CH471121 Genomic DNA Translation: EAW52832.1
CH471121 Genomic DNA Translation: EAW52833.1
CH471121 Genomic DNA Translation: EAW52834.1
CH471121 Genomic DNA Translation: EAW52835.1
CH471121 Genomic DNA Translation: EAW52837.1
CH471121 Genomic DNA Translation: EAW52838.1
CH471121 Genomic DNA Translation: EAW52839.1
CH471121 Genomic DNA Translation: EAW52840.1
AF142669 Genomic DNA Translation: AAD37582.1
AH010757 Genomic DNA Translation: AAK52913.1
AH010758 Genomic DNA Translation: AAK52914.1
AJ251334 Genomic DNA Translation: CAB82829.1
AJ251335 Genomic DNA Translation: CAC07175.1
M14666 Genomic DNA Translation: AAA51937.1
CCDSiCCDS41417.1 [P15812-1]
CCDS41418.1 [P15812-2]
CCDS41419.1 [P15812-4]
CCDS41420.1 [P15812-9]
CCDS41421.1 [P15812-3]
CCDS41422.1 [P15812-10]
CCDS53384.1 [P15812-7]
CCDS53385.1 [P15812-5]
CCDS53386.1 [P15812-6]
CCDS53387.1 [P15812-13]
CCDS53388.1 [P15812-11]
CCDS53389.1 [P15812-12]
CCDS53390.1 [P15812-8]
PIRiS07716 HLHUR2
RefSeqiNP_001036048.1, NM_001042583.2 [P15812-2]
NP_001036049.1, NM_001042584.2 [P15812-3]
NP_001036050.1, NM_001042585.2 [P15812-4]
NP_001036051.1, NM_001042586.2 [P15812-9]
NP_001036052.1, NM_001042587.2 [P15812-10]
NP_001172036.1, NM_001185107.1 [P15812-5]
NP_001172037.1, NM_001185108.1 [P15812-7]
NP_001172039.1, NM_001185110.1 [P15812-12]
NP_001172041.1, NM_001185112.1 [P15812-8]
NP_001172042.1, NM_001185113.1 [P15812-11]
NP_001172043.1, NM_001185114.1 [P15812-13]
NP_001172044.1, NM_001185115.1 [P15812-6]
NP_112155.2, NM_030893.3 [P15812-1]
XP_011508436.1, XM_011510134.2 [P15812-3]
UniGeneiHs.249217

Genome annotation databases

EnsembliENST00000368154; ENSP00000357136; ENSG00000158488 [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488 [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488 [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488 [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488 [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488 [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488 [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488 [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488 [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488 [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488 [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488 [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488 [P15812-8]
GeneIDi913
KEGGihsa:913
UCSCiuc001fry.4 human [P15812-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD1E_HUMAN
AccessioniPrimary (citable) accession number: P15812
Secondary accession number(s): B4DZV3
, E7EP01, Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: September 12, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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