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Protein

T-cell surface glycoprotein CD1e, membrane-associated

Gene

CD1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endogenous lipid antigen binding Source: GO_Central
  • exogenous lipid antigen binding Source: GO_Central
  • lipopeptide binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity
LigandLipid-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-cell surface glycoprotein CD1e, membrane-associated
Short name:
hCD1e
Alternative name(s):
R2G1
CD_antigen: CD1e
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD1E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158488.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1638 CD1E

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
188411 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P15812

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei305 – 325HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
913

Open Targets

More...
OpenTargetsi
ENSG00000158488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26197

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD1E

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763260

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001458220 – 388T-cell surface glycoprotein CD1e, membrane-associatedAdd BLAST369
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000037978020 – 31Removed in sCD1eAdd BLAST12
ChainiPRO_000037978132 – 388T-cell surface glycoprotein CD1e, solubleAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi230 ↔ 285PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Mono-ubiquitinated.1 Publication
Proteolytically cleaved in late endosomes to yield a soluble form.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P15812

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15812

PeptideAtlas

More...
PeptideAtlasi
P15812

PRoteomics IDEntifications database

More...
PRIDEi
P15812

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53210
53211 [P15812-10]
53212 [P15812-11]
53213 [P15812-12]
53214 [P15812-2]
53215 [P15812-3]
53216 [P15812-4]
53217 [P15812-5]
53218 [P15812-6]
53219 [P15812-7]
53220 [P15812-8]
53221 [P15812-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P15812

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P15812

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158488 Expressed in 96 organ(s), highest expression level in thymus

CleanEx database of gene expression profiles

More...
CleanExi
HS_CD1E

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P15812 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15812 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057769

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107351, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357149

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P15812

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15812

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 301Ig-likeAdd BLAST111

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITU1 Eukaryota
ENOG4111EG6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153274

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004453

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15812

KEGG Orthology (KO)

More...
KOi
K06448

Identification of Orthologs from Complete Genome Data

More...
OMAi
MGANTQD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0H36

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P15812

TreeFam database of animal gene trees

More...
TreeFami
TF336723

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P15812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW
60 70 80 90 100
AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY
110 120 130 140 150
FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF
160 170 180 190 200
QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA
210 220 230 240 250
GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE
260 270 280 290 300
QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH
310 320 330 340 350
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM
360 370 380
GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW
Length:388
Mass (Da):43,626
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6503AE9608C6568
GO
Isoform 2 (identifier: P15812-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Show »
Length:376
Mass (Da):42,350
Checksum:i52F553915C2B64C6
GO
Isoform 3 (identifier: P15812-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:290
Mass (Da):32,724
Checksum:i424FE9E60BE8A14C
GO
Isoform 4 (identifier: P15812-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Show »
Length:321
Mass (Da):36,381
Checksum:i89D16362E367AF3F
GO
Isoform 5 (identifier: P15812-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Show »
Length:298
Mass (Da):33,553
Checksum:i1F49C172E6EDCDE0
GO
Isoform 6 (identifier: P15812-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Show »
Length:286
Mass (Da):32,276
Checksum:i87E830F20FD041B0
GO
Isoform 7 (identifier: P15812-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Show »
Length:231
Mass (Da):26,308
Checksum:i453FEB8FE4A34853
GO
Isoform 8 (identifier: P15812-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Show »
Length:199
Mass (Da):22,263
Checksum:i51D51CBAF23FA31E
GO
Isoform 9 (identifier: P15812-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Show »
Length:187
Mass (Da):20,987
Checksum:iDB1402070352AEF8
GO
Isoform 10 (identifier: P15812-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:101
Mass (Da):11,361
Checksum:i41978EA9D317C67E
GO
Isoform 11 (identifier: P15812-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Show »
Length:144
Mass (Da):16,294
Checksum:iD433B9593AE045AB
GO
Isoform 12 (identifier: P15812-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Show »
Length:132
Mass (Da):15,018
Checksum:i146E065421A1E709
GO
Isoform 13 (identifier: P15812-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-119: APQALQSYHL...ASAGQFQLEY → D

Show »
Length:289
Mass (Da):32,303
Checksum:i4377F02F388916F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y345H0Y345_HUMAN
T-cell surface glycoprotein CD1e, m...
CD1E
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA33100 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti209V → A in BAG64215 (PubMed:14702039).Curated1
Sequence conflicti248E → G in BAG64215 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194 (PubMed:12144626, PubMed:11019917, PubMed:18325888). The sequence shown is that of allele CD1E*01.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05603515G → E. Corresponds to variant dbSNP:rs3180089Ensembl.1
Natural variantiVAR_058324102H → R in allele CD1E*05. 1 PublicationCorresponds to variant dbSNP:rs2873587Ensembl.1
Natural variantiVAR_010191106Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. 3 PublicationsCorresponds to variant dbSNP:rs1065457Ensembl.1
Natural variantiVAR_058325149S → N in allele CD1E*05. 1 PublicationCorresponds to variant dbSNP:rs35116276Ensembl.1
Natural variantiVAR_010192164R → W in allele CD1E*03. 2 PublicationsCorresponds to variant dbSNP:rs199655202Ensembl.1
Natural variantiVAR_010193194L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. 2 PublicationsCorresponds to variant dbSNP:rs200741122Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03770820 – 208Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_04696120 – 119APQAL…FQLEY → D in isoform 13. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_037709119 – 209YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_037710248 – 302Missing in isoform 4, isoform 7, isoform 11 and isoform 12. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_037711268 – 290YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_037712291 – 388Missing in isoform 3 and isoform 10. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_037713334 – 345Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14975 Genomic DNA Translation: CAA33100.1 Sequence problems.
AJ289111 mRNA Translation: CAB93150.1
AJ289112 mRNA Translation: CAB93151.1
AJ289113 mRNA Translation: CAB93152.1
AJ289114 mRNA Translation: CAB93153.1
AJ289115 mRNA Translation: CAB93154.1
AJ289116 mRNA Translation: CAB93155.1
AJ289117 mRNA Translation: CAB93156.1
AJ289118 mRNA Translation: CAB93157.1
AJ289119 mRNA Translation: CAB93158.1
AJ289120 mRNA Translation: CAB93159.1
AJ289121 mRNA Translation: CAB93160.1
AJ289122 mRNA Translation: CAB93161.1
AK303108 mRNA Translation: BAG64215.1
AK311643 mRNA No translation available.
AL121986 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52828.1
CH471121 Genomic DNA Translation: EAW52830.1
CH471121 Genomic DNA Translation: EAW52831.1
CH471121 Genomic DNA Translation: EAW52832.1
CH471121 Genomic DNA Translation: EAW52833.1
CH471121 Genomic DNA Translation: EAW52834.1
CH471121 Genomic DNA Translation: EAW52835.1
CH471121 Genomic DNA Translation: EAW52837.1
CH471121 Genomic DNA Translation: EAW52838.1
CH471121 Genomic DNA Translation: EAW52839.1
CH471121 Genomic DNA Translation: EAW52840.1
AF142669 Genomic DNA Translation: AAD37582.1
AH010757 Genomic DNA Translation: AAK52913.1
AH010758 Genomic DNA Translation: AAK52914.1
AJ251334 Genomic DNA Translation: CAB82829.1
AJ251335 Genomic DNA Translation: CAC07175.1
M14666 Genomic DNA Translation: AAA51937.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41417.1 [P15812-1]
CCDS41418.1 [P15812-2]
CCDS41419.1 [P15812-4]
CCDS41420.1 [P15812-9]
CCDS41421.1 [P15812-3]
CCDS41422.1 [P15812-10]
CCDS53384.1 [P15812-7]
CCDS53385.1 [P15812-5]
CCDS53386.1 [P15812-6]
CCDS53387.1 [P15812-13]
CCDS53388.1 [P15812-11]
CCDS53389.1 [P15812-12]
CCDS53390.1 [P15812-8]

Protein sequence database of the Protein Information Resource

More...
PIRi
S07716 HLHUR2

NCBI Reference Sequences

More...
RefSeqi
NP_001036048.1, NM_001042583.2 [P15812-2]
NP_001036049.1, NM_001042584.2 [P15812-3]
NP_001036050.1, NM_001042585.2 [P15812-4]
NP_001036051.1, NM_001042586.2 [P15812-9]
NP_001036052.1, NM_001042587.2 [P15812-10]
NP_001172036.1, NM_001185107.1 [P15812-5]
NP_001172037.1, NM_001185108.1 [P15812-7]
NP_001172039.1, NM_001185110.1 [P15812-12]
NP_001172041.1, NM_001185112.1 [P15812-8]
NP_001172042.1, NM_001185113.1 [P15812-11]
NP_001172043.1, NM_001185114.1 [P15812-13]
NP_001172044.1, NM_001185115.1 [P15812-6]
NP_112155.2, NM_030893.3 [P15812-1]
XP_011508436.1, XM_011510134.2 [P15812-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.249217

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368154; ENSP00000357136; ENSG00000158488 [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488 [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488 [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488 [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488 [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488 [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488 [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488 [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488 [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488 [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488 [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488 [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488 [P15812-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
913

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:913

UCSC genome browser

More...
UCSCi
uc001fry.4 human [P15812-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14975 Genomic DNA Translation: CAA33100.1 Sequence problems.
AJ289111 mRNA Translation: CAB93150.1
AJ289112 mRNA Translation: CAB93151.1
AJ289113 mRNA Translation: CAB93152.1
AJ289114 mRNA Translation: CAB93153.1
AJ289115 mRNA Translation: CAB93154.1
AJ289116 mRNA Translation: CAB93155.1
AJ289117 mRNA Translation: CAB93156.1
AJ289118 mRNA Translation: CAB93157.1
AJ289119 mRNA Translation: CAB93158.1
AJ289120 mRNA Translation: CAB93159.1
AJ289121 mRNA Translation: CAB93160.1
AJ289122 mRNA Translation: CAB93161.1
AK303108 mRNA Translation: BAG64215.1
AK311643 mRNA No translation available.
AL121986 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52828.1
CH471121 Genomic DNA Translation: EAW52830.1
CH471121 Genomic DNA Translation: EAW52831.1
CH471121 Genomic DNA Translation: EAW52832.1
CH471121 Genomic DNA Translation: EAW52833.1
CH471121 Genomic DNA Translation: EAW52834.1
CH471121 Genomic DNA Translation: EAW52835.1
CH471121 Genomic DNA Translation: EAW52837.1
CH471121 Genomic DNA Translation: EAW52838.1
CH471121 Genomic DNA Translation: EAW52839.1
CH471121 Genomic DNA Translation: EAW52840.1
AF142669 Genomic DNA Translation: AAD37582.1
AH010757 Genomic DNA Translation: AAK52913.1
AH010758 Genomic DNA Translation: AAK52914.1
AJ251334 Genomic DNA Translation: CAB82829.1
AJ251335 Genomic DNA Translation: CAC07175.1
M14666 Genomic DNA Translation: AAA51937.1
CCDSiCCDS41417.1 [P15812-1]
CCDS41418.1 [P15812-2]
CCDS41419.1 [P15812-4]
CCDS41420.1 [P15812-9]
CCDS41421.1 [P15812-3]
CCDS41422.1 [P15812-10]
CCDS53384.1 [P15812-7]
CCDS53385.1 [P15812-5]
CCDS53386.1 [P15812-6]
CCDS53387.1 [P15812-13]
CCDS53388.1 [P15812-11]
CCDS53389.1 [P15812-12]
CCDS53390.1 [P15812-8]
PIRiS07716 HLHUR2
RefSeqiNP_001036048.1, NM_001042583.2 [P15812-2]
NP_001036049.1, NM_001042584.2 [P15812-3]
NP_001036050.1, NM_001042585.2 [P15812-4]
NP_001036051.1, NM_001042586.2 [P15812-9]
NP_001036052.1, NM_001042587.2 [P15812-10]
NP_001172036.1, NM_001185107.1 [P15812-5]
NP_001172037.1, NM_001185108.1 [P15812-7]
NP_001172039.1, NM_001185110.1 [P15812-12]
NP_001172041.1, NM_001185112.1 [P15812-8]
NP_001172042.1, NM_001185113.1 [P15812-11]
NP_001172043.1, NM_001185114.1 [P15812-13]
NP_001172044.1, NM_001185115.1 [P15812-6]
NP_112155.2, NM_030893.3 [P15812-1]
XP_011508436.1, XM_011510134.2 [P15812-3]
UniGeneiHs.249217

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S6CX-ray2.90A32-303[»]
ProteinModelPortaliP15812
SMRiP15812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107351, 36 interactors
STRINGi9606.ENSP00000357149

PTM databases

iPTMnetiP15812
PhosphoSitePlusiP15812

Polymorphism and mutation databases

BioMutaiCD1E
DMDMi254763260

Proteomic databases

MaxQBiP15812
PaxDbiP15812
PeptideAtlasiP15812
PRIDEiP15812
ProteomicsDBi53210
53211 [P15812-10]
53212 [P15812-11]
53213 [P15812-12]
53214 [P15812-2]
53215 [P15812-3]
53216 [P15812-4]
53217 [P15812-5]
53218 [P15812-6]
53219 [P15812-7]
53220 [P15812-8]
53221 [P15812-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368154; ENSP00000357136; ENSG00000158488 [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488 [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488 [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488 [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488 [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488 [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488 [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488 [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488 [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488 [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488 [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488 [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488 [P15812-8]
GeneIDi913
KEGGihsa:913
UCSCiuc001fry.4 human [P15812-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
913
DisGeNETi913
EuPathDBiHostDB:ENSG00000158488.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD1E
HGNCiHGNC:1638 CD1E
HPAiHPA057769
MIMi188411 gene
neXtProtiNX_P15812
OpenTargetsiENSG00000158488
PharmGKBiPA26197

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITU1 Eukaryota
ENOG4111EG6 LUCA
GeneTreeiENSGT00940000153274
HOVERGENiHBG004453
InParanoidiP15812
KOiK06448
OMAiMGANTQD
OrthoDBiEOG091G0H36
PhylomeDBiP15812
TreeFamiTF336723

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD1E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
913

Protein Ontology

More...
PROi
PR:P15812

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158488 Expressed in 96 organ(s), highest expression level in thymus
CleanExiHS_CD1E
ExpressionAtlasiP15812 baseline and differential
GenevisibleiP15812 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD1E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15812
Secondary accession number(s): B4DZV3
, E7EP01, Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: December 5, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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