Transcription factor E2-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• bHLH transcription factor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.12

    "Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements."
    Wilson-Rawls J., Rhee J.M., Rawls A.
    J. Biol. Chem. 279:37685-37692(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH TCF15.
  • Ref.18

    "Tcf15 primes pluripotent cells for differentiation."
    Davies O.R., Lin C.Y., Radzisheuskaya A., Zhou X., Taube J., Blin G., Waterhouse A., Smith A.J., Lowell S.
    Cell Rep. 3:472-484(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH TCF15; NEUROD1 AND TWIST1.
  • "Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs."
    Lu J.-R., Richardson J.A., Olson E.N.
    Mech. Dev. 73:23-32(1998) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis."
    Kassouf M.T., Chagraoui H., Vyas P., Porcher C.
    Blood 112:1056-1067(2008) [PubMed] [Europe PMC] [Abstract]
  • "SCL and associated proteins distinguish active from repressive GATA transcription factor complexes."
    Tripic T., Deng W., Cheng Y., Zhang Y., Vakoc C.R., Gregory G.D., Hardison R.C., Blobel G.A.
    Blood 113:2191-2201(2009) [PubMed] [Europe PMC] [Abstract]
• cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2."
    Nakagawa O., Arnold M., Nakagawa M., Hamada H., Shelton J.M., Kusano H., Harris T.M., Childs G., Campbell K.P., Richardson J.A., Nishino I., Olson E.N.
    Genes Dev. 19:2066-2077(2005) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: UniProtKB
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCLInferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements."
    Wilson-Rawls J., Rhee J.M., Rawls A.
    J. Biol. Chem. 279:37685-37692(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH TCF15.
• DNA-binding transcription factor binding Source: UniProtKB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• E-box binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements."
    Wilson-Rawls J., Rhee J.M., Rawls A.
    J. Biol. Chem. 279:37685-37692(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH TCF15.
  • Ref.15

    "E protein dosage influences brain development more than family member identity."
    Ravanpay A.C., Olson J.M.
    J. Neurosci. Res. 86:1472-1481(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NEUROD2, DNA-BINDING, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• identical protein binding Source: MGIInferred from physical interactionⁱ
  • "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway."
    Gazit R., Krizhanovsky V., Ben-Arie N.
    Development 131:903-913(2004) [PubMed] [Europe PMC] [Abstract]
• mitogen-activated protein kinase kinase kinase binding Source: MGI
• PDZ domain binding Source: MGI
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "E protein dosage influences brain development more than family member identity."
    Ravanpay A.C., Olson J.M.
    J. Neurosci. Res. 86:1472-1481(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NEUROD2, DNA-BINDING, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• protein homodimerization activity Source: UniProtKB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter."
    Sigvardsson M., Clark D.R., Fitzsimmons D., Doyle M., Akerblad P., Breslin T., Bilke S., Li R., Yeamans C., Zhang G., Hagman J.
    Mol Cell Biol 22:8539-8551(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
  • "Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex."
    Masui T., Long Q., Beres T.M., Magnuson M.A., MacDonald R.J.
    Genes Dev 21:2629-2643(2007) [PubMed] [Europe PMC] [Abstract]
  • "Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin."
    Lavoie P.L., Budry L., Balsalobre A., Drouin J.
    Mol Endocrinol 22:1647-1657(2008) [PubMed] [Europe PMC] [Abstract]
• transmembrane receptor protein tyrosine kinase activator activity Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• vitamin D response element binding Source: MGI

GO - Biological processⁱ

• B cell lineage commitment Source: UniProtKB
• cell development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J Exp Med 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• erythrocyte differentiation Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]
• gastrulation Source: BHF-UCLInferred from genetic interactionⁱ
  • "HEB and E2A function as SMAD/FOXH1 cofactors."
    Yoon S.J., Wills A.E., Chuong E., Gupta R., Baker J.C.
    Genes Dev 25:1654-1661(2011) [PubMed] [Europe PMC] [Abstract]
• histone H3 acetylation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
• histone H4 acetylation Source: MGIInferred from mutant phenotypeⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
• immunoglobulin V(D)J recombination Source: MGIInferred from mutant phenotypeⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
• lymphocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene."
    Jia J., Dai M., Zhuang Y.
    Eur J Immunol 38:2806-2820(2008) [PubMed] [Europe PMC] [Abstract]
• natural killer cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J Exp Med 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• nervous system development Source: UniProtKB-KW
• Peyer's patch development Source: MGIInferred from genetic interactionⁱ
  • "Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity."
    Boos M.D., Yokota Y., Eberl G., Kee B.L.
    J Exp Med 204:1119-1130(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell proliferation Source: UniProtKB
• positive regulation of cell cycle Source: UniProtKB
• positive regulation of DNA-binding transcription factor activity Source: UniProtKB
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene."
    Jia J., Dai M., Zhuang Y.
    Eur J Immunol 38:2806-2820(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "E protein dosage influences brain development more than family member identity."
    Ravanpay A.C., Olson J.M.
    J. Neurosci. Res. 86:1472-1481(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NEUROD2, DNA-BINDING, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• positive regulation of transcription, DNA-templated Source: MGIInferred from genetic interactionⁱ
  • "Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding."
    McFadden D.G., McAnally J., Richardson J.A., Charite J., Olson E.N.
    Development 129:3077-3088(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]
• protein stabilization Source: MGIInferred from direct assayⁱ
  • "Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1."
    Vinals F., Ventura F.
    J Biol Chem 279:45766-45772(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • Ref.11

    "Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain."
    Heng J.I.T., Tan S.-S.
    J. Biol. Chem. 277:43152-43159(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH RALGAPA1, SUBCELLULAR LOCATION.
  • "Differential cooperation between dHAND and three different E-proteins."
    Murakami M., Kataoka K., Tominaga J., Nakagawa O., Kurihara H.
    Biochem Biophys Res Commun 323:168-174(2004) [PubMed] [Europe PMC] [Abstract]
  • "Netrins and neogenin promote myotube formation."
    Kang J.-S., Yi M.J., Zhang W., Feinleib J.L., Cole F., Krauss R.S.
    J. Cell Biol. 167:493-504(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors."
    Nishiyama A., Xin L., Sharov A.A., Thomas M., Mowrer G., Meyers E., Piao Y., Mehta S., Yee S., Nakatake Y., Stagg C., Sharova L., Correa-Cerro L.S., Bassey U., Hoang H., Kim E., Tapnio R., Qian Y.

    , Dudekula D., Zalzman M., Li M., Falco G., Yang H.T., Lee S.L., Monti M., Stanghellini I., Islam M.N., Nagaraja R., Goldberg I., Wang W., Longo D.L., Schlessinger D., Ko M.S.
    Cell Stem Cell 5:420-433(2009) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells."
    Lazorchak A.S., Schlissel M.S., Zhuang Y.
    Mol Cell Biol 26:810-821(2006) [PubMed] [Europe PMC] [Abstract]
• T cell differentiation in thymus Source: MGIInferred from mutant phenotypeⁱ
  • "E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene."
    Jia J., Dai M., Zhuang Y.
    Eur J Immunol 38:2806-2820(2008) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation."
    Xu Y., Leung C.G., Lee D.C., Kennedy B.K., Crispino J.D.
    Leukemia 20:1261-1269(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bHLH transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.12

    "Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements."
    Wilson-Rawls J., Rhee J.M., Rawls A.
    J. Biol. Chem. 279:37685-37692(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH TCF15.
  • Ref.18

    "Tcf15 primes pluripotent cells for differentiation."
    Davies O.R., Lin C.Y., Radzisheuskaya A., Zhou X., Taube J., Blin G., Waterhouse A., Smith A.J., Lowell S.
    Cell Rep. 3:472-484(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH TCF15; NEUROD1 AND TWIST1.
  • "Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs."
    Lu J.-R., Richardson J.A., Olson E.N.
    Mech. Dev. 73:23-32(1998) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor binding Source: UniProtKB
• identical protein binding Source: MGIInferred from physical interactionⁱ
  • "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway."
    Gazit R., Krizhanovsky V., Ben-Arie N.
    Development 131:903-913(2004) [PubMed] [Europe PMC] [Abstract]
• mitogen-activated protein kinase kinase kinase binding Source: MGI
• PDZ domain binding Source: MGI
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "E protein dosage influences brain development more than family member identity."
    Ravanpay A.C., Olson J.M.
    J. Neurosci. Res. 86:1472-1481(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NEUROD2, DNA-BINDING, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• protein homodimerization activity Source: UniProtKB
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer."
    Dai Y.S., Cserjesi P.
    J Biol Chem 277:12604-12612(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG 
        60         70         80         90        100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG 
       110        120        130        140        150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY 
       160        170        180        190        200
YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA 
       210        220        230        240        250
YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL 
       260        270        280        290        300
APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 
       310        320        330        340        350
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS 
       360        370        380        390        400
PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLSKM EDRLDEAIHV 
       410        420        430        440        450
LRSHAVGTAS DLHGLLPGHG ALTTSFTGPM SLGGRHAGLV GGSHPEEGLT 
       460        470        480        490        500
SGASLLHNHA SLPSQPSSLP DLSQRPPDSY SGLGRAGTTA GASEIKREEK 
       510        520        530        540        550
EDEEIASVAD AEEDKKDLKV PRTRTSPDED EDDLLPPEQK AEREKERRVA 
       560        570        580        590        600
NNARERLRVR DINEAFKELG RMCQLHLSSE KPQTKLLILH QAVAVILSLE 
       610        620        630        640        650
QQVRERNLNP KAACLKRREE EKVSGVVGDP QLALSAAHPG LGEAHNPAGH 

L                                                      

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG 
        60         70         80         90        100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG 
       110        120        130        140        150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY 
       160        170        180        190        200
YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA 
       210        220        230        240        250
YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL 
       260        270        280        290        300
APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 
       310        320        330        340        350
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS 
       360        370        380        390        400
PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLSKM EDRLDEAIHV 
       410        420        430        440        450
LRSHAVGTAS DLHGLLPGHG ALTTSFTGPM SLGGRHAGLV GGSHPEEGLT 
       460        470        480        490        500
SGASLLHNHA SLPSQPSSLP DLSQRPPDSY SGLGRAGTTA GASEIKREEK 
       510        520        530        540        550
EDEEIASVAD AEEDKKDLKV PRTRTSSTDE VLSLEEKDLR DRERRMANNA 
       560        570        580        590        600
RERVRVRDIN EAFRELGRMC QLHLKSDKAQ TKLLILQQAV QVILGLEQQV 
       610        620        630        640 
RERNLNPKAA CLKRREEEKV SGVVGDPQLA LSAAHPGLGE AHNPAGHL   

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references