Tcf3

Functionⁱ

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.1 Publication

GO - Molecular functionⁱ

bHLH transcription factor binding Source: MGI
chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 18550854
- 19011221
DNA binding
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 16673016
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
mitogen-activated protein kinase kinase kinase binding Source: MGI
PDZ domain binding Source: MGI
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 14757642
repressing transcription factor binding Source: MGI
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 12446773
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12446773
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 12446773
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12446773
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcription coactivator activity Source: UniProtKB
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9545521
vitamin D response element binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell lineage commitment Source: UniProtKB
cell development
Source: MGI
Inferred from genetic interactionⁱ
- 17452521
erythrocyte differentiation
Source: MGI
Traceable author statementⁱ
- 16673016
gastrulation
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 21828274
histone H3 acetylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16428437
histone H4 acetylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16428437
immunoglobulin V(D)J recombination
Source: MGI
Inferred from mutant phenotypeⁱ
- 16428437
lymphocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 18958875
natural killer cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17452521
negative regulation of erythrocyte differentiation
Source: MGI
Inferred from direct assayⁱ
- 16673016
negative regulation of transcription by RNA polymerase II Source: MGI
Peyer's patch development
Source: MGI
Inferred from genetic interactionⁱ
- 17452521
positive regulation of B cell proliferation Source: UniProtKB
positive regulation of cell cycle Source: UniProtKB
positive regulation of DNA-binding transcription factor activity Source: UniProtKB
positive regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 18958875
positive regulation of neuron differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
positive regulation of protein tyrosine kinase activity
Source: MGI
Inferred from direct assayⁱ
- 16673016
positive regulation of signaling receptor activity
Source: MGI
Inferred from direct assayⁱ
- 16673016
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 11812799
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 11812799
protein stabilization
Source: MGI
Inferred from direct assayⁱ
- 15322112
regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 19796622
response to drug
Source: MGI
Inferred from mutant phenotypeⁱ
- 16428437
response to lipopolysaccharide
Source: MGI
Inferred from mutant phenotypeⁱ
- 16428437
T cell differentiation in thymus
Source: MGI
Inferred from mutant phenotypeⁱ
- 18958875
transcription, DNA-templated Source: MGI
transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16673016

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375170 CDO in myogenesis R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-MMU-375170 CDO in myogenesis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor E2-alpha Alternative name(s): Immunoglobulin enhancer-binding factor E12/E47 Transcription factor 3 Short name: TCF-3 Transcription factor A1
Gene namesⁱ	Name:Tcf3 Synonyms:Alf2, Me2, Tcfe2a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:98510 Tcf3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127468	1 – 651	Transcription factor E2-alphaAdd BLAST		651

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	135	PhosphoserineBy similarity	1
Modified residueⁱ	140	PhosphoserineBy similarity	1
Modified residueⁱ	353	PhosphothreonineCombined sources	1
Modified residueⁱ	357	PhosphoserineCombined sources	1
Modified residueⁱ	369	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	377	PhosphoserineBy similarity	1
Cross-linkⁱ	496	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	526	PhosphoserineBy similarity	1
Cross-linkⁱ	622	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Isoform E47 (identifier: P15806-2)
Modified residueⁱ	528	PhosphothreonineCombined sources	1
Modified residueⁱ	533	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated following NGF stimulation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P15806
PaxDbⁱ	P15806
PRIDEⁱ	P15806

PTM databases

iPTMnetⁱ	P15806
PhosphoSitePlusⁱ	P15806

Expressionⁱ

Developmental stageⁱ

Expressed during the development of the nervous system.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020167 Expressed in 272 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_ME2 MM_TCF3 MM_TCFE2A
ExpressionAtlasⁱ	P15806 baseline and differential
Genevisibleⁱ	P15806 MM

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with TWIST2. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Isoform E12 interacts with RALGAPA1 and FIGLA. Interacts with EP300. Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Homodimer. Heterodimer. Forms a heterodimer with MYOG; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with PTF1A, TGFB1I1 and UBE2I. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2. Interacts with BHLHA9. Forms a heterodimer with ATOH8; repress transcription of TCF3 and TCF3/NEUROG3 dimer-induced transactivation of E box-dependent promoters.By similarity10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Hand1	Q64279	2	EBI-81370,EBI-81361
Hand2	Q61039	2	EBI-81370,EBI-81388
Id2	P41136	6	EBI-413585,EBI-309167
Tal1	P22091	4	EBI-81370,EBI-8006437

GO - Molecular functionⁱ

bHLH transcription factor binding Source: MGI
mitogen-activated protein kinase kinase kinase binding Source: MGI
PDZ domain binding Source: MGI
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 14757642
repressing transcription factor binding Source: MGI
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 9545521

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204015, 103 interactors
CORUMⁱ	P15806
Database of interacting proteins More...DIPⁱ	DIP-30940N
IntActⁱ	P15806, 15 interactors
Molecular INTeraction database More...MINTⁱ	P15806
STRINGⁱ	10090.ENSMUSP00000100979

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	548 – 574	Combined sources		27
Helixⁱ	585 – 602	Combined sources		18

Show more details

3D structure databases

ProteinModelPortalⁱ	P15806
SMRⁱ	P15806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P15806

EvolutionaryTraceⁱ

P15806

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	546 – 599	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	387 – 422	Leucine-zipperAdd BLAST		36

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046438
HOVERGENⁱ	HBG003854
InParanoidⁱ	P15806
KEGG Orthology (KO) More...KOⁱ	K09063
PhylomeDBⁱ	P15806

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform E12 (identifier: P15806-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG 
        60         70         80         90        100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG 
       110        120        130        140        150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY 
       160        170        180        190        200
YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA 
       210        220        230        240        250
YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL 
       260        270        280        290        300
APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 
       310        320        330        340        350
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS 
       360        370        380        390        400
PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLSKM EDRLDEAIHV 
       410        420        430        440        450
LRSHAVGTAS DLHGLLPGHG ALTTSFTGPM SLGGRHAGLV GGSHPEEGLT 
       460        470        480        490        500
SGASLLHNHA SLPSQPSSLP DLSQRPPDSY SGLGRAGTTA GASEIKREEK 
       510        520        530        540        550
EDEEIASVAD AEEDKKDLKV PRTRTSPDED EDDLLPPEQK AEREKERRVA 
       560        570        580        590        600
NNARERLRVR DINEAFKELG RMCQLHLSSE KPQTKLLILH QAVAVILSLE 
       610        620        630        640        650
QQVRERNLNP KAACLKRREE EKVSGVVGDP QLALSAAHPG LGEAHNPAGH 

L

Length:651

Mass (Da):67,701

Last modified:August 16, 2004 - v2

Checksum:ⁱ7904ABB37B8D39CB

GO

Isoform E47 (identifier: P15806-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
527-598: PDEDEDDLLP...LHQAVAVILS → STDEVLSLEE...LQQAVQVILG

« Hide

        10         20         30         40         50
MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG 
        60         70         80         90        100
LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG 
       110        120        130        140        150
GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY 
       160        170        180        190        200
YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA 
       210        220        230        240        250
YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL 
       260        270        280        290        300
APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT 
       310        320        330        340        350
SGHTPPVSGA AAESLLGTRG TTASSSGDAL GKALASIYSP DHSSNNFSPS 
       360        370        380        390        400
PSTPVGSPQG LPGTSQWPRA GAPSALSPNY DAGLHGLSKM EDRLDEAIHV 
       410        420        430        440        450
LRSHAVGTAS DLHGLLPGHG ALTTSFTGPM SLGGRHAGLV GGSHPEEGLT 
       460        470        480        490        500
SGASLLHNHA SLPSQPSSLP DLSQRPPDSY SGLGRAGTTA GASEIKREEK 
       510        520        530        540        550
EDEEIASVAD AEEDKKDLKV PRTRTSSTDE VLSLEEKDLR DRERRMANNA 
       560        570        580        590        600
RERVRVRDIN EAFRELGRMC QLHLKSDKAQ TKLLILQQAV QVILGLEQQV 
       610        620        630        640 
RERNLNPKAA CLKRREEEKV SGVVGDPQLA LSAAHPGLGE AHNPAGHL

Show »

Length:648

Mass (Da):67,417

Checksum:ⁱ5C1B68DDBF29A93B

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PWE2	E9PWE2_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	653	Annotation score:
E9PVV1	E9PVV1_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	650	Annotation score:
E9PVV2	E9PVV2_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	649	Annotation score:
E9PWE4	E9PWE4_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	648	Annotation score:
E9PWE3	E9PWE3_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	645	Annotation score:
E9PWE5	E9PWE5_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	648	Annotation score:
A0A0R4J011	A0A0R4J011_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	649	Annotation score:
A0A0R4J014	A0A0R4J014_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	652	Annotation score:
F6T941	F6T941_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	638	Annotation score:
D3Z037	D3Z037_MOUSE	Transcription factor E2-alpha Transcription factor E2-alpha	Tcf3	66	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	156	S → N in AAK18618 (PubMed:11309385).Curated	1
Sequence conflictⁱ	164	D → N in AAK18618 (PubMed:11309385).Curated	1
Sequence conflictⁱ	167	L → LA in AAH18260 (PubMed:15489334).Curated	1
Sequence conflictⁱ	294	P → T in BAB30842 (PubMed:16141072).Curated	1
Sequence conflictⁱ	633	A → P in AAH06860 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱ	387	L → LQ1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011354	527 – 598	PDEDE…AVILS → STDEVLSLEEKDLRDRERRM ANNARERVRVRDINEAFREL GRMCQLHLKSDKAQTKLLIL QQAVQVILG in isoform E47. 4 PublicationsAdd BLAST		72

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF352579 mRNA Translation: AAK18618.1 AK017617 mRNA Translation: BAB30842.1 AK038738 mRNA Translation: BAC30118.1 AK156265 mRNA Translation: BAE33647.1 BC006860 mRNA Translation: AAH06860.1 BC018260 mRNA Translation: AAH18260.1 X17500 mRNA Translation: CAA35541.1 D16631 mRNA Translation: BAA04057.1 D16632 mRNA Translation: BAA04058.1 D16633 mRNA Translation: BAA04059.1 D16634 mRNA Translation: BAA04060.1 D16635 mRNA Translation: BAA04061.1 D16636 mRNA Translation: BAA04062.1 D16637 mRNA Translation: BAA04063.1 D16638 mRNA Translation: BAA04064.1 D29919 mRNA Translation: BAA06218.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24022.1 [P15806-2] CCDS48630.1 [P15806-1]
PIRⁱ	S08410
NCBI Reference Sequences More...RefSeqⁱ	NP_001157620.1, NM_001164148.1 NP_001157621.1, NM_001164149.1 [P15806-1] NP_001157623.1, NM_001164151.1 NP_035678.3, NM_011548.4 [P15806-2]
UniGeneⁱ	Mm.3406

Genome annotation databases

Ensemblⁱ	ENSMUST00000105345; ENSMUSP00000100982; ENSMUSG00000020167 [P15806-2] ENSMUST00000105346; ENSMUSP00000100983; ENSMUSG00000020167 [P15806-1]
GeneIDⁱ	21423
KEGGⁱ	mmu:21423
UCSC genome browser More...UCSCⁱ	uc007gdg.2 mouse [P15806-2] uc007gdi.2 mouse [P15806-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P15806	Transcription factor E2-alpha		MESAU		649	UniRef90_P15806
Transcription factor E2-alpha		RAT		649
Transcription factor E2-alpha		MOUSE		653
Transcription factor-like protein (Fragment)		Daphnia magna		148
Transcription factor E2-alpha		CRIGR		643
+54

Protein	Similar proteins		Species	Score	Length	Source
P15806	Transcription factor E2-alpha		MESAU		649	UniRef50_P15806
Transcription factor E2-alpha		RAT		649
Transcription factor E2-alpha		MOUSE		653
Transcription factor-like protein (Fragment)		Daphnia magna		148
Transcription factor E2-alpha		CRIGR		643
+358

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF352579 mRNA Translation: AAK18618.1 AK017617 mRNA Translation: BAB30842.1 AK038738 mRNA Translation: BAC30118.1 AK156265 mRNA Translation: BAE33647.1 BC006860 mRNA Translation: AAH06860.1 BC018260 mRNA Translation: AAH18260.1 X17500 mRNA Translation: CAA35541.1 D16631 mRNA Translation: BAA04057.1 D16632 mRNA Translation: BAA04058.1 D16633 mRNA Translation: BAA04059.1 D16634 mRNA Translation: BAA04060.1 D16635 mRNA Translation: BAA04061.1 D16636 mRNA Translation: BAA04062.1 D16637 mRNA Translation: BAA04063.1 D16638 mRNA Translation: BAA04064.1 D29919 mRNA Translation: BAA06218.1
CCDSⁱ	CCDS24022.1 [P15806-2] CCDS48630.1 [P15806-1]
PIRⁱ	S08410
RefSeqⁱ	NP_001157620.1, NM_001164148.1 NP_001157621.1, NM_001164149.1 [P15806-1] NP_001157623.1, NM_001164151.1 NP_035678.3, NM_011548.4 [P15806-2]
UniGeneⁱ	Mm.3406

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2QL2	X-ray	2.50	A/C	547-606	[»]
ProteinModelPortalⁱ	P15806
SMRⁱ	P15806
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204015, 103 interactors
CORUMⁱ	P15806
DIPⁱ	DIP-30940N
IntActⁱ	P15806, 15 interactors
MINTⁱ	P15806
STRINGⁱ	10090.ENSMUSP00000100979

PTM databases

iPTMnetⁱ	P15806
PhosphoSitePlusⁱ	P15806

Proteomic databases

MaxQBⁱ	P15806
PaxDbⁱ	P15806
PRIDEⁱ	P15806

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000105345; ENSMUSP00000100982; ENSMUSG00000020167 [P15806-2] ENSMUST00000105346; ENSMUSP00000100983; ENSMUSG00000020167 [P15806-1]
GeneIDⁱ	21423
KEGGⁱ	mmu:21423
UCSCⁱ	uc007gdg.2 mouse [P15806-2] uc007gdi.2 mouse [P15806-1]

Organism-specific databases

CTDⁱ	6929
MGIⁱ	MGI:98510 Tcf3

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
GeneTreeⁱ	ENSGT00510000046438
HOVERGENⁱ	HBG003854
InParanoidⁱ	P15806
KOⁱ	K09063
PhylomeDBⁱ	P15806

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375170 CDO in myogenesis R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-MMU-375170 CDO in myogenesis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Miscellaneous databases

ChiTaRSⁱ	Tcf3 mouse
EvolutionaryTraceⁱ	P15806
Protein Ontology More...PROⁱ	PR:P15806
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020167 Expressed in 272 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_ME2 MM_TCF3 MM_TCFE2A
ExpressionAtlasⁱ	P15806 baseline and differential
Genevisibleⁱ	P15806 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFE2_MOUSE
Accessionⁱ	P15806Primary (citable) accession number: P15806 Secondary accession number(s): Q3U153 , Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
	Last sequence update:	August 16, 2004
	Last modified:	September 12, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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Proteomes

Annotation systems

Supporting data

UniProtKB - P15806 (TFE2_MOUSE)

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Transcription factor E2-alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ